RNA, Neoplasm

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  Subject Areas on Research

  • A cytokine cocktail directly modulates the phenotype of DC-enriched anti-tumor T cells to convey potent anti-tumor activities in a murine model. 
  • A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer. 
  • A genomic- and proteomic-based hypothesis on the eclectic effects of systemic interleukin-2 administration in the context of melanoma-specific immunization. 
  • A novel human cancer culture model for the study of prostate cancer. 
  • A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line. 
  • Acquisition of a side population fraction augments malignant phenotype in ovarian cancer. 
  • Altered genetic response to beta-adrenergic receptor activation in late passage C6 glioma cells. 
  • Analytical validation of a practical molecular assay prognostic of survival in nonsquamous non-small cell lung cancer. 
  • Antineoplastic activity of a series of boron analogues of alpha-amino acids. 
  • Antineoplastic activity of tetrakis-mu-(trimethylamine-boranecarboxylato)-bis (trimethylamine-carboxyborane)dicopper (II) in Ehrlich ascites carcinoma. 
  • Array CGH profiling of favourable histology Wilms tumours reveals novel gains and losses associated with relapse. 
  • Association between ratio of matrix metalloproteinase-1 to tissue inhibitor of metalloproteinase-1 and local recurrence, metastasis, and survival in human chondrosarcoma. 
  • Association of genomic subtypes of lower-grade gliomas with shape features automatically extracted by a deep learning algorithm. 
  • BP1, a new homeobox gene, is frequently expressed in acute leukemias. 
  • Biobanking of human pancreas cancer tissue: impact of ex-vivo procurement times on RNA quality. 
  • Bone Morphogenetic Proteins Are Expressed by Both Bone-Forming and Non-Bone-Forming Lesions. 
  • Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors. 
  • CDKN2 in HPV-positive and HPV-negative cervical-carcinoma cell lines. 
  • Cell cycle regulation of human pancreatic cancer by tamoxifen. 
  • Characterization of platelet-derived growth factor and platelet-derived growth factor receptor expression in asbestos-induced rat mesothelioma. 
  • Cloning of DNA corresponding to rare transcripts of rat brain: evidence of transcriptional and post-transcriptional control and of the existence of nonpolyadenylated transcripts. 
  • Co-expression of urokinase with haptoglobin in human carcinomas. 
  • Comprehensive molecular portraits of human breast tumours. 
  • Cooperation between transcription factor AP-1 and NF-kappaB in the induction of interleukin-8 in human pancreatic adenocarcinoma cells by hypoxia. 
  • Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein. 
  • Dendritic cells pulsed with pancreatic cancer total tumor RNA generate specific antipancreatic cancer T cells. 
  • Detection of DNA damage in transcriptionally active genes by RT-PCR and assessment of repair of cisplatin-induced damage in the glutathione S-transferase-pi gene in human glioblastoma cells. 
  • Development and Verification of an RNA Sequencing (RNA-Seq) Assay for the Detection of Gene Fusions in Tumors. 
  • Development and validation of a method for using breast core needle biopsies for gene expression microarray analyses. 
  • Different effects of glucose starvation on expression and stability of VEGF mRNA isoforms in murine ovarian cancer cells. 
  • Differential expression of ros oncogene in primary human astrocytomas and astrocytoma cell lines. 
  • Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines. 
  • Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs. 
  • Direct and Label-Free Detection of MicroRNA Cancer Biomarkers using SERS-Based Plasmonic Coupling Interference (PCI) Nanoprobes. 
  • Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia. 
  • Effective treatment of experimental DU-145 prostate cancers with targeted cytotoxic somatostatin analog AN-238. 
  • Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy. 
  • Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. 
  • Evaluation of expression based markers for the detection of breast cancer cells. 
  • Expression and amplification of the HER-2/neu (c-erbB-2) protooncogene in epithelial ovarian tumors and cell lines. 
  • Expression and prognostic impact of lncRNAs in acute myeloid leukemia. 
  • Expression of insulin-like growth factor II in spontaneously immortalized rat mesothelial and spontaneous mesothelioma cells: a potential autocrine role of insulin-like growth factor II. 
  • Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta. 
  • Expression profiling of non-small cell lung carcinoma identifies metastatic genotypes based on lymph node tumor burden. 
  • Gastrin-releasing peptide gene expression in small cell and large cell undifferentiated lung carcinomas. 
  • Gene expression profiles for the prediction of progression-free survival in diffuse large B cell lymphoma: results of a DASL assay. 
  • Genetic basis for p53 overexpression in human breast cancer. 
  • Glial fibrillary acidic protein synthesized in vitro using messenger RNA from a human glioma cell line. 
  • Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays. 
  • Gremlin is overexpressed in lung adenocarcinoma and increases cell growth and proliferation in normal lung cells. 
  • HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. 
  • High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. 
  • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. 
  • Human ovarian cancers express somatostatin receptors. 
  • Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA. 
  • Identification of an amplified, highly expressed gene in a human glioma. 
  • Identification of prohibitin and prohibiton as novel factors binding to the p53 induced gene 3 (PIG3) promoter (TGYCC)(15) motif. 
  • Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells. 
  • Immunotherapy of cancer with dendritic cell-based vaccines. 
  • Immunotherapy of cancer with dendritic-cell-based vaccines. 
  • Impact of Specimen Heterogeneity on Biomarkers in Repository Samples from Patients with Acute Myeloid Leukemia: A SWOG Report. 
  • Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. 
  • Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells. 
  • Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor RNA. 
  • Induction of transformational changes in normal endothelial cells by cultured human astrocytoma cells. 
  • Induction of tumor immunity and cytotoxic T lymphocyte responses using dendritic cells transfected with messenger RNA amplified from tumor cells. 
  • Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma. 
  • Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer. 
  • Integrative gene expression profiling reveals G6PD-mediated resistance to RNA-directed nucleoside analogues in B-cell neoplasms. 
  • JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. 
  • Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1. 
  • Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 derived miniRNA as a novel plasma-based biomarker for diagnosing prostate cancer. 
  • Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis. 
  • Maintenance of p53 alterations throughout breast cancer progression. 
  • Marshall Urist Award. Interstitial collagenase gene expression correlates with in vitro invasion in human chondrosarcoma. 
  • Maspin expression profile in human prostate cancer (CaP) and in vitro induction of Maspin expression by androgen ablation. 
  • Metastatic clear cell renal cell carcinoma: Circulating biomarkers to guide antiangiogenic and immune therapies. 
  • Micro-RNA-181a regulates osteopontin-dependent metastatic function in hepatocellular cancer cell lines. 
  • Molecular classification of human carcinomas by use of gene expression signatures. 
  • Molecular prediction of recurrence of breast cancer. 
  • Molecular staging of malignant melanoma: correlation with clinical outcome. 
  • Outcomes of Hormone-Receptor Positive, HER2-Negative Breast Cancers by Race and Tumor Biological Features. 
  • Overexpression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor. 
  • PC3 is a cell line characteristic of prostatic small cell carcinoma. 
  • PD-L1 expression is low in large B-cell lymphoma with MYC or double-hit translocation. 
  • PIG-A, DAF and proto-oncogene expression in paroxysmal nocturnal haemoglobinuria-associated acute myelogenous leukaemia blasts. 
  • Pancreatic adenocarcinoma cell line, MDAPanc-28, with features of both acinar and ductal cells. 
  • Placenta-Specific Protein 1 Expression in Human Papillomavirus 16/18-Positive Cervical Cancers Is Associated With Tumor Histology. 
  • Polymerase chain reaction detection of the BCR-ABL fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in 346 patients. 
  • Pre-clinical evaluation of SN-38 and novel camptothecin analogs against human chronic B-cell lymphocytic leukemia lymphocytes. 
  • Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines. 
  • Prediction of optimal versus suboptimal cytoreduction of advanced-stage serous ovarian cancer with the use of microarrays. 
  • Prognostic value and function of KLF4 in prostate cancer: RNAa and vector-mediated overexpression identify KLF4 as an inhibitor of tumor cell growth and migration. 
  • Protection against daunorubicin cytotoxicity by expression of a cloned human carbonyl reductase cDNA in K562 leukemia cells. 
  • Protein expression and functional analysis of the FHIT gene in human tumor cells. 
  • RNA transfected dendritic cells as cancer vaccines. 
  • RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. 
  • Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study. 
  • Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids. 
  • Reduced expression of mismatch repair genes measured by multiplex reverse transcription-polymerase chain reaction in human gliomas. 
  • Results of a Phase I study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children with Stage 4 neuroblastoma. 
  • Results of a phase 1 study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children and young adults with brain cancer. 
  • Retinoic acid modulation of alpha(1-->2) fucosyltransferase activity and sensitivity of tumor cells to LAK-mediated cytotoxicity. 
  • Ribonucleic acid components of BAI strain A (myeloblastosis) avian tumor virus. 
  • SET alpha and SET beta mRNA isoforms in chronic lymphocytic leukaemia. 
  • Selection and validation of endogenous reference genes using a high throughput approach. 
  • Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. 
  • Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217. 
  • Synergy between tumor immunotherapy and antiangiogenic therapy. 
  • Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1. 
  • Targeted suppression of beta-catenin blocks intestinal adenoma formation in APC Min mice. 
  • Targeting the Wnt-Regulatory Protein CTNNBIP1 by microRNA-214 Enhances the Stemness and Self-Renewal of Cancer Stem-Like Cells in Lung Adenocarcinomas. 
  • The colorectal microRNAome. 
  • The efficacy and safety of gemcitabine, cisplatin, prednisone, thalidomide versus CHOP in patients with newly diagnosed peripheral T-cell lymphoma with analysis of biomarkers. 
  • The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype. 
  • The role of ribosomal subunits and 80-S monomers in polysome formation in an ascites tumour cell. 
  • The synthesis and anti-neoplastic activity of N2-isobutyryl-2'-deoxyguanosine-N7-cyanoborane derivatives. 
  • Transcript expression in endometrial cancers from Black and White patients. 
  • Transfection of RNA encoding tumor antigens following maturation of dendritic cells leads to prolonged presentation of antigen and the generation of high-affinity tumor-reactive cytotoxic T lymphocytes. 
  • Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells. 
  • Transforming growth factor-beta differentially inhibits epithelial ovarian carcinoma cells from primary and metastatic isolates without up-regulation of p21WAF1. 
  • Treatment of murine peritoneal macrophages with bacterial lipopolysaccharide alters expression of c-fos and c-myc oncogenes. 
  • Tumor interferon signaling and suppressive myeloid cells are associated with CAR T-cell failure in large B-cell lymphoma. 
  • Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. 
  • Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma. 
  • Virus-induced genitourinary malignancy. Macromolecular identity. 
  • [GIPC: a new target for therapy in pancreatic adenocarcinoma?]. 
  • miR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology