Subject Areas on Research
- A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy.
- Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells.
- Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues.
- Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues.
- Different obscurin isoforms localize to distinct sites at sarcomeres.
- Distinguishing hypertrophic cardiomyopathy-associated mutations from background genetic noise.
- Drebrin-like protein DBN-1 is a sarcomere component that stabilizes actin filaments during muscle contraction.
- Effect of a dominant negative ras on myocardial hypertrophy by using adenoviral-mediated gene transfer.
- Feedback-control induced pattern formation in cardiac myocytes: a mathematical modeling study.
- HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
- Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration.
- Morphology and mechanics of tongue movement in the African pig-nosed frog Hemisus marmoratum: a muscular hydrostatic model.
- Morphology and ultrastructure of differentiating three-dimensional mammalian skeletal muscle in a collagen gel.
- Morphomechanic phenotypic variability of sarcomeric cardiomyopathies: A multifactorial polygenic perspective.
- Muscle giants: molecular scaffolds in sarcomerogenesis.
- Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases.
- Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly.
- Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.
- Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice.
- Pacemaker-induced transient asynchrony suppresses heart failure progression.
- Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations.
- Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi.
- S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes.
- Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model.
- Stretching single protein molecules: titin is a weird spring.
- Structural remodeling of cardiac myocytes in patients with ischemic cardiomyopathy.
- The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy.
- The basketweave form of the Z-band is expanded relative to the small-square form.
- The clash in titin.
- The influence of masseter and temporalis sarcomere length operating ranges as determined by laser diffraction on architectural estimates of muscle force and excursion in macaques (Macaca fascicularis and Macaca mulatta).
- The morphology of the masticatory apparatus facilitates muscle force production at wide jaw gapes in tree-gouging common marmosets (Callithrix jacchus).
- VDAC2 as a novel target for heart failure: Ca2+ at the sarcomere, mitochondria and SR.
- Variant R94C in TNNT2-Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction.
- p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.
- zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation.