Receptors, Fc
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Subject Areas on Research
- A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors.
- A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic.
- A glycoengineered anti-CD19 antibody with potent antibody-dependent cellular cytotoxicity activity in vitro and lymphoma growth inhibition in vivo.
- A serial study of splenic reticuloendothelial system Fc receptor functional activity in systemic lupus erythematosus.
- An analysis of the presence of Fc receptors on bone marrow lymphoblasts in acute lymphoblastic leukemia. A Pediatric Oncology Group study.
- Analysis of Fc gamma receptors on human peripheral blood leukocytes by flow microfluorometry. I. Receptor distributions on monocytes, T gamma cells and cells labeled with the 3Al anti-T cell monoclonal antibody.
- Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses.
- Application of area scaling analysis to identify natural killer cell and monocyte involvement in the GranToxiLux antibody dependent cell-mediated cytotoxicity assay.
- Binding of immunoglobulin- and complement-coated erythrocytes to human neutrophil subpopulations.
- Bleeding and mortality outcomes in ITP clinical trials: a review of thrombopoietin mimetics data.
- CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo.
- CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques.
- Characterization of B-cell type chronic lymphocytic leukemia cells by surface markers and a monoclonal antibody.
- Characterization of lymphoma-derived cell lines: comparison of cell lines positive and negative for Epstein-Barr virus nuclear antigen. II. Surface markers.
- Circulating immune complexes in dermatologic disease.
- Circulating natural killer cell phenotypes in men and women with major depression. Relation to cytotoxic activity and severity of depression.
- Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1.
- Decline in rates of clearance of IgG-sensitized erythrocytes with increasing age.
- Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: studies in patients with dermatitis herpetiformis and normal subjects.
- Defective reticuloendothelial system Fc-receptor function in patients with acquired immunodeficiency syndrome.
- Demonstration of defective C3-receptor-mediated clearance by the reticuloendothelial system in patients with acquired immunodeficiency syndrome.
- Donor type natural killer cells after haploidentical T cell-depleted bone marrow stem cell transplantation in a patient with adenosine deaminase-deficient severe combined immunodeficiency.
- Early activation and cell cycle entry of resting B cells after Fab-anti-Ig treatment: role of receptor crosslinking.
- Enhanced neonatal Fc receptor function improves protection against primate SHIV infection.
- Exploring variation in binding of Protein A and Protein G to immunoglobulin type G by isothermal titration calorimetry.
- Fc Receptor-Mediated Activities of Env-Specific Human Monoclonal Antibodies Generated from Volunteers Receiving the DNA Prime-Protein Boost HIV Vaccine DP6-001.
- GP120 specific cellular cytotoxicity in HIV-1 seropositive individuals. Evidence for circulating CD16+ effector cells armed in vivo with cytophilic antibody.
- Gamma (immune) interferon production by leukocytes from a patient with a TG cell proliferative disease.
- Human C5a modulates monocyte Fc and C3 receptor expression.
- Human T lymphocyte antigens as defined by monoclonal antibodies.
- Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.
- Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. I. Characterization of the lymphocyte subset reactive with B73.1.
- Human neutrophils increase expression of C3bi as well as C3b receptors upon activation.
- Identification of a second class of IgG Fc receptors on human neutrophils. A 40 kilodalton molecule also found on eosinophils.
- IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis.
- IgE Fc receptor positive T and B lymphocytes in patients with the hyper IgE syndrome.
- IgE Fc receptor positive T, B and NK cells in patients with the hyper-IgE syndrome.
- Impact of self-administration of romiplostim by patients with chronic immune thrombocytopenia compared with administration by a healthcare provider.
- In vitro studies of IgE synthesis by human blood mononuclear cells.
- Integrated analysis of long-term safety in patients with chronic immune thrombocytopaenia (ITP) treated with the thrombopoietin (TPO) receptor agonist romiplostim.
- Interactions of monomeric IgG bearing covalently bound C3b with polymorphonuclear leucocytes.
- Interferon action: effects of mouse alpha and beta interferons on rosette formation, phagocytosis, and surface-antigen expression of cells of the macrophage-type line RAW 309Cr.1.
- Interferon suppresses pinocytosis but stimulates phagocytosis in mouse peritoneal macrophages: related changes in cytoskeletal organization.
- Ligation of MHC class I and class II molecules can lead to heterologous desensitization of signal transduction pathways that regulate homotypic adhesion in human lymphocytes.
- Mixed cryoglobulinemia: association of glomerulonephritis with defective reticuloendothelial system Fc receptor function.
- Modulation of FcR function by complement: subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages.
- Monocyte receptors for the Fc portion of IgG are increased in systemic lupus erythematosus.
- Monocyte receptors for the Fc portion of IgG increase in number in autoimmune hemolytic anemia and other hemolytic states and are decreased by glucocorticoid therapy.
- Monocyte receptors for the Fc portion of IgG studies with monomeric human IgG1: normal in vitro expression of Fc gamma receptors in HLA-B8/Drw3 subjects with defective Fc gamma-mediated in vivo clearance.
- Monokines released during short-term Fc gamma receptor phagocytosis up-regulate polymorphonuclear leukocytes and monocyte-phagocytic function.
- NIH Conference: Immunoglobulin G Fc receptor-mediated clearance in autoimmune diseases.
- Neutrophil CD11b, L-selectin and Fc IgA receptors in patients with dermatitis herpetiformis.
- New insights and therapeutics for immune-mediated thrombocytopenia.
- Noncanonical placental Fc receptors: What is their role in modulating transplacental transfer of maternal IgG?
- Phenotypic and functional characterization of human malignant T cells.
- Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture.
- Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes.
- Positively selected Leu-11a (CD16+) cells require the presence of accessory cells or factors for the lysis of herpes simplex virus-infected fibroblasts but not herpes simplex virus-infected Raji.
- Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification.
- Reticuloendothelial system fc receptor function in rheumatoid arthritis.
- Role of complement and Fc receptors in the pathogenesis of HIV-1 infection.
- Sjögren's syndrome (Sicca syndrome): current issues.
- Studies of phagocytosis in chronic granulomatous disease.
- Studies of reticuloendothelial system function in immune complex disease.
- The effects of IL-1, IL-2, and tumor necrosis factor on polymorphonuclear leukocyte Fc gamma receptor-mediated phagocytosis. IL-2 down-regulates the effect of tumor necrosis factor.
- The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors.
- The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice.
- The phenotype of human placental macrophages and its variation with gestational age.
- The reticuloendothelial system and autoimmune disease in man.
- The road to romiplostim approval and beyond.
- Tumor necrosis factor-alpha induces increased hydrogen peroxide production and Fc receptor expression, but not increased Ia antigen expression by peritoneal macrophages.
- Tumor recognition and lytic competence of IL-2-activated lymphocytes: regulation of both antibody-independent and -dependent cellular cytotoxicity via P75 IL-2 receptor.
- Use of a thrombopoietin mimetic for chronic immune thrombocytopenic purpura in pregnancy.
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Keywords of People
- Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine, Immunology