Receptors, Fc

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  Subject Areas on Research

  • A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic. 
  • A glycoengineered anti-CD19 antibody with potent antibody-dependent cellular cytotoxicity activity in vitro and lymphoma growth inhibition in vivo. 
  • An analysis of the presence of Fc receptors on bone marrow lymphoblasts in acute lymphoblastic leukemia. A Pediatric Oncology Group study. 
  • Analysis of Fc gamma receptors on human peripheral blood leukocytes by flow microfluorometry. I. Receptor distributions on monocytes, T gamma cells and cells labeled with the 3Al anti-T cell monoclonal antibody. 
  • Antagonism of the Neonatal Fc Receptor as an Emerging Treatment for Myasthenia Gravis. 
  • Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses. 
  • Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses. 
  • Application of area scaling analysis to identify natural killer cell and monocyte involvement in the GranToxiLux antibody dependent cell-mediated cytotoxicity assay. 
  • CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo. 
  • CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques. 
  • Characterization of B-cell type chronic lymphocytic leukemia cells by surface markers and a monoclonal antibody. 
  • Circulating immune complexes in dermatologic disease. 
  • Circulating natural killer cell phenotypes in men and women with major depression. Relation to cytotoxic activity and severity of depression. 
  • Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1. 
  • Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: studies in patients with dermatitis herpetiformis and normal subjects. 
  • Donor type natural killer cells after haploidentical T cell-depleted bone marrow stem cell transplantation in a patient with adenosine deaminase-deficient severe combined immunodeficiency. 
  • Early activation and cell cycle entry of resting B cells after Fab-anti-Ig treatment: role of receptor crosslinking. 
  • Effectiveness and Safety of Romiplostim Among Patients with Newly Diagnosed, Persistent and Chronic Immune Thrombocytopenia in European Clinical Practice. 
  • Enhanced neonatal Fc receptor function improves protection against primate SHIV infection. 
  • Exploring variation in binding of Protein A and Protein G to immunoglobulin type G by isothermal titration calorimetry. 
  • Fc Receptor-Mediated Activities of Env-Specific Human Monoclonal Antibodies Generated from Volunteers Receiving the DNA Prime-Protein Boost HIV Vaccine DP6-001. 
  • Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission. 
  • Fc-mOX40L fusion protein produces complete remission and enhanced survival in 2 murine tumor models. 
  • Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE. 
  • GP120 specific cellular cytotoxicity in HIV-1 seropositive individuals. Evidence for circulating CD16+ effector cells armed in vivo with cytophilic antibody. 
  • Gamma (immune) interferon production by leukocytes from a patient with a TG cell proliferative disease. 
  • Human FcRn expression and Type I Interferon signaling control Echovirus 11 pathogenesis in mice. 
  • Human T lymphocyte antigens as defined by monoclonal antibodies. 
  • Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products. 
  • Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. I. Characterization of the lymphocyte subset reactive with B73.1. 
  • IRTA1 positivity helps identify a MALT-lymphoma-like subset of primary cutaneous marginal zone lymphomas, largely but not exclusively defined by IgM expression. 
  • IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis. 
  • IgA transcytosis and antigen recognition govern ovarian cancer immunity. 
  • IgE Fc receptor positive T and B lymphocytes in patients with the hyper IgE syndrome. 
  • IgE Fc receptor positive T, B and NK cells in patients with the hyper-IgE syndrome. 
  • In vitro studies of IgE synthesis by human blood mononuclear cells. 
  • Interactions of monomeric IgG bearing covalently bound C3b with polymorphonuclear leucocytes. 
  • Interferon suppresses pinocytosis but stimulates phagocytosis in mouse peritoneal macrophages: related changes in cytoskeletal organization. 
  • Lessons Learned Using Real-World Data to Emulate Randomized Trials: A Case Study of Treatment Effectiveness for Newly Diagnosed Immune Thrombocytopenia. 
  • Ligation of MHC class I and class II molecules can lead to heterologous desensitization of signal transduction pathways that regulate homotypic adhesion in human lymphocytes. 
  • Maternal gatekeepers: How maternal antibody Fc characteristics influence passive transfer and infant protection. 
  • Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model. 
  • Monkeying Around: Using Non-human Primate Models to Study NK Cell Biology in HIV Infections. 
  • Monocyte receptors for the Fc portion of IgG studies with monomeric human IgG1: normal in vitro expression of Fc gamma receptors in HLA-B8/Drw3 subjects with defective Fc gamma-mediated in vivo clearance. 
  • Neutrophil CD11b, L-selectin and Fc IgA receptors in patients with dermatitis herpetiformis. 
  • Phenotypic and functional characterization of human malignant T cells. 
  • Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture. 
  • Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes. 
  • Positively selected Leu-11a (CD16+) cells require the presence of accessory cells or factors for the lysis of herpes simplex virus-infected fibroblasts but not herpes simplex virus-infected Raji. 
  • Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification. 
  • Reticuloendothelial system fc receptor function in rheumatoid arthritis. 
  • Role of complement and Fc receptors in the pathogenesis of HIV-1 infection. 
  • Safety, Tolerability, and Activity of ALXN1830 Targeting the Neonatal Fc Receptor in Chronic Pemphigus. 
  • Second-line treatments in children with immune thrombocytopenia: Effect on platelet count and patient-centered outcomes. 
  • Targeting Endoglin-Expressing Regulatory T Cells in the Tumor Microenvironment Enhances the Effect of PD1 Checkpoint Inhibitor Immunotherapy. 
  • The Roles of Host and Viral Antibody Fc Receptors in Herpes Simplex Virus (HSV) and Human Cytomegalovirus (HCMV) Infections and Immunity. 
  • The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors. 
  • The neonatal Fc receptor is a pan-echovirus receptor. 
  • The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice. 
  • The phenotype of human placental macrophages and its variation with gestational age. 
  • The road to romiplostim approval and beyond. 
  • Tumor necrosis factor-alpha induces increased hydrogen peroxide production and Fc receptor expression, but not increased Ia antigen expression by peritoneal macrophages. 
  • Tumor recognition and lytic competence of IL-2-activated lymphocytes: regulation of both antibody-independent and -dependent cellular cytotoxicity via P75 IL-2 receptor. 
  • Use of a thrombopoietin mimetic for chronic immune thrombocytopenic purpura in pregnancy. 
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  Keywords of People

  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Immunology