Respiratory Function Tests

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  Subject Areas on Research

  • A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging. 
  • A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis. 
  • A micro-CT analysis of murine lung recruitment in bleomycin-induced lung injury. 
  • A randomised trial of lung sealant versus medical therapy for advanced emphysema. 
  • ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma. 
  • ATS Core Curriculum 2015. Part I: Adult Pulmonary Medicine. 
  • Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. 
  • Airway contractility and remodeling: links to asthma symptoms. 
  • Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. 
  • Airways obstruction among older construction and trade workers at Department of Energy nuclear sites. 
  • Altered expression of myosin heavy chain in the vastus lateralis muscle in patients with COPD. 
  • Alveolar barrier function assessed by hydrophobic and hydrophilic fluorescent solutes in rabbit lung. 
  • Amyloid myopathy presenting with respiratory failure. 
  • An Exploratory Radiomics Approach to Quantifying Pulmonary Function in CT Images. 
  • An industrial study of the biological effects of cotton dust and cigarette smoke exposure. 
  • Assessment of the protective effect of amifostine on radiation-induced pulmonary toxicity. 
  • Association between RT-induced changes in lung tissue density and global lung function. 
  • Association of Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists With Asthma Control in Patients With Uncontrolled, Persistent Asthma: A Systematic Review and Meta-analysis. 
  • Asthma rehabilitation program. 
  • Beneficial effects of albuterol therapy driven by heliox versus by oxygen in severe asthma exacerbation. 
  • Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle. 
  • Biobehavioral Prognostic Factors in Chronic Obstructive Pulmonary Disease: Results From the INSPIRE-II Trial. 
  • Body mass index-percentile and diagnostic accuracy of childhood asthma. 
  • Bronchial provocation tests before and after cessation of smoking. 
  • Bronchiolitis management preferences and the influence of pulse oximetry and respiratory rate on the decision to admit. 
  • Bronchiolitis obliterans syndrome in lung transplant recipients: correlation of computed tomography findings with bronchiolitis obliterans syndrome stage. 
  • COPD risk among older construction workers-Updated analyses 2020. 
  • CT metrics of airway disease and emphysema in severe COPD. 
  • Can we predict radiation-induced changes in pulmonary function based on the sum of predicted regional dysfunction? 
  • Carbon monoxide diffusion capacity: how low can you go for hematopoietic cell transplantation eligibility? 
  • Cardiovascular Function in Long-Term Hematopoietic Cell Transplantation Survivors. 
  • Case report: bronchiolitis obliterans organizing pneumonia in a spice process technician. 
  • Characteristics of lung cancer in elderly patients. 
  • Characterizing respiratory capacity in belugas (Delphinapterus leucas). 
  • Children with Chronic Lung Disease: Facilitating Smoking Cessation for their Caregivers. 
  • Children with asthma have improved pulmonary functions after massage therapy. 
  • Chronic thromboembolic pulmonary hypertension. 
  • Clinical and pathologic features of familial interstitial pneumonia. 
  • Clinical findings for residents near a polyurethane foam manufacturing plant. 
  • Colonization with small conidia Aspergillus species is associated with bronchiolitis obliterans syndrome: a two-center validation study. 
  • Computational multiscale toxicodynamic modeling of silver and carbon nanoparticle effects on mouse lung function. 
  • Conventional vs high-frequency jet ventilation in a piglet model of meconium aspiration: comparison of pulmonary and hemodynamic effects. 
  • Correlation between the %MinVol setting and work of breathing during adaptive support ventilation in patients with respiratory failure. 
  • Cross-sectional and prospective study of lung function in adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study. 
  • Cut to the Chase: Cut-Points for Use in Interpretation of Pulmonary Function Tests. 
  • Data quality from a longitudinal study of adolescent health at schools near industrial livestock facilities. 
  • Decreased Antibiotic Utilization After Sinus Surgery in Cystic Fibrosis Patients With Lung Transplantation. 
  • Differential aerosol challenge studies in byssinosis. 
  • Diffusing Capacity of Carbon Monoxide in Assessment of COPD. 
  • Disease Severity and Quality of Life in Patients With Idiopathic Pulmonary Fibrosis: A Cross-Sectional Analysis of the IPF-PRO Registry. 
  • Distinctive clinical features of portopulmonary hypertension. 
  • Does age impact the obese asthma phenotype? Longitudinal asthma control, airway function, and airflow perception among mild persistent asthmatics. 
  • Does the clinical examination predict airflow limitation? 
  • ERS/ATS technical standard on interpretive strategies for routine lung function tests. 
  • Effect of Antimicrobial Therapy on Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis: The CleanUP-IPF Randomized Clinical Trial. 
  • Effect of obesity on sinonasal disease in asthma. 
  • Effects of N-acetylcysteine in ozone-induced chronic obstructive pulmonary disease model. 
  • Effects of air pollution on respiratory health of adults in three Chinese cities. 
  • Efficacy of single-dose, multilevel paravertebral nerve blockade for analgesia after thoracoscopic procedures. 
  • Elevated serum immunoglobulin G levels and bronchoalveolar lymphocytosis as predictors of clinical course in pulmonary sarcoidosis. 
  • Emission-particle-induced ventilatory abnormalities in a rat model of pulmonary hypertension. 
  • End tidal-to-arterial CO2 and O2 gas gradients at low- and high-altitude during dynamic end-tidal forcing. 
  • Endobronchial coils for emphysema: Dual mechanism of action on lobar residual volume reduction. 
  • Evaluating patient-reported outcome measurement comparability between paper and alternate versions, using the lung function questionnaire as an example. 
  • Evaluation and comparison of Tranquility and AutoSet T autotitrating CPAP machines. 
  • Executive Summary: 2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung. 
  • Exertional dyspnea in heart failure: a symptom unrelated to pulmonary function at rest or during exercise. Duke University Clinical Cardiology Studies (DUCCS) Exercise Group. 
  • Extending semiautomatic ventilation defect analysis for hyperpolarized (129)Xe ventilation MRI. 
  • Femur fractures and lung complications: a prospective randomized study of reaming. 
  • Finding signals amidst the noise in pulmonary function testing. 
  • Functional polymorphisms of CHRNA3 predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese. 
  • Gastro-oesophageal reflux and worse asthma control in obese children: a case of symptom misattribution? 
  • General considerations for lung function testing. 
  • Genetic ancestry-smoking interactions and lung function in African Americans: a cohort study. 
  • Genome-wide association analysis identifies six new loci associated with forced vital capacity. 
  • Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. 
  • Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study. 
  • Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. 
  • Health effects of a mixture of indoor air volatile organics, their ozone oxidation products, and stress. 
  • High spinal anesthesia for cardiac surgery: effects on beta-adrenergic receptor function, stress response, and hemodynamics. 
  • Homozygous sickle cell disease and cystic fibrosis in an adolescent. 
  • How does autism spectrum disorder affect the risk and severity of childhood asthma? 
  • Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice. 
  • Hyperlucent lung after radiation therapy. 
  • Hyperpolarized 129Xenon Magnetic Resonance Imaging to Quantify Regional Ventilation Differences in Mild to Moderate Asthma: A Prospective Comparison Between Semiautomated Ventilation Defect Percentage Calculation and Pulmonary Function Tests. 
  • Idiopathic Pulmonary Fibrosis: The Association between the Adaptive Multiple Features Method and Fibrosis Outcomes. 
  • Idiopathic Pulmonary Hemosiderosis as a Mimic of Pulmonary Vasculitis: A Case Report and Review of the Literature. 
  • Imaging techniques for small animal models of pulmonary disease: MR microscopy. 
  • Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection. 
  • Implementation of guideline recommendations and outcomes in patients with idiopathic pulmonary fibrosis: Data from the IPF-PRO registry. 
  • Indium lung disease. 
  • Indoor air pollution and lung function growth among children in four Chinese cities. 
  • Indoor environmental determinants of lung function in children. 
  • Inhaled steroids as prophylaxis for delayed pulmonary toxicity syndrome in breast cancer patients undergoing high-dose chemotherapy and autologous stem cell transplantation. 
  • Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor-β1 in airway fibroblasts in asthma. 
  • Interpretative strategies for lung function tests. 
  • Intersession variability in single-breath diffusing capacity in diabetics without overt lung disease. 
  • Isoflurane for life-threatening bronchospasm: a 15-year single-center experience. 
  • Laparoscopic anti-reflux surgery for idiopathic pulmonary fibrosis at a single centre. 
  • Long-term benefits of deflazacort treatment for boys with Duchenne muscular dystrophy in their second decade. 
  • Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study. 
  • Low-Flow Domiciliary Oxygen as a Mechanism of Ongoing Oxidative Stress. 
  • Lung mechanics and pulmonary function testing in cetaceans. 
  • Lung transplantation for lymphangioleiomyomatosis: role of imaging in the assessment of complications related to the underlying disease. 
  • MR grid-tagging using hyperpolarized helium-3 for regional quantitative assessment of pulmonary biomechanics and ventilation. 
  • Macular sub-layer thinning and association with pulmonary function tests in Amyotrophic Lateral Sclerosis. 
  • Management of spontaneous pneumothorax: an American College of Chest Physicians Delphi consensus statement. 
  • Marital adjustment among patients with chronic obstructive pulmonary disease who are participating in pulmonary rehabilitation. 
  • Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice. 
  • Measuring diffusion limitation with a perfusion-limited gas--hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis. 
  • Mechanisms of functional loss in patients with chronic lung disease. 
  • Medical qualification of a commercial spaceflight participant: not your average astronaut. 
  • Metabolic Syndrome and the Lung. 
  • Mild cystic fibrosis in a consanguineous family. 
  • Mixing oxygen with hyperpolarized (3)He for small-animal lung studies. 
  • Models of toxicity of diacetyl and alternative diones. 
  • Monitoring During Mechanical Ventilation. 
  • Monitoring respiratory function. 
  • Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time. 
  • Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers. 
  • Multireader Determination of Clinically Significant Obstruction Using Hyperpolarized 129Xe-Ventilation MRI. 
  • NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold. 
  • Natural surfactant and hyperoxic lung injury in primates. I. Physiology and biochemistry. 
  • Observations on man in an oxygen-helium environment at 380 mm. Hg total pressure. II. Respiratory. 
  • Obstructive lung disease after allogeneic marrow transplantation. Clinical presentation and course. 
  • Outbreak of bronchiolitis obliterans associated with consumption of Sauropus androgynus in Taiwan. 
  • Overview and Challenges of Bronchiolar Disorders. 
  • Overweight children report qualitatively distinct asthma symptoms: analysis of validated symptom measures. 
  • Partial liquid ventilation with perflubron attenuates in vivo oxidative damage to proteins and lipids. 
  • Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation. 
  • Pathologic findings and long-term sequelae in Legionnaires' disease. 
  • Perioperative pulmonary function in acute respiratory failure: effect of ventilator type and gas mixture. 
  • Physiorack: an integrated MRI safe/conditional, gas delivery, respiratory gating, and subject monitoring solution for structural and functional assessments of pulmonary function. 
  • Plastic bronchitis: resolution after heart transplantation. 
  • Practical Recommendations for Diagnosis and Management of Respiratory Muscle Weakness in Late-Onset Pompe Disease. 
  • Predictors of Response to Endobronchial Coil Therapy in Patients With Advanced Emphysema. 
  • Predictors of pulmonary complications in blunt traumatic spinal cord injury. 
  • Pressure support mode improves ventilation in "asleep-awake-asleep" craniotomy. 
  • Prognosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. 
  • Prognostic significance of early pulmonary function changes after onset of chronic lung allograft dysfunction. 
  • Prognostic validation of the body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index in inoperable non-small-cell lung cancer. 
  • Propofol sedation for longitudinal pediatric neuroimaging research. 
  • Prospective assessment of dosimetric/physiologic-based models for predicting radiation pneumonitis. 
  • Psychological and cognitive outcomes of a randomized trial of exercise among patients with chronic obstructive pulmonary disease. 
  • Pulmonary Function Tests for the Radiologist. 
  • Pulmonary Manifestations of Rheumatic Diseases in Children. 
  • Pulmonary aspects of treatment of long bone fractures in the polytrauma patient. 
  • Pulmonary eosinophilic granuloma. 25-year follow-up. 
  • Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers. 
  • Pulmonary function abnormalities in long-term survivors of childhood cancer. 
  • Pulmonary function in patients with acute coronary syndrome treated with ticagrelor or clopidogrel (from the Platelet Inhibition and Patient Outcomes [PLATO] pulmonary function substudy). 
  • Pulmonary function of rats exposed to ethanol and gasoline fumes. 
  • Pulmonary function testing: coding and billing issues. 
  • Pulmonary function tests do not predict pulmonary complications after thoracoscopic lobectomy. 
  • Pulmonary kinematics from tagged hyperpolarized helium-3 MRI. 
  • Pulmonary outcome measures in long-term survivors of infantile Pompe disease on enzyme replacement therapy: A case series. 
  • Pulmonary toxicity of induction chemotherapy prior to standard or high-dose chemotherapy with autologous hematopoietic support. 
  • Quantitative analysis of hyperpolarized 129Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease. 
  • Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial of BMS-986020, a Lysophosphatidic Acid Receptor Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis. 
  • Real-time gas analysis improves the measurement of single-breath diffusing capacity. 
  • Recombinant human pentraxin-2 therapy in patients with idiopathic pulmonary fibrosis: safety, pharmacokinetics and exploratory efficacy. 
  • Recommendations for a Standardized Pulmonary Function Report. An Official American Thoracic Society Technical Statement. 
  • Relationship between diffusion capacity and small airway abnormality in COPDGene. 
  • Relationship of Right Ventricular Size and Function with Respiratory Status in Duchenne Muscular Dystrophy. 
  • Reply to Johnson: Improve Pulmonary Function Test Reporting. 
  • Rescue therapy in adult and pediatric patients with pH1N1 influenza infection: a tertiary center intensive care unit experience from April to October 2009. 
  • Resource use, costs, and utility estimates for patients with cystic fibrosis with mild impairment in lung function: analysis of data collected alongside a 48-week multicenter clinical trial. 
  • Respiratory dysfunction in Guillain-Barré syndrome. 
  • Respiratory effects of pressor and depressor agents in conscious rats. 
  • Respiratory muscle training in late-onset Pompe disease: Results of a sham-controlled clinical trial. 
  • Role of right ventricular and pulmonary functional abnormalities in limiting exercise capacity in adults with congenital heart disease. 
  • S-nitrosothiol repletion by an inhaled gas regulates pulmonary function. 
  • Safety and potential efficacy of an aerosolized surfactant in human sepsis-induced adult respiratory distress syndrome. 
  • Salmeterol powder compared with albuterol aerosol as maintenance therapy for asthma in adolescent and adult patients. 
  • Sarcoidosis: correlation of pulmonary parenchymal pattern at CT with results of pulmonary function tests. 
  • Semiautomated Ventilation Defect Quantification in Exercise-induced Bronchoconstriction Using Hyperpolarized Helium-3 Magnetic Resonance Imaging: A Repeatability Study. 
  • Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats. 
  • Severe laryngomalacia and bronchomalacia in DiGeorge syndrome and CHARGE association. 
  • Sex differences in respiratory and circulatory cost during hypoxic walking: potential impact on oxygen saturation. 
  • Should High-Frequency Ventilation in the Adult Be Abandoned? 
  • Sildenafil preserves exercise capacity in patients with idiopathic pulmonary fibrosis and right-sided ventricular dysfunction. 
  • Single-dose extended-release epidural morphine for pain following hip arthroplasty. 
  • Staging of Bilateral Lung Transplantation for High-Risk Patients With Interstitial Lung Disease: One Lung at a Time. 
  • Standardisation of lung function testing: the authors' replies to readers' comments. 
  • Standardisation of the single-breath determination of carbon monoxide uptake in the lung. 
  • Surgical management of aortic abdominal aneurysms in patients with severe pulmonary insufficiency. 
  • Surveillance of respiratory diseases among construction and trade workers at Department of Energy nuclear sites. 
  • Survey of clinical infant lung function testing practices. 
  • Text data extraction for a prospective, research-focused data mart: implementation and validation. 
  • The 1995 update of recommendations for a standard technique for measuring the single-breath carbon monoxide diffusing capacity (transfer factor). 
  • The ACTN3 R577X Polymorphism Is Associated with Cardiometabolic Fitness in Healthy Young Adults. 
  • The Association Between Lung Hyperinflation and Coronary Artery Disease in Smokers. 
  • The Sarcoidosis Health Questionnaire: a new measure of health-related quality of life. 
  • The UCSD shortness of breath questionnaire has longitudinal construct validity in idiopathic pulmonary fibrosis. 
  • The association of chronic lung disease with early mortality and respiratory adverse events after aortic valve replacement. 
  • The effects of a telehealth coping skills intervention on outcomes in chronic obstructive pulmonary disease: primary results from the INSPIRE-II study. 
  • The effects of providing lung age and respiratory symptoms feedback on community college smokers' perceived smoking-related health risks, worries and desire to quit. 
  • The future of pulmonary function testing. 
  • The pressure to understand the mechanism of lung compression and its effect on lung function. 
  • The prevalence and impact of scoliosis in Pompe disease: lessons learned from the Pompe Registry. 
  • The relationship of plasma transfusion from female and male donors with outcome after cardiac surgery. 
  • The state of genome-wide association studies in pulmonary disease: a new perspective. 
  • The statistical reliability of indices derived from the closing volume and flow volume traces. 
  • The use of a personal computer in the pulmonary function tests of laboratory rats. 
  • Trends in the clinical characteristics of the U.S. cystic fibrosis patient population from 1995 to 2005. 
  • Triple versus dual inhaler therapy in moderate-to-severe COPD: A systematic review and meta-analysis of randomized controlled trials. 
  • Updated assessment of the six-minute walk test as predictor of acute radiation-induced pneumonitis. 
  • Use of pulmonary function test demographic data to identify high-risk patients for lung cancer screening. 
  • Using hyperpolarized 129Xe MRI to quantify regional gas transfer in idiopathic pulmonary fibrosis. 
  • VA/Q abnormalities during gram negative sepsis. 
  • Vagal innervation is required for pulmonary function phenotype in Htr4-/- mice. 
  • Validation of a Noninvasive Assessment of Pulmonary Gas Exchange During Exercise in Hypoxia. 
  • Validation of spirometry prediction equations in western Kenya. 
  • Ventilation and gas exchange before and after voluntary static surface breath-holds in clinically healthy bottlenose dolphins, Tursiops truncatus. 
  • Ventilation defects on hyperpolarized helium-3 MRI in asthma are predictive of 2-year exacerbation frequency. 
  • Ventilatory drive and carbon dioxide response in ventilatory failure due to myasthenia gravis and Guillain-Barré syndrome. 
  • Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function. 
  • [Not Available]. 
  • l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells. 
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  Keywords of People

  • Dement, John McCray, Professor Emeritus in Family Medicine and Community Health, Family Medicine & Community Health,Occupational & Environmental Medicine
  • Driehuys, Bastiaan, Professor of Radiology, Biomedical Engineering
  • Reed, Shelby Derene, Professor in Population Health Sciences, Duke Science & Society