Receptors, Complement

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  Subject Areas on Research

  • A role for immunogenic DNA in the pathogenesis of systemic lupus erythematosus. 
  • AIDS. Do antibodies enhance the infection of cells by HIV? 
  • Antibody response to a T-dependent antigen requires B cell expression of complement receptors. 
  • Antibody-dependent enhancement of simian immunodeficiency virus (SIV) infection in vitro by plasma from SIV-infected rhesus macaques. 
  • Binding site for C4b-binding protein in vitamin K-dependent protein S fully contained in carboxy-terminal laminin-G-type repeats. A study using recombinant factor IX-protein S chimeras and surface plasmon resonance. 
  • Blood group antigens on complement receptor/regulatory proteins. 
  • Characterization of B-cell type chronic lymphocytic leukemia cells by surface markers and a monoclonal antibody. 
  • Characterization of human T lymphocytes that express the C3b receptor. 
  • Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT. 
  • Circulating immune complexes in dermatologic disease. 
  • Complement factor H protects tumor cell-derived exosomes from complement-dependent lysis and phagocytosis. 
  • Complement-mediated antibody-dependent enhancement of HIV-1 infection requires CD4 and complement receptors. 
  • Complement-mediated, antibody-dependent enhancement of HIV-1 infection in vitro is characterized by increased protein and RNA syntheses and infectious virus release. 
  • Complement-targeted therapies in kidney transplantation-insights from preclinical studies. 
  • Continuous complement (C) inhibition using soluble C receptor type 1 (sCR1): effect on hyperacute rejection (HAR) of pig-to-primate cardiac xenografts. 
  • Correlation between erythrocyte CR1 reduction and other blood proteinase markers in patients with malignant and inflammatory disorders. 
  • Cross-desensitization of chemoattractant receptors occurs at multiple levels. Evidence for a role for inhibition of phospholipase C activity. 
  • Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation. 
  • Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization. 
  • Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts. 
  • Effect of soluble complement receptor type 1 on natural antibody levels during xenograft rejection. 
  • Effect of soluble complement receptor-1 on neutrophil accumulation after traumatic brain injury in rats. 
  • Epstein Barr virus binding induces internalization of the C3d receptor: a novel immunotoxin delivery system. 
  • Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. 
  • Evaluation of lymphocyte differentiation in primary and secondary immunodeficiency diseases. 
  • Expression and modulation of RPE cell membrane complement regulatory proteins. 
  • Expression of C3b receptors on human be cells and myelomonocytic cells but not natural killer cells. 
  • Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody. 
  • Histiocytes in familial and infection-induced/idiopathic hemophagocytic syndromes may exhibit phenotypic differences. 
  • Identification of a 145,000 Mr membrane protein as the C3d receptor (CR2) of human B lymphocytes. 
  • Identification of human erythrocyte blood group antigens on the C3b/C4b receptor. 
  • Increased efficiency of binding of nascent C3b to the erythrocytes of chronic cold agglutinin disease. 
  • Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19. 
  • Longitudinal study of differential protein expression in an Alzheimer's mouse model lacking inducible nitric oxide synthase. 
  • Minimal role for the alternative pathway in complement activation by HIT immune complexes. 
  • Pharmacokinetics and safety of TP10, soluble complement receptor 1, in infants undergoing cardiopulmonary bypass. 
  • Phenotype of infiltrating cells in an ex vivo model of human antiporcine hyperacute cardiac xenograft rejection. 
  • Receptor class desensitization of leukocyte chemoattractant receptors. 
  • Role of complement activation in obliterative bronchiolitis post-lung transplantation. 
  • Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia. 
  • Stimulation of Sky tyrosine phosphorylation by bovine protein S--domains involved in the receptor-ligand interaction. 
  • Stimulus-specific effects of pentoxifylline on neutrophil CR3 expression, degranulation, and superoxide production. 
  • The Complement Receptors C3aR and C5aR Are a New Class of Immune Checkpoint Receptor in Cancer Immunotherapy. 
  • The effect of soluble complement receptor type 1 on hyperacute allograft rejection. 
  • The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts. 
  • The effect of soluble complement receptor type 1 on hyperacute xenograft rejection. 
  • The phagocytic cell: summary. 
  • The phenotype of human placental macrophages and its variation with gestational age. 
  • The role of receptors for complement in the induction of polyclonal B-cell proliferation and differentiation. 
  • The use of TP10, soluble complement receptor 1, in cardiopulmonary bypass. 
  • Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation. 
  • alpha 2-Macroglobulin, complement, and biologic defense: antigens, growth factors, microbial proteases, and receptor ligation. 
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  Keywords of People

  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology