Ribonucleoproteins
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Subject Areas on Research
- 60 kD Ro and nRNP A frequently initiate human lupus autoimmunity.
- 60-kDa Ro protein autoepitopes identified using recombinant polypeptides.
- A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein.
- A host protein (La) binds to a unique species of minus-sense leader RNA during replication of vesicular stomatitis virus.
- A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen.
- A small yeast RNA blocks hepatitis C virus internal ribosome entry site (HCV IRES)-mediated translation and inhibits replication of a chimeric poliovirus under translational control of the HCV IRES element.
- A specific 31-nucleotide domain of U1 RNA directly interacts with the 70K small nuclear ribonucleoprotein component.
- A two-phase innate host response to alphavirus infection identified by mRNP-tagging in vivo.
- Acute myeloid leukemia ontogeny is defined by distinct somatic mutations.
- Alu RNA-protein complexes formed in vitro react with a novel lupus autoantibody.
- Analysis of autoantibody binding to different regions of the human La antigen expressed in recombinant fusion proteins.
- Anti-La antibodies.
- Anti-La antibody production by MRL-1pr/1pr mice. Analysis of fine specificity.
- Anti-Ro and anti-nRNP response in unaffected family members of SLE patients.
- Antigenicity of a recombinant Ro (SS-A) fusion protein.
- Association between the 7 S RNA and the lupus La protein varies among cell types.
- Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin.
- Biochemical fractionation and assembly of the membrane components that mediate nascent chain targeting and translocation.
- Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides.
- Cellular and viral splicing factors can modify the splicing pattern of CFTR transcripts carrying splicing mutations.
- Chaperone-mediated cross-priming: a hitchhiker's guide to vesicle transport (review).
- Characterization and idiotypic analysis of an anti-RNP monoclonal antibody.
- Characterization of a Drosophila U snRNP RNA-binding protein.
- Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway.
- Connections between the processing and nuclear export of mRNA: evidence for an export license?
- Coordinated posttranscriptional mRNA population dynamics during T-cell activation.
- Development of autoantibodies before the clinical onset of systemic lupus erythematosus.
- Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs.
- Direct interactions between autoantigen La and human immunodeficiency virus leader RNA.
- Direct interactions between autoantigen La and human immunodeficiency virus leader RNA.
- Disruption of mRNA-RNP formation and sorting to dendritic synapses by antisense oligodeoxynucleotides.
- EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity.
- ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation.
- ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system.
- ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells.
- Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry.
- Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression.
- Engineered Ribonucleoprotein Granules Inhibit Translation in Protocells.
- Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome.
- Eukaryotic mRNPs may represent posttranscriptional operons.
- Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III.
- Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus.
- Gene expression analysis of messenger RNP complexes.
- Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma.
- Genome-wide regulatory analysis using en masse nuclear run-ons and ribonomic profiling with autoimmune sera.
- Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.
- Genomic structure and amino acid sequence domains of the human La autoantigen.
- Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation.
- Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs.
- Human La antigen is required for the hepatitis C virus internal ribosome entry site-mediated translation.
- Hybridoma SLE autoantibodies: insights for the pathogenesis of autoimmune disease.
- Identification and activity of the functional complex between hnRNPL and the pseudoexfoliation syndrome-associated lncRNA, LOXL1-AS1.
- Identification of casein kinase II and phosphorylated proteins associated with messenger ribonucleoproteins particles from reticulocytes.
- Identification of cis elements directing termination of yeast nonpolyadenylated snoRNA transcripts.
- Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays.
- Immunization with the Sm nuclear antigen induces anti-Sm antibodies in normal and MRL mice.
- Independent expression of autoantibodies in systemic lupus erythematosus.
- Interactions of plus and minus strand leader RNAs of the New Jersey serotype of vesicular stomatitis virus with the cellular La protein.
- Isolation and analysis of cDNA clones expressing human lupus La antigen.
- La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate.
- La gets its wings.
- Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions.
- Linked folding and anion binding of the Bacillus subtilis ribonuclease P protein.
- Localization of S1 and elongation factor-1 alpha mRNA in rat brain and liver by non-radioactive in situ hybridization.
- Lymphocytic lymphoma and systemic lupus erythematosus: their coexistence with antibody to the Sm antigen.
- Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor.
- Mechanisms coordinating ELAV/Hu mRNA regulons.
- Messenger ribonucleoprotein complexes containing human ELAV proteins: interactions with cytoskeleton and translational apparatus.
- Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading.
- Molecular analysis of the 60-kDa human Ro ribonucleoprotein.
- Molecular biology of nuclear autoantigens.
- Molecular composition of Ro small ribonucleoprotein complexes in human cells. Intracellular localization of the 60- and 52-kD proteins.
- Molecular structure of the La and Ro autoantigens and their use in autoimmune diagnostics.
- Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex.
- Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta.
- Nucleotide sequence and host La protein interactions of rabies virus leader RNA.
- Organizing mRNA export.
- Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
- Picornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complex.
- Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies.
- Presentations and outcomes of interstitial lung disease and the anti-Ro52 autoantibody.
- Proteomic analysis of mitotic RNA polymerase II reveals novel interactors and association with proteins dysfunctional in disease.
- Purification of messenger ribonucleoprotein particles from rabbit reticulocytes by zonal centrifugation in metrizamide.
- Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA.
- Quantitative immunoassay of anti-La antibodies using purified recombinant La antigen.
- RIP-Chip: the isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts.
- RNA binding specificity of a Drosophila snRNP protein that shares sequence homology with mammalian U1-A and U2-B" proteins.
- RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins.
- RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice.
- Rapid inhibition of processing and assembly of small nuclear ribonucleoproteins after infection with vesicular stomatitis virus.
- Recognition of U1 and U2 small nuclear RNAs can be altered by a 5-amino-acid segment in the U2 small nuclear ribonucleoprotein particle (snRNP) B" protein and through interactions with U2 snRNP-A' protein.
- Redirecting Vesicular Transport to Improve Nonviral Delivery of Molecular Cargo.
- Reduced expression of TRIM21/Ro52 predicts poor prognosis in diffuse large B-cell lymphoma patients with and without rheumatic disease.
- Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays.
- Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome.
- Ribotrap : targeted purification of RNA-specific RNPs from cell lysates through immunoaffinity precipitation to identify regulatory proteins and RNAs.
- Role of chaperones in antigen processing.
- Selective small antigenic structures are capable of inducing widespread autoimmunity which closely mimics the humoral fine specificity of human SLE.
- Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity.
- Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens.
- Structure and morphogenesis of type-C retroviruses.
- Systematic analysis of posttranscriptional gene expression.
- Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions.
- Temporal correlation of antibody responses to different epitopes of the human La autoantigen.
- The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme.
- The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P.
- The U1 RNA-binding site of the U1 small nuclear ribonucleoprotein (snRNP)-associated A protein suggests a similarity with U2 snRNPs.
- The anti-La response of a single MRL/Mp-lpr/lpr mouse: specificity for DNA and VH gene usage.
- The fine specificity of anti-La antibodies induced in mice by immunization with recombinant human La autoantigen.
- The fine specificity of monoclonal anti-DNA antibodies induced in normal mice by immunization with bacterial DNA.
- The genetics of autoantibody production in MRL/lpr lupus mice.
- The origins of defective interfering particles of the negative-strand RNA viruses.
- The ribonome: a dominant force in co-ordinating gene expression.
- The suppression of testis-brain RNA binding protein and kinesin heavy chain disrupts mRNA sorting in dendrites.
- Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus.
- U1-snRNP-A protein selects a ten nucleotide consensus sequence from a degenerate RNA pool presented in various structural contexts.
- Viral transcription is necessary and sufficient for vesicular stomatitis virus to inhibit maturation of small nuclear ribonucleoproteins.
- Why is Hu where? Shuttling of early-response-gene messenger RNA subsets.
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Keywords of People
- Oas, Terrence Gilbert, Professor of Biochemistry, Biochemistry