Renin

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  Subject Areas on Research

  • (Pro)renin receptor is expressed in human retinal pigment epithelium and participates in extracellular matrix remodeling. 
  • A comparative evaluation of hemodynamic and neurohumoral effects of nitroglycerin and nifedipine in congestive heart failure. 
  • A comparative study of the distributions of renin and angiotensinogen messenger ribonucleic acids in rat and mouse tissues. 
  • A cooperative multicenter study of captopril in congestive heart failure: hemodynamic effects and long-term response. 
  • A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. 
  • A lack of genetic linkage of renin gene restriction fragment length polymorphisms with human hypertension. 
  • A major role for the EP4 receptor in regulation of renin. 
  • A monoclonal antibody specific for the amino terminal sequence of human prorenin identifies a common epitope on renal and amniotic fluid inactive renins. 
  • A new cardiac MASTer switch for the renin-angiotensin system. 
  • ATAC-ing the mechanisms of renin regulation. 
  • Abundant androgen regulated mRNAs in mouse submandibular gland: cell-free translation of renin precursor mRNA. 
  • Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment. 
  • Altered sodium regulation of renal angiotensinogen mRNA in the spontaneously hypertensive rat. 
  • An international cohort study of autosomal dominant tubulointerstitial kidney disease due to REN mutations identifies distinct clinical subtypes. 
  • Ang II accumulation in rat renal endosomes during Ang II-induced hypertension: role of AT(1) receptor. 
  • Angiotensin AT1 receptor inhibition. Effects on hypertrophic remodeling and ACE expression in rats with pressure-overload hypertrophy due to ascending aortic stenosis. 
  • Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation. 
  • Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration. 
  • Angiotensin converting enzyme in renal ontogeny: hypothesis for multiple roles. 
  • Angiotensin mediates stimulation of ventilation after vasopressin V1 receptor blockade. 
  • Antibodies as specific renin inhibitors: studies with polyclonal and monoclonal antibodies and Fab fragments. 
  • Arterial pressure, left ventricular mass, and aldosterone in essential hypertension. 
  • Assessing genetic association with human survival at multi-allelic loci. 
  • Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring. 
  • Association of parental obesity with concentrations of select systemic biomarkers in nonobese offspring: the Framingham Heart Study. 
  • Atrial natriuretic factor-specific antibody as a tool for physiological studies. Evidence for role of atrial natriuretic factor in aldosterone and renal electrolyte regulation. 
  • Atrial natriuretic factor: pharmacokinetics and cyclic GMP response in relation to biologic effects in severe heart failure. 
  • Beta2-adrenergic receptor genotype affects the renin-angiotensin-aldosterone system response to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern. 
  • Biochemical and immunological properties of dog brain isorenin. 
  • Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction. 
  • Biosynthesis of renin: multiplicity of active and intermediate forms. 
  • Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene. 
  • Cell-dependent posttranslational processing and secretion of recombinant mouse renin-2. 
  • Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease. 
  • Characterization of a monoclonal antibody specific for human active renin. 
  • Characterization of antibodies to canine renal renin. Studies of interspecies homology of renin using antibodies as probe. 
  • Characterization of human prorenin expressed in mammalian cells from cloned cDNA. 
  • Characterization of inactive renin from human kidney and plasma. Evidence of a renal source of circulating inactive renin. 
  • Characterization of prorenin activation using a synthetic peptide substrate. 
  • Characterization of purified rabbit uterine renin: influence of pregnancy on uterine inactive renin. 
  • Circulating versus local renin-angiotensin system in cardiovascular homeostasis. 
  • Classical Renin-Angiotensin system in kidney physiology. 
  • Clinical profile and prognostic significance of natriuretic peptide trajectory following hospitalization for worsening chronic heart failure: findings from the ASTRONAUT trial. 
  • Comparison of renin-specific IgG and antibody fragments in studies of blood pressure regulation. 
  • Compensatory response to hemorrhage in conscious dogs on normal and low salt intake. 
  • Complete purification of dog renal renin. 
  • Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community. 
  • Cultured glomerular mesangial cells contain renin: influence of calcium and isoproterenol. 
  • Decongestion strategies and renin-angiotensin-aldosterone system activation in acute heart failure. 
  • Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition. 
  • Developmental renin expression in mice with a defective renin-angiotensin system. 
  • Dietary sodium and blood pressure. 
  • Different secretory pathways of renin from mouse cells transfected with the human renin gene. 
  • Differential effects of captopril and enalapril on tissue renin-angiotensin systems in experimental heart failure. 
  • Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice. 
  • Differentiation of hemodynamic, humoral and metabolic responses to beta 1- and beta 2-adrenergic stimulation in man using atenolol and propranolol. 
  • Distinct nuclear proteins competing for an overlapping sequence of cyclic adenosine monophosphate and negative regulatory elements regulate tissue-specific mouse renin gene expression. 
  • Distinct renin/aldosterone activity profiles correlate with renal function, natriuretic response, decongestive ability and prognosis in acute heart failure. 
  • Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. 
  • Dog inactive renin: biochemical characterization and secretion into renal plasma and lymph. 
  • Dual natriuretic peptide system in experimental heart failure. 
  • During acute hypercapnia vasopressin inhibits an angiotensin drive to ventilation in conscious dogs. 
  • Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial. 
  • Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure: the ASTRONAUT randomized trial. 
  • Effect of captopril on the release of the components of the renin-angiotensin system into plasma and lymph. 
  • Effect of exogenous angiotensin II infusion after one year of captopril therapy in essential hypertension. 
  • Effect of intrarenal administration of dopamine on renin release in conscious dogs. 
  • Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney. 
  • Efficacy of eplerenone added to renin-angiotensin blockade in elderly hypertensive patients: the Jichi-Eplerenone Treatment (JET) study. 
  • Endothelial renin-angiotensin pathway: evidence for intracellular synthesis and secretion of angiotensins. 
  • Evidence for renin in rat brain: differentiation from other reninlike enzymes. 
  • Evidence for the existence of renin in the heart. 
  • Evidence for two cellular pathways of renin secretion by the mouse submandibular gland. 
  • Failure of angiotensin II to reduce plasma renin activity in hypertensive pregnant women. 
  • Functional human renin promoter in transfected cells: evidence for cell-specific expression. 
  • Gene expression of the renin-angiotensin system in human tissues. Quantitative analysis by the polymerase chain reaction. 
  • Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease. 
  • Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2). 
  • Genes and longevity: lessons from studies of centenarians. 
  • Genetic control of blood pressure and the angiotensinogen locus. 
  • Genetic manipulation of the renin-angiotensin system. 
  • Glycosylation influences intracellular transit time and secretion rate of human prorenin in transfected cells. 
  • Hormonal control of angiotensinogen production. 
  • Human neutrophils release serine proteases capable of activating prorenin. 
  • Human renin biosynthesis and secretion in normal and ischemic kidneys. 
  • Hybridization studies with a renin cDNA probe: evidence for widespread expression of renin in the mouse. 
  • Hyperrenin-hyperaldosterone-dependent malignant hypertension in polyarteritis nodosa. 
  • Hypertension associated with alcohol withdrawal: assessment of mechanisms and complications. 
  • Hyponatremia in congestive heart failure: implications for neurohumoral activation and responses to orthostasis. 
  • Identification of a negative regulatory element involved in tissue-specific expression of mouse renin genes. 
  • Identification of a novel set of genes regulated by a unique liver X receptor-alpha -mediated transcription mechanism. 
  • Identification of negative and positive regulatory elements in the human renin gene. 
  • Identification of potential regulatory regions in the renin gene. 
  • Identification of renin and angiotensinogen messenger RNA sequences in mouse and rat brains. 
  • Identification of renin and renin-like enzymes in rat brain by a renin-specific antibody. 
  • Immunoaffinity chromatography of canine high-molecular-weight renin: partial purification and characterization. 
  • Immunohistochemical studies of cell differentiation in a juxtaglomerular tumor. 
  • In vivo identification of a negative regulatory element in the mouse renin gene using direct gene transfer. 
  • In vivo inhibition of renin by antirenin antibodies: potential experimental and clinical applications. 
  • Influence of androgen on translatable renin mRNA in the mouse submandibular gland. 
  • Inhibition of renin-like activity in marmoset tissues by the renin inhibitor CGP 29 287. 
  • Interaction of signals influencing renin release. 
  • Intravenous nisoldipine in severe congestive heart failure. 
  • Is plasma renin activity associated with worse outcomes in acute heart failure? A secondary analysis from the BLAST-AHF trial. 
  • Is renin a factor in the etiology of essential hypertension? 
  • Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct. 
  • LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression. 
  • Left ventricular myocardial blood flow, metabolism, and effects of treatment with enalapril: further insights into the mechanisms of canine experimental pacing-induced heart failure. 
  • Liver X receptors alpha and beta regulate renin expression in vivo. 
  • Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytes. 
  • Mapping of the human renin transcription start site: evidence for a single functional promoter. 
  • Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. 
  • Molecular and physiological aspects of tissue renin-angiotensin system: emphasis on cardiovascular control. 
  • Molecular biology and pathophysiology of the intrarenal renin-angiotensin system. 
  • Molecular biology of the renin-angiotensin system. 
  • Molecular mechanism of tissue-specific regulation of mouse renin gene expression by cAMP. Identification of an inhibitory protein that binds nuclear transcriptional factor. 
  • Molecular mechanisms that control renin secretion. 
  • Molecular studies of human renin structure and synthesis using monoclonal antibodies. 
  • Molecular studies of human renin synthesis and gene expression. 
  • Monoclonal antibodies as molecular probes to study structural heterogeneity between human and animal renins and other aspartyl proteinases. 
  • Monoclonal antibodies binding renal renin. 
  • Monoclonal antibodies specific for human renin. 
  • Morning blood pressure surge, morning platelet aggregation, and silent cerebral infarction in older Japanese hypertensive patients. 
  • Mouse models of diabetic nephropathy. 
  • Multiple sites of regulation of mouse renin expression in ontogeny. 
  • Negative control elements and cAMP responsive sequences in the tissue-specific expression of mouse renin genes. 
  • Neurohumoral mechanisms in heart failure: role in pathogenesis, therapy, and drug tolerance. 
  • Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation. 
  • Novel and effective gene transfer technique for study of vascular renin angiotensin system. 
  • Nuclear receptor LXRalpha is involved in cAMP-mediated human renin gene expression. 
  • Obstructive nephropathy in the rat: possible roles for the renin-angiotensin system, prostaglandins, and thromboxanes in postobstructive renal function. 
  • Partial purification of a prorenin activating enzyme in the aortic wall. 
  • Pathophysiology of vascular smooth muscle in renin promoter-T-antigen transgenic mice. 
  • Peptides and neurotransmitters that affect renin secretion. 
  • Pharmacokinetics, hemodynamic, renal, and neurohormonal effects of atrial natriuretic factor in experimental heart failure. 
  • Phosphodiesterase 5 inhibition improves beta-cell function in metabolic syndrome. 
  • Physiological effects of synthetic atrial natriuretic factor in normal conscious dogs. 
  • Plasma atrial natriuretic factor during chronic thoracic inferior vena caval constriction. 
  • Plasma renin activity following operations for renovascular hypertension. 
  • Plasma renin activity, response to aliskiren, and clinical outcomes in patients hospitalized for heart failure: the ASTRONAUT trial. 
  • Plasma renin testing to guide antihypertensive therapy. 
  • Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease. 
  • Possible prorenin activating mechanisms in the blood vessel wall. 
  • Post-transplant hypertension in the rat: effects of captopril and native nephrectomy. 
  • Posttransplant diastolic hypertension: associations with intragraft transforming growth factor-beta, endothelin, and renin transcription. 
  • Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors. 
  • Prevention of experimental cyclosporin-induced interstitial fibrosis by losartan and enalapril. 
  • Probing the renin active site by collisional quenching of endogenous fluorescence. 
  • Processing of one-chain to two-chain renin in the mouse submandibular gland is influenced by androgen. 
  • Prospective analysis of strategies for diagnosing renovascular hypertension. 
  • Prostacyclin protects against elevated blood pressure and cardiac fibrosis. 
  • Purification and characterization of one-chain and two-chain renins from mouse submandibular gland. 
  • Purification of human renal renin. 
  • Racial Differences in Diuretic Efficiency, Plasma Renin, and Rehospitalization in Subjects With Acute Heart Failure. 
  • Rapid ventricular pacing in the dog: pathophysiologic studies of heart failure. 
  • Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells. 
  • Recent advances involving the renin-angiotensin system. 
  • Reciprocal feedback regulation of kidney angiotensinogen and renin mRNA expressions by angiotensin II. 
  • Recycle: Do It for the Kids. 
  • Regulation of extra-renal renin during ontogeny. 
  • Regulation of intrarenal and circulating renin-angiotensin systems in severe heart failure in the rat. 
  • Regulation of tissue renin and angiotensin gene expressions. 
  • Relation of the renin-angiotensin-aldosterone system to clinical state in congestive heart failure. 
  • Renal endosomes contain angiotensin peptides, converting enzyme, and AT(1A) receptors. 
  • Renal growth and development in mice lacking AT1A receptors for angiotensin II. 
  • Renal vascular reactivity in mice: AngII-induced vasoconstriction in AT1A receptor null mice. 
  • Renal vein renins: inability to predict response to revascularization in patients with hypertension. 
  • Renin and angiotensinogen mRNA expression in the kidneys of rats subjected to long-term bile duct ligation. 
  • Renin and myocardial infarction in hypertension. 
  • Renin expression by vascular endothelial cells in culture. 
  • Renin gene expression, biosynthesis, and cellular pathways of secretion. 
  • Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia. 
  • Renin synthesis by canine aortic smooth muscle cells in culture. 
  • Renin-angiotensin system gene expression in post-transplant hypertension predicts allograft function. 
  • Renin-angiotensin system stimulates respiration during acute hypotension but not during hypercapnia. 
  • Renin-angiotensin-aldosterone genotype influences ventricular remodeling in infants with single ventricle. 
  • Renin-angiotensin-aldosterone system in nephrotic syndrome. 
  • Renin-specific antibody for study of cardiovascular homeostasis. 
  • Renovascular hypertension in blacks. 
  • Report of the Joint Nomenclature and Standardization Committee of the International Society of Hypertension, American Heart Association and the World Health Organization. 
  • Responsiveness of atrial natriuretic factor to reduction in right atrial pressure in patients with chronic congestive heart failure. 
  • Role of brain serotonergic pathways and hypothalamus in regulation of renin secretion. 
  • Role of microsomal prostaglandin E synthase 1 in the kidney. 
  • Sequential renal hemodynamics in experimental benign and malignant hypertension. 
  • Significance of the vascular renin-angiotensin pathway. 
  • Similar prevalence of renovascular hypertension in selected blacks and whites. 
  • Sodium regulation of angiotensinogen mRNA expression in rat kidney cortex and medulla. 
  • Sox6 as a new modulator of renin expression in the kidney. 
  • Stimulus-response curve of the renal baroreceptor: effect of converting enzyme inhibition and changes in salt intake. 
  • Studies of the biosynthesis of renin with a cell-free translation system. 
  • Surgical treatment of primary hyperaldosteronism. 
  • Sustained effectiveness of converting-enzyme inhibition in patients with severe congestive heart failure. 
  • Synthetic peptide inhibitors of prorenin activation. 
  • Targeting genes in the renin-angiotensin system. 
  • Temperature-sensitive SV40 immortalized rat proximal tubule cell line has functional renin-angiotensin system. 
  • The DASH diet enhances the blood pressure response to losartan in hypertensive patients. 
  • The feedback regulation of angiotensinogen production by components of the renin-angiotensin system. 
  • The impact of angiotensin II receptor blockade and the DASH diet on markers of endogenous fibrinolysis. 
  • The nature of renin precursor and inactive renin. 
  • Tissue angiotensin system in cardiovascular medicine. A paradigm shift? 
  • Tissue specificity of renin promoter activity and regulation in mice. 
  • Tissue-specific regulation of renin expression in the mouse. 
  • Transcription factor decoy to study the molecular mechanism of negative regulation of renin gene expression in the liver in vivo. 
  • Treatment Persistence of Renin-Angiotensin-Aldosterone-System Inhibitors Over Time in Heart Failure with Reduced Ejection Fraction. 
  • Updated report on comparative effectiveness of ACE inhibitors, ARBs, and direct renin inhibitors for patients with essential hypertension: much more data, little new information. 
  • Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression. 
  • Vascular renin-angiotensin: a possible autocrine or paracrine system in control of vascular function. 
  • Vascular wall renin-angiotensin pathway in control of the circulation. A hypothesis. 
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  Keywords of People

  • Yancy Jr., William Samuel, Professor of Medicine, Medicine, General Internal Medicine