RNA Precursors
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Subject Areas on Research
- 5' exon replacement and repair by spliceosome-mediated RNA trans-splicing.
- A compensatory base change in human U2 snRNA can suppress a branch site mutation.
- A single nucleotide linked to a switch in metal ion reactivity preference in the HDV ribozymes.
- Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer.
- Ankyrin regulation: an alternatively spliced segment of the regulatory domain functions as an intramolecular modulator.
- Co-transcriptional splicing of pre-messenger RNAs: considerations for the mechanism of alternative splicing.
- Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution.
- Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.
- Difference between mitochondrial RNase P and nuclear RNase P.
- Dynamic microRNA gene transcription and processing during T cell development.
- Evaluating group I intron catalytic efficiency in mammalian cells.
- Exon circularization in mammalian nuclear extracts.
- Exploiting pre-rRNA processing in Diamond Blackfan anemia gene discovery and diagnosis.
- Generation and characterization of circular Bacillus subtilis RNase P RNA; activation by RNase P protein.
- Generation of nuclease resistant circular RNA decoys for HIV-Tat and HIV-Rev by autocatalytic splicing.
- Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage.
- Group I intron self-splicing with adenosine: evidence for a single nucleoside-binding site.
- Group I permuted intron-exon (PIE) sequences self-splice to produce circular exons.
- Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers.
- Identification of cis elements directing termination of yeast nonpolyadenylated snoRNA transcripts.
- Identification of cis-acting elements and splicing factors involved in the regulation of BIM Pre-mRNA splicing.
- Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability.
- Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II.
- PGC-1α senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII.
- Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway.
- Phospho-carboxyl-terminal domain binding and the role of a prolyl isomerase in pre-mRNA 3'-End formation.
- Positive patches and negative noodles: linking RNA processing to transcription?
- Proximity-dependent and proximity-independent trans-splicing in mammalian cells.
- RNA as an RNA polymerase: net elongation of an RNA primer catalyzed by the Tetrahymena ribozyme.
- Regulation of Co-transcriptional Pre-mRNA Splicing by m6 A through the Low-Complexity Protein hnRNPG.
- Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing.
- Structural plasticity and Mg2+ binding properties of RNase P P4 from combined analysis of NMR residual dipolar couplings and motionally decoupled spin relaxation.
- Structure and function of the native and recombinant mitochondrial MRP1/MRP2 complex from Trypanosoma brucei.
- The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p.
- The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P.
- The conserved dinucleotide AG of the 3' splice site may be recognized twice during in vitro splicing of mammalian mRNA precursors.
- The deafness-associated mitochondrial DNA mutation at position 7445, which affects tRNASer(UCN) precursor processing, has long-range effects on NADH dehydrogenase subunit ND6 gene expression.
- The natural 5' splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA.
- The poly(A) site sequence in HDV RNA alters both extent and rate of self-cleavage of the antigenomic ribozyme.
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Keywords of People
- Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
- Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology