Subject Areas on Research
- Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs.
- Identification of gemin5 as a novel 7-methylguanosine cap-binding protein.
- Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance.
- MAPK signal-integrating kinase controls cap-independent translation and cell type-specific cytotoxicity of an oncolytic poliovirus.
- Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.
- Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression.
- Pol II docking and pausing at growth and stress genes in C. elegans.
- Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression.
- Ribosomal RACK1:Protein Kinase C βII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation.
- Sequential synthesis of small capped RNA transcripts in vitro by vesicular stomatitis virus.
- Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing.
- The Carboxyl-terminal Domain of RNA Polymerase II Is Not Sufficient to Enhance the Efficiency of Pre-mRNA Capping or Splicing in the Context of a Different Polymerase.
- The eukaryotic translation initiation factor 4E is not modified during the course of vaccinia virus replication.
- The metabolic fate of independently initiated VSV mRNA transcripts.
- mRNA translation is compartmentalized to the endoplasmic reticulum following physiological inhibition of cap-dependent translation.
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