Receptors, Nicotinic

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  Subject Areas on Research

  • 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling. 
  • 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans. 
  • 2-[18F]F-A-85380: a PET radioligand for alpha4beta2 nicotinic acetylcholine receptors. 
  • 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. 
  • 5-substituted derivatives of 6-halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with low picomolar affinity for alpha4beta2 nicotinic acetylcholine receptor and wide range of lipophilicity: potential probes for imaging with positron emission tomography. 
  • 6-[18F]fluoro-A-85380, a novel radioligand for in vivo imaging of central nicotinic acetylcholine receptors. 
  • A cortical circuit for gain control by behavioral state. 
  • AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats. 
  • Acute and chronic nicotinic interactions with dopamine systems and working memory performance. 
  • Acute stimulation of ornithine decarboxylase in neonatal rat brain regions by nicotine: a central receptor-mediated process? 
  • Additive and synergistic effects of fetal nicotine and dexamethasone exposure on cholinergic synaptic function in adolescence and adulthood: Implications for the adverse consequences of maternal smoking and pharmacotherapy of preterm delivery. 
  • Administration of nicotine to adolescent rats evokes regionally selective upregulation of CNS alpha 7 nicotinic acetylcholine receptors. 
  • Adolescent nicotine exposure causes persistent upregulation of nicotinic cholinergic receptors in rat brain regions. 
  • Adolescent nicotine exposure produces immediate and long-term changes in CNS noradrenergic and dopaminergic function. 
  • Adolescent nicotine treatment changes the response of acetylcholine systems to subsequent nicotine administration in adulthood. 
  • Adolescent vs. adult-onset nicotine self-administration in male rats: duration of effect and differential nicotinic receptor correlates. 
  • Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation. 
  • Alpha7 nicotinic acetylcholine receptor: a link between inflammation and neurodegeneration. 
  • Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos. 
  • Antidepressant effects of nicotine in an animal model of depression. 
  • Antidepressant-like effects of nicotine and reduced nicotinic receptor binding in the Fawn-Hooded rat, an animal model of co-morbid depression and alcoholism. 
  • Assessing causal relationships using genetic proxies for exposures: an introduction to Mendelian randomization. 
  • Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats. 
  • Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans. 
  • Autoradiographic distribution of high affinity muscarinic and nicotinic cholinergic receptors labeled with [3H]acetylcholine in rat brain. 
  • Baseline expression of alpha4beta2* nicotinic acetylcholine receptors predicts motivation to self-administer nicotine. 
  • Behavioral effects of acute hexamethonium in rats chronically intoxicated with nicotine. 
  • Blockade of nicotinic acetylcholine receptors suppresses hippocampal long-term potentiation in wild-type but not ApoE4 targeted replacement mice. 
  • Brain nicotinic acetylcholine receptor availability and response to smoking cessation treatment: a randomized trial. 
  • Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette. 
  • Calcium channels reconstituted from the skeletal muscle dihydropyridine receptor protein complex and its alpha 1 peptide subunit in lipid bilayers. 
  • Capsaicin and nicotine both activate a subset of rat trigeminal ganglion neurons. 
  • Capsazepine, a vanilloid receptor antagonist, inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia. 
  • Characterization of the cognitive effects of combined muscarinic and nicotinic blockade. 
  • Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats. 
  • Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. 
  • Cholinergic receptors in heart and brainstem of rats exposed to nicotine during development: implications for hypoxia tolerance and perinatal mortality. 
  • Cholinergic regulatory lymphocytes re-establish neuromodulation of innate immune responses in sepsis. 
  • Chronic infusions of mecamylamine into the medial habenula: Effects on nicotine self-administration in rats. 
  • Chronic inhibition of alpha4beta2 nicotinic receptors in the ventral hippocampus of rats: impacts on memory and nicotine response. 
  • Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in rats. 
  • Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding. 
  • Chronic prenatal nicotine exposure sensitizes rat brain to acute postnatal nicotine challenge as assessed with ornithine decarboxylase. 
  • Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain. 
  • Chronic underactivity of medial frontal cortical beta2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats. 
  • Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors. 
  • Co-exposure to pyridostigmine bromide, DEET, and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity. 
  • Co-expression of nAChRs and molecules of the bitter taste transduction pathway by epithelial cells of intrapulmonary airways. 
  • Cognitive effects of nicotine. 
  • Complex relationships of nicotinic receptor actions and cognitive functions. 
  • Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior. 
  • Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions. 
  • Correlation of IgG autoantibodies against acetylcholine receptors and desmogleins in patients with pemphigus treated with steroid sparing agents or rituximab. 
  • Decreasing nicotinic receptor activity and the spatial learning impairment caused by the NMDA glutamate antagonist dizocilpine in rats. 
  • Depressive characteristics of FSL rats: involvement of central nicotinic receptors. 
  • Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands. 
  • Development of [3H]nicotine binding sites in brain regions of rats exposed to nicotine prenatally via maternal injections or infusions. 
  • Development of ligands for in vivo imaging of cerebral nicotinic receptors. 
  • Developmental neurotoxicity of chlorpyrifos: cellular mechanisms. 
  • Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats. 
  • Disrupting nicotine reinforcement: from cigarette to brain. 
  • Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. 
  • Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory. 
  • Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging. 
  • Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats. 
  • Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. 
  • Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brain. 
  • Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats. 
  • Effects of chronic sazetidine-A, a selective α4β2 neuronal nicotinic acetylcholine receptors desensitizing agent on pharmacologically-induced impaired attention in rats. 
  • Effects of combined muscarinic and nicotinic blockade on choice accuracy in the radial-arm maze. 
  • Effects of diisopropyl phosphorofluoridate (DFP) on CA3 and CA1 responses in rat hippocampus. 
  • Effects of nicotinic dimethylaminoethyl esters on working memory performance of rats in the radial-arm maze. 
  • Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats. 
  • Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats. 
  • Effects of the nicotinic receptor blocker mecamylamine on radial-arm maze performance in rats. 
  • Effects of the sazetidine-a family of compounds on the body temperature in wildtype, nicotinic receptor β2-/- and α7-/- mice. 
  • Engineered site-directed labeling of nicotinic acetylcholine receptors using reactive epibatidine derivatives: appraisal of epibatidine-docking models in neuronal and muscular receptors. 
  • Epilepsy due to 20q13.33 subtelomere deletion masquerading as pyridoxine-dependent epilepsy. 
  • Evaluation of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-methyl-2-(S)-pyrrolidinylmethoxy)pyridine and its analogues as PET radioligands for imaging nicotinic acetylcholine receptors. 
  • Experimental partial epileptogenesis. 
  • Fetal nicotine or cocaine exposure: which one is worse? 
  • Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. 
  • Fluorescent epibatidine agonists for neuronal and muscle-type nicotinic acetylcholine receptors. 
  • Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors. 
  • Functional polymorphisms of CHRNA3 predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese. 
  • Gain modulation by nicotine in macaque v1. 
  • Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans. 
  • Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. 
  • Genome-wide meta-analyses identify multiple loci associated with smoking behavior. 
  • Genome-wide meta-analyses of smoking behaviors in African Americans. 
  • Glutamate and nicotinic receptor interactions in working memory: importance for the cognitive impairment of schizophrenia. 
  • Graphical analysis of 2-[18F]FA binding to nicotinic acetylcholine receptors in rhesus monkey brain. 
  • Greater nicotinic acetylcholine receptor density in smokers than in nonsmokers: a PET study with 2-18F-FA-85380. 
  • Heterogeneity across brain regions and neurotransmitter interactions with nicotinic effects on memory function. 
  • Hippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory. 
  • Imidacloprid induces neurobehavioral deficits and increases expression of glial fibrillary acidic protein in the motor cortex and hippocampus in offspring rats following in utero exposure. 
  • Impact of fetal nicotine exposure on development of rat brain regions: critical sensitive periods or effects of withdrawal? 
  • Impact of short access nicotine self-administration on expression of α4β2* nicotinic acetylcholine receptors in non-human primates. 
  • Impairment of radial-arm maze performance in rats following lesions involving the cholinergic medial pathway: reversal by arecoline and differential effects of muscarinic and nicotinic antagonists. 
  • Improvement of attentional function with antagonism of nicotinic receptors in female rats. 
  • In search of a mechanism for receptor-mediated neurobehavioral teratogenesis by nicotine: catecholamine release by nicotine in immature rat brain regions. 
  • In vitro characterization of 6-[18F]fluoro-A-85380, a high-affinity ligand for alpha4beta2* nicotinic acetylcholine receptors. 
  • In vivo imaging of brain nicotinic acetylcholine receptors with 5-[123I]iodo-A-85380 using single photon emission computed tomography. 
  • In vivo studies with [125I]5-I-A-85380, a nicotinic acetylcholine receptor radioligand. 
  • Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. 
  • Inhibition of the GABA receptor-gated chloride ion channel in brain by noncompetitive inhibitors of the nicotinic receptor-gated cation channel. 
  • Interaction of nicotinic and histamine H(3) systems in the radial-arm maze repeated acquisition task. 
  • Introduction to the idiopathic epilepsies. 
  • Is binding to nicotinic acetylcholine and dopamine receptors related to working memory in rats? 
  • Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination. 
  • Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood. 
  • Measurement of the alpha4beta2* nicotinic acetylcholine receptor ligand 2-[(18)F]Fluoro-A-85380 and its metabolites in human blood during PET investigation: a methodological study. 
  • Mecamylamine increases cigarette smoking in psychiatric patients. 
  • Menthol disrupts nicotine's psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice. 
  • Modulation of cerebral microvascular permeability by endothelial nicotinic acetylcholine receptors. 
  • Multiple brain pathways and receptors underlying tobacco addiction. 
  • Muscle autoantibodies in myasthenia gravis: beyond diagnosis? 
  • Myasthenia gravis: diagnosis. 
  • NDP-MSH inhibits neutrophil migration through nicotinic and adrenergic receptors in experimental peritonitis. 
  • NIDA522131, a new radioligand for imaging extrathalamic nicotinic acetylcholine receptors: in vitro and in vivo evaluation. 
  • Neuregulin-induced expression of the acetylcholine receptor requires endocytosis of ErbB receptors. 
  • Neuroanatomical evidence for a putative autocrine/paracrine signaling system involving nicotinic acetylcholine receptors, purinergic receptors, and nitric oxide synthase in the airways. 
  • Neuroanatomical relationships of substance P-immunoreactive intrapulmonary C-fibers and nicotinic cholinergic receptors. 
  • Neuronal nicotinic acetylcholine receptors in rat trigeminal ganglia. 
  • Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells. 
  • Nicotine and the adolescent brain: insights from an animal model. 
  • Nicotine evokes cell death in embryonic rat brain during neurulation. 
  • Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos. 
  • Nicotine therapy in adulthood reverses the synaptic and behavioral deficits elicited by prenatal exposure to phenobarbital. 
  • Nicotinic acetylcholine involvement in cognitive function in animals. 
  • Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. 
  • Nicotinic acetylcholine receptor expression and susceptibility to cholinergic immunomodulation in human monocytes of smoking individuals. 
  • Nicotinic acetylcholine receptor stimulation impairs epidermal permeability barrier function and recovery and modulates cornified envelope proteins. 
  • Nicotinic alpha7- or beta2-containing receptor knockout: effects on radial-arm maze learning and long-term nicotine consumption in mice. 
  • Nicotinic antagonist effects in the mediodorsal thalamic nucleus: regional heterogeneity of nicotinic receptor involvement in cognitive function. 
  • Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin. 
  • Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo. 
  • Nicotinic cholinergic receptors labeled by [3H]acetylcholine in rat brain. 
  • Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization. 
  • Nicotinic interactions with antipsychotic drugs, models of schizophrenia and impacts on cognitive function. 
  • Nicotinic involvement in memory function in zebrafish. 
  • Nicotinic mechanisms of memory: effects of acute local DHbetaE and MLA infusions in the basolateral amygdala. 
  • Nicotinic receptor gene variants interact with attention deficient hyperactive disorder symptoms to predict smoking trajectories from early adolescence to adulthood. 
  • Nicotinic receptor subtypes and cognitive function. 
  • Nicotinic receptors in the habenula: importance for memory. 
  • Nicotinic system involvement in Alzheimer's and Parkinson's diseases. Implications for therapeutics. 
  • Nicotinic systems and cognitive function. 
  • Nicotinic treatment for degenerative neuropsychiatric disorders such as Alzheimer's disease and Parkinson's disease. 
  • Nicotinic, muscarinic and dopaminergic actions in the ventral hippocampus and the nucleus accumbens: effects on spatial working memory in rats. 
  • Nicotinic-dopaminergic relationships and radial-arm maze performance in rats. 
  • Novel insights for systemic inflammation in sepsis and hemorrhage. 
  • Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats. 
  • Parasympathetic stimulation via the vagus nerve prevents systemic organ dysfunction by abrogating gut injury and lymph toxicity in trauma and hemorrhagic shock. 
  • Paternal Δ9-Tetrahydrocannabinol Exposure Prior to Mating Elicits Deficits in Cholinergic Synaptic Function in the Offspring. 
  • Perinatal diazinon exposure compromises the development of acetylcholine and serotonin systems. 
  • Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain. 
  • Pharmacological and toxicological evaluation of 2-fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomography. 
  • Prenatal dexamethasone augments the sex-selective developmental neurotoxicity of chlorpyrifos: implications for vulnerability after pharmacotherapy for preterm labor. 
  • Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just "different?". 
  • Presynaptic nicotinic cholinergic receptors labeled by [3H]acetylcholine on catecholamine and serotonin axons in brain. 
  • Probing the Allosteric Role of the α5 Subunit of α3β4α5 Nicotinic Acetylcholine Receptors by Functionally Selective Modulators and Ligands. 
  • Quantification of alpha4beta2* nicotinic receptors in the rat brain with microPET and 2-[18F]F-A-85380. 
  • Quantification of nicotinic acetylcholine receptors in the human brain with PET: bolus plus infusion administration of 2-[18F]F-A85380. 
  • Quantitative autoradiography of nicotinic [3H]acetylcholine binding sites in rat brain. 
  • Quantitative myasthenia gravis score: assessment of responsiveness and longitudinal validity. 
  • Radiosynthesis and preliminary evaluation of 5-[123/125I]iodo-3-(2(S)-azetidinylmethoxy)pyridine: a radioligand for nicotinic acetylcholine receptors. 
  • Radiosynthesis of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-[(11)C]methyl-2-(S)-pyrrolidinylmethoxy)pyridine, a high affinity ligand for studying nicotinic acetylcholine receptors by positron emission tomography. 
  • Receptor targeting and heterogeneity at interneuronal nicotinic cholinergic synapses in vivo. 
  • Regulatory mechanisms that govern nicotinic synapse formation in neurons. 
  • Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. 
  • Role of nicotinic receptors in the lateral habenula in the attenuation of amphetamine-induced prepulse inhibition deficits of the acoustic startle response in rats. 
  • Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats. 
  • Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats. 
  • Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats. 
  • Separate or sequential exposure to nicotine prenatally and in adulthood: persistent effects on acetylcholine systems in rat brain regions. 
  • Spatial working and reference memory in rats bred for autonomic sensitivity to cholinergic stimulation: acquisition, accuracy, speed, and effects of cholinergic drugs. 
  • Structural conservation of ion conduction pathways in K channels and glutamate receptors. 
  • Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. 
  • Synthesis and evaluation of a novel series of 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine analogues as potential positron emission tomography imaging agents for nicotinic acetylcholine receptors. 
  • The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation. 
  • The anti-inflammatory potential of selective cholinergic agonists. 
  • The biology of tobacco and nicotine: bench to bedside. 
  • The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. 
  • The importance of nicotinic acetylcholine receptors in schizophrenia, bipolar disorder and Tourette's syndrome. 
  • The neuronal strategy for inflammation. 
  • The nicotinic acetylcholine receptor gene family of the silkworm, Bombyx mori. 
  • The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors. 
  • The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish. 
  • The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice. 
  • The vagus nerve and the nicotinic anti-inflammatory pathway. 
  • Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5 and beta-4 subunits of neuronal nicotinic acetylcholine receptors: preferential transcription of the alpha-3 and beta-4 genes by immature CD4 + 8 + thymocytes. 
  • Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5, and beta-4 subunits of neuronal nicotinic acetylcholine receptors. Preferential transcription of the alpha-3 and beta-4 genes by immature CD4+8+ thymocytes and evidence for response to nicotine in thymocytes. 
  • Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density. 
  • Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis. 
  • Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers. 
  • Validation of an extracerebral reference region approach for the quantification of brain nicotinic acetylcholine receptors in squirrel monkeys with PET and 2-18F-fluoro-A-85380. 
  • Ventral hippocampal NMDA blockade and nicotinic effects on memory function. 
  • Ventral hippocampal alpha 7 nicotinic receptor blockade and chronic nicotine effects on memory performance in the radial-arm maze. 
  • Ventral hippocampal alpha4beta2 nicotinic receptors and chronic nicotine effects on memory. 
  • Ventral hippocampal alpha7 and alpha4beta2 nicotinic receptor blockade and clozapine effects on memory in female rats. 
  • Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjects. 
  • [Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population]. 
  • alpha7 Nicotinic acetylcholine receptors and temporal memory: synergistic effects of combining prenatal choline and nicotine on reinforcement-induced resetting of an interval clock. 
  • beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. 
  • α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats. 
  • α7-Nicotinic receptors and cognition. 
  • α7-cholinergic receptor mediates vagal induction of splenic norepinephrine. 
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  Keywords of People

  • Schwartz-Bloom, Rochelle D., Professor Emeritus of Pharmacology & Cancer Biology, Duke Science & Society