Receptors, Serotonin

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  Subject Areas on Research

  • 5-HT receptors: implications for the neuropharmacology of alcohol and alcoholism. 
  • 5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools. 
  • 5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation. 
  • 8-hydroxy-2-(di-n-propylamino)tetralin-responsive 5-hydroxytryptamine4-like receptor expressed in bovine pulmonary artery smooth muscle cells. 
  • Acetylenics. 2. Synthesis and pharmacology of certain N,N-diakyl-3-phenylpropyn-2-amines. Some analogues with tryptamine-like behavioral effects in mice. 
  • Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase. 
  • Autoreceptor control of serotonin dynamics. 
  • Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine. 
  • Behavioral differences between two inbred strains of Fawn-Hooded rat: a model of serotonin dysfunction. 
  • Behavioral indications for serotonin receptor hypersensitivity in panic disorder. 
  • Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i). 
  • Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen. 
  • Clonazepam-induced up-regulation of serotonin1 and serotonin2 binding sites in rat frontal cortex. 
  • Clonazepam-induced up-regulation of serotonin1 binding sites in frontal cortex of rat. 
  • Critical prenatal and postnatal periods for persistent effects of dexamethasone on serotonergic and dopaminergic systems. 
  • Developmental Neurotoxicity of Tobacco Smoke Directed Toward Cholinergic and Serotonergic Systems: More Than Just Nicotine. 
  • Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. 
  • Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel. 
  • Dexamethasone suppression test identifies a subset of elderly depressed patients with reduced platelet serotonin transport and resistance to imipramine inhibition of transport. 
  • Differential ontogeny of opioid, dopaminergic and serotonergic regulation of prolactin secretion. 
  • Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein. 
  • Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats. 
  • Effector coupling mechanisms of the cloned 5-HT1A receptor. 
  • Efficacy of risperidone on positive features of schizophrenia. 
  • Ergotamine and dihydroergotamine: history, pharmacology, and efficacy. 
  • Functional expression of human 5-HT1A receptors and differential coupling to second messengers in CHO cells. 
  • Further selection of rat lines differing in 5-HT-1A receptor sensitivity: behavioral and functional correlates. 
  • Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism. 
  • Genetic serotonin deficiency and alcohol preference in the fawn hooded rats. 
  • Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. 
  • Identification of a rat glomerular mesangial cell mitogenic 5-HT2A receptor. 
  • Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe. 
  • Inhibition of GH in maternal separation may be mediated through altered serotonergic activity at 5-HT2A and 5-HT2C receptors. 
  • Is There a Critical Period for the Developmental Neurotoxicity of Low-Level Tobacco Smoke Exposure? 
  • LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system. 
  • Lasting effects of nicotine treatment and withdrawal on serotonergic systems and cell signaling in rat brain regions: separate or sequential exposure during fetal development and adulthood. 
  • Mimicking maternal smoking and pharmacotherapy of preterm labor: interactions of fetal nicotine and dexamethasone on serotonin and dopamine synaptic function in adolescence and adulthood. 
  • Molecular determinants of selectivity in 5-hydroxytryptamine1B receptor-G protein interactions. 
  • Molecular neurobiology. The chimaeras speak again. 
  • Neurobiological mechanisms in generalized anxiety disorder. 
  • Norepinephrine transport-mediated gene expression in noradrenergic neurogenesis. 
  • PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. 
  • Perinatal diazinon exposure compromises the development of acetylcholine and serotonin systems. 
  • Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age. 
  • Posttraumatic stress disorder: diagnosis and epidemiology, comorbidity and social consequences, biology and treatment. 
  • Potential mechanisms of action of atypical antipsychotic medications in treatment-resistant depression and anxiety. 
  • Prenatal dexamethasone, as used in preterm labor, worsens the impact of postnatal chlorpyrifos exposure on serotonergic pathways. 
  • Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function and cognition. 
  • Prenatal nicotine exposure alters the responses to subsequent nicotine administration and withdrawal in adolescence: Serotonin receptors and cell signaling. 
  • Rapid selection for serotonin-1A sensitivity in rats. 
  • Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway. 
  • Reduced inhibitory effect of imipramine on radiolabeled serotonin uptake into platelets in geriatric depression. 
  • Reduced serotonin receptors and transporters in normal aging adults: a meta-analysis of PET and SPECT imaging studies. 
  • Selective inhibition of alcohol intake in diverse alcohol-preferring rat strains by the 5-HT2A antagonists amperozide and FG 5974. 
  • Serotonergic cell signaling in an animal model of aging and depression: olfactory bulbectomy elicits different adaptations in brain regions of young adult vs aging rats. 
  • Serotonergic modulation of bladder afferent pathways. 
  • Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. 
  • Serotonin (1A) receptor ligands act on norepinephrine neuron firing through excitatory amino acid and GABA(A) receptors: a microiontophoretic study in the rat locus coeruleus. 
  • Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis. 
  • Serotonin-lesion myoclonic syndromes. I. Neurochemical profile and S-1 receptor binding. 
  • Short-term regulation of Na+/K+ adenosine triphosphatase by recombinant human serotonin 5-HT1A receptor expressed in HeLa cells. 
  • Structural conservation of ion conduction pathways in K channels and glutamate receptors. 
  • Swim test immobility co-segregates with serotonergic but not cholinergic sensitivity in cross-breeds of Flinders Line rats. 
  • The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]Pyrene: Effects on Cholinergic and Serotonergic Systems. 
  • The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. 
  • The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C. 
  • The resolution, isolation, and pharmacological characterization of the enantiomers of a benzamide containing a chiral sulfoxide. 
  • The sleep effects of lurasidone: a placebo-controlled cross-over study using a 4-h phase-advance model of transient insomnia. 
  • Voltammetric and mathematical evidence for dual transport mediation of serotonin clearance in vivo. 
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  Keywords of People

  • Tsalik, Ephraim, Associate Professor of Medicine, Molecular Genetics and Microbiology