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Subject Areas on Research
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A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors.
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A novel eye in 'eyeless' shrimp from hydrothermal vents of the Mid-Atlantic Ridge.
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A novel rhodopsin point mutation, proline-170-histidine, associated with sectoral retinitis pigmentosa.
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A pathologic study of degeneration of the rod and cone populations of the rhodopsin Pro347Leu transgenic pigs.
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Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.
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Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant.
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Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin.
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Analysis of the molecular interaction of the farnesyl moiety of transducin through the use of a photoreactive farnesyl analogue.
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Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice.
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Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin.
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Autosomal-dominant retinitis pigmentosa associated with an Arg-135-Trp point mutation of the rhodopsin gene. Clinical features and longitudinal observations.
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Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene.
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Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors.
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Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin.
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Coarse-grained modeling of allosteric regulation in protein receptors.
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Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin.
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Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice.
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Correlation of DNA fragmentation and chromatin condensation in apoptotic nuclei of the Ser 6 mouse retina.
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Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
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Crystallizing thinking about the beta2-adrenergic receptor.
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Cyclic phosphorylation-dephosphorylation of rhodopsin in retina by protein kinase FA (the activator of ATP.Mg-dependent protein phosphatase).
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Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin by latent phosphatase 2.
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Different structural changes occur in blue- and green-proteorhodopsins during the primary photoreaction.
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Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants.
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Early loss of synaptic protein PSD-95 from rod terminals of rhodopsin P347L transgenic porcine retina.
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Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations.
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Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocation.
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Enzymology of GTPase acceleration in phototransduction.
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Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.
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Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.
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Functional roles of the two domains of phosducin and phosducin-like protein.
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Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa.
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Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking.
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High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice.
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High-speed recording of neural spikes in awake mice and flies with a fluorescent voltage sensor.
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Identification and localization of a possible rhodopsin in the echinoderms Asterias forbesi (Asteroidea) and Ophioderma brevispinum (Ophiuroidea).
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Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity.
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Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.
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Immunocytochemical localization of photopigments in cephalopod retinae.
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Inhibition of the beta-adrenergic receptor kinase by polyanions.
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Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases.
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Lensectomy and vitrectomy decrease the rate of photoreceptor loss in rhodopsin P347L transgenic pigs.
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Light-dependent magnetoreception: quantum catches and opponency mechanisms of possible photosensitive molecules.
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Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase.
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Luminopsins integrate opto- and chemogenetics by using physical and biological light sources for opsin activation.
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Mechanisms involved in adrenergic receptor desensitization.
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Mechanisms regulating variability of the single photon responses of mammalian rod photoreceptors.
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Model systems for the study of seven-transmembrane-segment receptors.
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Modes of interactions between signaling pathways.
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Molecular basis for interactions of G protein betagamma subunits with effectors.
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Multifocal electroretinogram in rhodopsin P347L transgenic pigs.
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On the role of transducin GTPase in the quenching of a phosphodiesterase cascade of vision.
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Optical coherence tomography (OCT) abnormalities in rhodopsin mutant transgenic swine with retinal degeneration.
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Orientation of acidic polysaccharides and rhodopsin-oligosaccharides in frog retinal rod outer segments.
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PRCD Is a Small Disc-Specific Rhodopsin-Binding Protein of Unknown Function.
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Phenotypic stability of Pro347Leu rhodopsin transgenic pigs as indicated by photoreceptor cell degeneration.
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Phosphorylation of non-bleached rhodopsin in intact retinas and living frogs.
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Progressive Rod-Cone Degeneration (PRCD) Protein Requires N-Terminal S-Acylation and Rhodopsin Binding for Photoreceptor Outer Segment Localization and Maintaining Intracellular Stability.
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Protonation state of Glu142 differs in the green- and blue-absorbing variants of proteorhodopsin.
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R9AP targeting to rod outer segments is independent of rhodopsin and is guided by the SNARE homology domain.
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Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems.
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Recoverin undergoes light-dependent intracellular translocation in rod photoreceptors.
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Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin.
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Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP.
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Retinal rod photoreceptor-specific gene mutation perturbs cone pathway development.
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Retinitis pigmentosa associated with rhodopsin mutations: Correlation between phenotypic variability and molecular effects.
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Rhodopsin maturation antagonized by dominant rhodopsin mutants.
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Rhodopsin phosphorylation: from terminating single photon responses to photoreceptor dark adaptation.
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Rhodopsin transgenic pigs as a model for human retinitis pigmentosa.
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Rod outer segment structure influences the apparent kinetic parameters of cyclic GMP phosphodiesterase.
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Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase.
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Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.
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Role of the Fas-signaling pathway in photoreceptor neuroprotection.
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Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons.
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Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system.
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Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.
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Structural changes in the photoactive site of proteorhodopsin during the primary photoreaction.
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Structure and function of the beta 2-adrenergic receptor--homology with rhodopsin.
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Structure and function of the visual arrestin oligomer.
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Temporal resolution of single-photon responses in primate rod photoreceptors and limits imposed by cellular noise.
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The F220C and F45L rhodopsin mutations identified in retinitis pigmentosa patients do not cause pathology in mice.
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The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit.
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The carbohydrates in frog retinal rod outer segments.
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The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas.
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The effect of rhodopsin phosphorylation on the light-dependent activation of phosphodiesterase from bovine rod outer segments.
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The evolving capabilities of rhodopsin-based genetically encoded voltage indicators.
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The gain of rod phototransduction: reconciliation of biochemical and electrophysiological measurements.
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The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice.
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The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.
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The superfamily of heptahelical receptors.
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Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems.
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Transplantation of full-thickness retina in the rhodopsin transgenic pig.
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Two-dimensional rhodopsin crystals from disk membranes of frog retinal rod outer segments.
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alpha-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro.
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