Retroviridae

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  Subject Areas on Research

  • A determination of the outer dimensions of oncornaviruses by several electron microscopic procedures. 
  • A genetically tractable model of human glioma formation. 
  • A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen. 
  • A model for assembly of type-c oncornaviruses. 
  • A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. 
  • A novel human cancer culture model for the study of prostate cancer. 
  • A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase. 
  • A research for the relationship between human papillomavirus and human uterine cervical carcinoma. II. Molecular genetic and ultrastructural study on the transforming activity of recombinant retrovirus containing human papillomavirus type 16 subgenomic sequences. 
  • A retroviral-derived peptide phosphorylates protein kinase D/protein kinase Cmu involving phospholipase C and protein kinase C. 
  • A single genetic locus determines the efficacy of serum therapy against murine adenocarcinoma 755a. 
  • A synthetic peptide homologous to the envelope proteins of retroviruses inhibits monocyte-mediated killing by inactivating interleukin 1. 
  • Adult olfactory epithelium contains multipotent progenitors that give rise to neurons and non-neural cells. 
  • Allocation of epiblast cells to germ layer derivatives during mouse gastrulation as studied with a retroviral vector. 
  • Alteration of the CD34+ Tf-1 beta cell line profile in response to long-term exposure to IL-15. 
  • Amendment to Clinical Research Project. Project 90-C-195. April 1, 1993. Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with autologous lymphocytes transduced with a human ADA gene. 
  • An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein. 
  • An in vitro system for efficiently evaluating gene therapy approaches to hemoglobinopathies. 
  • An ultrastructural study of C-type virion assembly in mouse cells. 
  • Angiogenesis-like activity of endothelial cells co-cultured with VEGF-producing smooth muscle cells. 
  • Anti-inflammatory and vasoprotective activity of a retroviral-derived peptide, homologous to human endogenous retroviruses: endothelial cell effects. 
  • Antiinflammatory proteins associated with human and murine neoplasms. 
  • Antiretroviral restriction factors in mice. 
  • Antisense TGF-beta2 immunotherapy for hepatocellular carcinoma: treatment in a rat tumor model. 
  • Assembly of type C oncornaviruses: a model. 
  • Association of the human type C retrovirus with a subset of adult T-cell cancers. 
  • B-MuX: a unique murine C-type virus containing the "env" gene of xenotropic viruses and the "gag" gene of the ecotropic virus. 
  • Biological, immunological, and biochemical evidence that HIX virus is a recombinant between Moloney leukemia virus and a murine xenotropic C type virus. 
  • Biomaterial-mediated retroviral gene transfer using self-assembled monolayers. 
  • C-type virus particles in human urogenital tumours after heterotransplantation into nude mice. 
  • CTL cross reactivity between HIV strains. 
  • Cell lines producing human T-cell lymphoma virus show altered HLA expression. 
  • Cell-dependent posttranslational processing and secretion of recombinant mouse renin-2. 
  • Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion. 
  • Characterization of antigens in SSV nonproducer cells. 
  • Clinical efficacy of gene-modified stem cells in adenosine deaminase-deficient immunodeficiency. 
  • Clonal contributions of small numbers of retrovirally marked hematopoietic stem cells engrafted in unirradiated neonatal W/Wv mice. 
  • Clonal isolate of the simian sarcoma virus codes for a Gag-related 65,000-dalton protein. 
  • Coexistence of a chemotactic factor and a retroviral P15E-related chemotaxis inhibitor in human tumor cell culture supernatants. 
  • Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells. 
  • Consistent production of transgenic chickens using replication-deficient retroviral vectors and high-throughput screening procedures. 
  • Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. 
  • Correction of proliferative responses in purine nucleoside phosphorylase (PNP)-deficient T lymphocytes by retroviral-mediated PNP gene transfer and expression. 
  • Cross-clade inhibition of HIV-1 replication and cytopathology by using RNase P-associated external guide sequences. 
  • Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. 
  • Detection of a transformation-specific glycopeptide in SSV-infected cells. 
  • Detection of oncornavirus antigenic activity in human urothelial tissues. 
  • Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo. 
  • Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. 
  • Ectopic expression of transcription factor NF-E2 alters the phenotype of erythroid and monoblastoid cells. 
  • Effects of tumor growth on host defenses. 
  • Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. 
  • Endogenous avian retroviruses contain deficient promoter and leader sequences. 
  • Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency. 
  • Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells. 
  • Ependymal/subependymal zone cells of postnatal and adult songbird brain generate both neurons and nonneuronal siblings in vitro and in vivo. 
  • Evolutionary implications of primate endogenous retroviruses. 
  • Expression of retinoic acid receptor beta mediates retinoic acid-induced growth arrest and apoptosis in breast cancer cells. 
  • Function of nuclear factor kappaB in pancreatic cancer metastasis. 
  • Gene therapy for SCID--a complication after remarkable progress. 
  • Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans. 
  • Gene therapy for diabetes mellitus in rats by hepatic expression of insulin. 
  • Gene therapy for immunodeficiency due to adenosine deaminase deficiency. 
  • Gene therapy in tissue-engineered blood vessels. 
  • Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies. 
  • Genetic immunization with LYVE-1 cDNA yields function-blocking antibodies against native protein. 
  • Granulocyte colony-stimulating factor mobilized peripheral blood stem cells enter into G1 of the cell cycle and express higher levels of amphotropic retrovirus receptor mRNA. 
  • HIV-1 infection: fooling the gatekeeper. 
  • Human arteries engineered in vitro. 
  • Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy. 
  • Human immunodeficiency virus as a prototypic complex retrovirus. 
  • Human malignant and mitogen-transformed cells contain retroviral P15E-related antigen. 
  • Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1. 
  • Humans have antibodies capable of recognizing oncoviral glycoproteins: demonstration that these antibodies are formed in response to cellular modification of glycoproteins rather than as consequence of exposure to virus. 
  • Identification of a 20,000-dalton protein in SSV-transformed nonproducer cells. 
  • Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells. 
  • Identification of human T cell leukemia virus in a Japanese patient with adult T cell leukemia and cutaneous lymphomatous vasculitis. 
  • Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. 
  • Immortalization of a human prostate stromal cell line using a recombinant retroviral approach. 
  • Immunologic control of a retrovirus-associated murine adenocarcinoma. VI. Augmentation of antibody-dependent killing following quantitative and qualitative changes in host peritoneal cells. 
  • Immunologic control of a retrovirus-associated murine adenocarcinoma. VII. Tumor cell destruction by macrophages and IgG2A. 
  • Immunologic control of a retrovirus-associated murine adenocarcinoma. VIII. Corynebacterium parvum-activated natural killer cells as potent antibody-dependent cell-mediated cytotoxicity effectors. 
  • Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment. 
  • In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblasts. 
  • Inducible regulation of Runx2-stimulated osteogenesis. 
  • Infection with human retroviruses other than HIV-1: HIV-2, HTLV-1, HTLV-2, HTLV-3 and HTLV-4. 
  • Inhibiting effect of murine double minute-2 oncogene on apoptosis induced by retroviral-mediated wild-type p53. 
  • Inhibition of human natural killer cell activity by a synthetic peptide homologous to a conserved region in the retroviral protein, p15E. 
  • Inhibition of lymphocyte proliferation by a synthetic peptide homologous to envelope proteins of human and animal retroviruses. 
  • Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. 
  • Inhibition of nuclear factor-kappaB-mediated adhesion molecule expression in human endothelial cells. 
  • Inhibition of retinoic acid receptor function in normal human mammary epithelial cells results in increased cellular proliferation and inhibits the formation of a polarized epithelium in vitro. 
  • Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(E) structural protein of retroviruses. 
  • Interspecies reactivity of type C and D retrovirus p 15E and p 15C proteins. 
  • Intracellular cleavage of an SSV coded gag-related protein. 
  • In Vivo Expansion and Antitumor Activity of Coinfused CD28- and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia. 
  • Isolation and characterization of two group-specific antigens from feline leukemia virus. 
  • Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy. 
  • Journey to the center of the cell. 
  • KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer. 
  • Koala retrovirus genotyping analyses reveal a low prevalence of KoRV-A in Victorian koalas and an association with clinical disease. 
  • Local production of TGF beta1 inhibits cerebral edema, enhances TNF-alpha induced apoptosis and improves survival in a murine glioma model. 
  • Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. 
  • Long- and short-lived murine hematopoietic stem cell clones individually identified with retroviral integration markers. 
  • Lymphocyte subpopulations and responsiveness in rats bearing intracranial tumors induced by avian sarcoma virus. 
  • Mammalian C-type oncorna viruses. Relationships between structural virus and cell surface antigens and their possible significance in immunological defense mechanisms. 
  • Mammalian C-type oncornaviruses: relationships between viral structural and cell-surface antigens and their possible significance in immunological defense mechanisms. 
  • Mechanism of action of regulatory proteins encoded by complex retroviruses. 
  • Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. 
  • Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. 
  • Methotrexate and cytarabine inhibit progression of human lymphoma in NOD/SCID mice carrying a mutant dihydrofolate reductase and cytidine deaminase fusion gene. 
  • Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2. 
  • Monoclonal antibody against human T cell leukemia virus p19 defines a human thymic epithelial antigen acquired during ontogeny. 
  • Morphological, chemical, and antigenic organization of mammalian C-type viruses. 
  • Multiparameter-fluorescence activated cell sorting analysis of retroviral vector gene transfer into primitive umbilical cord blood cells. 
  • Murine malignant cells synthesize a 19,000-dalton protein that is physicochemically and antigenically related to the immunosuppressive retroviral protein, P15E. 
  • New shuttle vectors for direct cloning in Saccharomyces cerevisiae. 
  • Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert. 
  • Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations. 
  • Overexpression of wild-type retinoic acid receptor alpha (RARalpha) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia RARalpha-fusion genes. 
  • Platelet endothelial cell adhesion molecule-1 expression modulates endothelial cell migration in vitro. 
  • Polypeptides of endogenous avian C-type viruses: their detection in the plasma membrane of normal and infected cells. 
  • Polypeptides of mammalian oncornaviruses. I. Isolation and serological analysis polypeptides from murine and feline C-type viruses. 
  • Polypeptides of mammalian oncornaviruses. II Characterization of murine leukemia virus polypeptide (p 15) bearing interspecies reactivity. 
  • Potential leukemia virus subunit vaccines: discussion. 
  • Preliminary report on virus-like particles in canine leukemia and derived cell cultures. 
  • Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon. 
  • Prevalence of feline leukaemia virus and antibodies to feline immunodeficiency virus in cats in the United Kingdom. 
  • Prospects for the immunological management of lethal tumors. 
  • Prostate and transitional cell carcinoma: radioimmunoassay of viral tumor-associated antigens. 
  • RNA interference in human cells is restricted to the cytoplasm. 
  • Reconstitution of high affinity IL-2 receptor expression in a human T-cell line using a retroviral cDNA expression vector. 
  • Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. 
  • Regulated heat shock protein 27 expression in human retinal pigment epithelium. 
  • Relatedness by nucleic acid hybridization of new isolates of human T-cell leukemia-lymphoma virus (HTLV) and demonstration of provirus in uncultured leukemic blood cells. 
  • Relevance and safety of telomerase for human tissue engineering. 
  • Retinoic acid-mediated G1-S-phase arrest of normal human mammary epithelial cells is independent of the level of p53 protein expression. 
  • Retroviral DNA integration: viral and cellular determinants of target-site selection. 
  • Retroviral E-DNA: persistence and gene expression in nondividing immune cells. 
  • Retroviral gene transduction of circulating progenitor cells in patients with metastatic breast cancer. 
  • Retroviral vector gene expression in F9 embryonal carcinoma cells. 
  • Retroviral vectors for the transduction of the PML-RARalpha fusion product of acute promyelocytic leukemia. 
  • Retrovirally transduced human dendritic cells can generate T cells recognizing multiple MHC class I and class II epitopes from the melanoma antigen glycoprotein 100. 
  • Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice. 
  • Retroviruses and human cancer: evaluation of T-lymphocyte transformation by human T-cell leukemia-lymphoma virus. 
  • Retroviruses as model systems for the study of nuclear RNA export pathways. 
  • Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors. 
  • Role of ornithine decarboxylase in epidermal tumorigenesis. 
  • Selection of TCR V alpha by MHC class II predicts superantigen reactivity. 
  • Sequential roles of Hedgehog and Wnt signaling in osteoblast development. 
  • Short Communication: Potential Risk of Replication-Competent Virus in HIV-1 Env-Pseudotyped Virus Preparations. 
  • Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. 
  • Similarity between p15E of murine and feline leukaemia viruses and p21 of HTLV. 
  • Specific transforming potential of oncogenes encoding protein-tyrosine kinases. 
  • Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors. 
  • Structural components of rna tumor viruses. 
  • Structure and morphogenesis of type-C retroviruses. 
  • Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms. 
  • Suppression of human interferon-gamma production by a 17 amino acid peptide homologous to the transmembrane envelope protein of retroviruses: evidence for a primary role played by monocytes. 
  • Suppression of the respiratory burst of human monocytes by a synthetic peptide homologous to envelope proteins of human and animal retroviruses. 
  • Sustained gene expression in retrovirally transduced, engrafting human hematopoietic stem cells and their lympho-myeloid progeny. 
  • T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex. 
  • Technology evaluation: Rexin-G, Epeius Biotechnologies. 
  • Temporal and tissue-specific expression of distinct retrovirus-like (VL30) elements during mouse development. 
  • The Bel-1 protein of human foamy virus activates human immunodeficiency virus type 1 gene expression via a novel DNA target site. 
  • The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. 
  • The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor. 
  • The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. 
  • Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis. 
  • Transgene expression in zebrafish: A comparison of retroviral-vector and DNA-injection approaches. 
  • Tumor cells cotransduced with B7.1 and gamma-IFN induce effective rejection of established parental tumor. 
  • Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts. 
  • Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells. 
  • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. 
  • Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and ras effector expression to human tumor cell growth. 
  • Use of viral systems to study miRNA-mediated regulation of gene expression in human cells. 
  • Using retroviruses to study the nuclear export of mRNA. 
  • Viruses and oncogenes in brain tumors. 
  • Viruses in the treatment of brain tumors. 
  • [Chicken RNA tumor viruses: a model for virus-induced carcinogenesis]. 
  • [Morphogenesis and structure of RNA tumor viruses. Electron microscopy studies on C-type viruses]. 
  • [Murine Doube Minute 2 oncogene inhibited apoptosis induced by retroviral-mediated wild-type p53]. 
  • [Preparation of green fluorescent protein retrovirus and its application in mediating gene transfer into retinal pigment epithelial cells]. 
  • [Stimulation of immunoreactivity against endogenous retroviruses and protection against leukemia in aged AKR mice after vaccination with antibodies to viral surface components. The role of antibodies to p15(E)]. 
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  Keywords of People

  • Cianciolo, George James, Associate Professor in Pathology, Pathology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor, Cell Biology
  • Krangel, Michael S., Mary Bernheim Distinguished Professor of Immunology, Immunology
  • Luftig, Micah Alan, Associate Professor of Molecular Genetics and Microbiology, Immunology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine, Immunology