Regeneration

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  Subject Areas on Research

  • 2010 Nicolas Andry Award: Multipotent adult stem cells from adipose tissue for musculoskeletal tissue engineering. 
  • A Conserved Distal Lung Regenerative Pathway in Acute Lung Injury. 
  • A Regeneration Toolkit. 
  • A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. 
  • A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism. 
  • ABCB5 is a limbal stem cell gene required for corneal development and repair. 
  • ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia. 
  • Abi3bp regulates cardiac progenitor cell proliferation and differentiation. 
  • Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks. 
  • Accessories to Limb Regeneration. 
  • Activation of Wnt signaling in hematopoietic regeneration. 
  • Advances in understanding tissue regenerative capacity and mechanisms in animals. 
  • Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration. 
  • Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal. 
  • Anatomical correlates of functional recovery in the avian inner ear following aminoglycoside ototoxicity. 
  • Angiopoietin-1 enhances skeletal muscle regeneration in mice. 
  • Atherothrombotic disorders: new insights from hematology. 
  • Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration. 
  • BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors. 
  • Back in Black. 
  • Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. 
  • Beta-cell regeneration: epithelial mesenchymal transition pre-EMTpted by lineage tracing? 
  • Biaxial Stretch Improves Elastic Fiber Maturation, Collagen Arrangement, and Mechanical Properties in Engineered Arteries. 
  • Bile ducts and portal and central veins are major producers of tumor necrosis factor alpha in regenerating rat liver. 
  • Bioengineered lung epithelium: implications for basic and applied studies in lung tissue regeneration. 
  • Biomaterials for intervertebral disc regeneration and repair. 
  • Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression via ERK1/2 and PI3K/Akt Pathways in Intracerebral Hemorrhage. 
  • Building and re-building the heart by cardiomyocyte proliferation. 
  • C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway. 
  • Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. 
  • Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration. 
  • Cardiac regeneration strategies: Staying young at heart. 
  • Cardiac regeneration. 
  • Cardiac regenerative capacity and mechanisms. 
  • Cell biology and physiology of the uroepithelium. 
  • Cell cycle control in the terminally differentiated myocyte. A platform for myocardial repair? 
  • Cell therapy for heart failure: the need for a new therapeutic strategy. 
  • Cellular plasticity: 1712 to the present day. 
  • Characteristics of cat skeletal muscles grafted with intact nerves or with anastomosed nerves. 
  • Characterization of mesonephric development and regeneration using transgenic zebrafish. 
  • Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. 
  • Clinical and hematologic benefits of partial splenectomy for congenital hemolytic anemias in children. 
  • Clonally dominant cardiomyocytes direct heart morphogenesis. 
  • Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial design. 
  • Conserved microRNA program as key to mammalian cardiac regeneration: insights from zebrafish. 
  • Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. 
  • Cutaneous wound healing: recruiting developmental pathways for regeneration. 
  • Deciphering the molecular machinery of stem cells: a look at the neoblast gene expression profile. 
  • Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration. 
  • Delivery of primary autologous skeletal myoblasts into rabbit heart by coronary infusion: a potential approach to myocardial repair. 
  • Delta-like 1 homolog (dlk1): a marker for rhabdomyosarcomas implicated in skeletal muscle regeneration. 
  • Derivation of chondrogenically-committed cells from human embryonic cells for cartilage tissue regeneration. 
  • Design, evaluation, and application of engineered skeletal muscle. 
  • Development-dependent disappearance of caspase-3 in skeletal muscle is post-transcriptionally regulated. 
  • Developmental Morphogens & Recovery from Alcoholic Liver Disease. 
  • Developmental biology. Branching takes nerve. 
  • Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms. 
  • Effect of nandrolone decanoate administration on recovery from bupivacaine-induced muscle injury. 
  • Effects of red and blue light on the growth and morphogenesis of Acetabularia crenulata. 
  • Endogenous lung stem cells and contribution to disease. 
  • Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury. 
  • Endothelial progenitor cells: markers of vascular reparative capacity. 
  • Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. 
  • Engineering skeletal muscle repair. 
  • Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling. 
  • Epidermal growth factor regulates hematopoietic regeneration after radiation injury. 
  • Epithelial repair of the uterine cervix: assessment of morphologic features and correlations with cytologic diagnosis. 
  • Epithelial-mesenchymal interactions in the alteration of gene expression and morphology following lung injury. 
  • Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. 
  • Evolution of regeneration and fission in annelids: insights from engrailed- and orthodenticle-class gene expression. 
  • Explant culture of adult zebrafish hearts for epicardial regeneration studies. 
  • Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin. 
  • Expression of ZIC genes in the development of the chick inner ear and nervous system. 
  • Expression of reg/PSP, a pancreatic exocrine gene: relationship to changes in islet beta-cell mass. 
  • FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish. 
  • Factors regulating islet regeneration in the post-insulinoma NEDH rat. 
  • Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration. 
  • Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish. 
  • Fgfs control homeostatic regeneration in adult zebrafish fins. 
  • Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration. 
  • Functional and anatomic correlation of splenic regeneration following embolization. 
  • Future directions in chemosensory research. 
  • GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells. 
  • Genetic DISC-section of regeneration in Drosophila. 
  • Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. 
  • Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs. 
  • Getting Back to Normal: Can Enhanced Regeneration Maintain Health? 
  • Getting to the heart of regeneration in zebrafish. 
  • HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration. 
  • HDACs in skeletal muscle remodeling and neuromuscular disease. 
  • Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration. 
  • Heart regeneration in zebrafish. 
  • Hierarchical organization of lung progenitor cells: is there an adult lung tissue stem cell? 
  • Highly coordinated gene regulation in mouse skeletal muscle regeneration. 
  • Human lung stem cells: has the future arrived? 
  • Human umbilical cord blood endothelial progenitor cells decrease vein graft neointimal hyperplasia in SCID mice. 
  • Hydra. 
  • IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells. 
  • Immune reconstitution after unrelated cord blood transplantation. 
  • Immune reconstitution in patients with HIV infection. 
  • In vivo commitment and functional tissue regeneration using human embryonic stem cell-derived mesenchymal cells. 
  • In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations. 
  • In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. 
  • Induction of lef1 during zebrafish fin regeneration. 
  • Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration. 
  • Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas. 
  • Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. 
  • Intracardiac transplantation of skeletal myoblasts yields two populations of striated cells in situ. 
  • Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. 
  • Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease. 
  • Intramyocardial, autologous CD34+ cell therapy for refractory angina. 
  • Isoform-specific induction of a retinoid-responsive antigen after biolistic transfection of chimaeric retinoic acid/thyroid hormone receptors into a regenerating limb. 
  • Keeping at arm's length during regeneration. 
  • Leukocyte inflammatory response in a rat urinary bladder regeneration model using porcine small intestinal submucosa scaffold. 
  • Live Monitoring of Blastemal Cell Contributions during Appendage Regeneration. 
  • Live fate-mapping of joint-associated fibroblasts visualizes expansion of cell contributions during zebrafish fin regeneration. 
  • Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration. 
  • LungMAP: The Molecular Atlas of Lung Development Program. 
  • Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. 
  • Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. 
  • Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves. 
  • Mechanistic insights of rapid liver regeneration after associating liver partition and portal vein ligation for stage hepatectomy. 
  • Mechanobiology of the meniscus. 
  • Methodologies for Inducing Cardiac Injury and Assaying Regeneration in Adult Zebrafish. 
  • MicroRNA delivery for regenerative medicine. 
  • MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes. 
  • MicroRNAs and Cardiac Regeneration. 
  • Modulation of tissue repair by regeneration enhancer elements. 
  • Molecular analysis of the SCARECROW gene in maize reveals a common basis for radial patterning in diverse meristems. 
  • Molecular and cell-based therapies for protection, rescue, and repair of ischemic myocardium: reasons for cautious optimism. 
  • Monitoring Tissue Regeneration at Single-Cell Resolution. 
  • Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. 
  • Multicolor Cell Barcoding Technology for Long-Term Surveillance of Epithelial Regeneration in Zebrafish. 
  • Multipotent stem cells in cardiac regenerative therapy. 
  • Myocardial NF-κB activation is essential for zebrafish heart regeneration. 
  • Near-infrared lymphography as a minimally invasive modality for imaging lymphatic reconstitution in a rat orthotopic hind limb transplantation model. 
  • Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration. 
  • Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration. 
  • New regulators of vertebrate appendage regeneration. 
  • Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair. 
  • Nonsteroidal anti-inflammatory drugs and acetaminophen in the treatment of an acute muscle injury. 
  • Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells. 
  • Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. 
  • Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish. 
  • Optimization of flexor tendon tissue engineering with a cyclic strain bioreactor. 
  • Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. 
  • Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults. 
  • Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration. 
  • Partial splenectomy for hereditary spherocytosis: a multi-institutional review. 
  • Peripheral nerve grafts: the relationship of axonal growth cone and biomechanical properties. 
  • Persistent expression of MNF identifies myogenic stem cells in postnatal muscles. 
  • Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration. 
  • Plasticity in the lung: making and breaking cell identity. 
  • Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. 
  • Platelet-rich plasma and peripheral nerve regeneration: a potential contraindication to its use after tumor excision. 
  • Pleiotrophin mediates hematopoietic regeneration via activation of RAS. 
  • Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regeneration. 
  • Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. 
  • Proteomic analysis of regenerated rabbit lenses reveal crystallin expression characteristic of adult rabbits. 
  • RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation. 
  • Ras controls melanocyte expansion during zebrafish fin stripe regeneration. 
  • Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. 
  • Regeneration Genetics. 
  • Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells. 
  • Regeneration of amputated zebrafish fin rays from de novo osteoblasts. 
  • Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans. 
  • Regional variations in small intestinal submucosa evoke differences in inflammation with subsequent impact on tissue regeneration in the rat bladder augmentation model. 
  • Regulation of chondrocytic gene expression by biomechanical signals. 
  • Regulation of zebrafish heart regeneration by miR-133. 
  • Remodeling muscles with calcineurin. 
  • Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. 
  • Resolving Heart Regeneration by Replacement Histone Profiling. 
  • Response to "Animal Model of Chronic Perforation Is Best for Eardrum Regeneration Using Biological Materials". 
  • Restoring synaptic connections in the inner ear after noise damage. 
  • Results and performance after microfracture in National Basketball Association athletes. 
  • Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. 
  • Reversal of muscle differentiation during urodele limb regeneration. 
  • Reversibility of the mononucleate-to-multinucleate myogenic transition during amphibian limb regeneration. 
  • Roles for Fgf signaling during zebrafish fin regeneration. 
  • STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration. 
  • Scaffolding in tissue engineering: general approaches and tissue-specific considerations. 
  • Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats. 
  • Sexually dimorphic fin regeneration in zebrafish controlled by androgen/GSK3 signaling. 
  • Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration. 
  • Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair. 
  • Smoothened is a master regulator of adult liver repair. 
  • Spectrophotometry of cerebral cytochrome a, a3 in bloodless rats. 
  • Stacking of a dermal regeneration template for reconstruction of a soft-tissue defect after tumor excision from the palm of the hand: a case report. 
  • Stem cells and cell therapies in lung biology and lung diseases. 
  • Stem cells in lung disease, repair, and the potential for therapeutic interventions: State-of-the-art and future challenges. 
  • Stem cells of the adult lung: their development and role in homeostasis, regeneration, and disease. 
  • Stem cells, cancer, and cancer stem cells. 
  • Striated muscle function, regeneration, and repair. 
  • Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density. 
  • Subchondral Bone and the Osteochondral Unit: Basic Science and Clinical Implications in Sports Medicine. 
  • Sugar-coating wound repair: a review of FGF-10 and dermatan sulfate in wound healing and their potential application in burn wounds. 
  • Survival of adult rat retinal ganglion cells with regrown axons in peripheral nerve grafts: a comparison of graft attachment with suture of fibrin glue. 
  • Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury. 
  • Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease. 
  • Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice. 
  • Tales of regeneration in zebrafish. 
  • Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue. 
  • Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. 
  • Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. 
  • The Athena trials: Autologous adipose-derived regenerative cells for refractory chronic myocardial ischemia with left ventricular dysfunction. 
  • The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. 
  • The emerging concept of vascular remodeling. 
  • The epicardium as a hub for heart regeneration. 
  • The extracellular matrix protein agrin promotes heart regeneration in mice. 
  • The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion. 
  • The liver--a potential new player in islet regeneration? 
  • The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage. 
  • The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. 
  • The relationship between cardiac endothelium and fibroblasts: it's complicated. 
  • The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. 
  • The role of stem cells in airway repair: implications for the origins of lung cancer. 
  • The zebrafish as a model for complex tissue regeneration. 
  • Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury. 
  • Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker. 
  • To branch or not to branch: the role of pre-patterning in lateral root formation. 
  • Toward a blueprint for regeneration. 
  • Toxin injury-dependent switched expression between EF-1 alpha and its sister, S1, in rat skeletal muscle. 
  • Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. 
  • Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells. 
  • Transient laminin beta 1a Induction Defines the Wound Epidermis during Zebrafish Fin Regeneration. 
  • Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. 
  • Treatment of Fuchs Endothelial Dystrophy by Descemet Stripping Without Endothelial Keratoplasty. 
  • Umbilical cord blood transplantation in adults using myeloablative and nonmyeloablative preparative regimens. 
  • Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish. 
  • WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment. 
  • Zebrafish kit mutation reveals primary and secondary regulation of melanocyte development during fin stripe regeneration. 
  • beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium. 
  • tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. 
  • zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish. 
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  Keywords of People

  • Cartoni, Romain, Assistant Professor of Pharmacology and Cancer Biology, Neurobiology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Doan, Phuong Linh, Assistant Professor of Medicine, Duke Cancer Institute
  • Hilton, Matthew James, Associate Professor in Orthopaedic Surgery, Cell Biology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor, Cell Biology
  • Lee, Chang Lung, Assistant Professor in Radiation Oncology, Pathology
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. / Guidant Foundation Distinguished Professor of Cardiology, Medicine, Clinical Pharmacology