RNA, Double-Stranded
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Subject Areas on Research
- 5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage.
- A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila.
- A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling.
- Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor.
- Antiviral activity of mismatched double-stranded RNA against human immunodeficiency virus in vitro.
- B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster.
- Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK.
- Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.
- Clinical, immunological, and virological effects of ampligen, a mismatched double-stranded RNA, in patients with AIDS or AIDS-related complex.
- Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
- Crystal structure of an Escherichia coli Hfq Core (residues 2-69)-DNA complex reveals multifunctional nucleic acid binding sites.
- DNA and RNA topoisomerase activities of Top3β are promoted by mediator protein Tudor domain-containing protein 3.
- Derivation and function of small interfering RNAs and microRNAs.
- Design and implementation of high-throughput RNAi screens in cultured Drosophila cells.
- Differential Induction of Immunogenic Cell Death and Interferon Expression in Cancer Cells by Structured ssRNAs.
- Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures.
- Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer.
- Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays.
- Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease.
- FlyRNAi: the Drosophila RNAi screening center database.
- Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli.
- Human endometrial epithelial cells cyclically express Toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA.
- Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates.
- In vitro evaluation of mismatched double-stranded RNA (ampligen) for combination therapy in the treatment of acquired immunodeficiency syndrome.
- Inhibition of HIV-1 proviral DNA synthesis and RNA accumulation by mismatched dsRNA.
- Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma.
- Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages.
- Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA.
- Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide sequences of four distinct types including tonin.
- Kinetics of cytokine expression in melanoma metastases classifies immune responsiveness.
- Matter arising: off-targets and genome-scale RNAi screens in Drosophila.
- Mismatched dsRNA (ampligen) induces protection against genomic variants of the human immunodeficiency virus type 1 (HIV-1) in a multiplicity of target cells.
- PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling.
- RNA interference: antiviral defense and genetic tool.
- RNA modification of an RNA modifier prevents self-RNA sensing.
- Resolving the motional modes that code for RNA adaptation.
- Rotavirus RNA polymerase requires the core shell protein to synthesize the double-stranded RNA genome.
- Self-cleavage of hepatitis delta virus genomic strand RNA is enhanced under partially denaturing conditions.
- TLR3 Ligand Poly(I:C) Exerts Distinct Actions in Synovial Fibroblasts When Delivered by Extracellular Vesicles.
- The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site.
- The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis.
- The effects of CpG DNA on HMGB1 release by murine macrophage cell lines.
- The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation.
- The sequences of reovirus serotype 3 genome segments M1 and M3 encoding the minor protein mu 2 and the major nonstructural protein mu NS, respectively.
- Tombusvirus p19 Captures RNase III-Cleaved Double-Stranded RNAs Formed by Overlapping Sense and Antisense Transcripts in Escherichia coli.
- m(1)A and m(1)G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs.