Receptors, Fc

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  Subject Areas on Research

  • A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors. 
  • A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic. 
  • A glycoengineered anti-CD19 antibody with potent antibody-dependent cellular cytotoxicity activity in vitro and lymphoma growth inhibition in vivo. 
  • A serial study of splenic reticuloendothelial system Fc receptor functional activity in systemic lupus erythematosus. 
  • An analysis of the presence of Fc receptors on bone marrow lymphoblasts in acute lymphoblastic leukemia. A Pediatric Oncology Group study. 
  • Analysis of Fc gamma receptors on human peripheral blood leukocytes by flow microfluorometry. I. Receptor distributions on monocytes, T gamma cells and cells labeled with the 3Al anti-T cell monoclonal antibody. 
  • Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses. 
  • Application of area scaling analysis to identify natural killer cell and monocyte involvement in the GranToxiLux antibody dependent cell-mediated cytotoxicity assay. 
  • Binding of immunoglobulin- and complement-coated erythrocytes to human neutrophil subpopulations. 
  • CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo. 
  • Characterization of lymphoma-derived cell lines: comparison of cell lines positive and negative for Epstein-Barr virus nuclear antigen. II. Surface markers. 
  • Circulating immune complexes in dermatologic disease. 
  • Circulating natural killer cell phenotypes in men and women with major depression. Relation to cytotoxic activity and severity of depression. 
  • Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1. 
  • Decline in rates of clearance of IgG-sensitized erythrocytes with increasing age. 
  • Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: studies in patients with dermatitis herpetiformis and normal subjects. 
  • Defective reticuloendothelial system Fc-receptor function in patients with acquired immunodeficiency syndrome. 
  • Demonstration of defective C3-receptor-mediated clearance by the reticuloendothelial system in patients with acquired immunodeficiency syndrome. 
  • Donor type natural killer cells after haploidentical T cell-depleted bone marrow stem cell transplantation in a patient with adenosine deaminase-deficient severe combined immunodeficiency. 
  • Early activation and cell cycle entry of resting B cells after Fab-anti-Ig treatment: role of receptor crosslinking. 
  • Enhanced neonatal Fc receptor function improves protection against primate SHIV infection. 
  • Fc Receptor-Mediated Activities of Env-Specific Human Monoclonal Antibodies Generated from Volunteers Receiving the DNA Prime-Protein Boost HIV Vaccine DP6-001. 
  • GP120 specific cellular cytotoxicity in HIV-1 seropositive individuals. Evidence for circulating CD16+ effector cells armed in vivo with cytophilic antibody. 
  • Gamma (immune) interferon production by leukocytes from a patient with a TG cell proliferative disease. 
  • Human C5a modulates monocyte Fc and C3 receptor expression. 
  • Human T lymphocyte antigens as defined by monoclonal antibodies. 
  • Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products. 
  • Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. I. Characterization of the lymphocyte subset reactive with B73.1. 
  • Human neutrophils increase expression of C3bi as well as C3b receptors upon activation. 
  • Identification of a second class of IgG Fc receptors on human neutrophils. A 40 kilodalton molecule also found on eosinophils. 
  • IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis. 
  • IgE Fc receptor positive T and B lymphocytes in patients with the hyper IgE syndrome. 
  • IgE Fc receptor positive T, B and NK cells in patients with the hyper-IgE syndrome. 
  • Impact of self-administration of romiplostim by patients with chronic immune thrombocytopenia compared with administration by a healthcare provider. 
  • In vitro studies of IgE synthesis by human blood mononuclear cells. 
  • Integrated analysis of long-term safety in patients with chronic immune thrombocytopaenia (ITP) treated with the thrombopoietin (TPO) receptor agonist romiplostim. 
  • Interactions of monomeric IgG bearing covalently bound C3b with polymorphonuclear leucocytes. 
  • Interferon suppresses pinocytosis but stimulates phagocytosis in mouse peritoneal macrophages: related changes in cytoskeletal organization. 
  • Ligation of MHC class I and class II molecules can lead to heterologous desensitization of signal transduction pathways that regulate homotypic adhesion in human lymphocytes. 
  • Mixed cryoglobulinemia: association of glomerulonephritis with defective reticuloendothelial system Fc receptor function. 
  • Modulation of FcR function by complement: subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages. 
  • Monocyte receptors for the Fc portion of IgG are increased in systemic lupus erythematosus. 
  • Monocyte receptors for the Fc portion of IgG increase in number in autoimmune hemolytic anemia and other hemolytic states and are decreased by glucocorticoid therapy. 
  • Monocyte receptors for the Fc portion of IgG studies with monomeric human IgG1: normal in vitro expression of Fc gamma receptors in HLA-B8/Drw3 subjects with defective Fc gamma-mediated in vivo clearance. 
  • Monokines released during short-term Fc gamma receptor phagocytosis up-regulate polymorphonuclear leukocytes and monocyte-phagocytic function. 
  • NIH Conference: Immunoglobulin G Fc receptor-mediated clearance in autoimmune diseases. 
  • Neutrophil CD11b, L-selectin and Fc IgA receptors in patients with dermatitis herpetiformis. 
  • New insights and therapeutics for immune-mediated thrombocytopenia. 
  • Noncanonical placental Fc receptors: What is their role in modulating transplacental transfer of maternal IgG? 
  • Phase I clinical and pharmacokinetic trial of flavone acetic acid. 
  • Phenotypic and functional characterization of human malignant T cells. 
  • Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture. 
  • Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes. 
  • Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification. 
  • Reticuloendothelial system fc receptor function in rheumatoid arthritis. 
  • Role of complement and Fc receptors in the pathogenesis of HIV-1 infection. 
  • Serum antibodies to HIV-1 in recombinant vaccinia virus recipients boosted with purified recombinant gp160. NIAID AIDS Vaccine Clinical Trials Network. 
  • Sjögren's syndrome (Sicca syndrome): current issues. 
  • Studies of phagocytosis in chronic granulomatous disease. 
  • Studies of reticuloendothelial system function in immune complex disease. 
  • The effects of IL-1, IL-2, and tumor necrosis factor on polymorphonuclear leukocyte Fc gamma receptor-mediated phagocytosis. IL-2 down-regulates the effect of tumor necrosis factor. 
  • The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors. 
  • The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice. 
  • The phenotype of human placental macrophages and its variation with gestational age. 
  • The reticuloendothelial system and autoimmune disease in man. 
  • The road to romiplostim approval and beyond. 
  • Tumor necrosis factor-alpha induces increased hydrogen peroxide production and Fc receptor expression, but not increased Ia antigen expression by peritoneal macrophages. 
  • Tumor recognition and lytic competence of IL-2-activated lymphocytes: regulation of both antibody-independent and -dependent cellular cytotoxicity via P75 IL-2 receptor. 
  • Use of a thrombopoietin mimetic for chronic immune thrombocytopenic purpura in pregnancy. 
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  Keywords of People

  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Professor of Experimental Surgery, in the School of Medicine, Immunology