Receptors, Antigen, T-Cell

• 

  Subject Areas on Research

  • 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. 
  • 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis. 
  • 4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid inhibits CD3-T cell antigen receptor-stimulated Ca2+ influx in human T lymphocytes. 
  • A T cell-specific transcriptional enhancer within the human T cell receptor delta locus. 
  • A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution. 
  • A core-weighted fitting method for docking atomic structures into low-resolution maps: application to cryo-electron microscopy. 
  • A critical role for the autophagy gene Atg5 in T cell survival and proliferation. 
  • A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production. 
  • A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance. 
  • A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. 
  • A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes. 
  • A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection. 
  • A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression. 
  • A successful unrelated peripheral blood stem cell transplantation with reduced intensity-conditioning regimen in a patient with late-onset purine nucleoside phosphorylase deficiency. 
  • Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation. 
  • Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors. 
  • Activation of decidual invariant natural killer T cells promotes lipopolysaccharide-induced preterm birth. 
  • Adaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs. 
  • Aging is associated with a rapid decline in frequency, alterations in subset composition, and enhanced Th2 response in CD1d-restricted NKT cells from human peripheral blood. 
  • Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. 
  • Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl. 
  • Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice. 
  • Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes. 
  • Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients. 
  • Alternative pathways for the selection of antigen-specific peripheral T cells. 
  • An approach to modelling in immunology. 
  • An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. 
  • An essential role for c-FLIP in the efficient development of mature T lymphocytes. 
  • An expanded role of the tumor suppressor TSC1 in T cell tolerance. 
  • Analysis of clones derived from human CD7+CD4-CD8-CD3- thymocytes. 
  • Analysis of expression of CD2, CD3, and T cell antigen receptor molecules during early human fetal thymic development. 
  • Anti-receptor antibody-induced H-Y-specific delayed-type hypersensitivity responses in nonresponder mice. 
  • Antibodies against the CD44 p80, lymphocyte homing receptor molecule augment human peripheral blood T cell activation. 
  • Antibody valence and induced signal transduction: the role of antibody valence in anti-CD3-induced signal transduction in isolated normal T cells. 
  • Antibody, T-cell and dendritic cell immunotherapy for malignant brain tumors. 
  • Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice. 
  • Antibody-selected mimics of hepatitis C virus hypervariable region 1 activate both primary and memory Th lymphocytes. 
  • Antigen receptor repertoire profiling from RNA-seq data. 
  • Antiretroviral therapy restores diversity in the T-cell receptor Vbeta repertoire of CD4 T-cell subpopulations among human immunodeficiency virus type 1-infected children and adolescents. 
  • Association of CD8(+) T lymphocyte repertoire spreading with the severity of DRESS syndrome. 
  • Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. 
  • Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction. 
  • Astrocyte cytolysis by MHC class II-specific mouse T cell clones. 
  • Autoregulation of Tcr V region epitopes in autoimmune disease. 
  • B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheres. 
  • Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression. 
  • Binding kinetics of superantigen with TCR and MHC class II. 
  • Bone marrow dendritic cell-mediated regulation of TLR and B cell receptor signaling in B cells. 
  • Brain migration disorder and T-cell activation deficiency associated with abnormal signaling through TCR/CD3 complex and hyperactivity of Fyn tyrosine kinase. 
  • CD19-specific CAR T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor are Effective in Patients with PD-L1-positive B-Cell Lymphoma. 
  • CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation. 
  • CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. 
  • CD7+, CD4-, CD8- acute leukemia: a syndrome of malignant pluripotent lymphohematopoietic cells. 
  • CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor. 
  • Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. 
  • Cancer immunotherapy innovator James Allison receives the 2015 Lasker~DeBakey Clinical Medical Research Award. 
  • Cell membrane-anchored and tumor-targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors. 
  • Changes in thymic function with age and during the treatment of HIV infection. 
  • Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci. 
  • Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. 
  • Chronic activation of the kinase IKKβ impairs T cell function and survival. 
  • Clinical and basic implications of dynamic T cell receptor clonotyping in hematopoietic cell transplantation. 
  • Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities. 
  • Cloning of murine splenic T lymphocytes and natural killer (NK) cells on filter paper discs: detection of a novel NK/T phenotype. 
  • Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells. 
  • Computational investigations into the origins of short-term biochemical memory in T cell activation. 
  • Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals. 
  • Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells. 
  • Cooperative enhancement of specificity in a lattice of T cell receptors. 
  • Costimulator dependence of lymphokine secretion by naive and activated CD4+ T lymphocytes from TCR transgenic mice. 
  • Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition. 
  • Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK. 
  • Cutting edge: hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation. 
  • Cyclosporine A inhibits Ca2+-dependent stimulation of the Na+/H+ antiport in human T cells. 
  • Cytochalasins enhance the proliferation of CD4 cells through the CD3-Ti antigen receptor complex or the CD2 molecule through an effect on early events of activation. 
  • Defective T cell development and function in the absence of Abelson kinases. 
  • Deficiency of Mucosal-Associated Invariant T Cells in TCRJα18 Germline Knockout Mice. 
  • Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis. 
  • Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells. 
  • Differential regulation of accessory mitogenic signaling receptors by the T cell antigen receptor. 
  • Differentiation of human T cells. 
  • Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. 
  • Disruption of diacylglycerol metabolism impairs the induction of T cell anergy. 
  • Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. 
  • Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion. 
  • Diversity and organization of human T cell receptor delta variable gene segments. 
  • Donor Allospecific CD44high Central Memory T Cells Have Decreased Ability to Mediate Graft-vs.-Host Disease. 
  • Donor type natural killer cells after haploidentical T cell-depleted bone marrow stem cell transplantation in a patient with adenosine deaminase-deficient severe combined immunodeficiency. 
  • Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation. 
  • Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. 
  • E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex. 
  • EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss. 
  • EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma. 
  • Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment. 
  • Effect of vasoactive intestinal peptide (VIP) on cytokine production and expression of VIP receptors in thymocyte subsets. 
  • Efficient Culture of Human Naive and Memory B Cells for Use as APCs. 
  • Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation. 
  • Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix. 
  • Endothelial antigen presentation: stimulation of previously activated but not naïve TCR-transgenic mouse T cells. 
  • Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. 
  • Essential role of LAT in T cell development. 
  • Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR alpha beta + and TCR gamma delta + to human immunodeficiency virus infection: a mechanism for CD4+ (T4) lymphocyte depletion. 
  • Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency (scid) mutation or X-linked immunodeficiency (xid) defect. 
  • Expression of human T cell receptor-gamma delta structural forms. 
  • Expression of interleukin-1 alpha, interleukin-1 beta, and an interleukin-1 receptor antagonist in human retinal pigment epithelial cells. 
  • Extensive junctional diversity of rearranged human T cell receptor delta genes. 
  • Facial pain with localized and widespread manifestations: separate pathways of vulnerability. 
  • Feedback control of T-cell receptor activation. 
  • Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes. 
  • Follicle-Stimulating Hormone Receptor Is Expressed by Most Ovarian Cancer Subtypes and Is a Safe and Effective Immunotherapeutic Target. 
  • Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. 
  • Functional development of the T cell receptor for antigen. 
  • Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. 
  • Gene segment selection in V(D)J recombination: accessibility and beyond. 
  • Generation of CAR T cells for adoptive therapy in the context of glioblastoma standard of care. 
  • Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. 
  • Genomic organization of the human T-cell antigen-receptor alpha/delta locus. 
  • Glimpse of natural selection of long-lived T-cell clones in healthy life. 
  • Graft-versus-host disease: the viewpoint from the donor T cell. 
  • HBsAg-redirected T cells exhibit antiviral activity in HBV-infected human liver chimeric mice. 
  • HIV infection--induced posttranslational modification of T cell signaling molecules associated with disease progression. 
  • HLA class II molecules on monocytes regulate T cell proliferation through physical interaction in the CD3 activation pathway. 
  • Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VI. Evidence for different T cell receptors in cells that mediate H-21-restricted and H-2D-restricted cutaneous sensitivity responses. 
  • Hepatosplenic T-cell lymphoma: an unusual case of a gamma delta T-cell lymphoma with a blast-like terminal transformation. 
  • High level expression of CD43 inhibits T cell receptor/CD3-mediated apoptosis. 
  • Human T cell receptor gamma delta structure. 
  • Human T cell receptor-gamma and -delta chain pairing analyzed by transfection of a T cell receptor-delta negative mutant cell line. 
  • Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection. 
  • Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development. 
  • Hypermutation in T cells questioned. 
  • IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha. 
  • Id Proteins Suppress E2A-Driven Invariant Natural Killer T Cell Development prior to TCR Selection. 
  • Identification of a putative second T-cell receptor. 
  • Identification of putative human T cell receptor delta complementary DNA clones. 
  • Immunochemical proof that a novel rearranging gene encodes the T cell receptor delta subunit. 
  • Immunoglobulin and T-cell receptor gene rearrangement and expression in human lymphoid leukemia cells at different stages of maturation. 
  • Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy. 
  • Immunological findings in thymoma and thymoma-related syndromes. 
  • Immunology of vascularized composite allotransplantation: a primer for hand surgeons. 
  • Immunophenotypic and diagnostic characterization of angioimmunoblastic T-cell lymphoma by advanced flow cytometric technology. 
  • Immunotherapy for Glioblastoma: Adoptive T-cell Strategies. 
  • In Vitro Pre-Clinical Validation of Suicide Gene Modified Anti-CD33 Redirected Chimeric Antigen Receptor T-Cells for Acute Myeloid Leukemia. 
  • In situ studies of the germinal center reaction. 
  • In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. 
  • In vitro analysis of the human antiporcine T-cell repertoire. 
  • In vitro and in vivo human T cell repertoire in kidney allograft rejection. 
  • In vitro autoantibody production by normal adult and cord blood B cells. 
  • In vivo identification of a negative regulatory element in the mouse renin gene using direct gene transfer. 
  • In-vivo impaired T helper 1 cell development in submandibular lymph nodes due to IL-12 deficiency following antigen injection into the anterior chamber of the eye. 
  • Inclusion of a sensitivity control to add a quality-control parameter and improve reproducibility in BCR, immunoglobulin, and T-cell receptor gene-rearrangement studies. 
  • Induced sensitization of tumor stroma leads to eradication of established cancer by T cells. 
  • Induction of CD56 and TCR-independent activation of T cells with aging. 
  • Induction of T cell CD7 gene transcription by nonmitogenic ionomycin-induced transmembrane calcium flux. 
  • Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells. 
  • Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma. 
  • Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. 
  • In Vivo Expansion and Antitumor Activity of Coinfused CD28- and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia. 
  • Kinetics of TCR use in response to repeated epitope-specific immunization. 
  • Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development. 
  • LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. 
  • LAT-mediated signaling in CD4+CD25+ regulatory T cell development. 
  • LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. 
  • Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. 
  • Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture. 
  • Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-β Signaling. 
  • Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding. 
  • Lymphoproliferative disease of granular lymphocytes. 
  • MHC class I-peptide interactions and TCR recognition. 
  • Maintaining T lymphocyte homeostasis: another duty of autophagy. 
  • MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium. 
  • MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3. 
  • Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development. 
  • Mixed-phenotype large granular lymphocytic leukemia: a rare subtype in the large granular lymphocytic leukemia spectrum. 
  • Modeling Sjögren's syndrome with Id3 conditional knockout mice. 
  • Modified T-cell receptor ligands: moving beyond a strict occupancy model for T-cell activation by antigen. 
  • Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. 
  • Modulation of CD45 tyrosine phosphatase activity by antigen. 
  • Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity. 
  • Molecular analysis of highly enriched populations of T-cell-depleted monocytes. 
  • Molecular basis of T cell inactivation by CTLA-4. 
  • Molecular composition of an antigen-specific, Ly-1 T suppressor inducer factor. One molecule binds antigen and is I-J-; another is I-J+, does not bind antigen, and imparts an Igh-variable region-linked restriction. 
  • Molecular dissection of lymphocyte signal transduction pathways. 
  • Monoclonal antibody OKT3-induced T cell proliferation: differential role of HLA class II determinants expressed by T cells and monocytes. 
  • Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression. 
  • Mutations in a dominant Nef epitope of simian immunodeficiency virus diminish TCR:epitope peptide affinity but not epitope peptide:MHC class I binding. 
  • Negative control of diacylglycerol kinase ζ-mediated inhibition of T cell receptor signaling by nuclear sequestration in mice. 
  • Negative regulation of TCR signaling by linker for activation of X cells via phosphotyrosine-dependent and -independent mechanisms. 
  • Negative regulation of lymphocyte activation by the adaptor protein LAX. 
  • Negative regulation of mTOR activation by diacylglycerol kinases. 
  • New surrogate markers for autoimmune disease activity. 
  • Next-Generation Sequencing of Minimal Residual Disease for Predicting Relapse after Tisagenlecleucel in Children and Young Adults with Acute Lymphoblastic Leukemia. 
  • Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination. 
  • Nonmyeloablative regimen preserves "niches" allowing for peripheral expansion of donor T-cells. 
  • Notch 1 signaling regulates peripheral T cell activation. 
  • OKT3 vs ALG induction therapy in combined pancreas-kidney transplantation. 
  • Oncolytic virus-derived type I interferon restricts CAR T cell therapy. 
  • PP6 controls T cell development and homeostasis by negatively regulating distal TCR signaling. 
  • Pathways-driven sparse regression identifies pathways and genes associated with high-density lipoprotein cholesterol in two Asian cohorts. 
  • Patient-reported quality of life after tisagenlecleucel infusion in children and young adults with relapsed or refractory B-cell acute lymphoblastic leukaemia: a global, single-arm, phase 2 trial. 
  • Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. 
  • Pertussis toxin triggers rapid second messenger production in human T lymphocytes. 
  • Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry. 
  • Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. 
  • Phospholipase D in TCR-Mediated Signaling and T Cell Activation. 
  • Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC. 
  • Piceatannol in combination with low doses of cyclosporine A prolongs kidney allograft survival in a stringent rat transplantation model. 
  • Pooled safety analysis of tisagenlecleucel in children and young adults with B cell acute lymphoblastic leukemia. 
  • Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis. 
  • Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells. 
  • Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism. 
  • Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response. 
  • Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. 
  • Quality control in the flow cytometric measurement of T-lymphocyte subsets: the multicenter AIDS cohort study experience. The Multicenter AIDS Cohort Study Group. 
  • Quantification of total T-cell receptor diversity by flow cytometry and spectratyping. 
  • Real-world evidence of tisagenlecleucel for pediatric acute lymphoblastic leukemia and non-Hodgkin lymphoma. 
  • Receptor signaling in immune cell development and function. 
  • Reconstitution of a T cell receptor-stimulated plasma membrane calcium transporter: lack of dependence on inositol phosphates. 
  • Redirecting cytotoxic T lymphocyte responses with T-cell receptor transgenes. 
  • Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo. 
  • Regulation of T cell function by microRNA-720. 
  • Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases. 
  • Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta. 
  • Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein. 
  • Regulation of lymphocyte development and activation by the LAT family of adapter proteins. 
  • Requirement for Abl kinases in T cell receptor signaling. 
  • Requirement for Ca2+/calmodulin-dependent kinase type IV/Gr in setting the thymocyte selection threshold. 
  • Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. 
  • Restriction in T-cell receptor repertoire in a patient affected by trichothiodystrophy and CD4+ lymphopenia. 
  • Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus. 
  • Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling. 
  • Role of LAT in the granule-mediated cytotoxicity of CD8 T cells. 
  • Role of diacylglycerol kinases in T cell development and function. 
  • Role of interleukin 12 and costimulators in T cell anergy in vivo. 
  • SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling. 
  • Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer. 
  • Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. 
  • Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome. 
  • ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis. 
  • Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease. 
  • Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. 
  • Somatic mosaicism caused by monoallelic reversion of a mutation in T cells of a patient with ADA-SCID and the effects of enzyme replacement therapy on the revertant phenotype. 
  • SpA: web-accessible spectratype analysis: data management, statistical analysis and visualization. 
  • Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. 
  • Stability of Th1 and Th2 populations. 
  • Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation. 
  • Stage-specific functions of E-proteins at the β-selection and T-cell receptor checkpoints during thymocyte development. 
  • Statistical analysis of antigen receptor spectratype data. 
  • Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx. 
  • Structurally divergent human T cell receptor gamma proteins encoded by distinct C gamma genes. 
  • Studies on the adapter molecule LAT. 
  • Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity. 
  • Synthetic autoantigens of immunoglobulins and T-cell receptors: their recognition in aging, infection, and autoimmunity. 
  • T Cell Receptor-Independent, CD31/IL-17A-Driven Inflammatory Axis Shapes Synovitis in Juvenile Idiopathic Arthritis. 
  • T cell activation deficiency associated with an aberrant pattern of protein tyrosine phosphorylation after CD3 perturbation in Down's syndrome. 
  • T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+. 
  • T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. 
  • T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation. 
  • T cell receptor gamma/delta expression on lymphocyte populations of breast cancer patients. 
  • T cell receptor repertoire as a prognosis marker for heat shock protein peptide complex-96 vaccine trial against newly diagnosed glioblastoma. 
  • T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10. 
  • T lymphocyte depletion of human peripheral blood and bone marrow using monoclonal antibodies and magnetic microspheres. 
  • T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex. 
  • T-Cell recovery in adults and children following umbilical cord blood transplantation. 
  • T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. 
  • T-cell receptor and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: understanding a hypersensitivity reaction. 
  • T-cell receptors of human suppressor cells. 
  • T-cell-receptor affinity and thymocyte positive selection. 
  • T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes. 
  • TCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeys. 
  • TCR repertoire and CDR3 motif analyses depict the role of αβ T cells in Ankylosing spondylitis. 
  • TCR repertoire characteristics predict clinical response to adoptive CTL therapy against nasopharyngeal carcinoma. 
  • TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function. 
  • Tandem mass spectrometry, but not T-cell receptor excision circle analysis, identifies newborns with late-onset adenosine deaminase deficiency. 
  • Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic. 
  • The Cancer Epitope Database and Analysis Resource: A Blueprint for the Establishment of a New Bioinformatics Resource for Use by the Cancer Immunology Community. 
  • The MicroRNA miR-191 Supports T Cell Survival Following Common γ Chain Signaling. 
  • The Role of Granulocyte Transfusions in Optimizing Candidacy for Chimeric Antigen Receptor T-cell Therapy in Patients With Treatment-refractory Infections. 
  • The diagnosis of severe combined immunodeficiency (SCID): The Primary Immune Deficiency Treatment Consortium (PIDTC) 2022 Definitions. 
  • The dynamics of T-cell receptor repertoire diversity following thymus transplantation for DiGeorge anomaly. 
  • The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage. 
  • The gamma delta T cell receptor. 
  • The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model. 
  • The importance of LAT in the activation, homeostasis, and regulatory function of T cells. 
  • The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation. 
  • The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition. 
  • The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity. 
  • The long and the short of telomeres in bone marrow recipient SCID patients. 
  • The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway. 
  • The molecular basis of class II MHC allelic control of T cell responses. 
  • The multiple causes of human SCID. 
  • The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus. 
  • The promise of chimeric antigen receptor (CAR) T cell therapy in multiple myeloma. 
  • The role and regulation of mTOR in T-lymphocyte function. 
  • The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling. 
  • The role of membrane-associated adaptors in T cell receptor signalling. 
  • The role of the L3T4 molecule in mitogen and antigen-activated signal transduction. 
  • The role of the LAT-PLC-gamma1 interaction in T regulatory cell function. 
  • The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. 
  • The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection. 
  • Three-Year Update of Tisagenlecleucel in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia in the ELIANA Trial. 
  • Thymic function after hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency. 
  • Thymic output, T-cell diversity, and T-cell function in long-term human SCID chimeras. 
  • Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients. 
  • Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia. 
  • Transcription-dependent mobilization of nucleosomes at accessible TCR gene segments in vivo. 
  • Transcriptional analysis of tumor-specific T-cell responses in cancer patients. 
  • Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements. 
  • Transplantation of thymus tissue in complete DiGeorge syndrome. 
  • Treatment Patterns, Survival, Quality of Life, and Healthcare Resource Use Among Patients With Triple-Class Refractory Multiple Myeloma in US Clinical Practice: Findings From the Connect MM Disease Registry. 
  • Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. 
  • Tumors as elusive targets of T-cell-based active immunotherapy. 
  • Two forms of the T-cell receptor gamma protein found on peripheral blood cytotoxic T lymphocytes. 
  • Understanding specificity and sensitivity of T-cell recognition. 
  • Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells. 
  • Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice. 
  • V(D)J hypermutation and DNA mismatch repair: vexed by fixation. 
  • Vaccination establishes clonal relatives of germinal center T cells in the blood of humans. 
  • Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci. 
  • Virally induced lytic cell death elicits the release of immunogenic GRP94/gp96. 
  • What keeps a resting T cell alive? 
  • ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis. 
  • ZAP-70-dependent and -independent activation of Erk in Jurkat T cells. Differences in signaling induced by H2o2 and Cd3 cross-linking. 
  • [Expression of presenilin 1 on the cell surface in motile polarized cells]. 
  • c-FLIP protects mature T lymphocytes from TCR-mediated killing. 
  • miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy. 
  • miR-181a is an intrinsic modulator of T cell sensitivity and selection. 
  • microRNAs at the regulatory frontier: an investigation into how microRNAs impact the development and effector functions of CD4 T cells. 
• 

  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology
  • Zhong, Xiaoping, Professor of Pediatrics, Integrative Immunobiology