RNA

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  Subject Areas on Research

  • 3D maps of RNA interhelical junctions. 
  • A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium. 
  • A Comparative Study of Serum Exosome Isolation Using Differential Ultracentrifugation and Three Commercial Reagents. 
  • A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila. 
  • A circular trans-acting hepatitis delta virus ribozyme. 
  • A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. 
  • A comparative analysis of the information content in long and short SAGE libraries. 
  • A comparison of methods for RNA extraction from lymphocytes for RT-PCR. 
  • A copper-regulated transporter required for copper acquisition, pigmentation, and specific stages of development in Drosophila melanogaster. 
  • A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. 
  • A genetically tractable model of human glioma formation. 
  • A light-inducible CRISPR-Cas9 system for control of endogenous gene activation. 
  • A major role for the EP4 receptor in regulation of renin. 
  • A method for analysis of gene expression patterns. 
  • A missense mutation in exon 4 of the human adenosine deaminase gene causes severe combined immunodeficiency. 
  • A mutation in the largest subunit of RNA polymerase II alters RNA chain elongation in vitro. 
  • A negative coregulator for the human ER. 
  • A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status. 
  • A novel process for optimizing musculoskeletal allograft tissue to improve safety, ultrastructural properties, and cell infiltration. 
  • A novel species-specific RNA related to alternatively spliced amyloid precursor protein mRNAs. 
  • A nuclear role for the Fragile X mental retardation protein. 
  • A paired-end sequencing strategy to map the complex landscape of transcription initiation. 
  • A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes. 
  • A small circular TAR RNA decoy specifically inhibits Tat-activated HIV-1 transcription. 
  • Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. 
  • Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans. 
  • Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. 
  • Activation of the heat shock transcription factor by hypoxia in mammalian cells. 
  • Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3' nontranslated region. 
  • Acute tubular necrosis. An experimental model detailing the biochemical events accompanying renal injury and recovery. 
  • Advances in the determination of nucleic acid conformational ensembles. 
  • Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by trans splicing. 
  • Alternative splicing in disease and therapy. 
  • Analysis of expression of multiple genes encoding calmodulin during spermatogenesis. 
  • Analyzing transcription dynamics during the budding yeast cell cycle 
  • Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory. 
  • Antimetastatic potential of PAI-1-specific RNA aptamers. 
  • Approximate reconstruction of continuous spatially complex domain motions by multialignment NMR residual dipolar couplings. 
  • Aptamers in immunotherapy. 
  • Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events. 
  • Association of the viral reverse transcriptase with an enzyme degrading the RNA moiety of RNA-DNA hybrids. 
  • Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway. 
  • Bacteriophage T4 helicase loader protein gp59 functions as gatekeeper in origin-dependent replication in vivo. 
  • Beta adrenergic control of macromolecule synthesis in neonatal rat heart, kidney and lung: relationship to sympathetic neuronal development. 
  • Beta-adrenergic control of c-fos expression in fetal and neonatal rat tissues: relationship to cell differentiation and teratogenesis. 
  • Beta-catenin mediates soft tissue contracture in clubfoot. 
  • Beyond static structures of RNA by NMR: folding, refolding, and dynamics at atomic resolution. 
  • Biochemical determinants of growth sparing during neonatal nutritional deprivation or enhancement: ornithine decarboxylase, polyamines, and macromolecules in brain regions and heart. 
  • Biochemical development of the rat lung: studies on cellular DNA, RNA and protein content in relation to maternal vitamin A status. 
  • Blocking the initiation of coagulation by RNA aptamers to factor VIIa. 
  • Blood-sample processing for the study of age-dependent gene expression in peripheral blood mononuclear cells. 
  • Bone marrow biopsy: RNA isolation with expression profiling in men with metastatic castration-resistant prostate cancer--factors affecting diagnostic success. 
  • Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos. 
  • Bone morphogenetic proteins are expressed by both bone-forming and non-bone-forming lesions. 
  • Brain-specific polyA- transcripts are detected in polyA+ RNA: do complex polyA- brain RNAs really exist? 
  • Calmodulin is required for cell-cycle progression during G1 and mitosis. 
  • Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans. 
  • Catecholaminergic cell lines from the brain and adrenal glands of tyrosine hydroxylase-SV40 T antigen transgenic mice. 
  • Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates. 
  • Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR. 
  • Characterization of the hyperpolarization-activated chloride current in dissociated rat sympathetic neurons. 
  • Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy. 
  • Characterizing the relative orientation and dynamics of RNA A-form helices using NMR residual dipolar couplings. 
  • Chemical evidence for early but unsustained growth in the obstructed mouse kidney. 
  • Chemical structure of carbamoylating groups and their relationship to bone marrow toxicity and antiglioma activity of bifunctionally alkylating and carbamoylating nitrosoureas. 
  • Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2. 
  • Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. 
  • Circular transcripts of the testis-determining gene Sry in adult mouse testis. 
  • Circularizing ribozymes and decoy-competitors by autocatalytic splicing in vitro and in vivo. 
  • Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. 
  • Cloning and characterization of three new murine genes encoding short homologues of RNase P RNA. 
  • Cloning of DNA corresponding to rare transcripts of rat brain: evidence of transcriptional and post-transcriptional control and of the existence of nonpolyadenylated transcripts. 
  • Coarse grained models reveal essential contributions of topological constraints to the conformational free energy of RNA bulges. 
  • Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements. 
  • Comparing reference-based RNA-Seq mapping methods for non-human primate data. 
  • Compensatory renal growth after unilateral ureteral obstruction. 
  • Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells. 
  • Complementary techniques: RNA amplification for gene profiling analysis. 
  • Complexity of cytoplasmic polyadenylated and nonpolyadenylated rat brain ribonucleic acids. 
  • Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. 
  • Computational Methods for RNA Structure Validation and Improvement. 
  • Computing. Successes and challenges. 
  • Concerning the mechanism of FSH action: rapid stimulation of testicular synthesis of nuclear RNA. 
  • Conditional telomerase induction causes proliferation of hair follicle stem cells. 
  • Constructing atomic-resolution RNA structural ensembles using MD and motionally decoupled NMR RDCs. 
  • Control of nucleic acid and protein synthesis in developing brain, kidney, and heart of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase. 
  • Coordinate reduction of rat pancreatic islet glucokinase and proinsulin mRNA by exercise training. 
  • Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses. 
  • Creation of human tumour cells with defined genetic elements. 
  • Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7. 
  • Cti6 is an Rpd3-Sin3 histone deacetylase-associated protein required for growth under iron-limiting conditions in Saccharomyces cerevisiae. 
  • DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. 
  • Deciphering the molecular machinery of stem cells: a look at the neoblast gene expression profile. 
  • Defective cellular immunity associated with chronic mucocutaneous moniliasis and recurrent staphylococcal botryomycosis: immunological reconstitution by allogeneic bone marrow. 
  • Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy. 
  • Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. 
  • Developmental neurotoxicity of chlorpyrifos: delayed targeting of DNA synthesis after repeated administration. 
  • Developmental pattern of the hepatic DNA, RNA and protein in relation to maternal vitamin A status in rats. 
  • Developmental regulation of calmodulin, actin, and tubulin RNAs during rat testis differentiation. 
  • Diagnostic potential of prostate-specific antigen expressing epithelial cells in blood of prostate cancer patients. 
  • Dietary regulation of rat intestinal cholecystokinin gene expression. 
  • Differential expression of genes encoding TGFs beta 1, beta 2, and beta 3 during murine palate formation. 
  • Differential gene expression of blood-derived cell lines in familial combined hyperlipidemia. 
  • Differential requirements for segment polarity genes in wingless signaling. 
  • Digital image analysis for rapid quantification of total RNA and cDNA for SMART-PCR. 
  • Direct assessment of articular cartilage and underlying subchondral bone reveals a progressive gene expression change in human osteoarthritic knees. 
  • Direct fluorescence detection of RNA on microarrays by surface-initiated enzymatic polymerization. 
  • Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble. 
  • Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. 
  • Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain. 
  • Do sympathetic neurons coordinate cellular development in the heart and kidney? Effects of neonatal central and peripheral catecholaminergic lesions on cardiac and renal nucleic acids and proteins. 
  • Doing molecular biophysics: finding, naming, and picturing signal within complexity. 
  • Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. 
  • Dynamics of large elongated RNA by NMR carbon relaxation. 
  • Dynamics-based amplification of RNA function and its characterization by using NMR spectroscopy. 
  • Early activation and cell cycle entry of resting B cells after Fab-anti-Ig treatment: role of receptor crosslinking. 
  • Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chloropyrifos. 
  • Early estrogen action: concomitant stimulations within two minutes of nuclear RNA synthesis and uptake of RNA precursor by the uterus. 
  • Early estrogen action: nuclear synthesis and accumulation of protein correlated with enhancement of two DNA-dependent RNA polymerase activities. 
  • Effect of RNA secondary structure on polyadenylation site selection. 
  • Effect of transient hydronephrosis on subsequent compensatory renal growth. 
  • Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors. 
  • Effects of alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase, on nucleic acids and proteins in developing rat brain: critical perinatal periods for regional selectivity. 
  • Effects of magnesium ions on the stabilization of RNA oligomers of defined structures. 
  • Effects of neonatal methylmercury exposure on development of nucleic acids and proteins in rat brain: regional specificity. 
  • Effects of prenatal nicotine exposure on biochemical development of rat brain regions: maternal drug infusions via osmotic minipumps. 
  • Effects of prenatal terbutaline exposure on cellular development in lung and liver of neonatal rat: ornithine decarboxylase activity and macromolecules. 
  • Effects of vitamin A and phenobarbital on liver endoplasmic reticulum of rats. 
  • Efficient and specific repair of sickle beta-globin RNA by trans-splicing ribozymes. 
  • Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences. 
  • Elongation by Drosophila RNA polymerase II. Transcription of 3'-extended DNA templates. 
  • Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approach. 
  • Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit. 
  • Emerging clinical applications of RNA. 
  • Encoded multichromophore response for simultaneous label-free detection. 
  • Endoglin gene polymorphism as a risk factor for sporadic intracerebral hemorrhage. 
  • Endotoxin-stimulated nitric oxide production inhibits expression of cytochrome c oxidase in ANA-1 murine macrophages. 
  • Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone. 
  • Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. 
  • Enhancing RNA repair efficiency by combining trans-splicing ribozymes that recognize different accessible sites on a target RNA. 
  • Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation. 
  • Essential amino acid deprivation induces monocytic differentiation of the human HL-60 myeloid leukemia cell line. 
  • Estrogen-induced synthesis of ovalbumin messenger RNA and its translation in a cell-free system. 
  • Evaluating and enhancing ribozyme reaction efficiency in mammalian cells. 
  • Evaluating whole transcriptome amplification for gene profiling experiments using RNA-Seq. 
  • Evidence for depression of nuclear protein synthesis and concomitant stimulation of nuclear RNA synthesis during early estrogen action. 
  • Evidence that electrostatic interactions dictate the ligand-induced arrest of RNA global flexibility. 
  • Excitatory amino acid receptor activation produces a selective and long-lasting modulation of gene expression in hippocampal neurons. 
  • Exon circularization in mammalian nuclear extracts. 
  • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. 
  • Expression of CD44 and variant isoforms in cultured human retinal pigment epithelial cells. 
  • Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. 
  • Expression of a chemokine by ciliary body epithelium in horses with naturally occurring recurrent uveitis and in cultured ciliary body epithelial cells. 
  • Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2. 
  • Expression of aquaporin-1 in human trabecular meshwork cells: role in resting cell volume. 
  • Expression of c-fos in parietal endoderm, amnion and differentiating F9 teratocarcinoma cells. 
  • Expression of photosynthesis genes in relation to nitrogen fixation in the diazotrophic filamentous nonheterocystous cyanobacterium Trichodesmium sp. IMS 101. 
  • Expression of transforming growth factor beta 2 RNA during murine embryogenesis. 
  • Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex. 
  • Extending the NMR spatial resolution limit for RNA by motional couplings. 
  • Extraction and comparison of gene expression patterns from 2D RNA in situ hybridization images. 
  • Female steroid hormones and target cell nuclei. 
  • Functional complexity and regulation through RNA dynamics. 
  • GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity. 
  • Gating currents from a delayed rectifier K+ channel with altered pore structure and function. 
  • Gene Expression Analysis of Neurons and Astrocytes Isolated by Laser Capture Microdissection from Frozen Human Brain Tissues 
  • Gene Expression Profiling in the Hibernating Primate, Cheirogaleus Medius. 
  • Gene expression in the rectus abdominus muscle of patients with and without pelvic organ prolapse. 
  • Gene expression profile in human trabecular meshwork from patients with primary open-angle glaucoma. 
  • Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. 
  • Generation and characterization of circular Bacillus subtilis RNase P RNA; activation by RNase P protein. 
  • Generation of nuclease resistant circular RNA decoys for HIV-Tat and HIV-Rev by autocatalytic splicing. 
  • Generation of nuclease resistant circular RNA decoys for HIV-Tat and HIV-Rev by autocatalytic splicing. 
  • Generation of species cross-reactive aptamers using "toggle" SELEX. 
  • Genetic basis of murine responses to hyperoxia-induced lung injury. 
  • Genomic convergence: identifying candidate genes for Parkinson's disease by combining serial analysis of gene expression and genetic linkage. 
  • Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF). 
  • Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray. 
  • Group I permuted intron-exon (PIE) sequences self-splice to produce circular exons. 
  • Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork Cells. 
  • HIV-1 Rev promotes the nuclear export of unspliced and singly spliced RNAs in a mammalian cell-free export system. 
  • HL-A antigenic loss in malignant transformation. 
  • HMGB1 and microparticles as mediators of the immune response to cell death. 
  • Hedgehog signaling patterns mesoderm in the sea urchin. 
  • Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene. 
  • Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells. 
  • Hierarchy of RNA functional dynamics. 
  • Human Schlemm's canal cells express the endothelial adherens proteins, VE-cadherin and PECAM-1. 
  • Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. 
  • Human dendritic cells transfected with RNA encoding prostate-specific antigen stimulate prostate-specific CTL responses in vitro. 
  • Human granulosa-luteal and cumulus cells express transforming growth factors-beta type 1 and type 2 mRNA. 
  • Human thymic epithelial cells produce IL-6, granulocyte-monocyte-CSF, and leukemia inhibitory factor. 
  • Human thymic epithelial cells produce granulocyte and macrophage colony-stimulating factors. 
  • Hybrid male sterility in Mimulus (Phrymaceae) is associated with a geographically restricted mitochondrial rearrangement. 
  • Hybridoma SLE autoantibodies: insights for the pathogenesis of autoimmune disease. 
  • Identification of Tat-SF1 cellular targets by exon array analysis reveals dual roles in transcription and splicing. 
  • Identification of an alternate promoter in the rat androgen-binding protein/sex hormone-binding globulin gene that regulates synthesis of a messenger RNA encoding a protein with altered function. 
  • Identification of genes expressed in a human scleral cDNA library. 
  • Identification of liver cancer-specific aptamers using whole live cells. 
  • Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. 
  • Identification of multiple species of calmodulin messenger RNA using a full length complementary DNA. 
  • Identification of the RNA recognition element of the RBPMS family of RNA-binding proteins and their transcriptome-wide mRNA targets. 
  • Immune (gamma) interferon production by a murine T cell lymphoma: requirements for macromolecular synthesis and lack of relationship with cell cycle. 
  • Impact of exercise stress testing on diagnostic gene expression in patients with obstructive and nonobstructive coronary artery disease. 
  • Impact of the genetic background of transgenic mice upon the formation and timing of choroid plexus papillomas. 
  • Implementing a cumulative supermatrix approach for a comprehensive phylogenetic study of the Teloschistales (Pezizomycotina, Ascomycota). 
  • In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: comparative studies with TGF beta 1 and beta 2. 
  • In vitro chick embryo cell response to strain MC29 avian leukosis virus. 
  • In vitro selection of RNA epitopes using autoimmune patient serum. 
  • In vitro selection of an RNA epitope immunologically cross-reactive with a peptide. 
  • In vitro selection of aptamers from RNA libraries. 
  • In vitro synthesis of laminin and entactin polypeptides. 
  • In vitro synthesis of type IV procollagen. 
  • In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization. 
  • In vivo selection of tumor-targeting RNA motifs. 
  • Incorporation of ribonucleoside 5'-(alpha-P-borano)triphosphates into a 20-mer RNA by T7 RNA polymerase. 
  • Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria. 
  • Increased expression of the glucose-regulated gene encoding the Mr 78,000 glucose-regulated protein in chemically and radiation-transformed C3H 10T1/2 mouse embryo cells. 
  • Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells. 
  • Induction of human dendritic cell maturation using transfection with RNA encoding a dominant positive toll-like receptor 4. 
  • Induction of immediate-early genes by angiotensin II and endothelin-1 in adult rat cardiomyocytes. 
  • Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA. 
  • Induction of uterine prostaglandin H synthase 2 by estradiol following fetal adrenalectomy. 
  • Inflammatory biomarkers in osteoarthritis. 
  • Influence of dimethylsulfoxide on RNA structure and ligand binding. 
  • Inhibition of LPS toxicity for macrophages by metallothionein-inducing agents. 
  • Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function. 
  • Inhibition of nucleic acid methylation by cordycepin. In vivo synthesis of S-3'-DEOXYADENOSYLMETHIONINE BY WI-L2 human lymphoblasts. 
  • Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2. 
  • Initial sequencing and analysis of the human genome. 
  • Insight into the CSA tensors of nucleobase carbons in RNA polynucleotides from solution measurements of residual CSA: towards new long-range orientational constraints. 
  • Insights into domain-domain motions in proteins and RNA from solution NMR. 
  • Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. 
  • Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels. 
  • Isolation and analysis of recombinant DNA molecules containing yeast DNA. 
  • Isolation and characterization of a new chemokine receptor gene, the putative chicken CXCR1. 
  • Isolation and characterization of the rat chromosomal gene for a polypeptide (pS1) antigenically related to statin. 
  • Isolation and expression of multiple forms of beta amyloid protein precursor cDNAs. 
  • Isolation of a candidate cDNA for the gene causing retinal degeneration in the rd mouse. 
  • Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies. 
  • Isolation of a nuclease-resistant decoy RNA that selectively blocks autoantibody binding to insulin receptors on human lymphocytes. 
  • Isolation of the structural gene for calmodulin. 
  • Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. 
  • Know thyself. 
  • Long-term protein and calorie restriction: alterations in nucleic acid levels of organs of male rats. 
  • Macromolecular levels, DNA synthesis and ornithine decarboxylase activity in leg muscles from 6-mercaptopurine-treated rats. 
  • Mapping Hfq-RNA interaction surfaces using tryptophan fluorescence quenching. 
  • Maternal vitamin A restriction alters biochemical development of the brain in rats. 
  • Maturation of sympathetic neurotransmission in the rat heart. IV. Effects guanethidine-induced sympathectomy on neonatal development of synaptic vesicles, synaptic terminal function and heart growth. 
  • Maximization of signal derived from cDNA microarrays. 
  • Mechanism of estrogen action: early transcriptional and translational events. 
  • Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. 
  • Mechanisms of chromium-induced suppression of RNA synthesis in cellular and cell-free systems: relationship to RNA polymerase arrest. 
  • Mediation of meiotic and early mitotic chromosome segregation in Drosophila by a protein related to kinesin. 
  • Mesotheliomas induced in rats by the fibrous mineral erionite are independent from p53 alterations. 
  • Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis. 
  • Methods for the study of alternative splicing. 
  • MicroRNA target site identification by integrating sequence and binding information. 
  • Microarray analysis of gene expression in human donor sclera. 
  • Microinjection of Rap2B protein or RNA induces rearrangement of pigment granules in Xenopus oocytes. 
  • Microparticles as autoadjuvants in the pathogenesis of SLE. 
  • Mineralocorticoid receptor antagonists modulate galectin-3 and interleukin-33/ST2 signaling in left ventricular systolic dysfunction after acute myocardial infarction. 
  • Minor RNA and other components of host origin intrinsic to avian leukosis virus particles. 
  • Mitochondrial DNA structure and expression in specialized subtypes of mammalian striated muscle. 
  • Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA. 
  • Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells. 
  • Modulating RNA Alignment Using Directional Dynamic Kinks: Application in Determining an Atomic-Resolution Ensemble for a Hairpin using NMR Residual Dipolar Couplings. 
  • Molecular analysis of mutations in a patient with purine nucleoside phosphorylase deficiency. 
  • Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5. 
  • Molecular cloning and nucleotide sequence of cDNA encoding human muscle glycogen debranching enzyme. 
  • Molecular cloning of protein phosphatase inhibitor-1 and its expression in rat and rabbit tissues. 
  • Molecular cloning of rat glucose-dependent insulinotropic peptide (GIP). 
  • Molecular cloning of the cDNA for ligatin. 
  • Molecular composition of Ro small ribonucleoprotein complexes in human cells. Intracellular localization of the 60- and 52-kD proteins. 
  • Molecular structure of the La and Ro autoantigens and their use in autoimmune diagnostics. 
  • Morphological and biochemical changes which occur during postnatal development and maturation of the rat testis. 
  • Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity. 
  • Murine polypyrimidine tract binding protein. Purification, cloning, and mapping of the RNA binding domain. 
  • Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis. 
  • Mutation analysis of the THRA1 gene in breast cancer: deletion/fusion of the gene to a novel sequence on 17q in the BT474 cell line. 
  • Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K. 
  • Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene. 
  • NMR studies of RNA dynamics and structural plasticity using NMR residual dipolar couplings. 
  • NMR studies of nucleic acid dynamics. 
  • New insights into the fundamental role of topological constraints as a determinant of two-way junction conformation. 
  • Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos. 
  • Novel late-onset Alzheimer disease loci variants associate with brain gene expression. 
  • Nuclear RNA export pathways. 
  • Nuclear RNA export. 
  • Nuclear RNA-binding proteins. 
  • Nuclear estrogen receptor in the avian liver: correlation with biologic response. 
  • Nucleocytoplasmic shuttling by protein nuclear import factors. 
  • Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. 
  • Optimized lymphocyte protein extraction performed simultaneously with DNA and RNA isolation: application to the study of factors affecting DNA, RNA, and protein recovery from lymphocytes of the oldest individuals. 
  • Optimizing aptamer activity for gene therapy applications using expression cassette SELEX. 
  • Origin of overstretching transitions in single-stranded nucleic acids. 
  • Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells. 
  • PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data. 
  • Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. 
  • Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers. 
  • Perinatal dietary supplementation with a commercial soy lecithin preparation: effects on behavior and brain biochemistry in the developing rat. 
  • Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer. 
  • Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicing. 
  • Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. 
  • Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy. 
  • Positive and negative elements regulate human interleukin 3 expression. 
  • Postlipopolysaccharide oxidative damage of mitochondrial DNA. 
  • Postmortem delay has minimal effect on brain RNA integrity. 
  • Potential treatment for clubfeet based on growth factor blockade. 
  • Probing motions between equivalent RNA domains using magnetic field induced residual dipolar couplings: accounting for correlations between motions and alignment. 
  • Probiotic administration reduces mortality and improves intestinal epithelial homeostasis in experimental sepsis. 
  • Processing of nuclear heterogeneous RNA: recent developments. 
  • Properties of an intermediate-sized androgen receptor: association with RNA. 
  • Prospects for personalized cardiovascular medicine: the impact of genomics. 
  • Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. 
  • Protection against oxidized low-density lipoprotein-induced vascular endothelial cell death by integrin-linked kinase. 
  • Protein biosynthesis in the testis. V. Concerning the mechanism of stimulation by follicle-stimulating hormone. 
  • Pseudouridine and N6-methyladenosine modifications weaken PUF protein/RNA interactions. 
  • Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice. 
  • Quantification of alternatively spliced FGFR2 RNAs using the RNA invasive cleavage assay. 
  • Quantification of microRNAs, splicing isoforms, and homologous mRNAs with the invader assay. 
  • Quantitative measurement of alternatively spliced amyloid precursor protein mRNA expression in Alzheimer's disease and normal brain by S1 nuclease protection analysis. 
  • RNA Vaccination Therapy: Advances in an Emerging Field. 
  • RNA aptamer to thrombin binds anion-binding exosite-2 and alters protease inhibition by heparin-binding serpins. 
  • RNA aptamers as reversible antagonists of coagulation factor IXa. 
  • RNA as an RNA polymerase: net elongation of an RNA primer catalyzed by the Tetrahymena ribozyme. 
  • RNA backbone is rotameric. 
  • RNA backbone rotamers--finding your way in seven dimensions. 
  • RNA backbone: consensus all-angle conformers and modular string nomenclature (an RNA Ontology Consortium contribution). 
  • RNA binding by Sxl proteins in vitro and in vivo. 
  • RNA dynamics by design: biasing ensembles towards the ligand-bound state. 
  • RNA dynamics: it is about time. 
  • RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue. 
  • RNA interference and single particle tracking analysis of hepatitis C virus endocytosis. 
  • RNA recognition by autoantigens and autoantibodies. 
  • RNA recognition: towards identifying determinants of specificity. 
  • RNA regulons: coordination of post-transcriptional events. 
  • RNA repair: a novel approach to gene therapy. 
  • RNA subunit of mitochondrial RNA-processing enzyme is induced by contractile activity in striated muscle. 
  • RNA surfaces as functional mimetics of proteins. 
  • RNA synthesis in liver nuclei of young rats fed varying amounts of vitamin A. 
  • RNA transfected dendritic cells as cancer vaccines. 
  • RNA-transfected dendritic cells in cancer immunotherapy. 
  • RNA∶DNA hybrids initiate quasi-palindrome-associated mutations in highly transcribed yeast DNA. 
  • RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development. 
  • Randomization and selection of RNA to identify targets for RRM RNA-binding proteins and antibodies. 
  • Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release. 
  • Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection. 
  • Receptor binding, endocytosis, and mitogenesis of insulin-like growth factors I and II in fetal rat brain neurons. 
  • Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids. 
  • Reduction of folic acid-induced acute tubular injury by diuresis: an experimental model. 
  • Regulation of HIV-1 gene expression. 
  • Regulation of ornithine decarboxylase activity in the developing heart of euthyroid or hyperthyroid rats. 
  • Regulation of rat heart ornithine decarboxylase: change in affinity for ornithine evoked by neuronal, hormonal, and ontogenetic stimuli. 
  • Regulation of the testis sertoli cell by follicle stimulating hormone. 
  • Relationship between adipose stromal-vascular cells and adipocytes in human adipose tissue. 
  • Reparative capacity of airway epithelium impacts deposition and remodeling of extracellular matrix. 
  • Restoration of the cystic fibrosis transmembrane conductance regulator function by splicing modulation. 
  • Resveratrol prevention of oxidative stress damage to lens epithelial cell cultures is mediated by forkhead box O activity. 
  • Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo. 
  • Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration. 
  • Ribozyme-mediated revision of RNA and DNA. 
  • Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines. 
  • Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer. 
  • SLICER: inferring branched, nonlinear cellular trajectories from single cell RNA-seq data. 
  • Secretion and movement of wingless protein in the epidermis of the Drosophila embryo. 
  • Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor. 
  • Selection of circularization sites in a group I IVS RNA requires multiple alignments of an internal template-like sequence. 
  • Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis. 
  • Selective regulation of expression of protein kinase C beta isoenzymes occurs via alternative splicing. 
  • Sequence complexity of nuclear RNAs in adult rat tissues. 
  • Sequence complexity of nuclear and cytoplasmic ribonucleic acids from clonal neurotumor cell lines and brain sections of the rat. 
  • Sequence requirements for Rev multimerization in vivo. 
  • Sequence requirements for micro RNA processing and function in human cells. 
  • Single- and dual-fractal analysis of hybridization binding kinetics: biosensor applications. 
  • Single-stranded RNA facilitates nucleocapsid: APOBEC3G complex formation. 
  • Slowdown of Interhelical Motions Induces a Glass Transition in RNA. 
  • Spatially restricted patterns of expression of the homeobox-containing gene Hox 2.1. during mouse embryogenesis. 
  • Specificity of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. 
  • Statistical analysis of RNA backbone. 
  • Stimulation of cartilage macromolecule synthesis by adenosine 3',5'-monophosphate. 
  • Stimulation of synthesis of ribonucleic acid in sub-apical sections of Avena coleoptile by indolyl-3-acetic acid. 
  • Structural dynamics of a single-stranded RNA-helix junction using NMR. 
  • Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage. 
  • Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold. 
  • Studies on mode of action of vitamin A. 
  • Subcellular partitioning of MRP RNA assessed by ultrastructural and biochemical analysis. 
  • Systematic analysis of posttranscriptional gene expression. 
  • TERC is not a major gene in human neural tube defects. 
  • Tagging ribozyme reaction sites to follow trans-splicing in mammalian cells. 
  • Targeted genetic repair: an emerging approach to genetic therapy. 
  • Targeted inhibition of alphavbeta3 integrin with an RNA aptamer impairs endothelial cell growth and survival. 
  • Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy. Preservation of systolic function. 
  • Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. 
  • Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells. 
  • Testosterone regulates cell proliferation in aggressive fibromatosis (desmoid tumour). 
  • The 5' and 3' splice sites come together via a three dimensional diffusion mechanism. 
  • The DNA sequence of the human X chromosome. 
  • The claret locus in Drosophila encodes products required for eyecolor and for meiotic chromosome segregation. 
  • The clinical and environmental determinants of airway transcriptional profiles in allergic asthma. 
  • The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas. 
  • The content of DNA and RNA in microparticles released by Jurkat and HL-60 cells undergoing in vitro apoptosis. 
  • The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor. 
  • The effect of a single boranophosphate substitution with defined configuration on the thermal stability and conformation of a DNA duplex. 
  • The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. 
  • The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. 
  • The molecular basis of disease variability among cystic fibrosis patients carrying the 3849+10 kb C-->T mutation. 
  • The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. 
  • The neuronatin gene resides in a "micro-imprinted" domain on human chromosome 20q11.2. 
  • The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic. 
  • The potassium channel MBK1 (Kv1.1) is expressed in the mouse retina. 
  • The prevalence and regulation of antisense transcripts in Schizosaccharomyces pombe. 
  • The properties of microparticles from RAW 264.7 macrophage cells undergoing in vitro activation or apoptosis. 
  • The ribonome: a dominant force in co-ordinating gene expression. 
  • The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation. 
  • The spliceosome assembly pathway in mammalian extracts. 
  • The virology-RNA biology connection. 
  • Tissue-specific expression in mammalian brain, heart, and muscle of S1, a member of the elongation factor-1 alpha gene family. 
  • Topological constraints: using RNA secondary structure to model 3D conformation, folding pathways, and dynamic adaptation. 
  • Topology links RNA secondary structure with global conformation, dynamics, and adaptation. 
  • Total RNA isolation by a rapid centrifugation method. 
  • Towards structural genomics of RNA: rapid NMR resonance assignment and simultaneous RNA tertiary structure determination using residual dipolar couplings. 
  • Trans-splicing reactions by ribozymes. 
  • Transcript length heterogeneity at the small heat shock protein genes of Drosophila. 
  • Transcription in mouse embryo cells permissively infected by murine cytomegalovirus. 
  • Transcriptional inhibition by carcinogenic chromate: relationship to DNA damage. 
  • Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade. 
  • Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans. 
  • Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. 
  • Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. 
  • Tumor acquisition for biomarker research in lung cancer. 
  • U1-snRNP-A protein selects a ten nucleotide consensus sequence from a degenerate RNA pool presented in various structural contexts. 
  • Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch. 
  • Unveiling Inherent Degeneracies in Determining Population-Weighted Ensembles of Interdomain Orientational Distributions Using NMR Residual Dipolar Couplings: Application to RNA Helix Junction Helix Motifs. 
  • Up-regulation of recombination activating gene expression by signal transduction through the surface Ig receptor. 
  • Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury. 
  • Use of SYTO 13, a fluorescent dye binding nucleic acids, for the detection of microparticles in in vitro systems. 
  • Utility of 1H NMR chemical shifts in determining RNA structure and dynamics. 
  • Variable helix elongation as a tool to modulate RNA alignment and motional couplings. 
  • Variation in DNA and RNA synthetic responses during activation of lymphocytes from inbred strains of mice. 
  • Visualizing transient Watson-Crick-like mispairs in DNA and RNA duplexes. 
  • Vitamin A supply and biochemical development of the rat heart: studies on cellular DNA, RNA and protein. 
  • Whole exome sequencing of a dominant retinitis pigmentosa family identifies a novel deletion in PRPF31. 
  • Whole genome expression profiling of normal human fetal and adult ocular tissues. 
  • Y353/B: a candidate multiple-copy spermiogenesis gene on the mouse Y chromosome. 
  • beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. 
  • hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. 
  • m(1)A and m(1)G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs. 
  • permGPU: Using graphics processing units in RNA microarray association studies. 
• 

  Keywords of People

  • Been, Michael Douglas, Professor Emeritus of Biochemistry, Biochemistry
  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Buckley, Rebecca Hatcher, James Buren Sidbury Professor of Pediatrics, in the School of Medicine, Immunology
  • Davis, Erica Ellen, Associate Professor of Pediatrics, Cell Biology
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Computer Science
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • Luftig, Micah Alan, Associate Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Meyer, Kathryn, Assistant Professor of Biochemistry, Neurobiology
  • Premont, Richard Thomas, Associate Professor in Medicine, Medicine, Gastroenterology
  • Richardson, David C., Professor of Biochemistry, Duke Cancer Institute
  • Roy Choudhury, Kingshuk, Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Swaminathan, Madhav, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Professor of Experimental Surgery, in the School of Medicine, Immunology