RNA Replicase

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  Subject Areas on Research

  • Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages. 
  • Characterizing the role of RNA silencing components in Cryptococcus neoformans. 
  • Cooperation between the Hepatitis C Virus p7 and NS5B Proteins Enhances Virion Infectivity. 
  • Detection and phylogenetic analysis of group 1 coronaviruses in South American bats. 
  • Detection of a novel and highly divergent coronavirus from asian leopard cats and Chinese ferret badgers in Southern China. 
  • Hepatitis C virus NS5B polymerase: QM/MM calculations show the important role of the internal energy in ligand binding. 
  • Inhibition of hepatitis C viral RNA-dependent RNA polymerase by α-P-boranophosphate nucleotides: exploring a potential strategy for mechanism-based HCV drug design. 
  • Interferon and ribavirin therapy does not select for resistance mutations in hepatitis C virus polymerase. 
  • Lack of evidence for VPg priming of poliovirus RNA synthesis in the host factor-dependent in vitro replicase reaction. 
  • Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. 
  • Multiple gene segments control the temperature sensitivity and attenuation phenotypes of ca B/Ann Arbor/1/66. 
  • Poliovirus replicase stimulation by terminal uridylyl transferase. 
  • Processing of SeMV polyproteins revisited. 
  • Purification of a terminal uridylyltransferase that acts as host factor in the in vitro poliovirus replicase reaction. 
  • RNA as an RNA polymerase: net elongation of an RNA primer catalyzed by the Tetrahymena ribozyme. 
  • Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. 
  • Rotavirus RNA polymerase requires the core shell protein to synthesize the double-stranded RNA genome. 
  • The origins of defective interfering particles of the negative-strand RNA viruses.