Receptors, Virus

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  Subject Areas on Research

  • A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor. 
  • AIDS. Do antibodies enhance the infection of cells by HIV? 
  • Adaptation of an ICAM-1-tropic enterovirus to the mouse respiratory tract. 
  • Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints. 
  • Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver. 
  • Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis. 
  • An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis. 
  • An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target. 
  • Aryl Hydrocarbon Receptor Signaling Controls CD155 Expression on Macrophages and Mediates Tumor Immunosuppression. 
  • Attachment of bovine parvovirus to O-linked alpha 2,3 neuraminic acid on glycophorin A. 
  • Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. 
  • CD4-independent binding of HIV-1 to the B lymphocyte receptor CR2 (CD21) in the presence of complement and antibody. 
  • Characterization of an Epstein-Barr virus receptor on human epithelial cells. 
  • Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site. 
  • Circulating Kidney Injury Molecule-1 Levels in Acute Heart Failure: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure). 
  • Clinical isolates of measles virus use CD46 as a cellular receptor. 
  • Complement-mediated binding of naturally glycosylated and glycosylation-modified human immunodeficiency virus type 1 to human CR2 (CD21). 
  • Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike. 
  • Determinants of poliovirus neurovirulence. 
  • Distinctive gene transduction efficiencies of commonly used viral vectors in the retina. 
  • Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence. 
  • Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy. 
  • Dynamin- and lipid raft-dependent entry of decay-accelerating factor (DAF)-binding and non-DAF-binding coxsackieviruses into nonpolarized cells. 
  • Emerging concepts in acute kidney injury following cardiac surgery. 
  • Engineered Oncolytic Poliovirus PVSRIPO Subverts MDA5-Dependent Innate Immune Responses in Cancer Cells. 
  • Engineering AAV receptor footprints for gene therapy. 
  • Epstein Barr virus binding induces internalization of the C3d receptor: a novel immunotoxin delivery system. 
  • Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. 
  • Establishing communication via gram-negative bacterial pili. 
  • Establishment of cell lines with increased susceptibility to EV71/CA16 by stable overexpression of SCARB2. 
  • Evaluation of IRES-mediated, cell-type-specific cytotoxicity of poliovirus using a colorimetric cell proliferation assay. 
  • Evaluation of lymphocyte differentiation in primary and secondary immunodeficiency diseases. 
  • Expression of CCR5 increases during monocyte differentiation and directly mediates macrophage susceptibility to infection by human immunodeficiency virus type 1. 
  • Expression of the human poliovirus receptor/CD155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis. 
  • Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog. 
  • Genetically divergent strains of human immunodeficiency virus type 2 use multiple coreceptors for viral entry. 
  • Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders. 
  • Granulocyte colony-stimulating factor mobilized peripheral blood stem cells enter into G1 of the cell cycle and express higher levels of amphotropic retrovirus receptor mRNA. 
  • Growth phenotypes and biosafety profiles in poliovirus-receptor transgenic mice of recombinant oncolytic polio/human rhinoviruses. 
  • HIV-1 GP120-mediated immune suppression and lymphocyte destruction in the absence of viral infection. 
  • HIV. A clever hijacker of the immune system. 
  • HTLV-III/LAV-neutralizing antibodies to an E. coli-produced fragment of the virus envelope. 
  • Human epithelial cell expression of an Epstein-Barr virus receptor. 
  • Identification of a human heme exporter that is essential for erythropoiesis. 
  • Intergeneric poliovirus recombinants for the treatment of malignant glioma. 
  • Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts. 
  • Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection. 
  • Molecular targets of anti-HIV-1 triterpenes. 
  • Multifaceted roles for lipids in viral infection. 
  • Multiple roles for sialylated glycans in determining the cardiopulmonary tropism of adeno-associated virus 4. 
  • Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4. 
  • Oncolytic polio virotherapy of cancer. 
  • Oncolytic viruses for cancer therapy I. Cell-external factors: virus entry and receptor interaction. 
  • Oncolytic viruses for cancer therapy II. Cell-internal factors for conditional growth in neoplastic cells. 
  • Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery. 
  • Phenotypic variation in the response to the human immunodeficiency virus among derivatives of the CEM T and WIL-2 B cell lines. 
  • Picornavirus entry. 
  • Poliovirus Receptor (CD155) Expression in Pediatric Brain Tumors Mediates Oncolysis of Medulloblastoma and Pleomorphic Xanthoastrocytoma. 
  • Poliovirus and its cellular receptor: a molecular genetic dissection of a virus/receptor affinity interaction. 
  • Poliovirus entry into human brain microvascular cells requires receptor-induced activation of SHP-2. 
  • Poliovirus receptor CD155-targeted oncolysis of glioma. 
  • Receptor Switching in Newly Evolved Adeno-associated Viruses. 
  • Recombinant Poliovirus for Cancer Immunotherapy. 
  • Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle. 
  • SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. 
  • SARS-CoV-2 and HIV-1 - a tale of two vaccines. 
  • Sensitivity and specificity of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 for the diagnosis of renal cell carcinoma. 
  • Single-round selection yields a unique retroviral envelope utilizing GPR172A as its host receptor. 
  • Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1. 
  • Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes. 
  • Targeted entry via somatostatin receptors using a novel modified retrovirus glycoprotein that delivers genes at levels comparable to those of wild-type viral glycoproteins. 
  • Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions. 
  • Targeted therapy for glioblastoma multiforme neoplastic meningitis with intrathecal delivery of an oncolytic recombinant poliovirus. 
  • Terminal N-linked galactose is the primary receptor for adeno-associated virus 9. 
  • The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. 
  • The distinct roles of JAM-A in reovirus pathogenesis. 
  • The human poliovirus receptor. Receptor-virus interaction and parameters of disease specificity. 
  • The motion of a single molecule, the lambda-receptor, in the bacterial outer membrane. 
  • The neonatal Fc receptor is a pan-echovirus receptor. 
  • The phenotype of human placental macrophages and its variation with gestational age. 
  • Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses. 
  • Treatment of intracerebral neoplasia and neoplastic meningitis with regional delivery of oncolytic recombinant poliovirus. 
  • Unique glycan signatures regulate adeno-associated virus tropism in the developing brain. 
  • Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas. 
  • Viral receptor-binding site antibodies with diverse germline origins. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology