Replicon
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Subject Areas on Research
- An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer.
- Broad host range vectors for stable genomic library construction.
- Cellular and humoral immune responses to alphavirus replicon vaccines expressing cytomegalovirus pp65, IE1, and gB proteins.
- Characterization and selection of HIV-1 subtype C isolates for use in vaccine development.
- Co-delivery of antigen and IL-12 by Venezuelan equine encephalitis virus replicon particles enhances antigen-specific immune responses and antitumor effects.
- Development and preclinical evaluation of an alphavirus replicon particle vaccine for cytomegalovirus.
- Development and preclinical evaluation of an alphavirus replicon vaccine for influenza.
- Increased immunogenicity of a DNA-launched Venezuelan equine encephalitis virus-based replicon DNA vaccine.
- Interaction between the T4 helicase-loading protein (gp59) and the DNA polymerase (gp43): a locking mechanism to delay replication during replisome assembly.
- Isolation and characterization of the replicon of a Thiobacillus intermedius plasmid.
- Isolation of human sequences that replicate autonomously in human cells.
- Molecular biology. Versatility of self-cleaving ribozymes.
- Mucosal and systemic adjuvant activity of alphavirus replicon particles.
- Plasmids for recombination-based screening.
- The contribution of type I interferon signaling to immunity induced by alphavirus replicon vaccines.
- Unusual chromosome architecture and behaviour at an HSR.
- Up-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication.
- Vaccination of macaques against pathogenic simian immunodeficiency virus with Venezuelan equine encephalitis virus replicon particles.
- Vaccination of macaques with SIV immunogens delivered by Venezuelan equine encephalitis virus replicon particle vectors followed by a mucosal challenge with SIVsmE660.
- Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge.