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Subject Areas on Research
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A determination of the outer dimensions of oncornaviruses by several electron microscopic procedures.
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A genetically tractable model of human glioma formation.
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A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen.
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A model for assembly of type-c oncornaviruses.
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A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice.
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A novel human cancer culture model for the study of prostate cancer.
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A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase.
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A retroviral-derived peptide phosphorylates protein kinase D/protein kinase Cmu involving phospholipase C and protein kinase C.
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A single genetic locus determines the efficacy of serum therapy against murine adenocarcinoma 755a.
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A synthetic peptide homologous to the envelope proteins of retroviruses inhibits monocyte-mediated killing by inactivating interleukin 1.
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Adult olfactory epithelium contains multipotent progenitors that give rise to neurons and non-neural cells.
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Allocation of epiblast cells to germ layer derivatives during mouse gastrulation as studied with a retroviral vector.
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Alteration of the CD34+ Tf-1 beta cell line profile in response to long-term exposure to IL-15.
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Amendment to Clinical Research Project. Project 90-C-195. April 1, 1993. Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with autologous lymphocytes transduced with a human ADA gene.
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An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein.
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An in vitro system for efficiently evaluating gene therapy approaches to hemoglobinopathies.
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An ultrastructural study of C-type virion assembly in mouse cells.
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Angiogenesis-like activity of endothelial cells co-cultured with VEGF-producing smooth muscle cells.
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Anti-inflammatory and vasoprotective activity of a retroviral-derived peptide, homologous to human endogenous retroviruses: endothelial cell effects.
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Antiinflammatory proteins associated with human and murine neoplasms.
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Assembly of type C oncornaviruses: a model.
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Association of the human type C retrovirus with a subset of adult T-cell cancers.
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B-MuX: a unique murine C-type virus containing the "env" gene of xenotropic viruses and the "gag" gene of the ecotropic virus.
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Biological, immunological, and biochemical evidence that HIX virus is a recombinant between Moloney leukemia virus and a murine xenotropic C type virus.
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Biomaterial-mediated retroviral gene transfer using self-assembled monolayers.
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C-type virus particles in human urogenital tumours after heterotransplantation into nude mice.
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CTL cross reactivity between HIV strains.
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Cell lines producing human T-cell lymphoma virus show altered HLA expression.
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Cell-dependent posttranslational processing and secretion of recombinant mouse renin-2.
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Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion.
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Characterization of antigens in SSV nonproducer cells.
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Clinical efficacy of gene-modified stem cells in adenosine deaminase-deficient immunodeficiency.
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Clonal contributions of small numbers of retrovirally marked hematopoietic stem cells engrafted in unirradiated neonatal W/Wv mice.
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Clonal isolate of the simian sarcoma virus codes for a Gag-related 65,000-dalton protein.
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Coexistence of a chemotactic factor and a retroviral P15E-related chemotaxis inhibitor in human tumor cell culture supernatants.
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Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells.
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Consistent production of transgenic chickens using replication-deficient retroviral vectors and high-throughput screening procedures.
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Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades.
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Correction of proliferative responses in purine nucleoside phosphorylase (PNP)-deficient T lymphocytes by retroviral-mediated PNP gene transfer and expression.
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Cross-clade inhibition of HIV-1 replication and cytopathology by using RNase P-associated external guide sequences.
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Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment.
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Detection of a transformation-specific glycopeptide in SSV-infected cells.
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Detection of oncornavirus antigenic activity in human urothelial tissues.
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Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo.
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Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain.
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Ectopic expression of transcription factor NF-E2 alters the phenotype of erythroid and monoblastoid cells.
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Effects of tumor growth on host defenses.
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Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow.
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Endogenous avian retroviruses contain deficient promoter and leader sequences.
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Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency.
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Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells.
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Ependymal/subependymal zone cells of postnatal and adult songbird brain generate both neurons and nonneuronal siblings in vitro and in vivo.
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Evolutionary implications of primate endogenous retroviruses.
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Function of nuclear factor kappaB in pancreatic cancer metastasis.
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Gene therapy for SCID--a complication after remarkable progress.
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Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans.
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Gene therapy for immunodeficiency due to adenosine deaminase deficiency.
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Gene therapy in tissue-engineered blood vessels.
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Genetic immunization with LYVE-1 cDNA yields function-blocking antibodies against native protein.
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Granulocyte colony-stimulating factor mobilized peripheral blood stem cells enter into G1 of the cell cycle and express higher levels of amphotropic retrovirus receptor mRNA.
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HIV-1 infection: fooling the gatekeeper.
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Human arteries engineered in vitro.
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Human immunodeficiency virus as a prototypic complex retrovirus.
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Human malignant and mitogen-transformed cells contain retroviral P15E-related antigen.
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Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1.
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Humans have antibodies capable of recognizing oncoviral glycoproteins: demonstration that these antibodies are formed in response to cellular modification of glycoproteins rather than as consequence of exposure to virus.
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Identification of a 20,000-dalton protein in SSV-transformed nonproducer cells.
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Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells.
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Identification of human T cell leukemia virus in a Japanese patient with adult T cell leukemia and cutaneous lymphomatous vasculitis.
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Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.
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Immunologic control of a retrovirus-associated murine adenocarcinoma. VI. Augmentation of antibody-dependent killing following quantitative and qualitative changes in host peritoneal cells.
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Immunologic control of a retrovirus-associated murine adenocarcinoma. VII. Tumor cell destruction by macrophages and IgG2A.
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Immunologic control of a retrovirus-associated murine adenocarcinoma. VIII. Corynebacterium parvum-activated natural killer cells as potent antibody-dependent cell-mediated cytotoxicity effectors.
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In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblasts.
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Inducible regulation of Runx2-stimulated osteogenesis.
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Inhibition of human natural killer cell activity by a synthetic peptide homologous to a conserved region in the retroviral protein, p15E.
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Inhibition of lymphocyte proliferation by a synthetic peptide homologous to envelope proteins of human and animal retroviruses.
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Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins.
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Inhibition of nuclear factor-kappaB-mediated adhesion molecule expression in human endothelial cells.
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Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(E) structural protein of retroviruses.
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Interspecies reactivity of type C and D retrovirus p 15E and p 15C proteins.
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Intracellular cleavage of an SSV coded gag-related protein.
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In Vivo Expansion and Antitumor Activity of Coinfused CD28- and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia.
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Isolation and characterization of two group-specific antigens from feline leukemia virus.
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Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy.
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Journey to the center of the cell.
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KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
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Local production of TGF beta1 inhibits cerebral edema, enhances TNF-alpha induced apoptosis and improves survival in a murine glioma model.
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Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase.
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Long- and short-lived murine hematopoietic stem cell clones individually identified with retroviral integration markers.
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Lymphocyte subpopulations and responsiveness in rats bearing intracranial tumors induced by avian sarcoma virus.
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Mammalian C-type oncorna viruses. Relationships between structural virus and cell surface antigens and their possible significance in immunological defense mechanisms.
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Mammalian C-type oncornaviruses: relationships between viral structural and cell-surface antigens and their possible significance in immunological defense mechanisms.
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Mechanism of action of regulatory proteins encoded by complex retroviruses.
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Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts.
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Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation.
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Methotrexate and cytarabine inhibit progression of human lymphoma in NOD/SCID mice carrying a mutant dihydrofolate reductase and cytidine deaminase fusion gene.
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Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2.
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Monoclonal antibody against human T cell leukemia virus p19 defines a human thymic epithelial antigen acquired during ontogeny.
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Morphological, chemical, and antigenic organization of mammalian C-type viruses.
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Multiparameter-fluorescence activated cell sorting analysis of retroviral vector gene transfer into primitive umbilical cord blood cells.
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Murine malignant cells synthesize a 19,000-dalton protein that is physicochemically and antigenically related to the immunosuppressive retroviral protein, P15E.
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Myocardial injury-induced fibroblast proliferation facilitates retroviral-mediated gene transfer to the rat heart in vivo.
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Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert.
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Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations.
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Overexpression of wild-type retinoic acid receptor alpha (RARalpha) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia RARalpha-fusion genes.
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Platelet endothelial cell adhesion molecule-1 expression modulates endothelial cell migration in vitro.
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Polypeptides of endogenous avian C-type viruses: their detection in the plasma membrane of normal and infected cells.
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Polypeptides of mammalian oncornaviruses. I. Isolation and serological analysis polypeptides from murine and feline C-type viruses.
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Polypeptides of mammalian oncornaviruses. II Characterization of murine leukemia virus polypeptide (p 15) bearing interspecies reactivity.
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Potential leukemia virus subunit vaccines: discussion.
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Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon.
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Prospects for the immunological management of lethal tumors.
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Prostate and transitional cell carcinoma: radioimmunoassay of viral tumor-associated antigens.
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RNA interference in human cells is restricted to the cytoplasm.
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Reconstitution of high affinity IL-2 receptor expression in a human T-cell line using a retroviral cDNA expression vector.
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Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2.
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Regulated heat shock protein 27 expression in human retinal pigment epithelium.
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Relatedness by nucleic acid hybridization of new isolates of human T-cell leukemia-lymphoma virus (HTLV) and demonstration of provirus in uncultured leukemic blood cells.
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Relevance and safety of telomerase for human tissue engineering.
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Reprogramming of cellular metabolic pathways by human oncogenic viruses.
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Retroviral DNA integration: viral and cellular determinants of target-site selection.
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Retroviral E-DNA: persistence and gene expression in nondividing immune cells.
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Retroviral gene transduction of circulating progenitor cells in patients with metastatic breast cancer.
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Retroviral vector gene expression in F9 embryonal carcinoma cells.
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Retroviral vectors for the transduction of the PML-RARalpha fusion product of acute promyelocytic leukemia.
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Retrovirally transduced human dendritic cells can generate T cells recognizing multiple MHC class I and class II epitopes from the melanoma antigen glycoprotein 100.
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Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice.
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Retroviruses and human cancer: evaluation of T-lymphocyte transformation by human T-cell leukemia-lymphoma virus.
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Retroviruses as model systems for the study of nuclear RNA export pathways.
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Risk factors for retrovirus and hepatitis virus infections in accepted blood donors.
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Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors.
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Selection of TCR V alpha by MHC class II predicts superantigen reactivity.
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Sequential roles of Hedgehog and Wnt signaling in osteoblast development.
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Short Communication: Potential Risk of Replication-Competent Virus in HIV-1 Env-Pseudotyped Virus Preparations.
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Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.
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Similarity between p15E of murine and feline leukaemia viruses and p21 of HTLV.
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Specific transforming potential of oncogenes encoding protein-tyrosine kinases.
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Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors.
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Structural components of rna tumor viruses.
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Structure and morphogenesis of type-C retroviruses.
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Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms.
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Suppression of human interferon-gamma production by a 17 amino acid peptide homologous to the transmembrane envelope protein of retroviruses: evidence for a primary role played by monocytes.
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Suppression of the respiratory burst of human monocytes by a synthetic peptide homologous to envelope proteins of human and animal retroviruses.
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Sustained gene expression in retrovirally transduced, engrafting human hematopoietic stem cells and their lympho-myeloid progeny.
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T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex.
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Technology evaluation: Rexin-G, Epeius Biotechnologies.
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Temporal and tissue-specific expression of distinct retrovirus-like (VL30) elements during mouse development.
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The Bel-1 protein of human foamy virus activates human immunodeficiency virus type 1 gene expression via a novel DNA target site.
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The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis.
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The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor.
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The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway.
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Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis.
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Transgene expression in zebrafish: A comparison of retroviral-vector and DNA-injection approaches.
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Tumor cells cotransduced with B7.1 and gamma-IFN induce effective rejection of established parental tumor.
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Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.
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Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and ras effector expression to human tumor cell growth.
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Use of viral systems to study miRNA-mediated regulation of gene expression in human cells.
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Using retroviruses to study the nuclear export of mRNA.
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Viruses and oncogenes in brain tumors.
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Viruses in the treatment of brain tumors.
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[Chicken RNA tumor viruses: a model for virus-induced carcinogenesis].
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[Morphogenesis and structure of RNA tumor viruses. Electron microscopy studies on C-type viruses].
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[Preparation of green fluorescent protein retrovirus and its application in mediating gene transfer into retinal pigment epithelial cells].
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[Stimulation of immunoreactivity against endogenous retroviruses and protection against leukemia in aged AKR mice after vaccination with antibodies to viral surface components. The role of antibodies to p15(E)].
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Keywords of People
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Cianciolo, George James,
Associate Professor in Pathology,
Pathology
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Hogan, Brigid L. M.,
George Barth Geller Distinguished Professor for Research in Molecular Biology,
Cell Biology
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Krangel, Michael S.,
George Barth Geller Distinguished Professor of Immunology,
Immunology
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Luftig, Micah Alan,
Associate Professor of Molecular Genetics and Microbiology,
Immunology
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Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Immunology
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Weinhold, Kent James,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine,
Immunology