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Subject Areas on Research
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450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy.
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4D MRI of polycystic kidneys from rapamycin-treated Glis3-deficient mice.
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A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist.
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A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement.
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A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes.
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A Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay.
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A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP.
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A binding site for Pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord.
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A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection.
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A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon.
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A comprehensive structure-function analysis of Arabidopsis SNI1 defines essential regions and transcriptional repressor activity.
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A conserved G₁ regulatory circuit promotes asynchronous behavior of nuclei sharing a common cytoplasm.
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A critical role of two positively charged amino acids in the Jas motif of Arabidopsis JAZ proteins in mediating coronatine- and jasmonoyl isoleucine-dependent interactions with the COI1 F-box protein.
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A de novo frame-shift mutation in the tuberin gene.
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A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus.
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A mechanism of COOH-terminal binding protein-mediated repression.
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A negative coregulator for the human ER.
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A new (heat) shocking player in cardiac hypertrophy.
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A non-oncogenic HPV 16 E6/E7 vaccine enhances treatment of HPV expressing tumors.
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A novel splice site mutation (156 + 1G-->A) in the TSC2 gene.
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A quantitative, high-throughput screen for protein stability.
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A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy.
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A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity.
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A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor.
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A three-dimensional ParF meshwork assembles through the nucleoid to mediate plasmid segregation.
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A threshold for central T cell tolerance to an inducible serum protein
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A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis.
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A transcription network of interlocking positive feedback loops maintains intracellular iron balance in archaea.
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A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line.
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ACE-inhibition increases podocyte number in experimental glomerular disease independent of proliferation.
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ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category.
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Abnormal cone ERGs in a family with congenital nystagmus and photophobia harboring a p.X423Lfs mutation in the PAX6 gene.
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Abrogation of P53 function by transfection of HPV16 E6 gene does not enhance resistance of human tumour cells to ionizing radiation.
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Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells.
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Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1.
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Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation.
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Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.
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Acute myeloid leukemia ontogeny is defined by distinct somatic mutations.
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Alternative Splicing of Rice WRKY62 and WRKY76 Transcription Factor Genes in Pathogen Defense.
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An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments.
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An MKP-MAPK protein phosphorylation cascade controls vascular immunity in plants.
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An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci.
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An essential role for Mad homology domain 1 in the association of Smad3 with histone deacetylase activity*.
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An intron facilitates activation of the calspermin gene by the testis-specific transcription factor CREM tau.
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Analysis of novel and recurrent mutations responsible for the tricho-rhino-phalangeal syndromes.
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Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment.
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Antidepressant actions of histone deacetylase inhibitors.
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Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF.
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Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest.
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Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4.
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Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling.
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BMP4 is essential for lens induction in the mouse embryo.
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BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene.
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Backbone dynamics of the monomeric lambda repressor denatured state ensemble under nondenaturing conditions.
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Bacterial effector activates jasmonate signaling by directly targeting JAZ transcriptional repressors.
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Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.
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Biallelic variants in PPP1R13L cause paediatric dilated cardiomyopathy.
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Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch.
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Binding of MetJ repressor to specific and nonspecific DNA and effect of S-adenosylmethionine on these interactions.
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Binding of the global response regulator protein CovR to the sag promoter of Streptococcus pyogenes reveals a new mode of CovR-DNA interaction.
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Bmp and Fgf signaling are essential for liver specification in zebrafish.
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Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene.
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Carcinogenicity of a nephrotoxic metabolite of the "nongenotoxic" carcinogen hydroquinone.
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Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.
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Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT.
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Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1.
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Cell biology: How to combat stress.
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Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae.
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Cell proliferation is insufficient, but loss of tuberin is necessary, for chemically induced nephrocarcinogenicity.
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Characterization of the DNA- and metal-binding properties of Vibrio anguillarum fur reveals conservation of a structural Zn(2+) ion.
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Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression.
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Characterization of the multiple transferable resistance repressor, MtrR, from Neisseria gonorrhoeae.
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Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci.
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Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/beta-catenin signaling.
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Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression.
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Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.
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Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement.
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Commensal Bacteria Regulate Gene Expression and Differentiation in Vertebrate Olfactory Systems Through Transcription Factor REST.
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Comment on 'A PAX6 gene polymorphism is associated with genetic predisposition to extreme myopia'.
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Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium.
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Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus.
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Conformational changes of purine repressor DNA-binding domain upon complexation with DNA.
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Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold.
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Contribution of a buried hydrogen bond to lambda repressor folding kinetics.
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Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting.
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Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia.
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CovR activation of the dipeptide permease promoter (PdppA) in Group A Streptococcus.
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Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices.
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Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the alpha C-terminal domain of RNA polymerase.
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Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
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Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization.
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Crystallization and preliminary X-ray analysis of an Escherichia coli purine repressor-hypoxanthine-DNA complex.
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Crystallization and preliminary X-ray studies on the co-repressor binding domain of the Escherichia coli purine repressor.
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Crystallization of a Complex Between MYC and Jas Motif.
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Crystallization of a complex of cro repressor with a 17 base-pair operator.
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Crystallization of the bifunctional biotin operon repressor.
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Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment.
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Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase.
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Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae.
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DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest.
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DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis.
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DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations With Cigarette Smoking and Subclinical Atherosclerosis.
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DNA repair proteins are directly involved in regulation of gene expression during plant immune response.
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Daily humidity oscillation regulates the circadian clock to influence plant physiology.
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Daughter-specific transcription factors regulate cell size control in budding yeast.
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De Novo Truncating Variants in ASXL2 Are Associated with a Unique and Recognizable Clinical Phenotype.
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Deciphering the molecular basis of multidrug recognition: crystal structures of the Staphylococcus aureus multidrug binding transcription regulator QacR.
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Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor.
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Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy.
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Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae.
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Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2.
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Determinants of Swe1p degradation in Saccharomyces cerevisiae.
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Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody.
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Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape.
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Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus.
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Differential effect of B lymphocyte-induced maturation protein (Blimp-1) expression on cell fate during B cell development.
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Diploid strains of the pathogenic basidiomycete Cryptococcus neoformans are thermally dimorphic.
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Direct analysis of backbone-backbone hydrogen bond formation in protein folding transition states.
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Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation.
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Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress.
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Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon.
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Dissecting the genetics of human high myopia: a molecular biologic approach.
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Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes.
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Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis.
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Division of labor: subsets of dorsal-appendage-forming cells control the shape of the entire tube.
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Drosophila Tcf and Groucho interact to repress Wingless signalling activity.
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E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins.
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ELF3 is a repressor of androgen receptor action in prostate cancer cells.
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EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor.
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Early de novo DNA methylation and prolonged demethylation in the muscle lineage.
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Ectopic Expression of OsJAZs Alters Plant Defense and Development.
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Effect of isopropyl-beta-D-thiogalactopyranosid induction of the lac operon on the specificity of spontaneous and doxorubicin-induced mutations in Escherichia coli.
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Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6.
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Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR.
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Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains.
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Escherichia coli purine repressor: key residues for the allosteric transition between active and inactive conformations and for interdomain signaling.
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Establishment of Expression in the SHORTROOT-SCARECROW Transcriptional Cascade through Opposing Activities of Both Activators and Repressors.
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Estrogen treatment enhances hereditary renal tumor development in Eker rats.
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Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci in Patients with Early Stages of Angle-Closure Disease.
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Evidence for the involvement of the Gli gene family in embryonic mouse lung development.
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Excision and transposition of Tn5 as an SOS activity in Escherichia coli.
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Explicit equilibrium modeling of transcription-factor binding and gene regulation.
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Expression and hormonal regulation of coactivator and corepressor genes.
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Expression of P120 catenin, Kaiso, and metastasis tumor antigen-2 in thymomas.
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FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis
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Failure of human rhombic lip differentiation underlies medulloblastoma formation.
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Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.
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Fill a Gab(1) in cardiac hypertrophy signaling: search a missing link between gp130 and ERK5 in hypertrophic remodeling in heart.
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First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.
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Foamy virus Bet proteins function as novel inhibitors of the APOBEC3 family of innate antiretroviral defense factors.
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Folding kinetics of a fluorescent variant of monomeric lambda repressor.
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Food-Grade TiO2
Particles Generate Intracellular Superoxide and Alter Epigenetic Modifiers in Human Lung Cells.
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FoxP2 expression in avian vocal learners and non-learners.
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Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence.
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Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.
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Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer.
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Functional analysis of SPINDLY in gibberellin signaling in Arabidopsis.
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Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling.
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Functional dissection of the HIV-1 Rev trans-activator--derivation of a trans-dominant repressor of Rev function.
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Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer.
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Further investigation of simian immunodeficiency virus Vif function in human cells.
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G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.
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Generalized dead-end elimination algorithms make large-scale protein side-chain structure prediction tractable: implications for protein design and structural genomics.
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Genetic and non-genetic factors associated with the phenotype of exceptional longevity & normal cognition.
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Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis.
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Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates.
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Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.
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Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci.
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Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.
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Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia.
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Genome-wide association study of retinopathy in individuals without diabetes.
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Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF).
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Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study.
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Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage.
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Gibberellin signaling: biosynthesis, catabolism, and response pathways.
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Gibberellins and the Green Revolution.
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Global Analysis of DELLA Direct Targets in Early Gibberellin Signaling in Arabidopsis
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Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci.
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GlpR Is a Direct Transcriptional Repressor of Fructose Metabolic Genes in Haloferax volcanii.
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Growth factor modulation of p53-mediated growth arrest versus apoptosis.
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HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development.
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HIV-1 Vif: counteracting innate antiretroviral defenses.
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Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4.
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Heat and cold denatured states of monomeric lambda repressor are thermodynamically and conformationally equivalent.
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Helix lap-joints as ion-binding sites: DNA-binding motifs and Ca-binding "EF hands" are related by charge and sequence reversal.
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Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation.
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Hemochromatosis drives acute lethal intestinal responses to hyperyersiniabactin-producing Yersinia pseudotuberculosis.
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Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription.
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Hereditary renal cell carcinoma in the Eker rat: a unique animal model for the study of cancer susceptibility.
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Heritable individual-specific and allele-specific chromatin signatures in humans.
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Herpes simplex virus proteins ICP27 and UL47 associate with polyadenylate-binding protein and control its subcellular distribution.
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High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins.
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High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice.
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High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins.
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Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements.
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Histone deacetylase 3 binds to and regulates the GCMa transcription factor.
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Hos2p/Set3p deacetylase complex signals secretory stress through the Mpk1p cell integrity pathway.
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HspR is a global negative regulator of heat shock gene expression in Deinococcus radiodurans.
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Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1.
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Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression.
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Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing.
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Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.
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Human papillomavirus type 16 infection and squamous cell carcinoma of the head and neck in never-smokers: a matched pair analysis.
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Hypervirulent group A Streptococcus emergence in an acaspular background is associated with marked remodeling of the bacterial cell surface.
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Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.
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Hypoxia-inducible factor pathway genes predict survival in metastatic clear cell renal cell carcinoma.
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Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts.
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Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome.
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Identification of MeCP2 mutations in a series of females with autistic disorder.
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Identification of Tgf beta1i4 as a downstream target of Foxc1.
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Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists.
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Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC.
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Identification of a novel germline SPOP mutation in a family with hereditary prostate cancer.
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Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.
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Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes.
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Identification of prohibitin and prohibiton as novel factors binding to the p53 induced gene 3 (PIG3) promoter (TGYCC)(15) motif.
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Identifying Synaptic Proteins by In Vivo BioID from Mouse Brain.
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Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene.
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Improved excitation pulse bandwidths using shaped pulses, with application to heteronuclear half filters in macromolecular NMR.
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Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells by using a bacterial CRISPR/Cas RNA-guided endonuclease.
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Induction of cytotoxic T lymphocytes with dendritic cells transfected with human papillomavirus E6 and E7 RNA: implications for cervical cancer immunotherapy.
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Inhibition of a yeast LTR retrotransposon by human APOBEC3 cytidine deaminases.
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Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma.
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Integrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF.
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Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation.
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Interaction between transcriptional activator protein LAC9 and negative regulatory protein GAL80.
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Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.
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Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis.
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Intracellular Generation of Superoxide by TiO2
Nanoparticles Decreases Histone Deacetylase 9 (HDAC9), an Epigenetic Modifier.
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JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling.
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Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor.
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Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator.
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Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu.
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Kinetic role of helix caps in protein folding is context-dependent.
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Laboratory diagnosis of creatine deficiency syndromes: a technical standard and guideline of the American College of Medical Genetics and Genomics.
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Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors.
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Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.
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Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia.
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Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.
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Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.
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Loss of Dependence on Continued Expression of the Human Papillomavirus 16 E7 Oncogene in Cervical Cancers and Precancerous Lesions Arising in Fanconi Anemia Pathway-Deficient Mice.
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Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma.
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LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo.
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MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.
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Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcription.
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Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor.
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Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor.
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MarR family proteins are important regulators of clinically relevant antibiotic resistance.
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Mechanism of corepressor-mediated specific DNA binding by the purine repressor.
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MetJ repressor interactions with DNA probed by in-cell NMR.
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Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans.
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Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
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Methed-up FOXOs can't in-Akt-ivate.
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Methionine oxidation of monomeric lambda repressor: the denatured state ensemble under nondenaturing conditions.
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Methylthioadenosine Suppresses Salmonella Virulence.
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Microsecond protein folding through a compact transition state.
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Misexpression of ptf1a in cortical pyramidal cells in vivo promotes an inhibitory peptidergic identity.
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Modulatory function of CREB.CREM alpha heterodimers depends upon CREM alpha phosphorylation.
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Molecular and clinicopathologic characteristics of gliomas with EP300::BCOR fusions.
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Molecular characterization and localization of the human MAFG gene.
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Molecular cloning and characterization of a novel histone deacetylase HDAC10.
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Multidrug-binding transcription factor QacR binds the bivalent aromatic diamidines DB75 and DB359 in multiple positions.
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Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression.
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Multiple proteins interact with the nuclear inhibitory protein repressor element in the human interleukin-3 promoter.
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Mutagenicity and carcinogenicity of biological reactive intermediate's derived from a "non-genotoxic" carcinogen.
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Mutation analysis of the TSC2 gene in an African-American family.
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Mutation and polymorphism analysis in the tuberous sclerosis 2 (TSC2) gene.
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Mutations in CIC and FUBP1 contribute to human oligodendroglioma.
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Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor.
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Negative feedback control of jasmonate signaling by an alternative splice variant of JAZ10.
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Negative regulation of CD4 gene expression by a HES-1-c-Myb complex.
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Negative regulation of TSHalpha target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation.
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New bedfellows in the mammalian sex-determination affair.
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New insights into the function of IAP proteins: modulation of the MYC/MAX/MAD network.
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Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein.
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Nomenclature: vertebrate mediators of TGFbeta family signals.
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Not-so-pseudo a substrate: Acm1-mediated inhibition of the APC.
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Novel human bronchial epithelial cell lines for cystic fibrosis research.
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Novel nucleocytoplasmic protein O-fucosylation by SPINDLY regulates diverse developmental processes in plants.
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Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator).
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Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride.
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Nuclear Localized O-Fucosyltransferase SPY Facilitates PRR5 Proteolysis to Fine-Tune the Pace of Arabidopsis Circadian Clock.
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Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae.
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Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity.
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Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.
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Optimal sequence selection in proteins of known structure by simulated evolution.
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PIL5, a phytochrome-interacting bHLH protein, regulates gibberellin responsiveness by binding directly to the GAI and RGA promoters in Arabidopsis seeds
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PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma.
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Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas.
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Partial agonist activity of the progesterone receptor antagonist RU486 mediated by an amino-terminal domain coactivator and phosphorylation of serine400.
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Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells.
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Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study.
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Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation.
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Phosphorylation of the group A Streptococcal CovR response regulator causes dimerization and promoter-specific recruitment by RNA polymerase.
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Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade
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Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.
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Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression.
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Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development.
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Positive feedback of G1 cyclins ensures coherent cell cycle entry.
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Positive selection in noncoding genomic regions of vocal learning birds is associated with genes implicated in vocal learning and speech functions in humans.
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Post-transcriptional regulation of MTA family by microRNAs in the context of cancer.
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Primary testicular diffuse large B-cell lymphoma displays distinct clinical and biological features for treatment failure in rituximab era: a report from the International PTL Consortium.
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Probing the DNA sequence specificity of Escherichia coli RECA protein.
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Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways.
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Prohibitin mutations are uncommon in prostate cancer families linked to chromosome 17q.
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Prokaryotic transcription regulators: more than just the helix-turn-helix motif.
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Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells.
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Prostate Cancer Foundation Hormone-Sensitive Prostate Cancer Biomarker Working Group Meeting Summary.
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Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.
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Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression.
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Protein folding dynamics: quantitative comparison between theory and experiment.
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Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux.
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Protein nanotechnology: the new frontier in biosciences.
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Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.
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Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus.
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Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex.
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Pyruvate kinase L/R links metabolism dysfunction to neuroendocrine differentiation of prostate cancer by ZBTB10 deficiency.
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QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization.
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Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association.
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REST and stress resistance in ageing and Alzheimer's disease.
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RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin.
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RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development.
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Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavity.
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Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION.
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Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4.
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Refining the nuclear auxin response pathway through structural biology.
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Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.
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Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates.
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Regulation of early adipose commitment by Zfp521.
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Regulation of iron transport related genes by boron in the marine bacterium Marinobacter algicola DG893.
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Regulation of streptokinase expression by CovR/S in Streptococcus pyogenes: CovR acts through a single high-affinity binding site.
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Regulation of systemic acquired resistance by NPR1 and its partners.
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Regulation of the amino-terminal transcription activation domain of progesterone receptor by a cofactor-induced protein folding mechanism.
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Regulation of transcription of the repA1 gene in the replication control region of IncFII plasmid NR1 by gene dosage of the repA2 transcription repressor protein.
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Relationship between expression of coactivators and corepressors of hormone receptors and resistance of ovarian cancers to growth regulation by steroid hormones.
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Repressing a repressor: gibberellin-induced rapid reduction of the RGA protein in Arabidopsis.
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Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells.
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Retrospective family study of childhood medulloblastoma.
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Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.
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SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development.
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SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators.
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SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc.
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SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression.
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SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.
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Segrosome structure revealed by a complex of ParR with centromere DNA.
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Selective inhibition of Alu retrotransposition by APOBEC3G.
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Sequence variants in the transforming growth beta-induced factor (TGIF) gene are not associated with high myopia.
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Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia.
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Serum Antibodies to HPV16 Early Proteins Warrant Investigation as Potential Biomarkers for Risk Stratification and Recurrence of HPV-Associated Oropharyngeal Cancer.
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Signatures of protein-DNA recognition in free DNA binding sites.
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Site-specific silencing of regulatory elements as a mechanism of X inactivation.
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Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion.
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Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia.
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Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets.
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Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor.
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Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development.
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Structural analysis of the purine repressor, an Escherichia coli DNA-binding protein.
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Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P.
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Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR.
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Structural basis for the differential regulation of DNA by the methionine repressor MetJ.
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Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis.
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Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
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Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain.
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Structural insights into alternative splicing-mediated desensitization of jasmonate signaling.
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Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose 6-phosphate and fructose 1,6-bisphosphate.
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Structural mechanism of organic hydroperoxide induction of the transcription regulator OhrR.
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Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein.
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Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR.
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Structural mechanisms of QacR induction and multidrug recognition.
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Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae.
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Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex.
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Structure and stability of monomeric lambda repressor: NMR evidence for two-state folding.
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Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family.
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Structure of the manganese-bound manganese transport regulator of Bacillus subtilis.
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Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190.
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Structure-function analyses of the HTLV-I Rex and HIV-1 Rev RNA response elements: insights into the mechanism of Rex and Rev action.
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Structures of Neisseria gonorrhoeae MtrR-operator complexes reveal molecular mechanisms of DNA recognition and antibiotic resistance-conferring clinical mutations.
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Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis.
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Structures of the Escherichia coli transcription activator and regulator of diauxie, XylR: an AraC DNA-binding family member with a LacI/GalR ligand-binding domain.
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Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants.
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Submillisecond folding of monomeric lambda repressor.
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Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate.
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Suppressor of fused negatively regulates beta-catenin signaling.
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Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models.
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Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma.
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Synergistic derepression of gibberellin signaling by removing RGA and GAI function in Arabidopsis thaliana.
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Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish.
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Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression.
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Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub.
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The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.
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The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA.
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The Arabidopsis RGA gene encodes a transcriptional regulator repressing the gibberellin signal transduction pathway.
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The CovR response regulator of group A streptococcus (GAS) acts directly to repress its own promoter.
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The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein.
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The Development of TALE Nucleases for Biotechnology.
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The ERF11 Transcription Factor Promotes Internode Elongation by Activating Gibberellin Biosynthesis and Signaling.
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The HMG-box transcription factor SoxNeuro acts with Tcf to control Wg/Wnt signaling activity.
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The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development.
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The MetJ regulon in gammaproteobacteria determined by comparative genomics methods.
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The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming.
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The SV40 core sequence functions as a repressor element in yeast.
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The Smads: transcriptional regulation and mouse models.
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The Snail repressor is required for PMC ingression in the sea urchin embryo.
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The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
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The TOR signal transduction cascade controls cellular differentiation in response to nutrients.
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The TetR family of transcriptional repressors.
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The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity.
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The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle.
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The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding.
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The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity.
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The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains.
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The effects of molecular noise and size control on variability in the budding yeast cell cycle.
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The energetic contribution of backbone--backbone hydrogen bonds to the thermodynamic stability of a hyperstable P22 Arc repressor mutant.
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The energy landscape of a fast-folding protein mapped by Ala-->Gly substitutions.
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The exon junction complex component Magoh controls brain size by regulating neural stem cell division.
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The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy.
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The gamma2 late glycoprotein K promoter of equine herpesvirus 1 is differentially regulated by the IE and EICP0 proteins.
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The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells.
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The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2.
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The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity.
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The intrinsic antiretroviral factor APOBEC3B contains two enzymatically active cytidine deaminase domains.
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The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2.
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The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking.
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The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus.
-
The new RGA locus encodes a negative regulator of gibberellin response in Arabidopsis thaliana.
-
The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor.
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The nucleotide messenger (p)ppGpp is an anti-inducer of the purine synthesis transcription regulator PurR in Bacillus.
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The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding.
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The presence of human papillomavirus-16/-18 E6, p53, and Bcl-2 protein in cervicovaginal smears from patients with invasive cervical cancer.
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The promoter of human T-cell leukemia virus type-I is repressed by the immediate-early gene region of human cytomegalovirus in primary blood lymphocytes.
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The protein kinase Tor1 regulates adhesin gene expression in Candida albicans.
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The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway.
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The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13.
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The role of cDermo-1 and cTwist in the avian embryo.
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The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions.
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The secretory pathway in control of endoplasmic reticulum homeostasis.
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The staphylococcal QacR multidrug regulator binds a correctly spaced operator as a pair of dimers.
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The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble.
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The structure of PurR mutant L54M shows an alternative route to DNA kinking.
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The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.
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The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates.
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The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian sin3B.
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The yeast Rab GTPase Ypt1 modulates unfolded protein response dynamics by regulating the stability of HAC1 RNA.
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Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST.
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Thermodynamic evaluation of binding interactions in the methionine repressor system of Escherichia coli using isothermal titration calorimetry.
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Thermodynamic stability measurements on multimeric proteins using a new H/D exchange- and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry-based method.
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Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans.
-
Transcription factor-dependent nuclear localization of a transcriptional repressor in jasmonate hormone signaling.
-
Transcription profiling of estrogen target genes in young and old mouse uterus.
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Transcription-associated mutation of lasR in Pseudomonas aeruginosa.
-
Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.
-
Transgenic targeting of a dominant negative corepressor to liver and analyses by cDNA microarray.
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Transgenic targeting of a dominant negative corepressor to liver blocks basal repression by thyroid hormone receptor and increases cell proliferation.
-
Transient requirement for ganglion cells during assembly of retinal synaptic layers.
-
Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene.
-
Two steps in Maf1-dependent repression of transcription by RNA polymerase III.
-
Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.
-
Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP.
-
Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23.
-
Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3.
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Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo.
-
Update on late relapse of germ cell tumor: a clinical and molecular analysis.
-
Vascular endothelial growth factor impairs the functional ability of dendritic cells through Id pathways.
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Vitamin D receptors repress basal transcription and exert dominant negative activity on triiodothyronine-mediated transcriptional activity.
-
WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells.
-
WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells.
-
Wnt activation promotes memory T cell polyfunctionality via epigenetic regulator PRMT1.
-
Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud.
-
c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts.
-
c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor.
-
cAMP-response element modulator tau is a positive regulator of testis angiotensin converting enzyme transcription.
-
ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans.
-
miR-27b shapes the presynaptic transcriptome and influences neurotransmission by silencing the polycomb group protein Bmi1.
-
miR-301a as an NF-κB activator in pancreatic cancer cells.
-
microRNA-214 promotes epithelial-mesenchymal transition and metastasis in lung adenocarcinoma by targeting the suppressor-of-fused protein (Sufu).
-
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
-
Keywords of People
-
Bejsovec, Amy,
Associate Professor of Biology,
Biology
-
Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
-
Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
-
Krangel, Michael S.,
George Barth Geller Distinguished Professor of Immunology,
Immunology
-
McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Cell Biology
-
McLendon, Roger Edwin,
Professor of Pathology,
Pathology
-
Yan, Hai,
Adjunct Professor of Pathology,
Pathology