Endosomes

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  Subject Areas on Research

  • A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation. 
  • A differential role for endocytosis in receptor-mediated activation of Nox1. 
  • A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes. 
  • A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. 
  • A new front in cell invasion: The invadopodial membrane. 
  • A quantitative study of the intracellular fate of pH-responsive doxorubicin-polypeptide nanoparticles. 
  • ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo. 
  • AQP2 is a substrate for endogenous PP2B activity within an inner medullary AKAP-signaling complex. 
  • ARF1 regulates Nef-induced CD4 degradation. 
  • Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production. 
  • Activation of the NLRP3 inflammasome by intracellular poly I:C. 
  • Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling. 
  • An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles. 
  • Ang II accumulation in rat renal endosomes during Ang II-induced hypertension: role of AT(1) receptor. 
  • Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes. 
  • Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosome. 
  • Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. 
  • Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABAA receptors. 
  • BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance. 
  • Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. 
  • Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. 
  • Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. 
  • CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. 
  • Calpain-mediated AQP2 proteolysis in inner medullary collecting duct. 
  • Chaperone-mediated cross-priming: a hitchhiker's guide to vesicle transport (review). 
  • Chemical Modulation of Endocytic Sorting Augments Adeno-associated Viral Transduction. 
  • Clathrin-coated vesicle assembly polypeptides: physical properties and reconstitution studies with brain membranes. 
  • Cloning of an aquaporin homologue present in water channel containing endosomes of toad urinary bladder. 
  • Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network. 
  • Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2. 
  • Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3. 
  • Cytosolic delivery of macromolecules: I. Synthesis and characterization of pH-sensitive acyloxyalkylimidazoles. 
  • Definition of distinct compartments in polarized Madin-Darby canine kidney (MDCK) cells for membrane-volume sorting, polarized sorting and apical recycling. 
  • Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs. 
  • Distinct effects of endosomal escape and inhibition of endosomal trafficking on gene delivery via electrotransfection. 
  • EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor. 
  • Effect of cytofectins on the immune response of murine macrophages to mammalian DNA. 
  • Effects of endocytosis on receptor-mediated signaling. 
  • Electric field-induced redistribution and postfield relaxation of low density lipoprotein receptors on cultured human fibroblasts. 
  • Electrophysiology of reactive oxygen production in signaling endosomes. 
  • Endosomal cAMP production broadly impacts the cellular phosphoproteome. 
  • Endosome and INPP4B. 
  • Energy transfer assays of rat renal cortical endosomal fusion: evidence for superfusion. 
  • Engineered modular recombinant transporters: application of new platform for targeted radiotherapeutic agents to alpha-particle emitting 211 At. 
  • Evidence of a role for heterotrimeric GTP-binding proteins in endosome fusion. 
  • Exploitation of intracellular pH gradients in the cellular delivery of macromolecules. 
  • Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes. 
  • Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes. 
  • Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. 
  • G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands. 
  • G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. 
  • G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning. 
  • GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. 
  • Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus. 
  • Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans. 
  • Gentamicin inhibits rat renal cortical homotypic endosomal fusion: role of megalin. 
  • Heavy endosomes isolated from the rat renal cortex show attributes of intermicrovillar clefts. 
  • Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages. 
  • Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor. 
  • In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. 
  • In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast. 
  • Interaction of EGF receptor and grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy. 
  • Isolation of renal brush borders. 
  • Isoprenylcysteine carboxylmethyltransferase function is essential for RAB4A-mediated integrin β3 recycling, cell migration and cancer metastasis. 
  • LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes. 
  • Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer. 
  • Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells. 
  • Membrane potential mediates H(+)-ATPase dependence of "degradative pathway" endosomal fusion. 
  • Morphologic demonstration of clathrin-coated pits in frog and turkey erythrocytes. 
  • Mouse mammary tumor virus uses mouse but not human transferrin receptor 1 to reach a low pH compartment and infect cells. 
  • Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation. 
  • Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA. 
  • Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. 
  • Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival. 
  • Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. 
  • Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae. 
  • Performance comparison between the high-speed Yokogawa spinning disc confocal system and single-point scanning confocal systems. 
  • Protein targeting in neurons and endocrine cells. 
  • Quantitative Mapping of the Spatial Distribution of Nanoparticles in Endo-Lysosomes by Local pH. 
  • RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization. 
  • Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. 
  • Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo. 
  • Rat kidney papilla contains abundant synaptobrevin protein that participates in the fusion of antidiuretic hormone-regulated water channel-containing endosomes in vitro. 
  • Receptor-mediated endocytosis of carcinoembryonic antigen by rat liver Kupffer cells. 
  • Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. 
  • Renal endosomes contain angiotensin peptides, converting enzyme, and AT(1A) receptors. 
  • Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex. 
  • RhoB-dependent modulation of postendocytic traffic in polarized Madin-Darby canine kidney cells. 
  • Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. 
  • SNX10 and caspase-5 sort out endosomal LPS for a gut-wrenching Slug-fest. 
  • Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules. 
  • Select de novo gene and protein expression during renal epithelial cell culture in rotating wall vessels is shear stress dependent. 
  • Signaling at the endosome: cryo-EM structure of a GPCR-G protein-beta-arrestin megacomplex. 
  • Single-cell quantification and dose-response of cytosolic siRNA delivery. 
  • Small Molecule Improvement of Trafficking Defects in Models of Neurodegeneration. 
  • Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. 
  • Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex. 
  • Substance P dependence of endosomal fusion during bladder inflammation. 
  • Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways. 
  • Systematic analysis of F-box proteins reveals a new branch of the yeast mating pathway. 
  • Targeting of the synaptic vesicle protein synaptobrevin in the axon of cultured hippocampal neurons: evidence for two distinct sorting steps. 
  • The Arp2/3 complex has essential roles in vesicle trafficking and transcytosis in the mammalian small intestine. 
  • The C2 domain protein Cts1 functions in the calcineurin signaling circuit during high-temperature stress responses in Cryptococcus neoformans. 
  • The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. 
  • The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins. 
  • The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. 
  • Transfer of GRP94(Gp96)-associated peptides onto endosomal MHC class I molecules. 
  • Transiently expressed ATG16L1 inhibits autophagosome biogenesis and aberrantly targets RAB11-positive recycling endosomes. 
  • Vesicular Trafficking Systems Impact TORC1-Controlled Transcriptional Programs in Saccharomyces cerevisiae. 
  • Visualization of retroviral replication in living cells reveals budding into multivesicular bodies. 
  • [Vesicular flow in epithelial cells: physiopathologic importance of two multiligand receptors]. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery