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Subject Areas on Research
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16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity.
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A lower Allred score for progesterone receptor is strongly associated with a higher recurrence score of 21-gene assay in breast cancer.
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A machine learning approach to radiogenomics of breast cancer: a study of 922 subjects and 529 DCE-MRI features.
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A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors.
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A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRA, in Saccharomyces cerevisiae.
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A phase II study of medroxyprogesterone acetate in patients with hormone receptor negative metastatic breast cancer: translational breast cancer research consortium trial 007.
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A truncated progesterone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration.
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Absence of mitochondrial progesterone receptor polymorphisms in women with spontaneous preterm birth.
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Abundance and Localization of Progesterone Receptor Isoforms in Endometrium in Women With and Without Endometriosis and in Peritoneal and Ovarian Endometriotic Implants.
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Actions of steroids in mitochondria.
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Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol.
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Adherence to Adjuvant Endocrine Therapy in Insured Black and White Breast Cancer Survivors: Exploring Adherence Measures in Patient Data.
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Aggressive fibromatosis.
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Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia.
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Are all aromatase inhibitors alike?
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Association of aspirin use and hormone receptor status with breast cancer risk.
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Axillary Nodal Evaluation in Elderly Breast Cancer Patients: Potential Effects on Treatment Decisions and Survival.
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BMI influences prognosis following surgery and adjuvant chemotherapy for lymph node positive breast cancer.
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Biological Subtype Predicts Risk of Locoregional Recurrence After Mastectomy and Impact of Postmastectomy Radiation in a Large National Database.
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Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.
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Breast cancer as heterogeneous disease: contributing factors and carcinogenesis mechanisms.
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Breast cancer survival in African-American women by hormone receptor subtypes.
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Breast medical oncologists' use of standard prognostic factors to predict a 21-gene recurrence score.
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CDB-4124 does not cause apoptosis in cultured fibroid cells.
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Characterization of progesterone receptor isoform expression in fetal membranes.
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Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites.
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Clinical Impact of 21-Gene Recurrence Score Test Within the Veterans Health Administration: Utilization and Receipt of Guideline-Concordant Care.
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Clinical application of array-based comparative genomic hybridization to define the relationship between multiple synchronous tumors.
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Cloning and expression of a novel, truncated, progesterone receptor.
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Connections and regulation of the human estrogen receptor.
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Creatine kinase activity as an indicator of unopposed estrogen action in the mouse uterus associated with anti-progesterone treatment.
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Cystosarcoma phylloides. A steroid receptor and ultrastructure analysis.
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Definition of the cellular mechanisms which distinguish between hormone and antihormone activated steroid receptors.
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Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor.
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Development of the human female reproductive tract.
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Differential cellular localization of CELSR2 and ING4 and correlations with hormone receptor status in breast cancer.
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Differential responsiveness of MCF-7 human breast cancer cell line stocks to the pineal hormone, melatonin.
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Effect of tumor subtype on survival and the graded prognostic assessment for patients with breast cancer and brain metastases.
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Effects of an oral contraceptive combination with or without androgen on mammary tissues: a study in rats.
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Effects of genistein or soy milk during late gestation and lactation on adult uterine organization in the rat.
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Endocrine therapy in metastatic breast cancer.
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Endocrine therapy with or without inhibition of epidermal growth factor receptor and human epidermal growth factor receptor 2: a randomized, double-blind, placebo-controlled phase III trial of fulvestrant with or without lapatinib for postmenopausal women with hormone receptor-positive advanced breast cancer-CALGB 40302 (Alliance).
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Endometrial receptivities after leuprolide suppression and gonadotropin stimulation: histology, steroid receptor concentrations, and implantation rates.
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Evaluating the addition of bevacizumab to endocrine therapy as first-line treatment for hormone receptor-positive metastatic breast cancer: a pooled analysis from the LEA (GEICAM/2006-11_GBG51) and CALGB 40503 (Alliance) trials.
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Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay.
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Expression of a mitochondrial progesterone receptor (PR-M) in leiomyomata and association with increased mitochondrial membrane potential.
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Expression of a mitochondrial progesterone receptor in human spermatozoa correlates with a progestin-dependent increase in mitochondrial membrane potential.
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Expression of functional chicken oviduct progesterone receptors in yeast (Saccharomyces cerevisiae).
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Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion.
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Frequency of breast cancer subtypes among African American women in the AMBER consortium.
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Fulvestrant-Based Combination Therapy for Second-Line Treatment of Hormone Receptor-Positive Advanced Breast Cancer.
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Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk.
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Heterogeneity in the hormonal responsiveness of clones derived from the 13762NF rat mammary tumor.
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High inhibitory activity of a new antiestrogen, RU 16117 (11alpha-methoxy ethinyl estradiol), on the development of dimethylbenz(a)anthracene-induced mammary tumors.
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High level expression of a truncated chicken progesterone receptor in Escherichia coli.
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High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples.
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Hormone therapy: physiological complexity belies therapeutic simplicity.
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Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo.
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Hormone-related factors and risk of breast cancer in relation to estrogen receptor and progesterone receptor status.
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Human epidermal growth factor receptor-2 and estrogen receptor expression, a demonstration project using the residual tissue repository of the Surveillance, Epidemiology, and End Results (SEER) program.
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Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.
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Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins.
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Identification of a negative regulatory function for steroid receptors.
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Identification of progesterone receptor in human subcutaneous adipose tissue.
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Identification of risk factors for toxicity in patients with hormone receptor-positive advanced breast cancer treated with bevacizumab plus letrozole: a CALGB 40503 (alliance) correlative study.
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Immunofluorescent localization of a novel progesterone receptor(s) in a T47D-Y breast cancer cell line lacking genomic progesterone receptor expression.
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Immunohistochemical expression of TAG-72 in normal and malignant endometrium: correlation of antigen expression with estrogen receptor and progesterone receptor levels.
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Impact of hormone receptor status on patterns of recurrence and clinical outcomes among patients with human epidermal growth factor-2-positive breast cancer in the National Comprehensive Cancer Network: a prospective cohort study.
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Inhibiting Nuclear Phospho-Progesterone Receptor Enhances Antitumor Activity of Onapristone in Uterine Cancer.
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Interactions of estrogen- and thyroid hormone receptors on a progesterone receptor estrogen response element (ERE) sequence: a comparison with the vitellogenin A2 consensus ERE.
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International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors.
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Intratumor heterogeneity and precision of microarray-based predictors of breast cancer biology and clinical outcome.
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Intratumoral heterogeneity as a source of discordance in breast cancer biomarker classification.
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Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study.
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Is Multifocal Regression a Risk Factor for Ipsilateral Breast Tumor Recurrence in the Modern Era After Neoadjuvant Chemotherapy and Breast Conservation Therapy?
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Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator.
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Ki67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance).
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Lack of expression of androgen receptor may play a critical role in transformation from in situ to invasive basal subtype of high-grade ductal carcinoma of the breast.
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Long-term prognostic implications of sex-steroid receptors in human cancer.
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Magnetic resonance imaging as a predictor of pathologic response in patients treated with neoadjuvant systemic treatment for operable breast cancer. Translational Breast Cancer Research Consortium trial 017.
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Male breast carcinoma: correlation of ER, PR, Ki-67, Her2-Neu, and p53 with treatment and survival, a study of 65 cases.
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Malignant effusions in recurrent breast cancer: steroid hormone receptor analysis of effusion fluid derived cells.
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Malignant transformation of the human endometrium is associated with overexpression of lactoferrin messenger RNA and protein.
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Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor.
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Mechanisms controlling agonist and antagonist potential of selective progesterone receptor modulators (SPRMs).
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Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer.
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Membrane-bound progesterone receptor expression in human aortic endothelial cells.
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Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells.
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Modulation of progesterone receptor binding to progesterone response elements by positioned nucleosomes.
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Molecular mechanisms of development of the human fetal female reproductive tract.
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Multimodal regulation of E2F1 gene expression by progestins.
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Multivariable analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer.
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Mutant and wild-type androgen receptors exhibit cross-talk on androgen-, glucocorticoid-, and progesterone-mediated transcription.
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Neoadjuvant Systemic Therapy for Breast Cancer: Factors Influencing Surgeons' Referrals.
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No relationship between ovarian cancer risk and progesterone receptor gene polymorphism in a population-based, case-control study in North Carolina.
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Novel Hormone Receptors Present in Apocrine Cystadenoma of the Eyelid.
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Novel prognostic markers for patients with triple-negative breast cancer.
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Palbociclib in Hormone-Receptor-Positive Advanced Breast Cancer.
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Partial agonist activity of the progesterone receptor antagonist RU486 mediated by an amino-terminal domain coactivator and phosphorylation of serine400.
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Pathology and pathophysiology of uterine smooth-muscle tumors.
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Performance of preoperative breast MRI based on breast cancer molecular subtype.
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Phase I/II dose-escalation study of PI3K inhibitors pilaralisib or voxtalisib in combination with letrozole in patients with hormone-receptor-positive and HER2-negative metastatic breast cancer refractory to a non-steroidal aromatase inhibitor.
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Phase II, randomized, placebo-controlled study of dovitinib in combination with fulvestrant in postmenopausal patients with HR+, HER2- breast cancer that had progressed during or after prior endocrine therapy.
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Phosphorylation of hen progesterone receptor by cAMP dependent protein kinase.
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Population and target considerations for triple-negative breast cancer clinical trials.
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Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506.
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Practical Treatment Strategies and Future Directions After Progression While Receiving CDK4/6 Inhibition and Endocrine Therapy in Advanced HR+/HER2- Breast Cancer.
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Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice.
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Pregnancy without progesterone in horses defines a second endogenous biopotent progesterone receptor agonist, 5α-dihydroprogesterone.
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Progesterone Increases Mitochondria Membrane Potential in Non-human Primate Oocytes and Embryos.
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Progesterone inhibits glucocorticoid-induced murine thymocyte apoptosis.
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Progesterone receptor activity in leiomyomatosis peritonealis disseminata.
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Progesterone receptor gene polymorphism and risk for breast and ovarian cancer.
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Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.
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Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways.
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Progesterone receptor membrane component 1 (PGRMC1) expression in fetal membranes among women with preterm premature rupture of the membranes (PPROM).
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Progesterone receptor membrane component 1 as the mediator of the inhibitory effect of progestins on cytokine-induced matrix metalloproteinase 9 activity in vitro.
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Progesterone receptor membrane component 1: is metabolism integral to its function and what other steroids are involved?
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Progesterone receptor promoter +331A polymorphism is associated with a reduced risk of endometrioid and clear cell ovarian cancers.
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Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis.
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Progesterone receptor-A and -B have opposite effects on proinflammatory gene expression in human myometrial cells: implications for progesterone actions in human pregnancy and parturition.
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Progesterone receptors in the human heart and great vessels.
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Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells.
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Progesterone, Inflammatory Cytokine (TNF-α), and Oxidative Stress (H2O2) Regulate Progesterone Receptor Membrane Component 1 Expression in Fetal Membrane Cells.
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Progestins Inhibit Tumor Necrosis Factor α-Induced Matrix Metalloproteinase 9 Activity via the Glucocorticoid Receptor in Primary Amnion Epithelial Cells.
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Prostate. III--A structural feature characteristic of the rat prostate 5 alpha-reductase active site.
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Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression.
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RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism.
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Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study.
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Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study.
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Racial disparities in individual breast cancer outcomes by hormone-receptor subtype, area-level socio-economic status and healthcare resources.
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Regulation of the amino-terminal transcription activation domain of progesterone receptor by a cofactor-induced protein folding mechanism.
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Relationship between expression of coactivators and corepressors of hormone receptors and resistance of ovarian cancers to growth regulation by steroid hormones.
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Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study.
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Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer.
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Risk factors by molecular subtypes of breast cancer across a population-based study of women 56 years or younger.
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Risk of positive nonsentinel nodes in women with 1-2 positive sentinel nodes related to age and molecular subtype approximated by receptor status.
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Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines.
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Roles of Progesterone Receptor Membrane Component 1 in Oxidative Stress-Induced Aging in Chorion Cells.
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Safety and efficacy of the selective progesterone receptor modulator asoprisnil for heavy menstrual bleeding with uterine fibroids: pooled analysis of two 12-month, placebo-controlled, randomized trials.
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Sex steroid receptor analysis in human melanoma.
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Sex steroid receptor concentration in breast carcinoma tissue: effect of devascularization during mastectomy.
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Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition.
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Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy.
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Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism.
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Steroids induce hypothalamic progestin receptors and facilitate female sexual behavior in neonatal rats.
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Structural organization and regulation of the chicken estrogen receptor.
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TBCRC 001: randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer.
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The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.
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The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene.
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The Association of Extent of Axillary Surgery and Survival in Women with N2-3 Invasive Breast Cancer.
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The Novel Progesterone Receptor Antagonists RTI 3021-012 and RTI3021-022 Exhibit Complex Glucocorticoid Receptor Antagonist Activities: Implications for the Development of Dissociated Antiprogestins.
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The Role of Progesterone and a Novel Progesterone Receptor, Progesterone Receptor Membrane Component 1, in the Inflammatory Response of Fetal Membranes to Ureaplasma parvum Infection.
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The Role of a Mitochondrial Progesterone Receptor (PR-M) in Progesterone Action.
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The association between progesterone receptor expression and survival in women with adult granulosa cell tumors.
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The effect of tumor subtype on the time from primary diagnosis to development of brain metastases and survival in patients with breast cancer.
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The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity.
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The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor.
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The molecular pharmacology of ovarian steroid receptors.
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The need to examine metastatic tissue at the time of progression of breast cancer: is re-biopsy a necessity or a luxury?
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The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor.
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The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features.
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The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding.
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Tissue interactions and estrogenic response during human female fetal reproductive tract development.
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Trends in Treatment Patterns and Outcomes for Ductal Carcinoma In Situ.
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Type and duration of exogenous hormone use affects breast cancer histology.
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Updated results from MONALEESA-2, a phase III trial of first-line ribociclib plus letrozole versus placebo plus letrozole in hormone receptor-positive, HER2-negative advanced breast cancer.
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Validation of a breast cancer risk prediction model developed for Black women.
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Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors.
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Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression.
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[Treatment of primary cancer of the breast in elderly women. Role of hormone therapy].
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Halabi, Susan,
Professor of Biostatistics and Bioinformatics,
Biostatistics & Bioinformatics
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McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Duke Innovation & Entrepreneurship
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Moorman, Patricia Gripka,
Professor in Family Medicine and Community Health,
Duke Cancer Institute