Recombinant Fusion Proteins
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Subject Areas on Research
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(1)H, (15)N and (13)C backbone and side chain assignments of PSD-95 PDZ3 protein.
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4.5 kb of the rat tyrosine hydroxylase 5' flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors.
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A CRISPR/Cas9-based system for reprogramming cell lineage specification.
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A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation.
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A PAK-like protein kinase is required for maturation of young hyphae and septation in the filamentous ascomycete Ashbya gossypii.
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A Phase II trial of Denileukin Diftitox in patients with previously treated advanced non-small cell lung cancer.
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A Prospective Study of Urinary Prostaglandin E2 Metabolite, Helicobacter pylori Antibodies, and Gastric Cancer Risk.
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A bistable Rb-E2F switch underlies the restriction point.
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A broad competence to respond to SHORT ROOT revealed by tissue-specific ectopic expression.
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A cis-acting sequence homologous to the yeast filamentation and invasion response element regulates expression of a pectinase gene from the bean pathogen Colletotrichum lindemuthianum.
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A comparison of alemtuzumab with basiliximab induction in simultaneous pancreas-kidney transplantation.
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A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.
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A conserved domain for glycogen binding in protein phosphatase-1 targeting subunits.
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A conserved family of enzymes that phosphorylate inositol hexakisphosphate.
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A cut above the other caspases.
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A depot-forming glucagon-like peptide-1 fusion protein reduces blood glucose for five days with a single injection.
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A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.
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A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice.
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A molecular clasp in the human immunodeficiency virus (HIV) type 1 TM protein determines the anti-HIV activity of gp41 derivatives: implication for viral fusion.
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A molecular mechanism for the differential regulation of TGF-beta1 expression due to the common SNP -509C-T (c. -1347C > T).
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A mutant of the motor protein kinesin that moves in both directions on microtubules.
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A new dominant selectable marker for use in Cryptococcus neoformans.
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A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.
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A nonradioactive assay for transfected chloramphenicol acetyltransferase activity using fluorescent substrates.
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A novel model of persistent retinal neovascularization for the development of sustained anti-VEGF therapies.
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A novel mutation in IFN-gamma receptor 2 with dominant negative activity: biological consequences of homozygous and heterozygous states.
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A novel role for XIAP in copper homeostasis through regulation of MURR1.
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A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO.
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A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRA, in Saccharomyces cerevisiae.
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A nuclear role for the Fragile X mental retardation protein.
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A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration.
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A phase Ib study of capecitabine and ziv-aflibercept followed by a phase II single-arm expansion cohort in chemotherapy refractory metastatic colorectal cancer.
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A point mutation in the microtubule binding region of the Ncd motor protein reduces motor velocity.
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A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels.
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A powerful combinatorial screen to identify high-affinity terbium(III)-binding peptides.
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A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II.
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A quantitative, high-throughput screen for protein stability.
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A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity.
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A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with Jak1 and is sufficient to activate the Jak-Stat pathway and induce an antiviral state.
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A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest.
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A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program.
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A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion.
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A role for the Ppz Ser/Thr protein phosphatases in the regulation of translation elongation factor 1Balpha.
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A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.
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A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.
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A solubility-enhancement tag (SET) for NMR studies of poorly behaving proteins.
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A specific 31-nucleotide domain of U1 RNA directly interacts with the 70K small nuclear ribonucleoprotein component.
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A specific domain of Gialpha required for the transactivation of Gialpha by tubulin is implicated in the organization of cellular microtubules.
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A tamoxifen inducible knock-in allele for investigation of E2A function.
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A threshold for central T cell tolerance to an inducible serum protein
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A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells†.
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A transgenic toolkit for visualizing and perturbing microtubules reveals unexpected functions in the epidermis.
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ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry.
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AMP-activated protein kinase kinase: detection with recombinant AMPK alpha1 subunit.
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APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases.
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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway.
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ATP hydrolysis by a CFTR domain: pharmacology and effects of G551D mutation.
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Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance.
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Access of HIV-2 to CD169-dependent dendritic cell-mediated trans infection pathway is attenuated.
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Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation.
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Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro.
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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.
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Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits.
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Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism.
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Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.
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Adaptive NK cell responses in HIV/SIV infections: A roadmap to cell-based therapeutics?
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Adducin promotes micrometer-scale organization of beta2-spectrin in lateral membranes of bronchial epithelial cells.
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Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.
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Adenovirus F protein as a delivery vehicle for botulinum B.
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Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo.
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Adenovirus infections in pediatric small bowel transplant recipients.
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Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia.
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Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas.
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Aflibercept Monotherapy or Bevacizumab First for Diabetic Macular Edema.
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Aflibercept for central retinal vein occlusion: an ongoing revolution or are we spinning in place?
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Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema.
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Aflibercept-related sterile inflammation.
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Agonist-specific regulation of delta-opioid receptor trafficking by G protein-coupled receptor kinase and beta-arrestin.
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Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates.
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Allelic diversity in the TGFB1 regulatory region: characterization of novel functional single nucleotide polymorphisms.
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Allosteric actuation of inverse phase transition of a stimulus-responsive fusion polypeptide by ligand binding.
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Allosteric inhibition of kinesin-5 modulates its processive directional motility.
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Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.
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Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors.
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Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev.
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An Analysis of Medicare Reimbursement to Ophthalmologists: Years 2012 to 2013.
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An EcoRI-RsrI chimeric restriction endonuclease retains parental sequence specificity.
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An HIV Envelope gp120-Fc Fusion Protein Elicits Effector Antibody Responses in Rhesus Macaques.
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An economic and quality-of-life assessment of basiliximab vs antithymocyte globulin immunoprophylaxis in renal transplantation.
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An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants.
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An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus.
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An evolutionarily conserved mechanism delimiting SHR movement defines a single layer of endodermis in plants.
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An exploratory study of the safety, tolerability and bioactivity of a single intravitreal injection of vascular endothelial growth factor Trap-Eye in patients with diabetic macular oedema.
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An insulin-like growth factor II (IGF-II) affinity-enhancing domain localized within extracytoplasmic repeat 13 of the IGF-II/mannose 6-phosphate receptor.
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An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface.
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An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro.
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Analysis of Npl4 deletion mutants in mammalian cells unravels new Ufd1-interacting motifs and suggests a regulatory role of Npl4 in ERAD.
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Analysis of Rho-GTPase Activity During Budding Yeast Cytokinesis.
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Analysis of autoantibody binding to different regions of the human La antigen expressed in recombinant fusion proteins.
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Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases.
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Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism.
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AnkB, a periplasmic ankyrin-like protein in Pseudomonas aeruginosa, is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide.
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Ankyrin-G promotes cyclic nucleotide-gated channel transport to rod photoreceptor sensory cilia.
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Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6.
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Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells.
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Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors.
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Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies.
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Anti-tumor activity of a novel monoclonal antibody, NPC-1C, optimized for recognition of tumor antigen MUC5AC variant in preclinical models.
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Antiangiogenic agents in combination with chemotherapy for the treatment of epithelial ovarian cancer.
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Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers.
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Antigenicity of a recombinant Ro (SS-A) fusion protein.
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Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors.
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Arc/Arg3.1 translation is controlled by convergent N-methyl-D-aspartate and Gs-coupled receptor signaling pathways.
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Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin.
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Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p.
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Assembly pathway of the anastral Drosophila oocyte meiosis I spindle.
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Assessment of antibody responses against gp41 in HIV-1-infected patients using soluble gp41 fusion proteins and peptides derived from M group consensus envelope.
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Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1.
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Association of Baseline Visual Acuity and Retinal Thickness With 1-Year Efficacy of Aflibercept, Bevacizumab, and Ranibizumab for Diabetic Macular Edema.
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Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization.
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Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics.
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Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family.
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AtDSEL, an Arabidopsis cytosolic DAD1-like acylhydrolase, is involved in negative regulation of storage oil mobilization during seedling establishment.
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Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis.
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Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance.
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BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein.
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BP1, a new homeobox gene, is frequently expressed in acute leukemias.
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Bacterial Growth Inhibition Screen (BGIS): harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function.
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Bacteriophage T4 UvsW protein is a helicase involved in recombination, repair and the regulation of DNA replication origins.
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Balance of cellular and humoral immunity determines the level of protection by HIV vaccines in rhesus macaque models of HIV infection.
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Baseline Factors Associated With 6-Month Visual Acuity and Retinal Thickness Outcomes in Patients With Macular Edema Secondary to Central Retinal Vein Occlusion or Hemiretinal Vein Occlusion: SCORE2 Study Report 4.
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Baseline factors associated with glycaemic response to treatment with once-weekly dulaglutide in patients with type 2 diabetes.
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Basiliximab decreases the incidence of acute rejection after intestinal transplantation.
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Belatacept and sirolimus prolong nonhuman primate islet allograft survival: adverse consequences of concomitant alefacept therapy.
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Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling.
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Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
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Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor.
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Beta-arrestin-mediated localization of smoothened to the primary cilium.
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Binding of G protein beta gamma-subunits to pleckstrin homology domains.
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Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling.
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Binding site for C4b-binding protein in vitamin K-dependent protein S fully contained in carboxy-terminal laminin-G-type repeats. A study using recombinant factor IX-protein S chimeras and surface plasmon resonance.
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Biochemical properties of recombinant human and mouse N-acetylglutamate synthase.
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Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6).
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Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse.
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Borg proteins control septin organization and are negatively regulated by Cdc42.
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Both heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusion.
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Brolucizumab Versus Aflibercept in Participants with Neovascular Age-Related Macular Degeneration: A Randomized Trial.
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C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independent.
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C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity.
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CAR T Cells Targeting Podoplanin Reduce Orthotopic Glioblastomas in Mouse Brains.
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CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
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CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival.
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CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H.
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CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates.
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CD44-SLC1A2 gene fusions in gastric cancer.
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CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.
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CDX-1307: a novel vaccine under study as treatment for muscle-invasive bladder cancer.
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CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin.
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COPII-cargo interactions direct protein sorting into ER-derived transport vesicles.
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CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates.
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Calmodulin is intrinsically LESS effective than troponin C in activating skeletal muscle contraction.
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Calmodulin is required for cell-cycle progression during G1 and mitosis.
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Calmodulin kinase II chimeras used to investigate the structural requirements for smooth muscle myosin light chain kinase autoinhibition and calmodulin-dependent activation.
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Calmodulin-cardiac troponin C chimeras. Effects of domain exchange on calcium binding and enzyme activation.
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Campath-1H in renal transplantation: The University of Wisconsin experience.
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Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation.
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Casein kinase Iepsilon plays a functional role in the transforming growth factor-beta signaling pathway.
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Cdk5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock.
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Cell surface polarization during yeast mating.
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Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
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Cellular trafficking of G protein-coupled receptor/beta-arrestin endocytic complexes.
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Centrosome and spindle function of the Drosophila Ncd microtubule motor visualized in live embryos using Ncd-GFP fusion proteins.
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Chaperones rescue luciferase folding by separating its domains.
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Characterization of RanBP2-associated molecular components in neuroretina.
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Characterization of a CD6 ligand(s) expressed on human- and murine-derived cell lines and murine lymphoid tissues.
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Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies.
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Characterization of a putative insulin-responsive element and its binding protein(s) in rat angiotensinogen gene promoter: regulation by glucose and insulin.
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Characterization of avian and viral p60src proteins expressed in yeast.
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Characterization of cis-regulatory regions responsible for developmental regulation of the gibberellin biosynthetic gene GA1 in Arabidopsis thaliana
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Characterization of the human Snrpn minimal promoter and cis elements within it.
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Characterization of the transmembrane orientation of aquaporin-1 using antibodies to recombinant fusion proteins.
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Chemokines have diverse abilities to form solid phase gradients.
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Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent.
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Chimeric anti-tumor necrosis factor-alpha monoclonal antibody treatment of patients with rheumatoid arthritis receiving methotrexate therapy.
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Chimeric calmodulin-cardiac troponin C proteins differentially activate calmodulin target enzymes.
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Chimeric spike mRNA vaccines protect against sarbecovirus challenge in mice
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Choroidal Changes After Suprachoroidal Injection of Triamcinolone Acetonide in Eyes With Macular Edema Secondary to Retinal Vein Occlusion.
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Chronic myelogenous leukemia.
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Clinical Efficacy and Safety of Baminercept, a Lymphotoxin β Receptor Fusion Protein, in Primary Sjögren's Syndrome: Results From a Phase II Randomized, Double-Blind, Placebo-Controlled Trial.
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Clinical and metabolic correction of pompe disease by enzyme therapy in acid maltase-deficient quail.
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Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions.
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Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters.
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Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand.
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Cloning, overexpression, purification, and immunobiology of an 85-kilodalton outer membrane protein from Haemophilus ducreyi.
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Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation.
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Collision-induced dissociative chemical cross-linking reagents and methodology: Applications to protein structural characterization using tandem mass spectrometry analysis.
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Comparative analysis of type 2b von Willebrand disease mutations: implications for the mechanism of von Willebrand factor binding to platelets.
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Comparative epitope mapping of sera from United States (US) and Japanese patients with bullous pemphigoid (BP) to fusion proteins encoded by BPAG1.
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Comparing Aflibercept Monotherapy With Aflibercept Plus Rescue Photodynamic Therapy in Polypoidal Choroidal Vasculopathy: PLANET or Asteroid?
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Comparison of Monthly vs Treat-and-Extend Regimens for Individuals With Macular Edema Who Respond Well to Anti-Vascular Endothelial Growth Factor Medications: Secondary Outcomes From the SCORE2 Randomized Clinical Trial.
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Comparison of four different immunosuppression protocols without long-term steroid therapy in kidney recipients monitored by surveillance biopsy: five-year outcomes.
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Comparison of vaccine strategies using recombinant env-gag-pol MVA with or without an oligomeric Env protein boost in the SHIV rhesus macaque model.
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Conformational changes at the carboxyl terminus of Galpha occur during G protein activation.
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Conformational preferences of a chimeric peptide HIV-1 immunogen from the C4-V3 domains of gp120 envelope protein of HIV-1 CAN0A based on solution NMR: comparison to a related immunogenic peptide from HIV-1 RF.
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Conserved functional organization of the human immunodeficiency virus type 1 and visna virus Rev proteins.
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Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features.
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Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer.
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Construction of a catalytically active iron superoxide dismutase by rational protein design.
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Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1.
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Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination.
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Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit.
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Convection-enhanced delivery of cintredekin besudotox (interleukin-13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: phase 1 study of final safety results.
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Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation.
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Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.
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Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.
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Costimulation blockade: towards clinical application.
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Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor.
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Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue.
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Coxiella burnetii effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replication.
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Creatine kinase activity as an indicator of unopposed estrogen action in the mouse uterus associated with anti-progesterone treatment.
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Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate.
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Current knowledge of the platelet glycoprotein IIb/IIIa receptor antagonists for the treatment of coronary artery disease.
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Cutting Edge: Localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development.
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Cyclin-binding motifs are essential for the function of p21CIP1.
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Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae.
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Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.
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Cytoplasmic domain truncation enhances fusion activity by the exterior glycoprotein complex of human immunodeficiency virus type 2 in selected cell types.
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Cytoprotective effects of hematopoietic growth factors on primary human acute myeloid leukemias are not mediated through changes in BCL-2, bax, or p21WAF1/CIP1.
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Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.
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Cytotoxicity of alpha-particle-emitting astatine-211-labelled antibody in tumour spheroids: no effect of hyperthermia.
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DAS181 Treatment of Severe Lower Respiratory Tract Parainfluenza Virus Infection in Immunocompromised Patients: A Phase 2 Randomized, Placebo-Controlled Study.
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Damage caused by Wegener's granulomatosis and its treatment: prospective data from the Wegener's Granulomatosis Etanercept Trial (WGET).
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Decoupling of nucleotide- and microtubule-binding sites in a kinesin mutant.
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Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody.
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Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia.
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Definition of the interferon-alpha receptor-binding domain on the TYK2 kinase.
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Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway.
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Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism.
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Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.
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Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy.
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Denileukin diftitox for the treatment of CD25 low-expression mycosis fungoides and Sézary syndrome.
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Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines.
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Depletion of human regulatory T cells.
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Design, synthesis, and evaluation of linear and cyclic peptide ligands for PDZ10 of the multi-PDZ domain protein MUPP1.
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Determinants of kinesin motor polarity.
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Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic.
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Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody.
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Developmental regulation of the gibberellin biosynthetic gene GA1 in Arabidopsis thaliana.
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Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro.
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Differential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate.
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Differential Response to Anti-VEGF Regimens in Age-Related Macular Degeneration Patients with Early Persistent Retinal Fluid.
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Differential activation of nitric-oxide synthase isozymes by calmodulin-troponin C chimeras.
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Differential effects of CD30 activation in anaplastic large cell lymphoma and Hodgkin disease cells.
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Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein.
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Dimerization of a chimeric CD4-interferon-alpha receptor reconstitutes the signaling events preceding STAT phosphorylation.
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Dimerized Drosophila myosin VIIa: a processive motor.
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Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer.
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Direct antidiabetic effect of leptin through triglyceride depletion of tissues.
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Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group.
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Directed evolution of recombinase specificity by split gene reassembly.
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Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis.
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Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
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Disproportionate relationship between APOBEC-1 expression and apolipoprotein B mRNA editing activity.
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Disrupted spermine homeostasis: a novel mechanism in polyglutamine-mediated aggregation and cell death.
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Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta.
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Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.
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Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene.
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Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.
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Distinct regions of the cadherin cytoplasmic domain are essential for functional interaction with Galpha 12 and beta-catenin.
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Disulfide-mediated dimerization of L1 Ig domains.
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Divergent gene regulation and growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin.
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Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR).
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Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth.
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Domain 3 of hepatitis C virus core protein is sufficient for intracellular lipid accumulation.
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Domain unfolding plays a role in superfibronectin formation.
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Dominant selection system for use in Cryptococcus neoformans.
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Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2.
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Drusen Volume as a Predictor of Disease Progression in Patients With Late Age-Related Macular Degeneration in the Fellow Eye.
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Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase.
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Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants.
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Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events.
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Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin-green fluorescent protein.
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E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins.
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E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites.
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EFFICACY AND SAFETY OF INTRAVITREAL AFLIBERCEPT AND RANIBIZUMAB IN ASIAN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: Subgroup Analyses From the VIEW Trials.
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EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor.
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Early elicitor induction in members of a novel multigene family coding for highly related RING-H2 proteins in Arabidopsis thaliana
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Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.
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Ectopic Ocular Surface Calcification in Patients With Hypophosphatasia Treated With Asfotase Alfa.
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Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity: A Randomized Clinical Trial.
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Effect of Intravitreous Aflibercept vs Vitrectomy With Panretinal Photocoagulation on Visual Acuity in Patients With Vitreous Hemorrhage From Proliferative Diabetic Retinopathy: A Randomized Clinical Trial.
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Effect of a dominant negative ras on myocardial hypertrophy by using adenoviral-mediated gene transfer.
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Effect of compressive force on unbinding specific protein-ligand complexes with force spectroscopy.
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Effect of heterologous factor V heavy chain sequences on the secretion of recombinant human factor VIII.
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Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study.
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Effect of protein fusion on the transition temperature of an environmentally responsive elastin-like polypeptide: a role for surface hydrophobicity?
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Effect of tissue transglutaminase on the solubility of proteins containing expanded polyglutamine repeats.
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Effectiveness and Safety of Romiplostim Among Patients with Newly Diagnosed, Persistent and Chronic Immune Thrombocytopenia in European Clinical Practice.
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Effects of Tirzepatide, a Dual GIP and GLP-1 RA, on Lipid and Metabolite Profiles in Subjects With Type 2 Diabetes.
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Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 : A Randomized Controlled Trial.
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Efficacy and Safety of Intravitreal Aflibercept for Polypoidal Choroidal Vasculopathy in the PLANET Study: A Randomized Clinical Trial.
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Efficacy and safety of brolucizumab versus aflibercept in eyes with polypoidal choroidal vasculopathy in Japanese participants of HAWK.
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Efficacy and safety of denileukin diftitox retreatment in patients with relapsed cutaneous T-cell lymphoma.
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Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials.
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Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE): two randomised, double-masked, phase 3 trials.
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Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow.
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Efficient intratracheal delivery of airway epithelial cells in mice and pigs.
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Elastin-like polypeptides as a purification tag for recombinant proteins.
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Elastin-like polypeptides: biomedical applications of tunable biopolymers.
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Elevated expression of a subset of interferon inducible genes in primary bone marrow cells expressing p185 Bcr-Abl versus p210 Bcr-Abl by DNA microarray analysis.
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Embryonic and neonatal cardiac gene transfer in vivo.
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Emergent properties during dorsal closure in Drosophila morphogenesis.
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Endophthalmitis Rates after Bilateral Same-Day Intravitreal Anti-Vascular Endothelial Growth Factor Injections.
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Endoplasmic reticulum chaperone GRP94 subunit assembly is regulated through a defined oligomerization domain.
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Engineered chimeric streptavidin tetramers as novel tools for bioseparations and drug delivery.
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Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active.
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Enhanced HIV-1 neutralization by a CD4-VH3-IgG1 fusion protein.
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Enhanced avidity maturation of antibody to human immunodeficiency virus envelope: DNA vaccination with gp120-C3d fusion proteins.
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Enhanced efficacy of an AAV vector encoding chimeric, highly secreted acid alpha-glucosidase in glycogen storage disease type II.
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Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells.
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Enrichment of peripheral blood stem cells in a primate model following administration of a single dose of rh-IL-1 beta.
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Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome.
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Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
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Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6.
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Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus.
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Erythropoietin mediates terminal granulocytic differentiation of committed myeloid cells with ectopic erythropoietin receptor expression.
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Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation.
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Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombe.
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Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay.
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Etanercept (enbrel)-associated inflammatory eye disease: case report and review of the literature.
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Etanercept-induced lupus-like syndrome in a patient with rheumatoid arthritis.
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Evaluation of very high- and very low-dose intravitreal aflibercept in patients with neovascular age-related macular degeneration.
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Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis.
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Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation.
-
Ex vivo pediatric brain tumors express Fas (CD95) and FasL (CD95L) and are resistant to apoptosis induction.
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Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network.
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Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period.
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Exploiting Pre-Existing CD4+ T Cell Help from Bacille Calmette-Guérin Vaccination to Improve Antiviral Antibody Responses.
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Expression and assay of recombinant ATM.
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Expression and functional characterization of chimeras between human and bovine vitamin-K-dependent protein-S-defining modules important for the species specificity of the activated protein C cofactor activity.
-
Expression and modification of Hox 2.1 protein in mouse embryos.
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Expression and purification of recombinant proteins from Escherichia coli: Comparison of an elastin-like polypeptide fusion with an oligohistidine fusion.
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Expression of active, membrane-bound human placental alkaline phosphatase by transfected simian cells.
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Expression of an EF-1 alpha-like rat cDNA, S1, in E. coli and production of a rabbit polyclonal antiserum to the recombinant protein.
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Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus.
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Expression of functional domains of beta G-spectrin disrupts epithelial morphology in cultured cells.
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Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders.
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Expression of the Pseudomonas syringae avirulence protein AvrB in plant cells alleviates its dependence on the hypersensitive response and pathogenicity (Hrp) secretion system in eliciting genotype-specific hypersensitive cell death.
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Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes.
-
FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae.
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FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.
-
FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis
-
Fabrication of a reversible protein array directly from cell lysate using a stimuli-responsive polypeptide.
-
Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis.
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Factors regulating islet regeneration in the post-insulinoma NEDH rat.
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Factors that enhance Escherichia coli-expressed TR beta binding to T3 and DNA.
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Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations.
-
Fc-mOX40L fusion protein produces complete remission and enhanced survival in 2 murine tumor models.
-
Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.
-
Fission yeast Cyk3p is a transglutaminase-like protein that participates in cytokinesis and cell morphogenesis.
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Five-Year Outcomes after Initial Aflibercept, Bevacizumab, or Ranibizumab Treatment for Diabetic Macular Edema (Protocol T Extension Study).
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Five-year efficacy and safety of asfotase alfa therapy for adults and adolescents with hypophosphatasia.
-
Flow cytometry sorting of recombinant mycobacterial species yields bacterial clones with enhanced insert expression.
-
Fluorescence in situ hybridization method for measuring transfection efficiency.
-
Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor.
-
Focal expression of mutant huntingtin in the songbird basal ganglia disrupts cortico-basal ganglia networks and vocal sequences.
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Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes.
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Formation of supercoiling domains in plasmid pBR322.
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FtsZ from Escherichia coli, Azotobacter vinelandii, and Thermotoga maritima--quantitation, GTP hydrolysis, and assembly.
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FtsZ from divergent foreign bacteria can function for cell division in Escherichia coli.
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Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif.
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Functional organization of the Bel-1 trans activator of human foamy virus.
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Functional reconstitution and characterization of AqpZ, the E. coli water channel protein.
-
Functional similarities between HIV-1 Tat and DNA sequence-specific transcriptional activators.
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Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.
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Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiae.
-
Fusion order controls expression level and activity of elastin-like polypeptide fusion proteins.
-
Fusions of elastin-like polypeptides to pharmaceutical proteins.
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G alpha t/G alpha i1 chimeras used to define structural basis of specific functions of G alpha t.
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G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans.
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G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning.
-
G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells.
-
G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95.
-
G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer.
-
GFP fusions to a microtubule motor protein to visualize meiotic and mitotic spindle dynamics in Drosophila.
-
GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila.
-
GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors.
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GSK2374697, a long duration glucagon-like peptide-1 (GLP-1) receptor agonist, reduces postprandial circulating endogenous total GLP-1 and peptide YY in healthy subjects.
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Gamma-globin gene promoter elements required for interaction with globin enhancers.
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Gene transfer of endothelial nitric oxide synthase reduces angiotensin II-induced endothelial dysfunction.
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Generation of a syngeneic mouse model to study the effects of vascular endothelial growth factor in ovarian carcinoma.
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Generation of neuronal intranuclear inclusions by polyglutamine-GFP: analysis of inclusion clearance and toxicity as a function of polyglutamine length.
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Genetic analysis indicates that the human foamy virus Bel-1 protein contains a transcription activation domain of the acidic class.
-
Genetic engineering of a single-chain antibody fragment for surface immobilization in an optical biosensor.
-
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.
-
Genetic evidence that the Tat proteins of human immunodeficiency virus types 1 and 2 can multimerize in the eukaryotic cell nucleus.
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Genetically Encoding Albumin Binding into Chemotherapeutic-loaded Polypeptide Nanoparticles Enhances Their Antitumor Efficacy.
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Genomic structure and embryonic expression of estrogen receptor beta a (ERbetaa) in zebrafish (Danio rerio).
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Genotypic effect of the -565C>T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis.
-
Glutathione S-transferase fusion proteins mimic receptor dimerization in permeabilized cells.
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Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition.
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Glycogen-targeting subunits and glucokinase differentially affect pathways of glycogen metabolism and their regulation in hepatocytes.
-
Going green in Cryptococcus neoformans: the recycling of a selectable drug marker.
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Gq signaling causes glomerular injury by activating TRPC6.
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Gradated assembly of multiple proteins into supramolecular nanomaterials.
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Green fluorescent protein as a tag for molecular motor proteins.
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HAWK and HARRIER: Ninety-Six-Week Outcomes from the Phase 3 Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration.
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HAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration.
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HER-2/c-erbB2 is phosphorylated by calmodulin-dependent protein kinase II on a single site in the cytoplasmic tail at threonine-1172.
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HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells.
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HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes.
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HIV-1 neutralization by chimeric CD4-CG10 polypeptides fused to human IgG1.
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HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency.
-
HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor.
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Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein.
-
High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors.
-
High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer.
-
High level expression of a truncated chicken progesterone receptor in Escherichia coli.
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High-level misincorporation of lysine for arginine at AGA codons in a fusion protein expressed in Escherichia coli.
-
High-level production of alpha-particle-emitting (211)At and preparation of (211)At-labeled antibodies for clinical use.
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Highly processive motility is not a general feature of the kinesins.
-
Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ.
-
Histone H1 enhances the DNA binding activity of the transcription factor EmBP-1.
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Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.
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Horizontal transfer of an adaptive chimeric photoreceptor from bryophytes to ferns
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Human IgG2 constant region enhances in vivo stability of anti-tenascin antibody 81C6 compared with its murine parent.
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Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid deposition.
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Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase.
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Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2.
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Human colon cancer cells express multiple glycoprotein ligands for E-selectin.
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Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.
-
Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize.
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Human topoisomerase I promotes HIV-1 proviral DNA synthesis: implications for the species specificity and cellular tropism of HIV-1 infection.
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Human/murine chimeric 81C6 F(ab')(2) fragment: preclinical evaluation of a potential construct for the targeted radiotherapy of malignant glioma.
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Hydrophobic residues Phe751 and Leu753 are essential for STAT5 transcriptional activity.
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IL-11 antagonist suppresses Th17 cell-mediated neuroinflammation and demyelination in a mouse model of relapsing-remitting multiple sclerosis.
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IL15 Agonists Overcome the Immunosuppressive Effects of MEK Inhibitors.
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IPLEX and the telephone game: the difficulty in separating myth from reality on the internet.
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Identification and cloning of a negative regulator of systemic acquired resistance, SNI1, through a screen for suppressors of npr1-1
-
Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells.
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Identification and functional characterization of a novel nuclear localization signal present in the yeast Nab2 poly(A)+ RNA binding protein.
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Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.
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Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system.
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Identification of ENV determinants in V3 that influence the molecular anatomy of CCR5 utilization.
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Identification of a new family of protein phosphatase 2A regulatory subunits.
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Identification of a region at the N-terminus of phospholipase C-beta 3 that interacts with G protein beta gamma subunits.
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Identification of functional regions on the tail of Acanthamoeba myosin-II using recombinant fusion proteins. I. High resolution epitope mapping and characterization of monoclonal antibody binding sites.
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Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.
-
Identification of the TBX5 transactivating domain and the nuclear localization signal.
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Identification of the activation domain of equine infectious anemia virus rev.
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Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand.
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Identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infection.
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Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase.
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Identifying Blood-Based Protein Biomarkers for Antiangiogenic Agents in the Clinic: A Decade of Progress.
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Identifying a transcription factor interaction site on RNA polymerase II.
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Identifying phosphoCTD-associating proteins.
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IgG antibodies from patients with bullous pemphigoid bind to fusion proteins encoded by BPAg1 cDNA.
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Iliac crest bone graft donor site pain after anterior lumbar interbody fusion: a prospective patient satisfaction outcome assessment.
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Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon.
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Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon.
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Immune status assay (ISA): a noninvasive procedure for studying allograft rejection.
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Immunotoxin FN18-CRM9 induces stronger T cell signaling than unconjugated monoclonal antibody FN18.
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Immunotoxin-treated rhesus monkeys: a model for renal allograft chronic rejection.
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Improved non-chromatographic purification of a recombinant protein by cationic elastin-like polypeptides.
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In Vitro Pre-Clinical Validation of Suicide Gene Modified Anti-CD33 Redirected Chimeric Antigen Receptor T-Cells for Acute Myeloid Leukemia.
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In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction.
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In situ growth of a PEG-like polymer from the C terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation.
-
In vitro and in vivo behavior of radiolabeled chimeric anti-EGFRvIII monoclonal antibody: comparison with its murine parent.
-
In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: pathogenic autoreactivity requires permissive light chains.
-
In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.
-
In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma.
-
In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration.
-
In vivo protein expression and immune responses generated by DNA vaccines expressing mycobacterial antigens fused with a reporter protein.
-
Incorporation of high levels of chimeric human immunodeficiency virus envelope glycoproteins into virus-like particles.
-
Increased calmodulin affects cell morphology and mRNA levels of cytoskeletal protein genes.
-
Increased envelope spike density and stability are not required for the neutralization resistance of primary human immunodeficiency viruses.
-
Increasing vaccine potency through exosome antigen targeting.
-
Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. A role for the high affinity receptor site.
-
Inducing unresponsiveness by the use of anti-CD3 immunotoxin, CTLA4-Ig, and anti-CD40 ligand.
-
Induction immunosuppression in liver transplantation: a review.
-
Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy.
-
Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41.
-
Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin.
-
Induction of nuclear factor kappaB by the CD30 receptor is mediated by TRAF1 and TRAF2.
-
Induction therapy with basiliximab allows delayed initiation of cyclosporine and preserves renal function after cardiac transplantation.
-
Infections after the use of alemtuzumab in solid organ transplant recipients: a comparative study.
-
Influence of myopic macular degeneration severity on treatment outcomes with intravitreal aflibercept in the MYRROR study.
-
Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function.
-
Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis.
-
Inhibition of human corneal epithelium with immunotoxin 454A12-rRA.
-
Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons.
-
Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.
-
Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening.
-
Insulin inhibits dexamethasone effect on angiotensinogen gene expression and induction of hypertrophy in rat kidney proximal tubular cells in high glucose.
-
Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes.
-
Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans.
-
Integrin functions play a key role in the differentiation of thymocytes in vivo.
-
Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation.
-
Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.
-
Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A.
-
Interactions of estrogen- and thyroid hormone receptors on a progesterone receptor estrogen response element (ERE) sequence: a comparison with the vitellogenin A2 consensus ERE.
-
Intersectional Cre driver lines generated using split-intein mediated split-Cre reconstitution.
-
Intracellular third loops in AT1 and AT2 receptors determine subtype specificity.
-
Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning.
-
Intravesical rAd-IFNα/Syn3 for Patients With High-Grade, Bacillus Calmette-Guerin-Refractory or Relapsed Non-Muscle-Invasive Bladder Cancer: A Phase II Randomized Study.
-
Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset.
-
Intravitreal Aflibercept Injection in Patients with Myopic Choroidal Neovascularization: The MYRROR Study.
-
Intravitreal Aflibercept for Diabetic Macular Edema: 100-Week Results From the VISTA and VIVID Studies.
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Intravitreal Aflibercept for Diabetic Macular Edema: 148-Week Results from the VISTA and VIVID Studies.
-
Intravitreal Pharmacotherapies for Diabetic Macular Edema: A Report by the American Academy of Ophthalmology.
-
Intravitreal aflibercept for diabetic macular edema.
-
Intrinsic activity of human immunodeficiency virus type 1 protease heterologous fusion proteins in mammalian cells.
-
InvB is a type III secretion chaperone specific for SspA.
-
Investigation of ALPL variant states and clinical outcomes: An analysis of adults and adolescents with hypophosphatasia treated with asfotase alfa.
-
Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis.
-
Involvement of protein tyrosine phosphorylation in immunotoxin effects on T lymphocytes.
-
Involvement of the mt1 melatonin receptor in human breast cancer.
-
Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.
-
Isoform specificity of ankyrin-B: a site in the divergent C-terminal domain is required for intramolecular association.
-
Isolation and characterization of cul1-7, a recessive allele of CULLIN1 that disrupts SCF function at the C terminus of CUL1 in Arabidopsis thaliana.
-
Isolation and characterization of effector-loop mutants of CDC42 in yeast.
-
Isolation and characterization of the CYP71D16 trichome-specific promoter from Nicotiana tabacum L.
-
Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.
-
Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator.
-
Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence.
-
L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity.
-
L1-dependent neuritogenesis involves ankyrinB that mediates L1-CAM coupling with retrograde actin flow.
-
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.
-
LFA-1 binding site in ICAM-3 contains a conserved motif and non-contiguous amino acids.
-
LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system.
-
Lanthanide-binding tags as versatile protein coexpression probes.
-
Late onset N-acetylglutamate synthase deficiency caused by hypomorphic alleles.
-
Lectin and epidermal growth factor domains of P-selectin at physiologic density are the recognition unit for leukocyte binding.
-
Lessons Learned Using Real-World Data to Emulate Randomized Trials: A Case Study of Treatment Effectiveness for Newly Diagnosed Immune Thrombocytopenia.
-
LexA protein of Escherichia coli represses expression of the Tn5 transposase gene.
-
Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast.
-
Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer.
-
Light-inducible spatiotemporal control of gene activation by customizable zinc finger transcription factors.
-
Liposome division by a simple bacterial division machinery.
-
Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis.
-
Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model.
-
Localization of functionally important epitopes within the second C-type domain of coagulation factor V using recombinant chimeras.
-
Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis.
-
Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease.
-
Lumenal sites and C terminus accessibility of the skeletal muscle calcium release channel (ryanodine receptor).
-
Lupus autoantibodies recognize the product of an alternative open reading frame of SmB/B'.
-
MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300.
-
MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction.
-
MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation.
-
MERLIN: Phase 3a, Multicenter, Randomized, Double-Masked Trial of Brolucizumab in Participants with Neovascular Age-Related Macular Degeneration and Persistent Retinal Fluid.
-
Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast.
-
Mapping of effector binding sites of transducin alpha-subunit using G alpha t/G alpha i1 chimeras.
-
Maspin expression profile in human prostate cancer (CaP) and in vitro induction of Maspin expression by androgen ablation.
-
Mature Drosophila meiosis I spindles comprise microtubules of mixed polarity.
-
Maximal stimulation of meiotic recombination by a yeast transcription factor requires the transcription activation domain and a DNA-binding domain.
-
Maximizing the efficacy of angiogenesis inhibitors.
-
Measurement of molecular interactions in living cells by fluorescence resonance energy transfer between variants of the green fluorescent protein.
-
Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells.
-
MegaGate: A toxin-less gateway molecular cloning tool.
-
Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads.
-
Mekk3 is essential for early embryonic cardiovascular development.
-
Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation.
-
Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha.
-
Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation.
-
Micellar Self-Assembly of Recombinant Resilin-/Elastin-Like Block Copolypeptides.
-
Microtubule cross-linking triggers the directional motility of kinesin-5.
-
Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas.
-
Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer.
-
Mining copper transport genes.
-
Mitochondrial FtsZ in a chromophyte alga
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Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions.
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Modulation of ligand binding affinity of the adipocyte lipid-binding protein by selective mutation. Analysis in vitro and in situ.
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Molecular analysis of the Cryptococcus neoformans ADE2 gene, a selectable marker for transformation and gene disruption.
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Molecular and genetic approaches for the analysis of C. elegans neuronal development.
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Molecular basis for the enterocyte tropism exhibited by Salmonella typhimurium type 1 fimbriae.
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Molecular basis of T cell inactivation by CTLA-4.
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Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction.
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Molecular cloning and characterization of Aspergillus nidulans cyclophilin B.
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Molecular cloning and functional expression of a recombinant 72.5 kDa fragment of the 110 kDa regulatory subunit of smooth muscle protein phosphatase 1M.
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Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family.
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Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites.
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Molecular determinants of selectivity in 5-hydroxytryptamine1B receptor-G protein interactions.
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Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.
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Molecular dissection of gating in the ClC-2 chloride channel.
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Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer.
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Monitoring guidance for patients with hypophosphatasia treated with asfotase alfa.
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Monoclonal antibodies that bind to the core of fusion-active glycoprotein 41.
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Monoclonal antibody interaction with the third immunoglobulin-like domain of N-CAM is sufficient to cause cell migration.
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Morphology and Visual Acuity in Aflibercept and Ranibizumab Therapy for Neovascular Age-Related Macular Degeneration in the VIEW Trials.
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Mouse/human chimeric Me1-14 antibody: genomic cloning of the variable region genes, linkage to human constant region genes, expression, and characterization.
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Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A.
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Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity.
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Multiple residues contribute to the inability of murine CCR-5 to function as a coreceptor for macrophage-tropic human immunodeficiency virus type 1 isolates.
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Mutants of the Drosophila ncd microtubule motor protein cause centrosomal and spindle pole defects in mitosis.
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Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX.
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Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding.
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Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module.
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Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit.
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Myc requires distinct E2F activities to induce S phase and apoptosis.
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Myocardial overexpression of adrenergic receptors and receptor kinases.
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Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes.
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Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo.
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Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene.
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N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.
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N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells.
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N-terminal and central regions of the human CD44 extracellular domain participate in cell surface hyaluronan binding.
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NMR-derived solution conformations of a hybrid synthetic peptide containing multiple epitopes of envelope protein gp120 from the RF strain of human immunodeficiency virus.
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Negative regulation of Armadillo, a Wingless effector in Drosophila.
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Neisseria gonorrhoeae FitA interacts with FitB to bind DNA through its ribbon-helix-helix motif.
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Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers.
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Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation.
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Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family.
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Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras.
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Neurotrophin-3 mediates the autocrine survival of the catecholaminergic CAD CNS neuronal cell line.
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Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity.
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Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.
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Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation.
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Non-chromatographic purification of recombinant elastin-like polypeptides and their fusions with peptides and proteins from Escherichia coli.
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Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic wingless signal transduction.
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Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo.
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Noninvasive visualization of retinoblastoma growth and metastasis via bioluminescence imaging.
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Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene.
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Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis.
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Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation.
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Novel adenovirus vectors 'capsid-displaying' a human complement inhibitor.
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Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans.
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Novel luciferase-based reporter system to monitor activation of ErbB2/Her2/neu pathway noninvasively during radiotherapy.
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Novel protein purification system utilizing an N-terminal fusion protein and a caspase-3 cleavable linker.
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Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1.
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Nuclear localization of NPR1 is required for activation of PR gene expression.
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Nuclear protein CBP is a coactivator for the transcription factor CREB.
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Nucleocytoplasmic shuttling by protein nuclear import factors.
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Nucleotide sequence, expression, and chromosomal mapping of Mrp and mapping of five related sequences.
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O-glycosylation as a sorting determinant for cell surface delivery in yeast.
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Odorant receptors and desensitization proteins colocalize in mammalian sperm.
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Oligomerization of expanded-polyglutamine domain fluorescent fusion proteins in cultured mammalian cells.
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Onasemnogene abeparvovec gene therapy for symptomatic infantile-onset spinal muscular atrophy in patients with two copies of SMN2 (STR1VE): an open-label, single-arm, multicentre, phase 3 trial.
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Optimization of a polyglutamine aggregation inhibitor peptide (QBP1) using a thioflavin T fluorescence assay.
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Orthogonal site-specific protein modification by engineering reversible thiol protection mechanisms.
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Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells.
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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
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Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
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Out with the old, in with the new? Comparing methods for measuring protein degradation.
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Outcomes of Eyes Lost to Follow-up with Neovascular Age-Related Macular Degeneration Receiving Intravitreal Anti-Vascular Endothelial Growth Factor.
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Outcomes of Eyes Lost to Follow-up with Proliferative Diabetic Retinopathy That Received Panretinal Photocoagulation versus Intravitreal Anti-Vascular Endothelial Growth Factor.
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Ovarian cancer: time to move beyond one size fits all.
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Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma.
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Overcoming the solubility limit with solubility-enhancement tags: successful applications in biomolecular NMR studies.
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Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block.
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PD-1 blockade synergizes with intratumoral vaccination of a therapeutic HPV protein vaccine and elicits regression of tumor in a preclinical model.
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PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.
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PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells.
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PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells.
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PROGRESSION OF MACULAR ATROPHY IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION UNDERGOING ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY.
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Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1.
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Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway.
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Parent-specific expression of a human keratin 18/beta-galactosidase fusion gene in transgenic mice.
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Peptide antagonists of the human estrogen receptor.
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Performance of Homologous and Heterologous Prime-Boost Immunization Regimens of Recombinant Adenovirus and Modified Vaccinia Virus Ankara Expressing an Ag85B-TB10.4 Fusion Protein against Mycobacterium tuberculosis.
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Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation.
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Pharmacodynamics of asfotase alfa in adults with pediatric-onset hypophosphatasia.
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Phase I study of immunization with dendritic cells modified with fowlpox encoding carcinoembryonic antigen and costimulatory molecules.
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Phase I study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self-antigens in cancer patients.
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Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma.
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Phospho-carboxyl-terminal domain binding and the role of a prolyl isomerase in pre-mRNA 3'-End formation.
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Phosphorylation of O6-alkylguanine-DNA alkyltransferase: experience with a GST-fusion protein and a new pull-down assay.
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Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.
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Physician Utilization Patterns for VEGF-Inhibitor Drugs in the 2012 United States Medicare Population: Bevacizumab, Ranibizumab, and Aflibercept.
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Pivotal phase III trial of two dose levels of denileukin diftitox for the treatment of cutaneous T-cell lymphoma.
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Plant Immunity Requires Conformational Changes of NPR1 via S-Nitrosylation and Thioredoxins
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Plasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema.
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Plasmids for expression of chimeric and truncated kinesin proteins.
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Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity.
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Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid.
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Plug-and-Play Protein Modification Using Homology-Independent Universal Genome Engineering.
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Polyglutamine domain proteins with expanded repeats bind neurofilament, altering the neurofilament network.
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Polyspecific binding of Escherichia coli beta-galactosidase by murine antibodies to DNA.
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Postremission therapy with low-dose interleukin 2 with or without intermediate pulse dose interleukin 2 therapy is well tolerated in elderly patients with acute myeloid leukemia: Cancer and Leukemia Group B study 9420.
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Posttranscriptional regulation of protein expression in human epithelial carcinoma cells by adenine-uridine-rich elements in the 3'-untranslated region of tumor necrosis factor-alpha messenger RNA.
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Precise arrangement of factor-binding sites is required for murine CD4 promoter function.
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Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line.
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Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody.
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Predicting transition temperatures of elastin-like polypeptide fusion proteins.
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Predictors of complete responses with denileukin diftitox in cutaneous T-cell lymphoma.
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Preparation and characterization of anti-tenascin monoclonal antibody-streptavidin conjugates for pretargeting applications.
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Principles and applications of a Tat-based assay for analyzing specific RNA-protein interactions in mammalian cells.
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Probing domain interactions in soluble guanylate cyclase.
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Probing the domain structure of FtsZ by random truncation and insertion of GFP.
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Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors.
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Proliferative lupus nephritis and leukocytoclastic vasculitis during treatment with etanercept.
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Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor.
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Prostaglandin F2 alpha receptors in the human trabecular meshwork.
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Proteasome inhibition by chronic oxidative stress in human trabecular meshwork cells.
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Protection against Mycobacterium avium by DNA vaccines expressing mycobacterial antigens as fusion proteins with green fluorescent protein.
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Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain.
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Protein phosphatase 1 regulation by inhibitors and targeting subunits.
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Protein purification by fusion with an environmentally responsive elastin-like polypeptide: effect of polypeptide length on the purification of thioredoxin.
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Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin.
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Protein targeting in neurons and endocrine cells.
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Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking.
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Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells.
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Protonation of the neutral repeats of the RNA polymerase II CTD.
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Purification of a 12,020-dalton protein that enhances the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase.
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Purification of an elastin-like fusion protein by microfiltration.
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Putative telomere-recruiting domain in the catalytic subunit of human telomerase.
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Quality-of-life improvements in cutaneous T-cell lymphoma patients treated with denileukin diftitox (ONTAK).
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Quantification of Change in Pigment Epithelial Detachment Volume and Morphology After Transition to Intravitreal Aflibercept in Eyes With Recalcitrant Neovascular AMD: 18-Month Results.
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R73A and H144Q mutants of the yeast mitochondrial cyclophilin Cpr3 exhibit a low prolyl isomerase activity in both peptide and protein-folding assays.
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RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues.
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Randomized, double-blind, placebo-controlled trial of the efficacy and safety of rilonacept in the treatment of systemic juvenile idiopathic arthritis.
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Rapid assembly dynamics of the Escherichia coli FtsZ-ring demonstrated by fluorescence recovery after photobleaching.
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Rapid identification of monospecific monoclonal antibodies using a human proteome microarray.
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Rapid selection of tetracycline-controlled inducible cell lines using a green fluorescent-transactivator fusion protein.
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Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites.
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Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo.
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Reaper-induced apoptosis in a vertebrate system.
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Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases.
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Receptors that induce erythroid differentiation of Ba/F3 cells: structural requirements and effect on STAT5 binding.
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Recombinant heregulin-Pseudomonas exotoxin fusion proteins: interactions with the heregulin receptors and antitumor activity in vivo.
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Recombinant vaccine-induced protection against the highly pathogenic simian immunodeficiency virus SIV(mac251): dependence on route of challenge exposure.
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Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription.
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Regions of the 110-kDa regulatory subunit M110 required for regulation of myosin-light-chain-phosphatase activity in smooth muscle.
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Regulated expression of a vitellogenin fusion gene in transgenic nematodes.
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Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein.
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Regulation of apoptosis in Xenopus egg extracts.
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Regulation of the amino-terminal transcription activation domain of progesterone receptor by a cofactor-induced protein folding mechanism.
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Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase.
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Regulation of the ribosome-membrane junction at early stages of presecretory protein translocation in the mammalian endoplasmic reticulum.
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Regulation of vitellogenin gene expression in transgenic Caenorhabditis elegans: short sequences required for activation of the vit-2 promoter.
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RelB cellular regulation and transcriptional activity are regulated by p100.
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Renal function with cyclosporine C2 monitoring, enteric-coated mycophenolate sodium and basiliximab: a 12-month randomized trial in renal transplant recipients.
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Reply.
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Repressing a repressor: gibberellin-induced rapid reduction of the RGA protein in Arabidopsis.
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Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1.
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Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4.
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Resolution of persistent pigment epithelial detachment secondary to polypoidal choroidal vasculopathy in response to Aflibercept.
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Response to: 'Comment on Transitioning to intravitreal aflibercept following a previous treat-and-extend dosing regimen in neovascular age-related macular degeneration: 24-month results'.
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Retinoic acid receptor expression vector inhibits differentiation of F9 embryonal carcinoma cells.
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Reversal of acute allograft rejection using immunotoxin.
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Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper.
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Rhegmatogenous Retinal Detachment after Intravitreal Injection of Anti-Vascular Endothelial Growth Factor.
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RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration.
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Rilonacept pharmacokinetics in children with systemic juvenile idiopathic arthritis.
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Risk of Inflammation, Retinal Vasculitis, and Retinal Occlusion-Related Events with Brolucizumab: Post Hoc Review of HAWK and HARRIER.
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Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae.
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Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.
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Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium.
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Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration.
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Role of the cytoplasmic tails of CXCR1 and CXCR2 in mediating leukocyte migration, activation, and regulation.
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Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.
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Rotavirus RNA polymerase requires the core shell protein to synthesize the double-stranded RNA genome.
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Rvs161p and sphingolipids are required for actin repolarization following salt stress.
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SOS induction as an in vivo assay of enzyme-DNA interactions.
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Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro.
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Saccharomyces cerevisiae Ntg1p and Ntg2p: broad specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria.
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Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer.
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Safety of intraparenchymal convection-enhanced delivery of cintredekin besudotox in early-phase studies.
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Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with advanced cancer.
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Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
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Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity.
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Second-line treatments in children with immune thrombocytopenia: Effect on platelet count and patient-centered outcomes.
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Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow.
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Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma.
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Selective targeting of human alloresponsive CD8+ effector memory T cells based on CD2 expression.
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Self-cleavable stimulus responsive tags for protein purification without chromatography.
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Sequential Sterile Intraocular Inflammation Associated With Consecutive Intravitreal Injections of Aflibercept and Ranibizumab.
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Signaling, desensitization, and trafficking of G protein-coupled receptors revealed by green fluorescent protein conjugates.
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Simian immunodeficiency virus DNA vaccine trial in macaques.
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Six-helix bundle assembly and characterization of heptad repeat regions from the F protein of Newcastle disease virus.
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Sotatercept (ACE-011) for the treatment of chemotherapy-induced anemia in patients with metastatic breast cancer or advanced or metastatic solid tumors treated with platinum-based chemotherapeutic regimens: results from two phase 2 studies.
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Sp1 activation of a TATA-less promoter requires a species-specific interaction involving transcription factor IID.
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Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites.
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Spatially addressable chemoselective C-terminal ligation of an intein fusion protein from a complex mixture to a hydrazine-terminated surface.
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Specific peptide probes for G-protein interaction with effectors.
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Specificity and regulation of a synaptic vesicle docking complex.
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Spindle dynamics during meiosis in Drosophila oocytes.
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Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein.
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Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2.
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Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling.
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Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.
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Stimulation of Sky tyrosine phosphorylation by bovine protein S--domains involved in the receptor-ligand interaction.
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Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology.
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Stretching single molecules into novel conformations using the atomic force microscope.
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Structural and functional analysis of the visna virus Rev-response element.
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Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody.
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Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.
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Structural domains that contribute to substrate specificity in facilitated glucose transporters are distinct from those involved in kinetic function: studies with GLUT-1/GLUT-2 chimeras.
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Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells.
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Structural requirements regulate endoproteolytic release of the L-selectin (CD62L) adhesion receptor from the cell surface of leukocytes.
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Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation.
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Structure of the water channel AqpZ from Escherichia coli revealed by electron crystallography.
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Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein.
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Studies of the conformation-dependent neutralizing epitopes of simian immunodeficiency virus envelope protein.
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Study of Cryptococcus neoformans actin gene regulation with a beta-galactosidase-actin fusion.
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Subcellular localization and functional analysis of the Arabidopsis GTPase RabE.
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Subcellular localization of spastin: implications for the pathogenesis of hereditary spastic paraplegia.
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Subcellular localization of the human immunodeficiency virus trans-acting art gene product.
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Subunit IV of cytochrome bc1 complex from Rhodobacter sphaeroides. Localization of regions essential for interaction with the three-subunit core complex.
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Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.
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Supratrigeminal Bilaterally Projecting Neurons Maintain Basal Tone and Enable Bilateral Phasic Activation of Jaw-Closing Muscles.
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Surface acoustic waves enable rotational manipulation of Caenorhabditis elegans.
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Sustained expression of human factor VIII in mice using a parvovirus-based vector.
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Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study.
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Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex.
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Synergism of accessory factors in functional expression of mammalian odorant receptors.
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Synergistic enhancement of both initiation and elongation by acidic transcription activation domains.
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Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist.
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Synthesis of programmable integrases.
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TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour.
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Targeted and untargeted CD137L fusion proteins for the immunotherapy of experimental solid tumors.
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Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice.
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Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells.
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Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions.
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Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase.
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Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis.
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Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus Macaques.
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Targeting HIV-1 envelope glycoprotein trimers to B cells by using APRIL improves antibody responses.
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Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
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Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins.
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Targeting of the synaptic vesicle protein synaptobrevin in the axon of cultured hippocampal neurons: evidence for two distinct sorting steps.
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Targeting the Effect of VEGF in Diabetic Macular Edema.
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Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.
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Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination.
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Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse.
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Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor.
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Tetramerization and single-stranded DNA binding properties of native and mutated forms of murine mitochondrial single-stranded DNA-binding proteins.
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The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.
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The Arabidopsis RGA gene encodes a transcriptional regulator repressing the gibberellin signal transduction pathway.
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The C2 domain protein Cts1 functions in the calcineurin signaling circuit during high-temperature stress responses in Cryptococcus neoformans.
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The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein.
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The DELLA motif is essential for gibberellin-induced degradation of RGA.
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The Epstein-Barr virus nuclear protein SM is both a post-transcriptional inhibitor and activator of gene expression.
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The Erwinia amylovora avrRpt2EA gene contributes to virulence on pear and AvrRpt2EA is recognized by Arabidopsis RPS2 when expressed in pseudomonas syringae.
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The Haemophilus influenzae Hia autotransporter contains an unusually short trimeric translocator domain.
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The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta.
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The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence.
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The PIG-A mutation and absence of glycosylphosphatidylinositol-linked proteins do not confer resistance to apoptosis in paroxysmal nocturnal hemoglobinuria.
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The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals.
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The V3 domain of SIVmac251 gp120 contains a linear neutralizing epitope.
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The ability of HIV type 1 to use CCR-3 as a coreceptor is controlled by envelope V1/V2 sequences acting in conjunction with a CCR-5 tropic V3 loop.
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The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor.
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The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes.
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The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription.
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The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.
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The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.
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The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.
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The binding site of human adenosine deaminase for CD26/Dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to cd26 but does not cause immune deficiency.
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The calmodulin-nitric oxide synthase interaction. Critical role of the calmodulin latch domain in enzyme activation.
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The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse.
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The chloride transporter Na(+)-K(+)-Cl- cotransporter isoform-1 contributes to intracellular chloride increases after in vitro ischemia.
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The conserved phosphoinositide 3-kinase pathway determines heart size in mice.
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The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells.
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The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.
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The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis.
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The dishevelled protein is modified by wingless signaling in Drosophila.
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The distal cytoplasmic domain of the erythropoietin receptor induces granulocytic differentiation in 32D cells.
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The effect of covalently immobilized rhIL-1ra-ELP fusion protein on the inflammatory profile of LPS-stimulated human monocytes.
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The effect of monastrol on the processive motility of a dimeric kinesin-5 head/kinesin-1 stalk chimera.
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The effects of Ca(2+) binding on the conformation of calbindin D(28K): a nuclear magnetic resonance and microelectrospray mass spectrometry study.
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The effects of local hyperthermia on the catabolism of a radioiodinated chimeric monoclonal antibody.
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The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis.
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The erythropoietin receptor transmembrane region is necessary for activation by the Friend spleen focus-forming virus gp55 glycoprotein.
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The essential sequence elements required for RNAP II carboxyl-terminal domain function in yeast and their evolutionary conservation.
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The fine specificity of anti-La antibodies induced in mice by immunization with recombinant human La autoantigen.
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The glitter of gold: biolistic transfection of fresh adult cardiac myocytes. Focus on "normal targeting of a tagged Kv1.5 channel acutely transfected into fresh adult cardiac myocytes by a biolistic method".
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The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome.
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The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells.
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The homeodomain protein HOXB13 regulates the cellular response to androgens.
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The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.
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The human plasminogen activator inhibitor type I gene promoter targets to kidney.
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The identification of a second actin-binding region in spinophilin/neurabin II.
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The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding.
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The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors.
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The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1.
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The mode of death of pig kidney cells infected with cowpox virus is governed by the expression of the crmA gene.
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The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus.
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The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits.
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The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor.
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The phosphoCTD-interacting domain of Topoisomerase I.
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The products of gene I and the overlapping in-frame gene XI are required for filamentous phage assembly.
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The regulation of DNA topoisomerase II by casein kinase II.
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The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism.
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The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.
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The risk and opportunity of homeostatic repopulation.
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The road to romiplostim approval and beyond.
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The role of Alzheimer's disease-related presenilin 1 in intercellular adhesion.
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The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.
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The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.
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The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2.
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Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans.
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Three-in-one chromatography-free purification, tag removal, and site-specific modification of recombinant fusion proteins using sortase A and elastin-like polypeptides.
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Tissue- and development-specific expression of the human phenylalanine hydroxylase/chloramphenicol acetyltransferase fusion gene in transgenic mice.
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Toll-like receptor agonists as third signals for dendritic cell-tumor fusion vaccines.
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Toxicity of expanded polyglutamine-domain proteins in Escherichia coli.
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Toxin-based targeted therapy for malignant brain tumors.
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Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination.
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Transactivation of the epidermal growth factor receptor by angiotensin II in glomerular podocytes.
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Transcriptional trans activators of human and simian foamy viruses contain a small, highly conserved activation domain.
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Transcytosis-blocking abs elicited by an oligomeric immunogen based on the membrane proximal region of HIV-1 gp41 target non-neutralizing epitopes.
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Transfer of CD8+ T cell memory using Bcl-2 as a marker.
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Transgenic indicator mice for studying activated retinoic acid receptors during development.
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Transgenic mice expressing a constitutively active retinoic acid receptor in the lens exhibit ocular defects.
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Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor.
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Transient requirement for ganglion cells during assembly of retinal synaptic layers.
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Transitioning to intravitreal aflibercept following a previous treat-and-extend dosing regimen in neovascular age-related macular degeneration: 24-month results.
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Transplantation of multipotent progenitors from the adult olfactory epithelium.
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Treatment with immunotoxin.
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Trends in Anti-Vascular Endothelial Growth Factor Agents and Panretinal Photocoagulation Use in Diabetic Retinopathy.
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Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli.
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Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.
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Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning.
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Two closely related human nuclear export factors utilize entirely distinct export pathways.
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Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A.
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Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes.
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Two-dimensional tracking of ncd motility by back focal plane interferometry.
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Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt.
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Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel.
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Ultra-high expression of a thermally responsive recombinant fusion protein in E. coli.
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Ultrastructure and function of the fractalkine mucin domain in CX(3)C chemokine domain presentation.
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Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).
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Understanding the mechanisms of action of antiangiogenic agents in metastatic colorectal cancer: a clinician's perspective.
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Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases.
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Use of a thrombopoietin mimetic for chronic immune thrombocytopenic purpura in pregnancy.
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Use of bacterial quorum-sensing components to regulate gene expression in plants.
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Use of recombinant adenovirus for metabolic engineering of mammalian cells.
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Using Tools from Optogenetics to Create Light-Responsive Biomaterials: LOVTRAP-PEG Hydrogels for Dynamic Peptide Immobilization.
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Using noisy gene expression mediated by engineered adenovirus to probe signaling dynamics in mammalian cells.
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Using viral species specificity to define a critical protein/RNA interaction surface.
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Utility of telomerase-pot1 fusion protein in vascular tissue engineering.
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Utility of the secreted placental alkaline phosphatase reporter enzyme.
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Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C.
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Utilization patterns and characteristics of users of biologic anti-inflammatory agents in a large, US commercially insured population.
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VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.
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Vaccination with the immediate-early protein ICP47 of herpes simplex virus-type 1 (HSV-1) induces virus-specific lymphoproliferation, but fails to protect against lethal challenge.
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Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.
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Visual Acuity, Vitreous Hemorrhage, and Other Ocular Outcomes After Vitrectomy vs Aflibercept for Vitreous Hemorrhage Due to Diabetic Retinopathy: A Secondary Analysis of a Randomized Clinical Trial.
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Visual and anatomical outcomes following intravitreal aflibercept in eyes with recalcitrant neovascular age-related macular degeneration: 12-month results.
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Visualization of P-selectin glycoprotein ligand-1 as a highly extended molecule and mapping of protein epitopes for monoclonal antibodies.
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Visualization of retroviral replication in living cells reveals budding into multivesicular bodies.
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Visualization of synaptic inhibition with an optogenetic sensor developed by cell-free protein engineering automation.
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Visualizing an olfactory sensory map.
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Vitamin D receptors repress basal transcription and exert dominant negative activity on triiodothyronine-mediated transcriptional activity.
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WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells.
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Wingless signaling generates pattern through two distinct mechanisms.
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Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends.
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Ziv-aflibercept: binding to more than VEGF-A--does more matter?
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beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation.
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beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors.
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beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.
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beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.
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p135tyk2, an interferon-alpha-activated tyrosine kinase, is physically associated with an interferon-alpha receptor.
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p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.
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p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene.
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tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2.
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Keywords of People
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Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
-
Erickson, Harold Paul,
Professor Emeritus of Cell Biology,
Cell Biology
-
Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
-
Krangel, Michael S.,
George Barth Geller Distinguished Professor of Immunology,
Immunology
-
Lee, Walter T,
Professor of Head and Neck Surgery & Communication Sciences,
Radiation Oncology
-
Linardic, Corinne Mary,
Associate Professor of Pediatrics,
Cell Biology
-
Luftig, Micah Alan,
Associate Professor of Molecular Genetics and Microbiology,
Cell Biology
-
McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Cell Biology
-
McLendon, Roger Edwin,
Professor of Pathology,
Pathology
-
Milano, Carmelo Alessio,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Surgery, Cardiovascular and Thoracic Surgery
-
Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Biomedical Engineering
-
Taylor, Gregory Alan,
Professor in Medicine,
Immunology
-
Tsalik, Ephraim,
Adjunct Associate Professor in the Department of Medicine,
Medicine, Infectious Diseases
-
Yan, Hai,
Adjunct Professor of Pathology,
Pathology
-
Zhong, Xiaoping,
Professor of Pediatrics,
Immunology