RNA-Directed DNA Polymerase

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  Subject Areas on Research

  • 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. 
  • A comparison of methods for RNA extraction from lymphocytes for RT-PCR. 
  • A method for analysis of gene expression patterns. 
  • A novel species-specific RNA related to alternatively spliced amyloid precursor protein mRNAs. 
  • A soluble inhibitor of T lymphocyte function induced by HIV-1 infection of CD4+ T cells: characterization of a cellular protein and its relationship to p15E. 
  • Anti-AIDS agents. 15. Synthesis and anti-HIV activity of dihydroseselins and related analogs. 
  • Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells. 
  • Antibody-dependent enhancement of human immunodeficiency virus type 1 (HIV-1) infection in vitro by serum from HIV-1-infected and passively immunized chimpanzees. 
  • Antibody-independent, complement-mediated enhancement of HIV-1 infection by mannosidase I and II inhibitors. 
  • Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes. 
  • Association of the viral reverse transcriptase with an enzyme degrading the RNA moiety of RNA-DNA hybrids. 
  • Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents. 
  • Complement-mediated, antibody-dependent enhancement of HIV-1 infection in vitro is characterized by increased protein and RNA syntheses and infectious virus release. 
  • Cytokine expression by models of human trophoblast as assessed by a semiquantitative reverse transcription-polymerase chain reaction technique. 
  • DNA polymerases versus HIV reverse transcriptase in AIDS therapy. 
  • Differential collagen I gene expression in fetal fibroblasts. 
  • Differential inhibition of HIV-1 cell binding and HIV-1-induced syncytium formation by low molecular weight sulphated polysaccharides. 
  • Drug resistance and HCV coinfection in former blood donors infected with HIV type 1 in China. 
  • Evidence of mRNA-mediated intron loss in the human-pathogenic fungus Cryptococcus neoformans. 
  • Evolutionarily conserved epitopes on human immunodeficiency virus type 1 (HIV-1) and feline immunodeficiency virus reverse transcriptases detected by HIV-1-infected subjects. 
  • Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. 
  • High-Frequency Illegitimate Strand Transfers of Nascent DNA Fragments During Reverse Transcription Result in Defective Retrovirus Genomes. 
  • Homotypic antibody responses to fresh clinical isolates of human immunodeficiency virus. 
  • In vitro assays for detecting neutralizing and fusion-inhibiting antibodies to SIVMAC251. 
  • In vitro selection and characterization of human immunodeficiency virus type 2 with decreased susceptibility to lopinavir. 
  • Incorporation of (alpha-P-borano)-2',3'-dideoxycytidine 5'-triphosphate into DNA by drug-resistant MMLV reverse transcriptase and Taq DNA polymerase. 
  • Initiation of antiretroviral therapy during primary HIV-1 infection induces rapid stabilization of the T-cell receptor beta chain repertoire and reduces the level of T-cell oligoclonality. 
  • Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase. 
  • Lack of enhancing effect of human anti-human immunodeficiency virus type 1 (HIV-1) antibody on HIV-1 infection of human blood monocytes and peritoneal macrophages. 
  • Letter: Role of reverse transcriptase. 
  • Misincorporation and mispaired primer extension by human immunodeficiency virus reverse transcriptase. 
  • Molecular genetic and immunohistochemical analysis of the tumor suppressor genes Rb and p53 in palmar and aggressive fibromatosis. 
  • Multiprotein HIV type 1 clade B DNA and MVA vaccines: construction, expression, and immunogenicity in rodents of the MVA component. 
  • Oligoclonal CD8 lymphocytes from persons with asymptomatic human immunodeficiency virus (HIV) type 1 infection inhibit HIV-1 replication. 
  • Ovalbumin gene: purification of the coding strand. 
  • Patterns of HIV-1 mRNA expression in transgenic mice are tissue-dependent. 
  • Porcine granulosa cells do not express transforming growth factor-beta 2 (TGF-beta 2) messenger ribonucleic acid: molecular basis for their inability to produce TGF-beta activity comparable to that of rat granulosa cells. 
  • Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes. 
  • Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal. 
  • Properties of prostatic cultures transformed by SV40. 
  • Purification of a terminal uridylyltransferase that acts as host factor in the in vitro poliovirus replicase reaction. 
  • Rapid 16S ribosomal DNA sequencing from a single colony without DNA extraction or purification. 
  • Rat thecal/interstitial cells express transforming growth factor-beta type 1 and 2, but only type 2 is regulated by gonadotropin in vitro. 
  • Restricted neutralization of divergent human T-lymphotropic virus type III isolates by antibodies to the major envelope glycoprotein. 
  • Selective antiviral activity of synthetic soluble L-tyrosine and L-dopa melanins against human immunodeficiency virus in vitro. 
  • Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR. 
  • Structural components of avian myeloblastosis virus. 
  • Structural components of rna tumor viruses. 
  • Structure and morphogenesis of type-C retroviruses. 
  • Synthesis of (3H)DNA complementary to ovalbumin messenger RNA: evidence for limited copies of the ovalbumin gene in chick oviduct. 
  • Synthesis of 5-(1-propynyl)-2'-deoxyuridine 5'-(alpha-P-borano)triphosphate and kinetic characterization as a substrate for mmlv reverse transcriptase. 
  • Synthesis of acyclothymidine triphosphate and alpha-P-boranotriphosphate and their substrate properties with retroviral reverse transcriptase. 
  • Synthesis of single-stranded hybridization probes from reusable DNA templates bound to solid support. 
  • The case for a family of reverse transcriptase viruses: Retraviridae. 
  • The initial nucleotide sequence of DNA transcribed from avian myeloblastosis virus 70 S RNA by RNA-dependent DNA polymerase. 
  • The polypurine tract, PPT, of HIV as target for antisense and triple-helix-forming oligonucleotides. 
  • Two DNA polymerases: HIV reverse transcriptase and the Klenow fragment of Escherichia coli DNA polymerase I. 
  • Use of a specific probe for ovalbumin messenger RNA to quantitate estrogen-induced gene transcripts. 
  • [Morphogenesis and structure of RNA tumor viruses. Electron microscopy studies on C-type viruses]. 
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  Keywords of People

  • Ferrari, Guido, Associate Professor of Surgery, Molecular Genetics and Microbiology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Professor of Experimental Surgery, in the School of Medicine, Immunology