Sarcomeres

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  Subject Areas on Research

  • A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy. 
  • Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. 
  • Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues. 
  • Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues. 
  • Different obscurin isoforms localize to distinct sites at sarcomeres. 
  • Distinguishing hypertrophic cardiomyopathy-associated mutations from background genetic noise. 
  • Drebrin-like protein DBN-1 is a sarcomere component that stabilizes actin filaments during muscle contraction. 
  • Effect of a dominant negative ras on myocardial hypertrophy by using adenoviral-mediated gene transfer. 
  • Feedback-control induced pattern formation in cardiac myocytes: a mathematical modeling study. 
  • HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. 
  • Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. 
  • Morphology and mechanics of tongue movement in the African pig-nosed frog Hemisus marmoratum: a muscular hydrostatic model. 
  • Morphology and ultrastructure of differentiating three-dimensional mammalian skeletal muscle in a collagen gel. 
  • Morphomechanic phenotypic variability of sarcomeric cardiomyopathies: A multifactorial polygenic perspective. 
  • Muscle giants: molecular scaffolds in sarcomerogenesis. 
  • Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases. 
  • Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly. 
  • Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction. 
  • Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice. 
  • Pacemaker-induced transient asynchrony suppresses heart failure progression. 
  • Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations. 
  • Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi. 
  • S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes. 
  • Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model. 
  • Stretching single protein molecules: titin is a weird spring. 
  • Structural remodeling of cardiac myocytes in patients with ischemic cardiomyopathy. 
  • The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy. 
  • The basketweave form of the Z-band is expanded relative to the small-square form. 
  • The clash in titin. 
  • The influence of masseter and temporalis sarcomere length operating ranges as determined by laser diffraction on architectural estimates of muscle force and excursion in macaques (Macaca fascicularis and Macaca mulatta). 
  • The morphology of the masticatory apparatus facilitates muscle force production at wide jaw gapes in tree-gouging common marmosets (Callithrix jacchus). 
  • VDAC2 as a novel target for heart failure: Ca2+ at the sarcomere, mitochondria and SR. 
  • Variant R94C in TNNT2-Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction. 
  • p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity. 
  • zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation.