Rhodopsin

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  Subject Areas on Research

  • A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors. 
  • A novel eye in 'eyeless' shrimp from hydrothermal vents of the Mid-Atlantic Ridge. 
  • A novel rhodopsin point mutation, proline-170-histidine, associated with sectoral retinitis pigmentosa. 
  • A pathologic study of degeneration of the rod and cone populations of the rhodopsin Pro347Leu transgenic pigs. 
  • Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase. 
  • Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant. 
  • Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin. 
  • Analysis of the molecular interaction of the farnesyl moiety of transducin through the use of a photoreactive farnesyl analogue. 
  • Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. 
  • Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin. 
  • Autosomal-dominant retinitis pigmentosa associated with an Arg-135-Trp point mutation of the rhodopsin gene. Clinical features and longitudinal observations. 
  • Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene. 
  • Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors. 
  • Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. 
  • Coarse-grained modeling of allosteric regulation in protein receptors. 
  • Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice. 
  • Correlation of DNA fragmentation and chromatin condensation in apoptotic nuclei of the Ser 6 mouse retina. 
  • Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. 
  • Crystallizing thinking about the beta2-adrenergic receptor. 
  • Cyclic phosphorylation-dephosphorylation of rhodopsin in retina by protein kinase FA (the activator of ATP.Mg-dependent protein phosphatase). 
  • Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin by latent phosphatase 2. 
  • Different structural changes occur in blue- and green-proteorhodopsins during the primary photoreaction. 
  • Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants. 
  • Early loss of synaptic protein PSD-95 from rod terminals of rhodopsin P347L transgenic porcine retina. 
  • Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations. 
  • Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocation. 
  • Enzymology of GTPase acceleration in phototransduction. 
  • Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. 
  • Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. 
  • Functional roles of the two domains of phosducin and phosducin-like protein. 
  • Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa. 
  • Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking. 
  • High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. 
  • High-speed recording of neural spikes in awake mice and flies with a fluorescent voltage sensor. 
  • Identification and localization of a possible rhodopsin in the echinoderms Asterias forbesi (Asteroidea) and Ophioderma brevispinum (Ophiuroidea). 
  • Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity. 
  • Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. 
  • Immunocytochemical localization of photopigments in cephalopod retinae. 
  • Inhibition of the beta-adrenergic receptor kinase by polyanions. 
  • Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases. 
  • Lensectomy and vitrectomy decrease the rate of photoreceptor loss in rhodopsin P347L transgenic pigs. 
  • Light-dependent magnetoreception: quantum catches and opponency mechanisms of possible photosensitive molecules. 
  • Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase. 
  • Luminopsins integrate opto- and chemogenetics by using physical and biological light sources for opsin activation. 
  • Mechanisms involved in adrenergic receptor desensitization. 
  • Mechanisms regulating variability of the single photon responses of mammalian rod photoreceptors. 
  • Model systems for the study of seven-transmembrane-segment receptors. 
  • Molecular basis for interactions of G protein betagamma subunits with effectors. 
  • Multifocal electroretinogram in rhodopsin P347L transgenic pigs. 
  • Neocortical disynaptic inhibition requires somatodendritic integration in interneurons. 
  • On the role of transducin GTPase in the quenching of a phosphodiesterase cascade of vision. 
  • Optical coherence tomography (OCT) abnormalities in rhodopsin mutant transgenic swine with retinal degeneration. 
  • Optogenetic probes. 
  • Orientation of acidic polysaccharides and rhodopsin-oligosaccharides in frog retinal rod outer segments. 
  • Phenotypic stability of Pro347Leu rhodopsin transgenic pigs as indicated by photoreceptor cell degeneration. 
  • Phosphorylation of non-bleached rhodopsin in intact retinas and living frogs. 
  • Progressive Rod-Cone Degeneration (PRCD) Protein Requires N-Terminal S-Acylation and Rhodopsin Binding for Photoreceptor Outer Segment Localization and Maintaining Intracellular Stability. 
  • Protonation state of Glu142 differs in the green- and blue-absorbing variants of proteorhodopsin. 
  • Putative digenic inheritance of heterozygous RP1L1 and C2orf71 null mutations in syndromic retinal dystrophy. 
  • R9AP targeting to rod outer segments is independent of rhodopsin and is guided by the SNARE homology domain. 
  • Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems. 
  • Recoverin undergoes light-dependent intracellular translocation in rod photoreceptors. 
  • Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin. 
  • Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP. 
  • Retinal rod photoreceptor-specific gene mutation perturbs cone pathway development. 
  • Retinitis pigmentosa associated with rhodopsin mutations: Correlation between phenotypic variability and molecular effects. 
  • Rhodopsin maturation antagonized by dominant rhodopsin mutants. 
  • Rhodopsin phosphorylation: from terminating single photon responses to photoreceptor dark adaptation. 
  • Rhodopsin transgenic pigs as a model for human retinitis pigmentosa. 
  • Rod outer segment structure influences the apparent kinetic parameters of cyclic GMP phosphodiesterase. 
  • Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. 
  • Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. 
  • Role of the Fas-signaling pathway in photoreceptor neuroprotection. 
  • Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons. 
  • Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system. 
  • Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. 
  • Striatonigral control of movement velocity in mice. 
  • Structural changes in the photoactive site of proteorhodopsin during the primary photoreaction. 
  • Structure and function of the beta 2-adrenergic receptor--homology with rhodopsin. 
  • Structure and function of the visual arrestin oligomer. 
  • The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit. 
  • The carbohydrates in frog retinal rod outer segments. 
  • The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas. 
  • The effect of rhodopsin phosphorylation on the light-dependent activation of phosphodiesterase from bovine rod outer segments. 
  • The evolving capabilities of rhodopsin-based genetically encoded voltage indicators. 
  • The gain of rod phototransduction: reconciliation of biochemical and electrophysiological measurements. 
  • The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice. 
  • The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. 
  • The superfamily of heptahelical receptors. 
  • Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems. 
  • Transplantation of full-thickness retina in the rhodopsin transgenic pig. 
  • Two-dimensional rhodopsin crystals from disk membranes of frog retinal rod outer segments. 
  • alpha-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute