Repetitive Sequences, Nucleic Acid

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  Subject Areas on Research

  • 50 million years of genomic stasis in endosymbiotic bacteria. 
  • A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region. 
  • A DNA sequence conferring high postmeiotic segregation frequency to heterozygous deletions in Saccharomyces cerevisiae is related to sequences associated with eucaryotic recombination hotspots. 
  • A T cell-specific transcriptional enhancer within the human T cell receptor delta locus. 
  • A compound nucleotide repeat in the neurofibromatosis (NF1) gene. 
  • A comprehensive panel of near-full-length clones and reference sequences for non-subtype B isolates of human immunodeficiency virus type 1. 
  • A disease locus for hereditary haemorrhagic telangiectasia maps to chromosome 9q33-34. 
  • A functional prodynorphin promoter polymorphism and opioid dependence. 
  • A genetic linkage map of the laboratory rat, Rattus norvegicus. 
  • A physical map of the human genome. 
  • A positive addition to a negative tail's tale. 
  • A radiation hybrid map of the distal short arm of human chromosome 11, containing the Beckwith-Wiedemann and associated embryonal tumor disease loci. 
  • A study of the repetitive structure and distribution of short motifs in human genomic sequences. 
  • Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population. 
  • Adenosine deaminase (ADA) deficiency due to deletion of the ADA gene promoter and first exon by homologous recombination between two Alu elements. 
  • Alu-PCR fingerprinting of YACs. 
  • An Exploration into Fern Genome Space. 
  • An extensive de novo deletion removing FMR1 in a patient with mental retardation and the fragile X syndrome phenotype. 
  • Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. 
  • Analysis of the junction between ribosomal RNA genes and single-copy chromosomal sequences in the yeast Saccharomyces cerevisiae. 
  • Angiotensin II can regulate gene expression by the AP-1 binding sequence via a protein kinase C-dependent pathway. 
  • Antiangiogenic treatment with the three thrombospondin-1 type 1 repeats recombinant protein in an orthotopic human pancreatic cancer model. 
  • COL5A1: fine genetic mapping and exclusion as candidate gene in families with nail-patella syndrome, tuberous sclerosis 1, hereditary hemorrhagic telangiectasia, and Ehlers-Danlos Syndrome type II. 
  • Characterization of human brain cDNA encoding the general isoform of beta-spectrin. 
  • Characterization of the transcriptional trans activator of human foamy retrovirus. 
  • Characterization of the variable-number tandem repeats in vrrA from different Bacillus anthracis isolates. 
  • Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor. 
  • Chromosomal translocations generated by high-frequency meiotic recombination between repeated yeast genes. 
  • Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair. 
  • Chromosome-specific alpha satellite DNA from human chromosome 1: hierarchical structure and genomic organization of a polymorphic domain spanning several hundred kilobase pairs of centromeric DNA. 
  • Compact organization of rRNA genes in the filamentous fungus Ashbya gossypii. 
  • Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. 
  • Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor. 
  • DNA- and PCR-fingerprinting in fungi. 
  • Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions. 
  • Dentatorubral-pallidoluysian atrophy and Haw River syndrome. 
  • Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae. 
  • Derivation and functional characterization of a consensus DNA binding sequence for the tas transcriptional activator of simian foamy virus type 1. 
  • Destabilization of simple repetitive DNA sequences by transcription in yeast. 
  • Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. 
  • Different models, different trees: the geographic origin of PTLV-I. 
  • Differentiation of strains in Mycobacterium tuberculosis complex by DNA sequence polymorphisms, including rapid identification of M. bovis BCG. 
  • Dinucleotide repeat polymorphism at the human erythropoietin receptor locus (EPOR) at 19p13. 
  • Dinucleotide repeat polymorphisms at the SCN4A locus suggest allelic heterogeneity of hyperkalemic periodic paralysis and paramyotonia congenita. 
  • Does the human immunodeficiency virus Tat trans-activator contain a discrete activation domain? 
  • Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. 
  • Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system. 
  • Endogenous avian retroviruses contain deficient promoter and leader sequences. 
  • Evolution of alpha satellite. 
  • Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network. 
  • Experimental determination of rates of concerted evolution. 
  • Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2. 
  • Functional analysis of the transcription control region located within the avian retroviral long terminal repeat. 
  • Functional characterization of a complex protein-DNA-binding domain located within the human immunodeficiency virus type 1 long terminal repeat leader region. 
  • Functional studies of the carboxy-terminal repeat domain of Drosophila RNA polymerase II in vivo. 
  • Genetic control of chromosome length in yeast. 
  • Genetic instability of microsatellites in endometrial carcinoma. 
  • Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. 
  • Genetic mapping of dinucleotide repeat polymorphisms and von Hippel-Lindau disease on chromosome 3p25-26. 
  • Genetic relationships and evolution of genotypes of yellow fever virus and other members of the yellow fever virus group within the Flavivirus genus based on the 3' noncoding region. 
  • Glycosyl phosphatidylinositol-linked blood group antigens and paroxysmal nocturnal hemoglobinuria. 
  • Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast. 
  • Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs. 
  • High-frequency meiotic gene conversion between repeated genes on nonhomologous chromosomes in yeast. 
  • Histone gene clusters of the newt notophthalmus are separated by long tracts of satellite DNA. 
  • Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element. 
  • Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing. 
  • Human immunodeficiency virus type 1 rev protein as a negative trans-regulator. 
  • Hypermutability and mismatch repair deficiency in RER+ tumor cells. 
  • Identification and functional characterization of a high-affinity Bel-1 DNA binding site located in the human foamy virus internal promoter. 
  • Identification of a U5-specific sequence required for efficient polyadenylation within the human immunodeficiency virus long terminal repeat. 
  • Identification of a W variant outbreak of Mycobacterium tuberculosis via population-based molecular epidemiology. 
  • Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers. 
  • Identification of a region of genetic variability among Bacillus anthracis strains and related species. 
  • Identification of the sex genes in an early diverged fungus. 
  • Identification of two regions of beta G spectrin that bind to distinct sites in brain membranes. 
  • Identification of yeast mutants with altered telomere structure. 
  • Inactivated whole-virus vaccine derived from a proviral DNA clone of simian immunodeficiency virus induces high levels of neutralizing antibodies and confers protection against heterologous challenge. 
  • Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population. 
  • Initial sequencing and analysis of the human genome. 
  • Initial sequencing and comparative analysis of the mouse genome. 
  • Instability of a plasmid-borne inverted repeat in Saccharomyces cerevisiae. 
  • Instability of simple sequence DNA in Saccharomyces cerevisiae. 
  • Instability of simple sequence repeats in a mammalian cell line. 
  • Intrachromosomal gene conversion and the maintenance of sequence homogeneity among repeated genes. 
  • Intrachromosomal gene conversion in yeast. 
  • Intragenic duplication and divergence in the spectrin superfamily of proteins. 
  • Inverted DNA repeats channel repair of distant double-strand breaks into chromatid fusions and chromosomal rearrangements. 
  • Isolation and characterization of a Ty element inserted into the ribosomal DNA of the yeast Saccharomyces cerevisiae. 
  • Isolation and characterization of cDNA clones encoding pig gastric mucin. 
  • Isolation and characterization of the replicon of a Thiobacillus intermedius plasmid. 
  • L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity. 
  • Linkage localization of X-linked Charcot-Marie-Tooth disease. 
  • Linkage of a locus for autosomal dominant familial spastic paraplegia to chromosome 2p markers. 
  • Linkage of frontotemporal dementia to chromosome 17: clinical and neuropathological characterization of phenotype. 
  • Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35. 
  • Long poly(A) tracts in the human genome are associated with the Alu family of repeated elements. 
  • Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes. 
  • Mismatch repair deficiency in phenotypically normal human cells. 
  • Mitotic and meiotic gene conversion of Ty elements and other insertions in Saccharomyces cerevisiae. 
  • Molecular analysis of recombination in a family with Duchenne muscular dystrophy and a large pericentric X chromosome inversion. 
  • Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeat. 
  • Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae. 
  • Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor. 
  • Nonconsensus Protein Binding to Repetitive DNA Sequence Elements Significantly Affects Eukaryotic Genomes. 
  • P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips. 
  • Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo. 
  • Polyglutamine domains are substrates of tissue transglutaminase: does transglutaminase play a role in expanded CAG/poly-Q neurodegenerative diseases? 
  • Polymerase chain reaction fingerprinting in fungi using single primers specific to minisatellites and simple repetitive DNA sequences: strain variation in Cryptococcus neoformans. 
  • Population bottlenecks as a potential major shaping force of human genome architecture. 
  • Population dynamics of a meiotic/mitotic expansion model for the fragile X syndrome. 
  • Positive patches and negative noodles: linking RNA processing to transcription? 
  • Posttranscriptional regulation of protein expression in human epithelial carcinoma cells by adenine-uridine-rich elements in the 3'-untranslated region of tumor necrosis factor-alpha messenger RNA. 
  • Prediction of genome-wide DNA methylation in repetitive elements. 
  • Prevention of graft-versus-host disease by peptides binding to class II major histocompatibility complex molecules. 
  • Probing the DNA sequence specificity of Escherichia coli RECA protein. 
  • Protein-DNA binding in the absence of specific base-pair recognition. 
  • RNA replication for the paramyxovirus simian virus 5 requires an internal repeated (CGNNNN) sequence motif. 
  • Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. 
  • Recent evolution of the human pathogen Cryptococcus neoformans by intervarietal transfer of a 14-gene fragment. 
  • Recombination between palindromes P5 and P1 on the human Y chromosome causes massive deletions and spermatogenic failure. 
  • Recombination of plasmids into the Saccharomyces cerevisiae chromosome is reduced by small amounts of sequence heterogeneity. 
  • Repeat polymorphisms within gene regions: phenotypic and evolutionary implications. 
  • Replication of the murine cytomegalovirus genome: structure and role of the termini in the generation and cleavage of concatenates. 
  • Retroviruses and human cancer: evaluation of T-lymphocyte transformation by human T-cell leukemia-lymphoma virus. 
  • Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome. 
  • Sequence of terminal regions of cowpox virus DNA: arrangement of repeated and unique sequence elements. 
  • Sequencing and analysis of genomic fragments from the NF1 locus. 
  • Seven-base-pair inverted repeats in DNA form stable hairpins in vivo in Saccharomyces cerevisiae. 
  • Sp1 transcription factor is required for in vitro basal and Tat-activated transcription from the human immunodeficiency virus type 1 long terminal repeat. 
  • Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites. 
  • Specific 33-residue repeat(s) of erythrocyte ankyrin associate with the anion exchanger. 
  • Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations. 
  • Structural organization of the human insulin receptor ectodomain. 
  • Structurally divergent human T cell receptor gamma proteins encoded by distinct C gamma genes. 
  • Substrate length requirements for efficient mitotic recombination in Saccharomyces cerevisiae. 
  • Suppressor and activator functions mediated by a repeated heptad sequence in the liver fatty acid-binding protein gene (Fabpl). Effects on renal, small intestinal, and colonic epithelial cell gene expression in transgenic mice. 
  • Tandemly repeated sequences are present at the ends of the DNA of raccoonpox virus. 
  • The ANK repeats of erythrocyte ankyrin form two distinct but cooperative binding sites for the erythrocyte anion exchanger. 
  • The Alacoil: a very tight, antiparallel coiled-coil of helices. 
  • The DNA sequence of the human X chromosome. 
  • The Haw River syndrome: dentatorubropallidoluysian atrophy (DRPLA) in an African-American family. 
  • The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development. 
  • The carboxyl-terminal repeat domain of RNA polymerase II is not required for transcription factor Sp1 to function in vitro. 
  • The compact chromatin structure of a Ty repeated sequence suppresses recombination hotspot activity in Saccharomyces cerevisiae. 
  • The human foamy virus Bel-1 transcription factor is a sequence-specific DNA binding protein. 
  • The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats. 
  • The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks. 
  • The rRNA-encoding DNA array has an altered structure in topoisomerase I mutants of Saccharomyces cerevisiae. 
  • The role of avian retroviral LTRs in the regulation of gene expression and viral replication. 
  • The role of the mismatch repair machinery in regulating mitotic and meiotic recombination between diverged sequences in yeast. 
  • The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system. 
  • The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. 
  • Transcription and ncRNAs: at the cent(rome)re of kinetochore assembly and maintenance. 
  • Transcriptional activity of avian retroviral long terminal repeats directly correlates with enhancer activity. 
  • Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis. 
  • Translocation of Y-linked genes to the dot chromosome in Drosophila pseudoobscura. 
  • Truncated forms of the insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor encompassing the IGF-II binding site: characterization of a point mutation that abolishes IGF-II binding. 
  • Unusual chromosome architecture and behaviour at an HSR. 
  • Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C. 
  • Wild-type p53 is a cell cycle checkpoint determinant following irradiation. 
  • α satellite DNA variation and function of the human centromere. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship