Serine

• 

  Subject Areas on Research

  • 14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening. 
  • A STE12 homolog is required for mating but dispensable for filamentation in candida lusitaniae. 
  • A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism. 
  • A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism. 
  • A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25. 
  • A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. 
  • ALSUntangled 38: L-serine. 
  • ATM functions at the peroxisome to induce pexophagy in response to ROS. 
  • ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. 
  • ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. 
  • ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. 
  • Acute in vivo genetic rescue demonstrates that phosphorylation of RIM1alpha serine 413 is not required for mossy fiber long-term potentiation. 
  • Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase. 
  • Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant. 
  • Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling. 
  • An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. 
  • Analysis of the structural properties of cAMP-responsive element-binding protein (CREB) and phosphorylated CREB. 
  • Angiotensin II-induced hypertrophy of rat vascular smooth muscle is associated with increased 18 S rRNA synthesis and phosphorylation of the rRNA transcription factor, upstream binding factor. 
  • ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. 
  • Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway. 
  • Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. 
  • Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s). 
  • C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats. 
  • Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. 
  • Cerebrospinal fluid amino acids glycine, serine, and threonine in nonketotic hyperglycinemia. 
  • Characterization of PDK2 activity against protein kinase B gamma. 
  • Characterization of the PC4 binding domain and its interactions with HNF4alpha. 
  • Characterization of the usage of the serine metabolic network in human cancer. 
  • Chemoattractant receptor-induced phosphorylation of L-selectin. 
  • Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest. 
  • Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1. 
  • Combinatorial control of cyclin B1 nuclear trafficking through phosphorylation at multiple sites. 
  • Control of proteoglycan synthesis. Studies on the activation of synthesis observed during culture of articular cartilages. 
  • Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport. 
  • Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. 
  • Cortisol responses to emotional stress in men: association with a functional polymorphism in the 5HTR2C gene. 
  • Covalently bound phosphate residues in bovine milk xanthine oxidase and in glucose oxidase from Aspergillus niger: a reevaluation. 
  • Cysteine-rich regions of pig gastric mucin contain von willebrand factor and cystine knot domains at the carboxyl terminal(1). 
  • DNA damage induces phosphorylation of the amino terminus of p53. 
  • DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells. 
  • Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion. 
  • Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs. 
  • Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease. 
  • Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. 
  • Effect of chemical modification of dihydrouridine in yeast transfer ribonucleic acid on amino acid acceptor activity and ribosomal binding. 
  • Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply. 
  • Efficacy of Glutamate Modulators in Tic Suppression: A Double-Blind, Randomized Control Trial of D-serine and Riluzole in Tourette Syndrome. 
  • Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers. 
  • Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase. 
  • Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes. 
  • Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth. 
  • Erythrocyte Webb-type glycophorin C variant lacks N-glycosylation due to an asparagine to serine substitution. 
  • Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats. 
  • Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. 
  • Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. 
  • Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases. 
  • Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease. 
  • Functional properties of hemoglobin Pôrto Alegre (alpha2A beta2 9Ser leads to Cys) and the reactivity of its extra cysteinyl residue. 
  • GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. 
  • Genetic selection for enhanced serine metabolism in cancer development. 
  • Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment. 
  • Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. 
  • Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutants. 
  • Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication. 
  • Identification and functional analysis of in vivo phosphorylation sites of the Arabidopsis BRASSINOSTEROID-INSENSITIVE1 receptor kinase. 
  • Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes. 
  • Identification of three protein kinases which phosphorylate threonyl-tRNA synthetase from rat liver. 
  • Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. 
  • In silico experimentation with a model of hepatic mitochondrial folate metabolism. 
  • In vitro toxicology of fumonisins and the mechanistic implications. 
  • Influence of amino acids cysteine and serine on aggregation kinetics of zinc and mercury sulfide colloids 
  • Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation. 
  • Intragenic modifiers of hereditary spastic paraplegia due to spastin gene mutations. 
  • Ionizing radiation activates the ATM kinase throughout the cell cycle. 
  • Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect? 
  • Juvenile bilateral lens dislocation and glaucoma associated with a novel mutation in the fibrillin 1 gene. 
  • Kinetic studies of tryptophan synthetase. Interaction of L-serine, indole, and tryptophan with the native enzyme. 
  • Kinetic studies of tryptophan synthetase. Interaction of substrates with the B subunit. 
  • Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway. 
  • L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro. 
  • Large-scale quantitative LC-MS/MS analysis of detergent-resistant membrane proteins from rat renal collecting duct. 
  • Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. 
  • Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. 
  • Mechanistic Insight into the Suppression of Polyglutamine Aggregation by SRCP1. 
  • Metabolic pathway alterations that support cell proliferation. 
  • Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9. 
  • Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression. 
  • Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA. 
  • Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women. 
  • Molecular determinants of nuclear protein phosphatase-1 regulation by NIPP-1. 
  • Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression. 
  • Mutation of bcl-x gene in non-Hodgkin's lymphoma. 
  • Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit. 
  • Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease. 
  • Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer. 
  • Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation. 
  • Oligonucleotides produced by digestion of bakers' yeast serine transfer ribonucleic acid with specific nucleases. 
  • Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. 
  • One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels. 
  • PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. 
  • PHAS-I as a link between mitogen-activated protein kinase and translation initiation. 
  • Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. 
  • Partial agonist activity of the progesterone receptor antagonist RU486 mediated by an amino-terminal domain coactivator and phosphorylation of serine400. 
  • Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. 
  • Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. 
  • Phosphorylation analysis of G protein-coupled receptor by mass spectrometry: identification of a phosphorylation site in V2 vasopressin receptor. 
  • Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). 
  • Phosphorylation of DHBV pre-S: identification of the major site of phosphorylation and effects of mutations on the virus life cycle. 
  • Phosphorylation of MeCP2 at Ser421 contributes to chronic antidepressant action. 
  • Phosphorylation of Ser136 is critical for potent bone sialoprotein-mediated nucleation of hydroxyapatite crystals. 
  • Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors. 
  • Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK. 
  • Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. 
  • Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. 
  • Phosphorylation of the cyclin b1 cytoplasmic retention sequence by mitogen-activated protein kinase and Plx. 
  • Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress. 
  • Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. 
  • Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor. 
  • Phosphorylation of the translational regulator, PHAS-I, by protein kinase CK2. 
  • Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro. 
  • Platelet-derived growth factor (PDGF) regulates Slingshot phosphatase activity via Nox1-dependent auto-dephosphorylation of serine 834 in vascular smooth muscle cells. 
  • Polymorphisms of TP53 Arg72Pro, but not p73 G4C14>A4TA4 and p21 Ser31Arg, contribute to risk of cutaneous melanoma. 
  • Protein kinase C phosphorylates nonmuscle myosin-II heavy chain from Drosophila but regulation of myosin function by this enzyme is not required for viability in flies. 
  • Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis. 
  • Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress. 
  • Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory. 
  • Purification of serine-specific transfer ribonucleic acid from bakers' yeast. 
  • Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. 
  • Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells. 
  • Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes. 
  • Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions. 
  • Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. 
  • Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2. 
  • Restriction of 480/270-kD ankyrin G to axon proximal segments requires multiple ankyrin G-specific domains. 
  • Revisiting the Role of Ser982 Phosphorylation in Stoichiometry Shift of the Electrogenic Na+/qHCO3- Cotransporter NBCe1. 
  • Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor. 
  • Role of myosin-II phosphorylation in V12Cdc42-mediated disruption of Drosophila cellularization. 
  • Role of unusual P loop ejection and autophosphorylation in HipA-mediated persistence and multidrug tolerance. 
  • Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes. 
  • SRCP1 Conveys Resistance to Polyglutamine Aggregation. 
  • Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity. 
  • Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism. 
  • Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape. 
  • Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer. 
  • Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCα enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells. 
  • Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells. 
  • Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism. 
  • Serine, glycine and one-carbon units: cancer metabolism in full circle. 
  • Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. 
  • Signal transduction. Unexpected mediators of protein phosphorylation. 
  • Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle. 
  • Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2. 
  • Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides. 
  • Sodium dodecyl sulfate-stable complexes between serpins and active or inactive proteinases contain the region COOH-terminal to the reactive site loop. 
  • Specific interaction of the transcription elongation regulator TCERG1 with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5, and Ser7 within the carboxyl-terminal domain repeat. 
  • Sphingolipid biosynthesis by rat liver cells: effects of serine, fatty acids and lipoproteins. 
  • Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion. 
  • Stimulation of different subtypes of angiotensin II receptors, AT1 and AT2 receptors, regulates STAT activation by negative crosstalk. 
  • Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P. 
  • Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose 6-phosphate and fructose 1,6-bisphosphate. 
  • Structure of macromolecular aggregates. II. Construction of model membranes from phospholipids and polypeptides. 
  • Structure-guided reprogramming of serine recombinase DNA sequence specificity. 
  • Sucrose Nonfermenting 1-Related Protein Kinase 1 Phosphorylates a Geminivirus Rep Protein to Impair Viral Replication and Infection. 
  • Suicide substrates for the alanine racemase of Escherichia coli B. 
  • TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877. 
  • TGF beta signals through a heteromeric protein kinase receptor complex. 
  • Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking. 
  • The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition. 
  • The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. 
  • The acceptor substrate specificity of porcine submaxillary UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase is dependent on the amino acid sequences adjacent to serine and threonine residues. 
  • The effect of fumonisin B1 on developing chick embryos: correlation between de novo sphingolipid biosynthesis and gross morphological changes. 
  • The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. 
  • The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition. 
  • The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation. 
  • The substrate specificity of cyclic AMP-dependent protein kinase: amino acid sequences at the phosphorylation sites of herring protamine (clupeine). 
  • Therapy of malignant hamster insulinomas with monoamine precursors. 
  • Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression. 
  • WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. 
  • beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Charles, Hal Cecil, Adjunct Associate Professor in the Department of Radiology, Radiology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Hsu-Kim, Heileen, Professor in the Department of Civil and Environmental Engineering, Civil and Environmental Engineering