Receptors, Transferrin

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  Subject Areas on Research

  • A combination of two immunotoxins exerts synergistic cytotoxic activity against human breast-cancer cell lines. 
  • A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. 
  • A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. 
  • Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. 
  • Antitransferrin receptor immunotoxin inhibits proliferating human retinal pigment epithelial cells. 
  • Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosome. 
  • Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. 
  • Balancing acts: molecular control of mammalian iron metabolism. 
  • Biomarkers of erythropoiesis response to intravenous iron in a crossover pilot study in unexplained anemia of the elderly. 
  • Biosynthesis of EGF receptor, transferrin receptor and colligin by cultured human keratinocytes and the effect of retinoic acid. 
  • Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. 
  • Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. 
  • Changes in hairy cells after alpha-interferon treatment as measured by flow cytometry. 
  • Clearance of antitransferrin receptor immunotoxin from the rabbit eye. 
  • Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. 
  • Differentiation of human T lymphocytes: II. Phenotypic difference in skin and blood malignant T-cells in cutaneous T-cell lymphoma. 
  • Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. 
  • Dissociation of thymidine incorporation and transferrin receptor expression from cell growth and c-myc accumulation in alpha-interferon-treated cells. 
  • Effects of Combined Tristetraprolin/Tumor Necrosis Factor Receptor Deficiency on the Splenic Transcriptome. 
  • Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus. 
  • Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation. 
  • Flow cytometric analysis of tumour-draining lymph nodes in breast cancer patients. 
  • Genes that modify the hemochromatosis phenotype in mice. 
  • Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells. 
  • Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. 
  • Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. 
  • Human splenic sinusoidal lining cells express antigens associated with monocytes, macrophages, endothelial cells, and T lymphocytes. 
  • Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor. 
  • Identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infection. 
  • Improving sensitivity and specificity of capturing and detecting targeted cancer cells with anti-biofouling polymer coated magnetic iron oxide nanoparticles. 
  • Inhibition of human corneal epithelium with immunotoxin 454A12-rRA. 
  • Inhibition of human subconjunctival fibroblast proliferation by immunotoxin. 
  • Inhibition of proliferating lens epithelium with antitransferrin receptor immunotoxin. 
  • Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis. 
  • Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress. 
  • Iron and HFE or TfR1 mutations as comorbid factors for development and progression of chronic hepatitis C. 
  • Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study. 
  • Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells. 
  • Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart. 
  • Lung injury after ozone exposure is iron dependent. 
  • Macrophages (histiocytes) in various reactive and inflammatory conditions express different antigenic phenotypes. 
  • Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle. 
  • Monensin enhances the cytotoxic effect of antitransferrin receptor immunotoxin on cultured RPE cells. 
  • Mouse mammary tumor virus uses mouse but not human transferrin receptor 1 to reach a low pH compartment and infect cells. 
  • NK susceptibility varies inversely with target cell class I HLA antigen expression. 
  • Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis. 
  • Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes. 
  • Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation. 
  • Protein targeting in neurons and endocrine cells. 
  • Rapid and Efficient Generation of Transgene-Free iPSC from a Small Volume of Cryopreserved Blood. 
  • Redox properties of human transferrin bound to its receptor. 
  • Scara5 is a ferritin receptor mediating non-transferrin iron delivery. 
  • Selective externalization of an ATP-binding protein structurally related to the clathrin-uncoating ATPase/heat shock protein in vesicles containing terminal transferrin receptors during reticulocyte maturation. 
  • Targeted drug delivery to C6 glioma by transferrin-coupled liposomes. 
  • Targeting of the synaptic vesicle protein synaptobrevin in the axon of cultured hippocampal neurons: evidence for two distinct sorting steps. 
  • The antiproliferative effect of a transferrin-toxin on human retinal pigment epithelial cells and rabbit fibroblasts. 
  • The genomic analysis of erythrocyte microRNA expression in sickle cell diseases. 
  • The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration. 
  • The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice. 
  • The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. 
  • Transferrin is required for early T-cell differentiation. 
  • Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses. 
  • Transferrin receptor 1 is differentially required in lymphocyte development. 
  • Transferrin receptor is necessary for development of erythrocytes and the nervous system. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute