Rhabdomyosarcoma

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  Subject Areas on Research

  • A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. 
  • Activity of intrathecal 4-hydroperoxycyclophosphamide in a nude rat model of human neoplastic meningitis. 
  • Advances in the Diagnosis and Management of Neonatal Sarcomas. 
  • An approach to conducting epidemiologic research within cooperative clinical trials groups. 
  • An evolutionary framework for treating pediatric sarcomas. 
  • An exploratory study of environmental and medical factors potentially related to childhood cancer. 
  • Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models. 
  • Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models. 
  • Cardiac rhabdomyosarcoma presenting as hypereosinophilic syndrome. 
  • Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit. 
  • Chemoradiation impairs myofiber hypertrophic growth in a pediatric tumor model. 
  • Childhood cancer and occupational radiation exposure in parents. 
  • Childhood rhabdomyosarcoma. Analysis of coordinated therapy and results. 
  • Clinical group and modified TNM stage for rhabdomyosarcoma: A review from the Children's Oncology Group. 
  • Cloning efficiency of cultured human tumor cell lines measured with the use of a Coulter particle counter. 
  • Current concepts. Cancer in children. 
  • Cutaneous Metastasis of Alveolar Rhabdomyosarcoma in a Child. 
  • Cytosine methylation and suppression of O6-methylguanine-DNA methyltransferase expression in human rhabdomyosarcoma cell lines and xenografts. 
  • Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells. 
  • Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors. 
  • Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan. 
  • Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta. 
  • Enhancement of melphalan-induced gastrointestinal toxicity in mice treated with regional hyperthermia and BSO-mediated glutathione depletion. 
  • Environmental factors in the etiology of rhabdomyosarcoma in childhood. 
  • Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target. 
  • Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion. 
  • Evaluation of BA1112 rhabdomyosarcoma oxygenation with microelectrodes, optical spectrophotometry, radiosensitivity, and magnetic resonance spectroscopy. 
  • Extremity soft tissue sarcomas presented as hematomas. 
  • Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma. 
  • Genetic modeling of Ras-induced human rhabdomyosarcoma. 
  • Genetic modeling of human rhabdomyosarcoma. 
  • Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species-Dependent Targeting of Specificity Protein Transcription Factors. 
  • Hyperthermia-induced enhancement of melphalan activity against a melphalan-resistant human rhabdomyosarcoma xenograft. 
  • Identification and targeting of a HES1-YAP1-CDKN1C functional interaction in fusion-negative rhabdomyosarcoma. 
  • Identification of nitrosourea-resistant human rhabdomyosarcomas by in situ immunostaining of O6-methylguanine-DNA methyltransferase. 
  • Incidence of anemia in children with solid tumors or Hodgkin disease. 
  • Increased local failure for patients with intermediate-risk rhabdomyosarcoma on ARST0531: A report from the Children's Oncology Group. 
  • Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors. 
  • Initial testing (stage 1) of the PARP inhibitor BMN 673 by the pediatric preclinical testing program: PALB2 mutation predicts exceptional in vivo response to BMN 673. 
  • Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program. 
  • Initial testing of cisplatin by the pediatric preclinical testing program. 
  • Initial testing of the multitargeted kinase inhibitor pazopanib by the Pediatric Preclinical Testing Program. 
  • Initial testing of the replication competent Seneca Valley virus (NTX-010) by the pediatric preclinical testing program. 
  • Insights into pediatric rhabdomyosarcoma research: Challenges and goals. 
  • Intensity-modulated radiation therapy for anal malignancies: a preliminary toxicity and disease outcomes analysis. 
  • Intraocular Teratoid Medulloepithelioma Presenting With a Completely Rhabdomyosarcomatous Distant Metastasis. 
  • Intrathecal melphalan therapy of human neoplastic meningitis in athymic nude rats. 
  • Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies. 
  • Local therapy for rhabdomyosarcoma of the hands and feet: is amputation necessary? A report from the Children's Oncology Group. 
  • Malignant mesothelioma with heterologous elements: clinicopathological correlation of 27 cases and literature review. 
  • Management of solid tumors in children. 
  • Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma. 
  • Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine. 
  • Molecular testing of rhabdomyosarcoma in clinical trials to improve risk stratification and outcome: A consensus view from European paediatric Soft tissue sarcoma Study Group, Children's Oncology Group and Cooperative Weichteilsarkom-Studiengruppe. 
  • More Than Meets the Eye? A Cautionary Tale of Malignant Ectomesenchymoma Treated as Low-risk Orbital Rhabdomyosarcoma. 
  • PAX3-FOXO1 fusion gene in rhabdomyosarcoma. 
  • Pathology of childhood rhabdomyosarcoma: A consensus opinion document from the Children's Oncology Group, European Paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe. 
  • Pediatric radiation oncology. 
  • Phase II testing of melphalan in children with newly diagnosed rhabdomyosarcoma: a model for anticancer drug development. 
  • Predicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients Using Deep Learning of H&E Images: A Report from the Children's Oncology Group. 
  • Pulmonary septic emboli mimicking metastatic rhabdomyosarcoma. 
  • Radioimmunotherapy of neoplastic meningitis in rats using an alpha-particle-emitting immunoconjugate. 
  • Rapid activation and down-regulation of protein kinase C alpha in 12-O-Tetradecanoylphorbol-13-acetate-induced differentiation of human rhabdomyosarcoma cells. 
  • Relationship between binding affinity, retention and sensitivity of human rhabdomyosarcoma xenografts to Vinca alkaloids. 
  • Relationship between tumor response at therapy completion and prognosis in patients with Group III rhabdomyosarcoma: A report from the Children's Oncology Group. 
  • Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma. 
  • Relationship of DNA ploidy to histology and prognosis in rhabdomyosarcoma. Comparison of flow cytometry and image analysis. 
  • Renal toxicity of ifosfamide in pilot regimens of the intergroup rhabdomyosarcoma study for patients with gross residual tumor. 
  • Rhabdomyosarcoma in adult prostate. 
  • Rhabdomyosarcoma of the parapharyngeal space in an adult patient: an immunohistochemical study. 
  • Rhabdomyosarcoma: current challenges and their implications for developing therapies. 
  • Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma. 
  • Salvage skull base reconstruction in the endoscopic era: Vastus lateralis free tissue transfer. 
  • Scanning with L-(13 N) glutamate: Assessment of the response to chemotherapy of a patient with embryonal rhabdomyosarcoma. 
  • Single-cell imaging of T cell immunotherapy responses in vivo. 
  • Spindle Cell/Sclerosing Rhabdomyosarcoma of the Orbit. 
  • Stage IV primitive-appearing sinus and orbital rhabdomyosarcoma presenting in a 68-year-old female previously treated for breast cancer. 
  • Surgical management of paratesticular rhabdomyosarcoma: A consensus opinion from the Children's Oncology Group, European paediatric Soft tissue sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe. 
  • Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft. 
  • The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence. 
  • The future of therapy for childhood rhabdomyosarcoma: clues from molecular biology. 
  • Therapeutic analysis of melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR. 
  • Treatment of childhood rhabdomyosarcoma at St. Jude Children's Research Hospital, 1962--78. 
  • Update on pediatric rhabdomyosarcoma: A report from the APSA Cancer Committee. 
  • Vertical Inhibition of the RAF-MEK-ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRAS^Q61X Mutant Rhabdomyosarcoma. 
  • Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish. 
  • miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma. 
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  Keywords of People

  • Deel, Michael D, Assistant Professor of Pediatrics, Pediatrics, Hematology-Oncology
  • Diao, Yarui, Assistant Professor of Cell Biology, Cell Biology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Cell Biology
  • Yoo, Sua, Associate Professor of Radiation Oncology, Radiation Oncology