Retroviridae

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  Subject Areas on Research

  • A determination of the outer dimensions of oncornaviruses by several electron microscopic procedures. 
  • A genetically tractable model of human glioma formation. 
  • A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen. 
  • A model for assembly of type-c oncornaviruses. 
  • A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. 
  • A novel human cancer culture model for the study of prostate cancer. 
  • A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase. 
  • A retroviral-derived peptide phosphorylates protein kinase D/protein kinase Cmu involving phospholipase C and protein kinase C. 
  • A single genetic locus determines the efficacy of serum therapy against murine adenocarcinoma 755a. 
  • A synthetic peptide homologous to the envelope proteins of retroviruses inhibits monocyte-mediated killing by inactivating interleukin 1. 
  • Allocation of epiblast cells to germ layer derivatives during mouse gastrulation as studied with a retroviral vector. 
  • Amendment to Clinical Research Project. Project 90-C-195. April 1, 1993. Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with autologous lymphocytes transduced with a human ADA gene. 
  • An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein. 
  • An ultrastructural study of C-type virion assembly in mouse cells. 
  • Anti-inflammatory and vasoprotective activity of a retroviral-derived peptide, homologous to human endogenous retroviruses: endothelial cell effects. 
  • Antiinflammatory proteins associated with human and murine neoplasms. 
  • Assembly of type C oncornaviruses: a model. 
  • Association of the human type C retrovirus with a subset of adult T-cell cancers. 
  • B-MuX: a unique murine C-type virus containing the "env" gene of xenotropic viruses and the "gag" gene of the ecotropic virus. 
  • Biological, immunological, and biochemical evidence that HIX virus is a recombinant between Moloney leukemia virus and a murine xenotropic C type virus. 
  • Biomaterial-mediated retroviral gene transfer using self-assembled monolayers. 
  • C-type virus particles in human urogenital tumours after heterotransplantation into nude mice. 
  • CTL cross reactivity between HIV strains. 
  • Cell lines producing human T-cell lymphoma virus show altered HLA expression. 
  • Cell-dependent posttranslational processing and secretion of recombinant mouse renin-2. 
  • Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion. 
  • Characterization of antigens in SSV nonproducer cells. 
  • Clinical efficacy of gene-modified stem cells in adenosine deaminase-deficient immunodeficiency. 
  • Clonal contributions of small numbers of retrovirally marked hematopoietic stem cells engrafted in unirradiated neonatal W/Wv mice. 
  • Clonal isolate of the simian sarcoma virus codes for a Gag-related 65,000-dalton protein. 
  • Coexistence of a chemotactic factor and a retroviral P15E-related chemotaxis inhibitor in human tumor cell culture supernatants. 
  • Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. 
  • Correction of proliferative responses in purine nucleoside phosphorylase (PNP)-deficient T lymphocytes by retroviral-mediated PNP gene transfer and expression. 
  • Cross-clade inhibition of HIV-1 replication and cytopathology by using RNase P-associated external guide sequences. 
  • Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. 
  • Detection of a transformation-specific glycopeptide in SSV-infected cells. 
  • Detection of oncornavirus antigenic activity in human urothelial tissues. 
  • Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo. 
  • Effects of tumor growth on host defenses. 
  • Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. 
  • Endogenous avian retroviruses contain deficient promoter and leader sequences. 
  • Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency. 
  • Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells. 
  • Ependymal/subependymal zone cells of postnatal and adult songbird brain generate both neurons and nonneuronal siblings in vitro and in vivo. 
  • Function of nuclear factor kappaB in pancreatic cancer metastasis. 
  • Gene therapy for SCID--a complication after remarkable progress. 
  • Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans. 
  • Gene therapy for immunodeficiency due to adenosine deaminase deficiency. 
  • Gene therapy in tissue-engineered blood vessels. 
  • Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies. 
  • Granulocyte colony-stimulating factor mobilized peripheral blood stem cells enter into G1 of the cell cycle and express higher levels of amphotropic retrovirus receptor mRNA. 
  • HIV-1 infection: fooling the gatekeeper. 
  • Human arteries engineered in vitro. 
  • Human immunodeficiency virus as a prototypic complex retrovirus. 
  • Human malignant and mitogen-transformed cells contain retroviral P15E-related antigen. 
  • Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1. 
  • Humans have antibodies capable of recognizing oncoviral glycoproteins: demonstration that these antibodies are formed in response to cellular modification of glycoproteins rather than as consequence of exposure to virus. 
  • Identification of a 20,000-dalton protein in SSV-transformed nonproducer cells. 
  • Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells. 
  • Identification of human T cell leukemia virus in a Japanese patient with adult T cell leukemia and cutaneous lymphomatous vasculitis. 
  • Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. 
  • Immortalization of a human prostate stromal cell line using a recombinant retroviral approach. 
  • Immunologic control of a retrovirus-associated murine adenocarcinoma. VI. Augmentation of antibody-dependent killing following quantitative and qualitative changes in host peritoneal cells. 
  • Immunologic control of a retrovirus-associated murine adenocarcinoma. VII. Tumor cell destruction by macrophages and IgG2A. 
  • Immunologic control of a retrovirus-associated murine adenocarcinoma. VIII. Corynebacterium parvum-activated natural killer cells as potent antibody-dependent cell-mediated cytotoxicity effectors. 
  • In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblasts. 
  • Inducible regulation of Runx2-stimulated osteogenesis. 
  • Inhibiting effect of murine double minute-2 oncogene on apoptosis induced by retroviral-mediated wild-type p53. 
  • Inhibition of human natural killer cell activity by a synthetic peptide homologous to a conserved region in the retroviral protein, p15E. 
  • Inhibition of lymphocyte proliferation by a synthetic peptide homologous to envelope proteins of human and animal retroviruses. 
  • Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. 
  • Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(E) structural protein of retroviruses. 
  • Interspecies reactivity of type C and D retrovirus p 15E and p 15C proteins. 
  • Intracellular cleavage of an SSV coded gag-related protein. 
  • Isolation and characterization of two group-specific antigens from feline leukemia virus. 
  • Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy. 
  • Journey to the center of the cell. 
  • KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer. 
  • Local production of TGF beta1 inhibits cerebral edema, enhances TNF-alpha induced apoptosis and improves survival in a murine glioma model. 
  • Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. 
  • Long- and short-lived murine hematopoietic stem cell clones individually identified with retroviral integration markers. 
  • Lymphocyte subpopulations and responsiveness in rats bearing intracranial tumors induced by avian sarcoma virus. 
  • Mammalian C-type oncorna viruses. Relationships between structural virus and cell surface antigens and their possible significance in immunological defense mechanisms. 
  • Mammalian C-type oncornaviruses: relationships between viral structural and cell-surface antigens and their possible significance in immunological defense mechanisms. 
  • Mechanism of action of regulatory proteins encoded by complex retroviruses. 
  • Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. 
  • Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. 
  • Methotrexate and cytarabine inhibit progression of human lymphoma in NOD/SCID mice carrying a mutant dihydrofolate reductase and cytidine deaminase fusion gene. 
  • Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2. 
  • Monoclonal antibody against human T cell leukemia virus p19 defines a human thymic epithelial antigen acquired during ontogeny. 
  • Morphological, chemical, and antigenic organization of mammalian C-type viruses. 
  • Multiparameter-fluorescence activated cell sorting analysis of retroviral vector gene transfer into primitive umbilical cord blood cells. 
  • Murine malignant cells synthesize a 19,000-dalton protein that is physicochemically and antigenically related to the immunosuppressive retroviral protein, P15E. 
  • Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert. 
  • Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations. 
  • Overexpression of wild-type retinoic acid receptor alpha (RARalpha) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia RARalpha-fusion genes. 
  • Polypeptides of endogenous avian C-type viruses: their detection in the plasma membrane of normal and infected cells. 
  • Polypeptides of mammalian oncornaviruses. I. Isolation and serological analysis polypeptides from murine and feline C-type viruses. 
  • Polypeptides of mammalian oncornaviruses. II Characterization of murine leukemia virus polypeptide (p 15) bearing interspecies reactivity. 
  • Potential leukemia virus subunit vaccines: discussion. 
  • Preliminary report on virus-like particles in canine leukemia and derived cell cultures. 
  • Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon. 
  • Prospects for the immunological management of lethal tumors. 
  • Prostate and transitional cell carcinoma: radioimmunoassay of viral tumor-associated antigens. 
  • RNA interference in human cells is restricted to the cytoplasm. 
  • Reconstitution of high affinity IL-2 receptor expression in a human T-cell line using a retroviral cDNA expression vector. 
  • Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. 
  • Regulated heat shock protein 27 expression in human retinal pigment epithelium. 
  • Relatedness by nucleic acid hybridization of new isolates of human T-cell leukemia-lymphoma virus (HTLV) and demonstration of provirus in uncultured leukemic blood cells. 
  • Relevance and safety of telomerase for human tissue engineering. 
  • Retroviral DNA integration: viral and cellular determinants of target-site selection. 
  • Retroviral E-DNA: persistence and gene expression in nondividing immune cells. 
  • Retroviral gene transduction of circulating progenitor cells in patients with metastatic breast cancer. 
  • Retroviral vectors for the transduction of the PML-RARalpha fusion product of acute promyelocytic leukemia. 
  • Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice. 
  • Retroviruses and human cancer: evaluation of T-lymphocyte transformation by human T-cell leukemia-lymphoma virus. 
  • Retroviruses as model systems for the study of nuclear RNA export pathways. 
  • Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors. 
  • Selection of TCR V alpha by MHC class II predicts superantigen reactivity. 
  • Sequential roles of Hedgehog and Wnt signaling in osteoblast development. 
  • Short Communication: Potential Risk of Replication-Competent Virus in HIV-1 Env-Pseudotyped Virus Preparations. 
  • Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. 
  • Similarity between p15E of murine and feline leukaemia viruses and p21 of HTLV. 
  • Specific transforming potential of oncogenes encoding protein-tyrosine kinases. 
  • Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors. 
  • Structural components of rna tumor viruses. 
  • Structure and morphogenesis of type-C retroviruses. 
  • Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms. 
  • Suppression of human interferon-gamma production by a 17 amino acid peptide homologous to the transmembrane envelope protein of retroviruses: evidence for a primary role played by monocytes. 
  • Suppression of the respiratory burst of human monocytes by a synthetic peptide homologous to envelope proteins of human and animal retroviruses. 
  • Sustained gene expression in retrovirally transduced, engrafting human hematopoietic stem cells and their lympho-myeloid progeny. 
  • T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex. 
  • Temporal and tissue-specific expression of distinct retrovirus-like (VL30) elements during mouse development. 
  • The Bel-1 protein of human foamy virus activates human immunodeficiency virus type 1 gene expression via a novel DNA target site. 
  • The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. 
  • The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor. 
  • The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. 
  • Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis. 
  • Tumor cells cotransduced with B7.1 and gamma-IFN induce effective rejection of established parental tumor. 
  • Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts. 
  • Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells. 
  • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. 
  • Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and ras effector expression to human tumor cell growth. 
  • Use of viral systems to study miRNA-mediated regulation of gene expression in human cells. 
  • Using retroviruses to study the nuclear export of mRNA. 
  • Viruses and oncogenes in brain tumors. 
  • Viruses in the treatment of brain tumors. 
  • [Chicken RNA tumor viruses: a model for virus-induced carcinogenesis] 
  • [Morphogenesis and structure of RNA tumor viruses. Electron microscopy studies on C-type viruses] 
  • [Murine Doube Minute 2 oncogene inhibited apoptosis induced by retroviral-mediated wild-type p53]. 
  • [Stimulation of immunoreactivity against endogenous retroviruses and protection against leukemia in aged AKR mice after vaccination with antibodies to viral surface components. The role of antibodies to p15(E)]. 
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  Keywords of People

  • Cianciolo, George James, Associate Professor in Pathology, Pathology
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology
  • Luftig, Micah Alan, Associate Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Professor of Experimental Surgery, in the School of Medicine, Immunology