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Subject Areas on Research
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A new and improved vitreoretinal erbium:YAG laser scalpel: long-term morphologic characteristics of retinal-choroidal injury.
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A pathologic study of degeneration of the rod and cone populations of the rhodopsin Pro347Leu transgenic pigs.
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AHI1 mutations cause both retinal dystrophy and renal cystic disease in Joubert syndrome.
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Activation of Rod Input in a Model of Retinal Degeneration Reverses Retinal Remodeling and Induces Formation of Functional Synapses and Recovery of Visual Signaling in the Adult Retina.
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Advancing therapeutic strategies for inherited retinal degeneration: recommendations from the Monaciano Symposium.
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Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice.
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Age-related retinal vasculopathy.
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Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant.
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Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin.
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An Xp22.1-p22.2 YAC contig encompassing the disease loci for RS, KFSD, CLS, HYP and RP15: refined localization of RS.
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Antisense oligonucleotides targeting mutant Ataxin-7 restore visual function in a mouse model of spinocerebellar ataxia type 7.
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Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration.
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Apoptosis in human retinal degenerations.
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Apoptosis leads to photoreceptor degeneration in inherited retinal dystrophy of RCS rats.
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Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice.
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Bayesian methods for highly correlated exposure data.
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Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration.
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C8ORF37 Is Required for Photoreceptor Outer Segment Disc Morphogenesis by Maintaining Outer Segment Membrane Protein Homeostasis.
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CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish.
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Calcineurin activation causes retinal ganglion cell degeneration.
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Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene.
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Characterization of Fatty Acid Binding Protein 7 (FABP7) in the Murine Retina.
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Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease.
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Defining the human macula transcriptome and candidate retinal disease genes using EyeSAGE.
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Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degeneration.
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Disrupted Blood-Retina Lysophosphatidylcholine Transport Impairs Photoreceptor Health But Not Visual Signal Transduction.
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Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.
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Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degeneration.
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ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration.
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Ectopic synaptogenesis during retinal degeneration in the royal college of surgeons rat.
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Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2: A Randomized Clinical Trial.
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Electroretinographic alterations in the Laurence-Moon-Bardet-Biedl phenotype.
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Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration.
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Enhanced transduction and improved photoreceptor survival of retinal degeneration by the combinatorial use of rAAV2 with a lower dose of adenovirus.
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Evaluation of a commercial recombinant tissue-type plasminogen activator preparation in the subretinal space of the cat.
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Fibrin directs early retinal damage after experimental subretinal hemorrhage.
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Fine mapping of a putative rd cDNA and its co-segregation with rd expression.
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Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa.
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Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.
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Identification of a Unique Subretinal Microglia Type in Retinal Degeneration Using Single Cell RNA-Seq.
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Increased Protein Citrullination as a Trigger for Resident Immune System Activation, Intraretinal Inflammation, and Promotion of Anti-retinal Autoimmunity: Intersecting Paths in Retinal Degenerations of Potential Therapeutic Relevance.
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Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration.
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Influence of early photoreceptor degeneration on lipofuscin in the retinal pigment epithelium.
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Isolation of a candidate cDNA for the gene causing retinal degeneration in the rd mouse.
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Knocking out lca5 in zebrafish causes cone-rod dystrophy due to impaired outer segment protein trafficking.
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Knockout of Nr2e3 prevents rod photoreceptor differentiation and leads to selective L-/M-cone photoreceptor degeneration in zebrafish.
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Lensectomy and vitrectomy decrease the rate of photoreceptor loss in rhodopsin P347L transgenic pigs.
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Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration.
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Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption.
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Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration.
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Mitochondrial dysfunction in NnaD mutant flies and Purkinje cell degeneration mice reveals a role for Nna proteins in neuronal bioenergetics.
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Mutation in collagen II alpha 1 isoforms delineates Stickler and Wagner syndrome phenotypes.
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Mutational hot spot potential of a novel base pair mutation of the CSPG2 gene in a family with Wagner syndrome.
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Opsin, G-protein and 48-kDa protein in normal and rd mouse retinas: developmental expression of mRNAs and proteins and light/dark cycling of mRNAs.
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Optical coherence tomography (OCT) abnormalities in rhodopsin mutant transgenic swine with retinal degeneration.
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Optical cross-sectional imaging of the macula with the retinal thickness analyzer in X-linked retinoschisis.
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Pathologic changes in highly myopic eyes of young males in Singapore.
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Pathology of hereditary retinal degeneration associated with hypobetalipoproteinemia.
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Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor loss.
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Phenotypic stability of Pro347Leu rhodopsin transgenic pigs as indicated by photoreceptor cell degeneration.
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Photoreceptors in a mouse model of Leigh syndrome are capable of normal light-evoked signaling.
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Predisciform senile macular degeneration.
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Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration.
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Proteomic identification of unique photoreceptor disc components reveals the presence of PRCD, a protein linked to retinal degeneration.
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Quantification of retinal microvasculature and neurodegeneration changes in branch retinal vein occlusion after resolution of cystoid macular edema on optical coherence tomography angiography.
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Reply to Corbeil et al.: Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degeneration.
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Retinal Degeneration After Accidental Intravitreal Injection of Ropivacaine During Strabismus Surgery.
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Retinal Microvascular and Neurodegenerative Changes in Alzheimer's Disease and Mild Cognitive Impairment Compared with Control Participants.
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Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase.
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Retinal pigment epithelial degeneration, partial retinal atrophy and macular hole in acute lymphocytic leukemia.
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Retinitis pigmentosa: clinical management based on current concepts.
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Role for the target enzyme in deactivation of photoreceptor G protein in vivo.
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Senior-Loken syndrome (familial renal-retinal dystrophy) and Coats' disease.
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Studies leading to the isolation of a cDNA for the gene causing retinal degeneration in the rd mouse.
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Subretinal Human Umbilical Tissue-Derived Cell Transplantation Preserves Retinal Synaptic Connectivity and Attenuates Müller Glial Reactivity.
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Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina.
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Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function.
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The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration.
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The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice.
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Transplantation of full-thickness retina in the rhodopsin transgenic pig.
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Treatment of adult-onset acute macular retinoschisis in enhanced s-cone syndrome with oral acetazolamide.
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Unusual chorioretinal degeneration associated with sarcoidosis.
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Urethan-induced retinopathy in pigmented rats.
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Why do mutations in the ubiquitously expressed housekeeping gene IMPDH1 cause retina-specific photoreceptor degeneration?
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mRNAs coding for proteins of the cGMP cascade in the degenerative retina of the rd mouse.
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Keywords of People
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Aldairy, Yousef,
Medical Instructor in the Department of Ophthalmology,
Ophthalmology, Vitreoretinal Diseases & Surgery
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Bowes Rickman, Catherine,
Professor of Ophthalmology,
Cell Biology
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Cartoni, Romain,
Assistant Professor of Pharmacology and Cancer Biology,
Neurobiology
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Ferreira, Paulo Alexandre,
Associate Professor in Ophthalmology,
Pathology
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Stinnett, Sandra Sue,
Associate Professor of Biostatistics and Bioinformatics,
Biostatistics & Bioinformatics
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Toth, Cynthia Ann,
Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology,
Biomedical Engineering