Sesquiterpenes

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  Subject Areas on Research

  • 1,2,4-Trioxanes as potential antimalarial agents. 
  • A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. 
  • A phase II trial of 6-hydroxymethylacylfulvene (MGI-114, irofulven) in patients with relapsed or refractory non-small cell lung cancer. 
  • A stereoselective formal synthesis of leucascandrolide A. 
  • Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice. 
  • Anti-HIV Agents 45 and Antitumor Agents 205. Two New Sesquiterpenes, Leitneridanins A and B, and the Cytotoxic and Anti-HIV Principles from Leitneria floridana 
  • Antiangiogenic agents protect liver sinusoidal lining cells from cold preservation injury in rat liver transplantation. 
  • Antitumor Agents, CLI. Bis(helenalinyl)Glutarate and Bis(isoalantodiol-B)-Glutarate, Potent Inhibitors of Human DNA Topoisomerase II 
  • Beta-caryophyllene enhances wound healing through multiple routes. 
  • Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate. 
  • Comparative efficacy of intramuscular artemether and intravenous quinine in Nigerian children with cerebral malaria. 
  • Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue. 
  • Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. 
  • Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis. 
  • Health agencies end in-fighting on malaria. 
  • Identification of multiple odorant receptors essential for pyrethrum repellency in Drosophila melanogaster. 
  • Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides. 
  • Iridoids and sesquiterpenoids from Valeriana jatamansi and their anti-influenza virus activities. 
  • Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases. 
  • Microsporidian methionine aminopeptidase type 2. 
  • Phase II study of MGI-114 administered intravenously for 5 days every 28 days to patients with metastatic colorectal cancer. 
  • Physiological mechanisms of sustained fumagillin-induced weight loss. 
  • Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease. 
  • Prenylated peptides in identification of specific binding proteins. 
  • Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release. 
  • Regression of metastatic breast cancer in a patient treated with the anti-angiogenic drug TNP-470. 
  • Relation between Irofulven (MGI-114) systemic exposure and tumor response in human solid tumor xenografts. 
  • Substrate binding is required for release of product from mammalian protein farnesyltransferase. 
  • TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. 
  • The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel. 
  • The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells. 
  • Toxicity and pharmacokinetics of the antibiotic fumagillin in yearling rainbow trout (Salmo gairdneri). 
  • cis-parthenolid-9-one from Anvillea garcinii. 
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  Keywords of People

  • Jordt, Sven Eric, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology