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Subject Areas on Research
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(Pro)renin receptor is expressed in human retinal pigment epithelium and participates in extracellular matrix remodeling.
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A comparative evaluation of hemodynamic and neurohumoral effects of nitroglycerin and nifedipine in congestive heart failure.
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A comparative study of the distributions of renin and angiotensinogen messenger ribonucleic acids in rat and mouse tissues.
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A cooperative multicenter study of captopril in congestive heart failure: hemodynamic effects and long-term response.
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A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice.
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A lack of genetic linkage of renin gene restriction fragment length polymorphisms with human hypertension.
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A major role for the EP4 receptor in regulation of renin.
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A monoclonal antibody specific for the amino terminal sequence of human prorenin identifies a common epitope on renal and amniotic fluid inactive renins.
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A new cardiac MASTer switch for the renin-angiotensin system.
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ATAC-ing the mechanisms of renin regulation.
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Abundant androgen regulated mRNAs in mouse submandibular gland: cell-free translation of renin precursor mRNA.
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Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment.
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Altered sodium regulation of renal angiotensinogen mRNA in the spontaneously hypertensive rat.
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An international cohort study of autosomal dominant tubulointerstitial kidney disease due to REN mutations identifies distinct clinical subtypes.
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Ang II accumulation in rat renal endosomes during Ang II-induced hypertension: role of AT(1) receptor.
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Angiotensin AT1 receptor inhibition. Effects on hypertrophic remodeling and ACE expression in rats with pressure-overload hypertrophy due to ascending aortic stenosis.
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Angiotensin II Short-Loop Feedback: Is There a Role of Ang II for the Regulation of the Renin System In Vivo?
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Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation.
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Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration.
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Angiotensin converting enzyme in renal ontogeny: hypothesis for multiple roles.
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Angiotensin mediates stimulation of ventilation after vasopressin V1 receptor blockade.
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Antibodies as specific renin inhibitors: studies with polyclonal and monoclonal antibodies and Fab fragments.
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Antihypertensive Drugs and Cancer Risk.
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Arterial pressure, left ventricular mass, and aldosterone in essential hypertension.
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Assessing genetic association with human survival at multi-allelic loci.
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Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring.
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Association of parental obesity with concentrations of select systemic biomarkers in nonobese offspring: the Framingham Heart Study.
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Atrial natriuretic factor-specific antibody as a tool for physiological studies. Evidence for role of atrial natriuretic factor in aldosterone and renal electrolyte regulation.
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Atrial natriuretic factor: pharmacokinetics and cyclic GMP response in relation to biologic effects in severe heart failure.
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Beta2-adrenergic receptor genotype affects the renin-angiotensin-aldosterone system response to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern.
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Biochemical and immunological properties of dog brain isorenin.
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Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction.
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Biosynthesis of renin: multiplicity of active and intermediate forms.
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Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene.
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Cell-dependent posttranslational processing and secretion of recombinant mouse renin-2.
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Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease.
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Characterization of a monoclonal antibody specific for human active renin.
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Characterization of antibodies to canine renal renin. Studies of interspecies homology of renin using antibodies as probe.
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Characterization of human prorenin expressed in mammalian cells from cloned cDNA.
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Characterization of inactive renin from human kidney and plasma. Evidence of a renal source of circulating inactive renin.
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Characterization of prorenin activation using a synthetic peptide substrate.
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Characterization of purified rabbit uterine renin: influence of pregnancy on uterine inactive renin.
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Circulating versus local renin-angiotensin system in cardiovascular homeostasis.
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Classical Renin-Angiotensin system in kidney physiology.
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Clinical profile and prognostic significance of natriuretic peptide trajectory following hospitalization for worsening chronic heart failure: findings from the ASTRONAUT trial.
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Comparison of renin-specific IgG and antibody fragments in studies of blood pressure regulation.
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Compensatory response to hemorrhage in conscious dogs on normal and low salt intake.
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Complete purification of dog renal renin.
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Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community.
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Cultured glomerular mesangial cells contain renin: influence of calcium and isoproterenol.
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Decongestion strategies and renin-angiotensin-aldosterone system activation in acute heart failure.
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Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition.
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Developmental renin expression in mice with a defective renin-angiotensin system.
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Dietary sodium and blood pressure.
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Different secretory pathways of renin from mouse cells transfected with the human renin gene.
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Differential effects of captopril and enalapril on tissue renin-angiotensin systems in experimental heart failure.
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Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice.
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Differentiation of hemodynamic, humoral and metabolic responses to beta 1- and beta 2-adrenergic stimulation in man using atenolol and propranolol.
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Distinct nuclear proteins competing for an overlapping sequence of cyclic adenosine monophosphate and negative regulatory elements regulate tissue-specific mouse renin gene expression.
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Distinct renin/aldosterone activity profiles correlate with renal function, natriuretic response, decongestive ability and prognosis in acute heart failure.
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Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system.
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Dog inactive renin: biochemical characterization and secretion into renal plasma and lymph.
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Dual natriuretic peptide system in experimental heart failure.
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During acute hypercapnia vasopressin inhibits an angiotensin drive to ventilation in conscious dogs.
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Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial.
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Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure: the ASTRONAUT randomized trial.
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Effect of captopril on the release of the components of the renin-angiotensin system into plasma and lymph.
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Effect of exogenous angiotensin II infusion after one year of captopril therapy in essential hypertension.
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Effect of intrarenal administration of dopamine on renin release in conscious dogs.
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Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney.
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Efficacy of eplerenone added to renin-angiotensin blockade in elderly hypertensive patients: the Jichi-Eplerenone Treatment (JET) study.
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Endothelial renin-angiotensin pathway: evidence for intracellular synthesis and secretion of angiotensins.
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Evidence for renin in rat brain: differentiation from other reninlike enzymes.
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Evidence for the existence of renin in the heart.
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Evidence for two cellular pathways of renin secretion by the mouse submandibular gland.
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Failure of angiotensin II to reduce plasma renin activity in hypertensive pregnant women.
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Functional human renin promoter in transfected cells: evidence for cell-specific expression.
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Gene expression of the renin-angiotensin system in human tissues. Quantitative analysis by the polymerase chain reaction.
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Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease.
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Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2).
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Genes and longevity: lessons from studies of centenarians.
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Genetic control of blood pressure and the angiotensinogen locus.
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Genetic manipulation of the renin-angiotensin system.
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Glycosylation influences intracellular transit time and secretion rate of human prorenin in transfected cells.
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Hormonal control of angiotensinogen production.
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Human neutrophils release serine proteases capable of activating prorenin.
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Human renin biosynthesis and secretion in normal and ischemic kidneys.
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Hybridization studies with a renin cDNA probe: evidence for widespread expression of renin in the mouse.
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Hyperrenin-hyperaldosterone-dependent malignant hypertension in polyarteritis nodosa.
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Hypertension associated with alcohol withdrawal: assessment of mechanisms and complications.
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Hyponatremia in congestive heart failure: implications for neurohumoral activation and responses to orthostasis.
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Identification of a negative regulatory element involved in tissue-specific expression of mouse renin genes.
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Identification of a novel set of genes regulated by a unique liver X receptor-alpha -mediated transcription mechanism.
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Identification of negative and positive regulatory elements in the human renin gene.
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Identification of potential regulatory regions in the renin gene.
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Identification of renin and angiotensinogen messenger RNA sequences in mouse and rat brains.
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Identification of renin and renin-like enzymes in rat brain by a renin-specific antibody.
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Immunoaffinity chromatography of canine high-molecular-weight renin: partial purification and characterization.
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Immunohistochemical studies of cell differentiation in a juxtaglomerular tumor.
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In vivo identification of a negative regulatory element in the mouse renin gene using direct gene transfer.
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In vivo inhibition of renin by antirenin antibodies: potential experimental and clinical applications.
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Influence of androgen on translatable renin mRNA in the mouse submandibular gland.
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Inhibition of renin-like activity in marmoset tissues by the renin inhibitor CGP 29 287.
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Interaction of signals influencing renin release.
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Intravenous nisoldipine in severe congestive heart failure.
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Is plasma renin activity associated with worse outcomes in acute heart failure? A secondary analysis from the BLAST-AHF trial.
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Is renin a factor in the etiology of essential hypertension?
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Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct.
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LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression.
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Left ventricular myocardial blood flow, metabolism, and effects of treatment with enalapril: further insights into the mechanisms of canine experimental pacing-induced heart failure.
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Liver X receptors alpha and beta regulate renin expression in vivo.
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Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytes.
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Mapping of the human renin transcription start site: evidence for a single functional promoter.
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Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha.
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Molecular and physiological aspects of tissue renin-angiotensin system: emphasis on cardiovascular control.
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Molecular biology and pathophysiology of the intrarenal renin-angiotensin system.
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Molecular biology of the renin-angiotensin system.
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Molecular mechanism of tissue-specific regulation of mouse renin gene expression by cAMP. Identification of an inhibitory protein that binds nuclear transcriptional factor.
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Molecular mechanisms that control renin secretion.
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Molecular studies of human renin structure and synthesis using monoclonal antibodies.
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Molecular studies of human renin synthesis and gene expression.
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Monoclonal antibodies as molecular probes to study structural heterogeneity between human and animal renins and other aspartyl proteinases.
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Monoclonal antibodies binding renal renin.
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Monoclonal antibodies specific for human renin.
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Morning blood pressure surge, morning platelet aggregation, and silent cerebral infarction in older Japanese hypertensive patients.
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Mouse models of diabetic nephropathy.
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Multiple sites of regulation of mouse renin expression in ontogeny.
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Negative control elements and cAMP responsive sequences in the tissue-specific expression of mouse renin genes.
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Neurohumoral mechanisms in heart failure: role in pathogenesis, therapy, and drug tolerance.
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Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation.
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Novel and effective gene transfer technique for study of vascular renin angiotensin system.
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Nuclear receptor LXRalpha is involved in cAMP-mediated human renin gene expression.
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Obstructive nephropathy in the rat: possible roles for the renin-angiotensin system, prostaglandins, and thromboxanes in postobstructive renal function.
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Partial purification of a prorenin activating enzyme in the aortic wall.
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Pathophysiology of vascular smooth muscle in renin promoter-T-antigen transgenic mice.
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Peptides and neurotransmitters that affect renin secretion.
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Pharmacokinetics, hemodynamic, renal, and neurohormonal effects of atrial natriuretic factor in experimental heart failure.
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Phosphodiesterase 5 inhibition improves beta-cell function in metabolic syndrome.
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Physiological effects of synthetic atrial natriuretic factor in normal conscious dogs.
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Plasma atrial natriuretic factor during chronic thoracic inferior vena caval constriction.
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Plasma renin activity following operations for renovascular hypertension.
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Plasma renin activity, response to aliskiren, and clinical outcomes in patients hospitalized for heart failure: the ASTRONAUT trial.
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Plasma renin testing to guide antihypertensive therapy.
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Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease.
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Possible prorenin activating mechanisms in the blood vessel wall.
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Post-transplant hypertension in the rat: effects of captopril and native nephrectomy.
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Posttransplant diastolic hypertension: associations with intragraft transforming growth factor-beta, endothelin, and renin transcription.
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Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors.
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Prevention of experimental cyclosporin-induced interstitial fibrosis by losartan and enalapril.
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Probing the renin active site by collisional quenching of endogenous fluorescence.
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Processing of one-chain to two-chain renin in the mouse submandibular gland is influenced by androgen.
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Prospective analysis of strategies for diagnosing renovascular hypertension.
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Prostacyclin protects against elevated blood pressure and cardiac fibrosis.
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Purification and characterization of one-chain and two-chain renins from mouse submandibular gland.
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Purification of human renal renin.
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Racial Differences in Diuretic Efficiency, Plasma Renin, and Rehospitalization in Subjects With Acute Heart Failure.
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Rapid ventricular pacing in the dog: pathophysiologic studies of heart failure.
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Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells.
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Recent advances involving the renin-angiotensin system.
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Reciprocal feedback regulation of kidney angiotensinogen and renin mRNA expressions by angiotensin II.
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Recycle: Do It for the Kids.
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Regulation of extra-renal renin during ontogeny.
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Regulation of intrarenal and circulating renin-angiotensin systems in severe heart failure in the rat.
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Regulation of tissue renin and angiotensin gene expressions.
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Relation of the renin-angiotensin-aldosterone system to clinical state in congestive heart failure.
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Renal endosomes contain angiotensin peptides, converting enzyme, and AT(1A) receptors.
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Renal growth and development in mice lacking AT1A receptors for angiotensin II.
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Renal vascular reactivity in mice: AngII-induced vasoconstriction in AT1A receptor null mice.
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Renal vein renins: inability to predict response to revascularization in patients with hypertension.
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Renin and angiotensinogen mRNA expression in the kidneys of rats subjected to long-term bile duct ligation.
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Renin and myocardial infarction in hypertension.
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Renin expression by vascular endothelial cells in culture.
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Renin gene expression, biosynthesis, and cellular pathways of secretion.
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Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia.
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Renin synthesis by canine aortic smooth muscle cells in culture.
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Renin-angiotensin system gene expression in post-transplant hypertension predicts allograft function.
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Renin-angiotensin system stimulates respiration during acute hypotension but not during hypercapnia.
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Renin-angiotensin-aldosterone genotype influences ventricular remodeling in infants with single ventricle.
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Renin-angiotensin-aldosterone system in nephrotic syndrome.
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Renin-specific antibody for study of cardiovascular homeostasis.
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Renovascular hypertension in blacks.
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Report of the Joint Nomenclature and Standardization Committee of the International Society of Hypertension, American Heart Association and the World Health Organization.
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Responsiveness of atrial natriuretic factor to reduction in right atrial pressure in patients with chronic congestive heart failure.
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Role of brain serotonergic pathways and hypothalamus in regulation of renin secretion.
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Role of microsomal prostaglandin E synthase 1 in the kidney.
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Sequential renal hemodynamics in experimental benign and malignant hypertension.
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Significance of the vascular renin-angiotensin pathway.
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Similar prevalence of renovascular hypertension in selected blacks and whites.
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Sodium regulation of angiotensinogen mRNA expression in rat kidney cortex and medulla.
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Sox6 as a new modulator of renin expression in the kidney.
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Stimulus-response curve of the renal baroreceptor: effect of converting enzyme inhibition and changes in salt intake.
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Studies of the biosynthesis of renin with a cell-free translation system.
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Surgical treatment of primary hyperaldosteronism.
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Sustained effectiveness of converting-enzyme inhibition in patients with severe congestive heart failure.
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Synthetic peptide inhibitors of prorenin activation.
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Targeting genes in the renin-angiotensin system.
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Temperature-sensitive SV40 immortalized rat proximal tubule cell line has functional renin-angiotensin system.
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The DASH diet enhances the blood pressure response to losartan in hypertensive patients.
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The feedback regulation of angiotensinogen production by components of the renin-angiotensin system.
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The impact of angiotensin II receptor blockade and the DASH diet on markers of endogenous fibrinolysis.
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The nature of renin precursor and inactive renin.
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Tissue angiotensin system in cardiovascular medicine. A paradigm shift?
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Tissue specificity of renin promoter activity and regulation in mice.
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Tissue-specific regulation of renin expression in the mouse.
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Transcription factor decoy to study the molecular mechanism of negative regulation of renin gene expression in the liver in vivo.
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Treatment Persistence of Renin-Angiotensin-Aldosterone-System Inhibitors Over Time in Heart Failure with Reduced Ejection Fraction.
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Updated report on comparative effectiveness of ACE inhibitors, ARBs, and direct renin inhibitors for patients with essential hypertension: much more data, little new information.
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Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression.
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Vascular renin-angiotensin: a possible autocrine or paracrine system in control of vascular function.
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Vascular wall renin-angiotensin pathway in control of the circulation. A hypothesis.
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Keywords of People