Serine Endopeptidases

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  Subject Areas on Research

  • A Fluorescent Cell-Based System for Imaging Zika Virus Infection in Real-Time. 
  • A Multibiomarker-Based Model for Estimating the Risk of Septic Acute Kidney Injury. 
  • A physical interaction network of dengue virus and human proteins. 
  • Additional considerations in presumptive brown recluse spider bites and dapsone therapy. 
  • Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network. 
  • Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study. 
  • Aminonaphthalenesulfonamides, a new class of modifiable fluorescent detecting groups and their use in substrates for serine protease enzymes. 
  • An inhibitor of nuclear scaffold protease blocks chemical transformation of fibroblasts. 
  • Analysis of the RELN gene as a genetic risk factor for autism. 
  • Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmin, angiotensinogen, and ovalbumin. 
  • Analysis of thiolester bond cleavage-dependent conformational changes in binary alpha 2-macroglobulin-proteinase complexes. 
  • Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. 
  • Biochemical comparison of fast- and slow-contracting squid muscle. 
  • Ca(2+)-regulated serine protease associated with the nuclear scaffold. 
  • Characteristics of the chemotactic activity of heparin cofactor II proteolysis products. 
  • Computational Analysis of Targeting SARS-CoV-2, Viral Entry Proteins ACE2 and TMPRSS2, and Interferon Genes by Host MicroRNAs. 
  • DNA damage responses in prokaryotes: regulating gene expression, modulating growth patterns, and manipulating replication forks. 
  • Degradation of the epidermal-dermal junction by proteolytic enzymes from human skin and human polymorphonuclear leukocytes. 
  • Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B. 
  • Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions. 
  • Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors. 
  • Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. 
  • Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: rationale and design of the ODYSSEY outcomes trial. 
  • Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia: A Systematic Review and Meta-analysis. 
  • Efficacy and safety of alirocumab, a monoclonal antibody to PCSK9, in statin-intolerant patients: design and rationale of ODYSSEY ALTERNATIVE, a randomized phase 3 trial. 
  • Enzymatic generation of the amino terminus of the beta-amyloid peptide. 
  • Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type I collagen mediated by the alpha2beta1 integrin. 
  • Evidence that non-caspase proteases are required for chromatin degradation during apoptosis. 
  • Excision and transposition of Tn5 as an SOS activity in Escherichia coli. 
  • Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer. 
  • Fibroblast activation protein, a potential diagnostic and therapeutic target for cancer-reply. 
  • First experience with direct, selective factor Xa inhibition in patients with non-ST-elevation acute coronary syndromes: results of the XaNADU-ACS Trial. 
  • Genetic composition of the Bacillus subtilis SOS system. 
  • Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis. 
  • Granulocyte-angiotensin system. Identification of angiotensinogen as the plasma protein substrate of leukocyte cathepsin G. 
  • Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus. 
  • Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. 
  • HEPSIN inhibits cell growth/invasion in prostate cancer cells. 
  • Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases. 
  • Heparin cofactor II-proteinase reaction products exhibit neutrophil chemoattractant activity. 
  • Human neutrophils release serine proteases capable of activating prorenin. 
  • Human skin chymotrypsin-like proteinase chymase. Subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans. 
  • Human skin chymotryptic proteinase. Isolation and relation to cathepsin g and rat mast cell proteinase I. 
  • Identification and Quantitation of Coding Variants and Isoforms of Pulmonary Surfactant Protein A. 
  • Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas. 
  • In vivo catabolism of alpha 1-antichymotrypsin is mediated by the Serpin receptor which binds alpha 1-proteinase inhibitor, antithrombin III and heparin cofactor II. 
  • Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy. 
  • Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. 
  • Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk. 
  • Is SARS-CoV-2 Infection a Risk Factor for Early Pregnancy Loss? ACE2 and TMPRSS2 Coexpression and Persistent Replicative Infection in Primitive Trophoblast. 
  • LexA protein of Escherichia coli represses expression of the Tn5 transposase gene. 
  • MMP20 and ARMS2/HTRA1 Are Associated with Neovascular Lesion Size in Age-Related Macular Degeneration. 
  • Mammalian beta-adrenergic receptors. Structural differences in beta 1 and beta 2 subtypes revealed by peptide maps. 
  • Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors. 
  • Mast cell tryptase: a new biomarker in patients with stable coronary artery disease. 
  • Mastocytosis: new understandings in cutaneous pathophysiology. 
  • Mechanisms of nonimmunological histamine and tryptase release from human cutaneous mast cells. 
  • Membrane topology and biogenesis of eukaryotic signal peptidase. 
  • Modification of the tandem reactive centres of human inter-alpha-trypsin inhibitor with butanedione and cis-dichlorodiammineplatinum(II). 
  • Modulation of the Coagulation Cascade Using Aptamers. 
  • Mouse Cntnap2 and Human CNTNAP2 ASD Alleles Cell Autonomously Regulate PV+ Cortical Interneurons. 
  • Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. 
  • Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). 
  • Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. 
  • Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. 
  • Normal neutrophil function in cathepsin G-deficient mice. 
  • Organization of the MASP2 locus and its expression profile in mouse and rat. 
  • PCSK9 Inhibitors and the Choice Between Innovation, Efficiency, and Affordability. 
  • Pathophysiologic and therapeutic importance of tissue ACE: a consensus report. 
  • Phosphorylation of telokin by cyclic nucleotide kinases and the identification of in vivo phosphorylation sites in smooth muscle. 
  • Placental Expression of ACE2 and TMPRSS2 in Maternal Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Are Placental Defenses Mediated by Fetal Sex? 
  • Proteases of Dermatophagoides pteronyssinus. 
  • Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation. 
  • Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3. 
  • Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. 
  • Purification and identification of two serine class proteinases from dog mast biochemically and immunologically similar to human proteinases tryptase and chymase. 
  • Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. 
  • Reaction of human skin chymotrypsin-like proteinase chymase with plasma proteinase inhibitors. 
  • Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration. 
  • Reelin signals survival through Src-family kinases that inactivate BAD activity. 
  • Relation of serum levels of mast cell tryptase of left ventricular systolic function, left ventricular volume or congestive heart failure. 
  • Restoration of the cystic fibrosis transmembrane conductance regulator function by splicing modulation. 
  • Role of Pseudomonas aeruginosa dinB-encoded DNA polymerase IV in mutagenesis. 
  • Role of laminin in localization of human dermal mast cells. 
  • SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. 
  • SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract. 
  • Serine proteinases in human cutaneous mastocytosis. 
  • Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma. 
  • Shift in S-layer protein expression responsible for antigenic variation in Campylobacter fetus. 
  • Simultaneous labeling of mast cell proteases and protease mRNAs at the bone-implant interface of aseptically loosened hip implants. 
  • Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. 
  • Specialty Pharmaceuticals for Hyperlipidemia--Impact on Insurance Premiums. 
  • Structural analysis, identification, and design of calcium-binding sites in proteins. 
  • Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia. 
  • Structural determinants of autoproteolysis of the Haemophilus influenzae Hap autotransporter. 
  • Structural determinants of the interaction between the Haemophilus influenzae Hap autotransporter and fibronectin. 
  • Substructure of human von Willebrand factor. Proteolysis by V8 and characterization of two functional domains. 
  • Surface array proteins of Campylobacter fetus block lectin-mediated binding to type A lipopolysaccharide. 
  • Synthetic effect between envelope stress and lack of outer membrane vesicle production in Escherichia coli. 
  • The complex genetics of gait speed: genome-wide meta-analysis approach. 
  • The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. 
  • The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3. 
  • The role of endothelium in factor Xa regulation: the effect of plasma proteinase inhibitors and hirudin. 
  • The role of the membrane in the expression of the vitamin K-dependent enzymes. 
  • Therapy and clinical trials. 
  • Thousands of human mobile element fragments undergo strong purifying selection near developmental genes. 
  • Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice. 
  • Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. 
  • Tryptase activates the mitogen-activated protein kinase/activator protein-1 pathway in human peripheral blood eosinophils, causing cytokine production and release. 
  • Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts. 
  • Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. 
  • Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. 
  • Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology