Sensory Receptor Cells

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  Subject Areas on Research

  • 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. 
  • A Method to Target and Isolate Airway-innervating Sensory Neurons in Mice. 
  • A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101. 
  • A neurally efficient implementation of sensory population decoding. 
  • A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae. 
  • A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. 
  • A synaptic and circuit basis for corollary discharge in the auditory cortex. 
  • Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation. 
  • Activity of neurons in monkey globus pallidus during oculomotor behavior compared with that in substantia nigra pars reticulata. 
  • Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice. 
  • Anatomic location of a sensory nerve to the lateral thigh flap: A novel option for sensate autologous tissue reconstruction. 
  • Anatomic location of a sensory nerve to the profunda artery perforator (PAP) flap: A novel option for sensate autologous tissue reconstruction. 
  • Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons. 
  • Behavioral and neural responses to gustatory stimuli delivered non-contingently through intra-oral cannulas. 
  • Bladder sensory physiology: neuroactive compounds and receptors, sensory transducers, and target-derived growth factors as targets to improve function. 
  • CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain. 
  • Cellular projections from sensory hair cells form polarity-specific scaffolds during synaptogenesis. 
  • Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition. 
  • Comparative analysis of behavioral and transcriptional variation underlying CO₂ sensory neuron function and development in Drosophila. 
  • Complement and CD4+ T cells drive context-specific corneal sensory neuropathy. 
  • Deafening drives cell-type-specific changes to dendritic spines in a sensorimotor nucleus important to learned vocalizations. 
  • Decreased cochlear DNA receptor staining in MRL.MpJ-Fas(lpr) autoimmune mice with hearing loss. 
  • Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. 
  • Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies. 
  • Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. 
  • ETAR and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia. 
  • Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation. 
  • Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond. 
  • Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine. 
  • Expectation and surprise determine neural population responses in the ventral visual stream. 
  • Frontal eye field neurons assess visual stability across saccades. 
  • G protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice. 
  • Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies. 
  • Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. 
  • High-Throughput Odorant Receptor Deorphanization Via Phospho-S6 Ribosomal Protein Immunoprecipitation and mRNA Profiling. 
  • High-frequency steering maneuvers mediated by tactile cues: antennal wall-following in the cockroach. 
  • How Do Sensory Neurons Sense Danger Signals? 
  • I Want It All and I Want It Now: How a Neural Circuit Encodes Odor with Speed and Accuracy. 
  • IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy. 
  • Identifying local and descending inputs for primary sensory neurons. 
  • Intracellular signaling in primary sensory neurons and persistent pain. 
  • Involvement of Sensory Neurone-TRPV4 in Acute and Chronic Itch Behaviours. 
  • Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone. 
  • Is Optogenetic Activation of Vglut1-Positive Aβ Low-Threshold Mechanoreceptors Sufficient to Induce Tactile Allodynia in Mice after Nerve Injury? 
  • Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila. 
  • Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels. 
  • Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation. 
  • MAP kinase and pain. 
  • Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. 
  • Modality representation in the lumbar and cervical fasciculus gracilis of squirrel monkeys. 
  • Molecular control limiting sensitivity of sweet taste neurons in Drosophila. 
  • Molecular mechanisms of TRPV4-mediated neural signaling. 
  • Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development. 
  • Neural circuits. Labeling of active neural circuits in vivo with designed calcium integrators. 
  • Neuroanatomical relationships of substance P-immunoreactive intrapulmonary C-fibers and nicotinic cholinergic receptors. 
  • Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response. 
  • New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms? 
  • Nociceptors are interleukin-1beta sensors. 
  • Olfactory marker protein mRNA is found in axons of olfactory receptor neurons. 
  • Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice. 
  • Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice. 
  • Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. 
  • Pleiotropic function of TRPV4 ion channels in the central nervous system. 
  • Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance). 
  • Prenatal and Early Postnatal Odorant Exposure Heightens Odor-Evoked Mitral Cell Responses in the Mouse Olfactory Bulb. 
  • Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling. 
  • Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome. 
  • RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization. 
  • Receptors, circuits, and behaviors: new directions in chemical senses. 
  • Regulation of neurogenesis and neuronal differentiation in primary and immortalized cells from mouse olfactory epithelium. 
  • Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons. 
  • Relationship between adapted neural population responses in MT and motion adaptation in speed and direction of smooth-pursuit eye movements. 
  • SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons. 
  • STING controls nociception via type I interferon signalling in sensory neurons. 
  • Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model. 
  • Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures. 
  • Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior. 
  • Sensory neural codes using multiplexed temporal scales. 
  • Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia. 
  • Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain. 
  • Sodium channels and mammalian sensory mechanotransduction. 
  • Somatic innervation of the feline lower urinary tract. 
  • Spinal sensory projection neuron responses to spinal cord stimulation are mediated by circuits beyond gate control. 
  • Subjective response to cigarette smoking following airway anesthetization. 
  • Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex. 
  • Systematic mapping of the monkey inferior colliculus reveals enhanced low frequency sound representation. 
  • TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation. 
  • TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. 
  • TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain. 
  • Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain. 
  • Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse. 
  • Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion. 
  • The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel. 
  • The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test. 
  • The cornea has "the nerve" to encourage immune rejection. 
  • The gustatory cortex and multisensory integration. 
  • The role of neutrophils in neuro-immune modulation. 
  • Trigeminal responses to thermal stimulation of the oral cavity in rattlesnakes (Crotalus viridis) before and after bilateral anesthetization of the facial pit organs. 
  • TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus. 
  • Unveiling the secrets to her heart. 
  • Urethral flow-responsive afferents in the cat sacral dorsal root ganglia. 
  • Vibrissa sensory neurons: Linking distinct morphology to specific physiology and function. 
  • Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice. 
  • β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel. 
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  Keywords of People

  • Bohorquez, Diego V., Associate Professor in Medicine, Neurobiology
  • De Caceres Bustos, Anabel, Research Scientist, Senior, Anesthesiology
  • Jordt, Sven Eric, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology
  • Nicolelis, Miguel Angelo L., Duke School of Medicine Distinguished Professor in Neuroscience, Neurobiology