Ribonucleases

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  Subject Areas on Research

  • "Active" conformation of an inactive semi-synthetic ribonuclease-S. 
  • A Sephadex dialysis method of determining small molecule-macromolecule binding constants. 
  • A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity. 
  • A high resolution structure of an inhibitor complex of the extracellular nuclease of Staphylococcus aureus. I. Experimental procedures and chain tracing. 
  • A model of ribonuclease based on chemical evidence. 
  • A new human slow skeletal troponin T (TnTs) mRNA isoform derived from alternative splicing of a single gene. 
  • Accuracy and precision of a new H/D exchange- and mass spectrometry-based technique for measuring the thermodynamic properties of protein-peptide complexes. 
  • Acrylamide-regulated neurofilament expression in rat pheochromocytoma cells. 
  • Alkaline ribonuclease in rat liver: effect of hypophysectomy and fasting. 
  • Analytical shape computation of macromolecules: II. Inaccessible cavities in proteins. 
  • Association of 3' terminal RNA sequences with avian leukosis viruses causing a high incidence of osteopetrosis. 
  • Association of the viral reverse transcriptase with an enzyme degrading the RNA moiety of RNA-DNA hybrids. 
  • Association of viral reverse transcriptase with an enzyme degrading the RNA moiety of RNA-DNA hybrids. 
  • Bacteriophage T7 Deoxyribonucleic acid replication in vitro. A protein of Escherichia coli required for bacteriophage T7 DNA polymerase activity. 
  • BiPS, a photocleavable, isotopically coded, fluorescent cross-linker for structural proteomics. 
  • Binding of phosphate ligands to ribonuclease A. 
  • Brain messenger RNA levels and ribonuclease activity in Alzheimer's disease. 
  • Calcitonin elevation in small cell lung cancer without ectopic production. 
  • Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae. 
  • Characterization of the 3' terminus of RNA isolated from vesicular stomatitis virus and from its defective interfering particles. 
  • Characterization of two mRNA-rRNA complexes implicated in the initiation of protein biosynthesis. 
  • Crystalline extracellular nuclease of Staphylococcus aureus. 
  • DO-RIP-seq to quantify RNA binding sites transcriptome-wide. 
  • Decreased expression of tissue inhibitor of metalloproteinase 1 in stunned myocardium. 
  • Developmental expression of the glucose-dependent insulinotropic polypeptide gene in rat intestine. 
  • Dhh1 regulates the G1/S-checkpoint following DNA damage or BRCA1 expression in yeast. 
  • Dietary regulation of glucose-dependent insulinotropic peptide (GIP) gene expression in rat small intestine. 
  • Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice. 
  • Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity. 
  • Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination. 
  • Enhanced Sensitivity for Detection of HIV-1 p24 Antigen by a Novel Nuclease-Linked Fluorescence Oligonucleotide Assay. 
  • Equilibrium measurements of the binding of cytidine 3'-phosphate to ribonuclease. 
  • Evolutionary dynamics of dual-specificity self-incompatibility alleles. 
  • Expression and trans-specific polymorphism of self-incompatibility RNases in coffea (Rubiaceae). 
  • Generation of nuclease resistant circular RNA decoys for HIV-Tat and HIV-Rev by autocatalytic splicing. 
  • Hepatic lysosomal enzymes in young rats fed retinol. 
  • High potency silencing by single-stranded boranophosphate siRNA. 
  • How do enzymes really work? 
  • Human apolipoprotein B transgenic mice generated with 207- and 145-kilobase pair bacterial artificial chromosomes. Evidence that a distant 5'-element confers appropriate transgene expression in the intestine. 
  • In vitro synthesis of phi-X-174 single-stranded DNA. 
  • In vivo production of an RNA-DNA copolymer after infection of Escherichia coli by bacteriophage T4. 
  • Inflammatory and epithelial responses in mouse strains that differ in sensitivity to hyperoxic injury. 
  • Isolation and functional analysis of the mouse RXRgamma1 gene promoter in anterior pituitary cells. 
  • Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies. 
  • Isolation of a nuclease-resistant decoy RNA that selectively blocks autoantibody binding to insulin receptors on human lymphocytes. 
  • Isolation of polyribosomes and characteristics of an amino acid-incorporation system from the liver of a primate (Papio papio). 
  • Isolation of protein factors from oviduct polysomes which stimulate protein synthesis. 
  • Kinetic and equilibrium studies of the ribonuclease-catalyzed hydrolysis of uridine 2',3'-cyclic phosphate. 
  • Kinetic properties of iodinated ribonuclease A. 
  • Localization of mRNA for three distinct alpha 1-adrenergic receptor subtypes in human tissues: implications for human alpha-adrenergic physiology. 
  • MECHANISM OF ENZYME CATALYSIS. 
  • Multiple conformational changes in enzyme catalysis. 
  • Multiple transcription start sites and 5' alternate splicing of murine IL-3 receptor beta-chain transcripts. 
  • Mutational origin of new mating type specificities in flowering plants. 
  • Mutations in ribonuclease L gene do not occur at a greater frequency in patients with familial prostate cancer compared with patients with sporadic prostate cancer. 
  • Oligonucleotides produced by digestion of bakers' yeast serine transfer ribonucleic acid with specific nucleases. 
  • On the origin of self-incompatibility haplotypes: transition through self-compatible intermediates. 
  • Optical rotatory dispersion of ribonuclease and ribonuclease--nucleotide complexes. 
  • Pancreatic adenocarcinoma cell line, MDAPanc-28, with features of both acinar and ductal cells. 
  • Pancreatic digestive enzyme gene expression: effects of CCK and soybean trypsin inhibitor. 
  • Pathways of folding of reduced bovine pancreatic ribonuclease. 
  • Patterns of variation within self-incompatibility loci. 
  • Phage fl mRNA processing in Escherichia coli: search for the upstream products of endonuclease cleavage, requirement for the product of the altered mRNA stability (ams) locus. 
  • Positive and negative elements regulate human interleukin 3 expression. 
  • Proinflammatory actions of thromboxane receptors to enhance cellular immune responses. 
  • Protein biosynthesis on chick oviduct polyribosomes. I. Changes during estrogen-mediated tissue differentiation. 
  • Protein biosynthesis on chick oviduct polyribosomes. II. Regulation by progesterone. 
  • Protein bisoynthesis in the testis. IV. Isolation and properties of polyribosomes. 
  • Protein synthesis, microsomes, and polyribosomes in oral tissues. 
  • Proteomic analysis of arginine adducts on glyoxal-modified ribonuclease. 
  • Purification of alpha-sarcin and an antifungal protein from Aspergillus giganteus by blue sepharose CL-6B affinity chromatography. 
  • RNA interference using boranophosphate siRNAs: structure-activity relationships. 
  • RNA-guided gene activation by CRISPR-Cas9-based transcription factors. 
  • Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. 
  • Relaxation spectra of ribonuclease. 3. Further investigation of the interaction of ribonuclease and cytidine 3'-phosphate. 
  • Relaxation spectra of ribonuclease. II. Isomerization of ribonuclease at neutral pH values. 
  • Relaxation spectra of ribonuclease. IV. The interaction of ribonuclease with cytidine 2':3'-cyclic phosphate. 
  • Relaxation spectra of ribonuclease. V. The interaction of ribonuclease with cytidylyl-3':5'-cytidine. 
  • Relaxation spectra of ribonuclease. VII. The interaction of ribonuclease with uridine 2',3'-cyclic phosphate. 
  • Relaxation spectrometry of biological systems. 
  • Ribonucleic acid components of BAI strain A (myeloblastosis) avian tumor virus. 
  • Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study. 
  • Selective regulation of expression of protein kinase C beta isoenzymes occurs via alternative splicing. 
  • Site-specific RNA cleavage generates the 3' end of a poxvirus late mRNA. 
  • Steroid hormone induction of a specific translatable messenger RNA. 
  • Structural and functional analysis of the visna virus Rev-response element. 
  • Structural features of the trans-activation response RNA element of equine infectious anemia virus. 
  • Synthesis and separation of diastereomers of uridine 2',3'-cyclic boranophosphate. 
  • Temperature-sensitive mRNA degradation is an early event in hepatocyte de-differentiation. 
  • The effect of salmeterol on nocturnal symptoms, airway function, and inflammation in asthma. 
  • The extracellular nuclease of Staphylococcus aureus: structures of the native enzyme and an enzyme-inhibitor complex at 4 A resolution. 
  • The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble. 
  • The vesicular glutamate transporter 1 (xVGlut1) is expressed in discrete regions of the developing Xenopus laevis nervous system. 
  • Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. 
  • Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation. 
  • Tissue specificity of renin promoter activity and regulation in mice. 
  • Use of SYTO 13, a fluorescent dye binding nucleic acids, for the detection of microparticles in in vitro systems. 
  • Virus-induced genitourinary malignancy. Macromolecular identity. 
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  Keywords of People

  • Oas, Terrence Gilbert, Professor of Biochemistry, Biochemistry
  • Reddy, Timothy E, Associate Professor of Biostatistics & Bioinformatics, Molecular Genetics and Microbiology