RNA, Small Nuclear

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  Subject Areas on Research

  • A compensatory base change in U1 snRNA suppresses a 5' splice site mutation. 
  • A compensatory base change in human U2 snRNA can suppress a branch site mutation. 
  • A rare example of lock-and-key RNA recognition. 
  • A sequence-specific conformational epitope on U1 RNA is recognized by a unique autoantibody. 
  • A specific 31-nucleotide domain of U1 RNA directly interacts with the 70K small nuclear ribonucleoprotein component. 
  • An ATP-independent U2 small nuclear ribonucleoprotein particle/precursor mRNA complex requires both splice sites and the polypyrimidine tract. 
  • Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA. 
  • Autoantibodies specific for U1 RNA and initiator methionine tRNA. 
  • Connections between the processing and nuclear export of mRNA: evidence for an export license? 
  • Downregulation of RNA polymerase III transcription of the hY3 gene in vitro. 
  • Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus. 
  • Group-I intron family in the nuclear ribosomal RNA small subunit genes of Cenococcum geophilum isolates. 
  • In vitro RNA selection of an autoimmune epitope on stem-loop II of U1 RNA. 
  • In vitro selection of RNA epitopes using autoimmune patient serum. 
  • In vitro selection of an RNA epitope immunologically cross-reactive with a peptide. 
  • Inhibitory effects of vesicular stomatitis virus on cellular and influenza viral RNA metabolism and protein synthesis. 
  • Interactions between small viral RNAs of vesicular stomatitis virus and components of cellular gene expression. 
  • Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions. 
  • Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA. 
  • RNA binding specificity of a Drosophila snRNP protein that shares sequence homology with mammalian U1-A and U2-B" proteins. 
  • RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins. 
  • Randomization and selection of RNA to identify targets for RRM RNA-binding proteins and antibodies. 
  • Recognition of U-rich RNA by Hfq from the Gram-positive pathogen Listeria monocytogenes. 
  • Recognition of U1 and U2 small nuclear RNAs can be altered by a 5-amino-acid segment in the U2 small nuclear ribonucleoprotein particle (snRNP) B" protein and through interactions with U2 snRNP-A' protein. 
  • Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. 
  • The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P. 
  • The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function. 
  • The natural 5' splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA. 
  • Trans-activating rev protein of the human immunodeficiency virus 1 interacts directly and specifically with its target RNA. 
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  Keywords of People

  • Shinohara, Mari L., Associate Professor of Immunology, Immunology