Smell

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  Subject Areas on Research

  • A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity. 
  • A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing. 
  • A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. 
  • Aberrant responses in social interaction of dopamine transporter knockout mice. 
  • Activation and odor conditioning of suckling behavior in 3-day-old albino rats. 
  • Altered olfactory acuity in the morbidly obese. 
  • An imaging-based approach to identify ligands for olfactory receptors. 
  • Appetitive conditioning in neonatal rats: conditioned ingestive responding to stimuli paired with oral infusions of milk. 
  • Axonal Odorant Receptors Mediate Axon Targeting. 
  • Behavioral effects of acute hexamethonium in rats chronically intoxicated with nicotine. 
  • Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization. 
  • Cell-Based Therapy Restores Olfactory Function in an Inducible Model of Hyposmia. 
  • Chemical differences between voided and bladder urine in the aye-aye (Daubentonia madagascariensis): implications for olfactory communication studies. 
  • Classically conditioned enhancement of hyperinsulinemia in the ob/ob mouse. 
  • Clinical evidence of decreased olfaction in Bardet-Biedl syndrome caused by a deletion in the BBS4 gene. 
  • Combination of flavor enhancement and chemosensory education improves nutritional status in older cancer patients. 
  • Combinatorial rules of precursor specification underlying olfactory neuron diversity. 
  • Commensal Bacteria Regulate Gene Expression and Differentiation in Vertebrate Olfactory Systems Through Transcription Factor REST. 
  • Conditioned changes in appetitive and consummatory responses to flavors paired with oral or nutrient reinforcement among adult rats. 
  • Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior. 
  • Decoding an olfactory mechanism of kin recognition and inbreeding avoidance in a primate. 
  • Desensitization-like changes in GABA receptor binding of rat fascia dentata after entorhinal lesion. 
  • Design, delivery and perception of condition-dependent chemical signals in strepsirrhine primates: implications for human olfactory communication. 
  • Developmental change in the access to olfactory memories. 
  • Developmental change in unilateral olfactory habituation is mediated by anterior commissure maturation. 
  • Discriminability of nicotine in tobacco smoke: implications for titration. 
  • Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates. 
  • Evaluating cell-surface expression and measuring activation of mammalian odorant receptors in heterologous cells. 
  • Forever young: Neoteny, neurogenesis and a critique of critical periods in olfaction. 
  • Functional analysis of a mammalian odorant receptor subfamily. 
  • Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans. 
  • Gastric bypass does not influence olfactory function in obese patients. 
  • Genetic elucidation of human hyperosmia to isovaleric acid. 
  • Genetic variation at MHC class II loci influences both olfactory signals and scent discrimination in ring-tailed lemurs. 
  • Genetic variation in a human odorant receptor alters odour perception. 
  • Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone. 
  • Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans. 
  • Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults. 
  • Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans. 
  • Global Study of Social Odor Awareness. 
  • High-speed recording of neural spikes in awake mice and flies with a fluorescent voltage sensor. 
  • Immunohistochemistry of the canine vomeronasal organ. 
  • Implausibility of the vibrational theory of olfaction. 
  • Inducible and targeted deletion of the ERK5 MAP kinase in adult neurogenic regions impairs adult neurogenesis in the olfactory bulb and several forms of olfactory behavior. 
  • Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay. 
  • Loss of BMI1 in mature olfactory sensory neurons leads to increased olfactory basal cell proliferation. 
  • Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures. 
  • Molecular profiling of activated olfactory neurons identifies odorant receptors for odors in vivo. 
  • Nasopalatine ducts and flehmen behavior in the mandrill: reevaluating olfactory communication in Old World primates. 
  • Night and day: the comparative study of strepsirrhine primates reveals socioecological and phylogenetic patterns in olfactory signals. 
  • Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. 
  • Noradrenergic induction of odor-specific neural habituation and olfactory memories. 
  • Odor coding by a Mammalian receptor repertoire. 
  • Odor coding in piriform cortex: mechanistic insights into distributed coding. 
  • Olfactory cuing of autobiographical memory. 
  • Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins. 
  • Olfactory fossa of Tremacebus harringtoni (platyrrhini, early Miocene, Sacanana, Argentina): implications for activity pattern. 
  • Olfactory recognition and discrimination in Caenorhabditis elegans. 
  • Pervasive olfactory impairment after bilateral limbic system destruction. 
  • Physiologic impairment of olfactory stimulus processing in schizophrenia. 
  • Prenatal and Early Postnatal Odorant Exposure Heightens Odor-Evoked Mitral Cell Responses in the Mouse Olfactory Bulb. 
  • RTP family members induce functional expression of mammalian odorant receptors. 
  • Receptors, circuits, and behaviors: new directions in chemical senses. 
  • Recurrent cortical circuits implement concentration-invariant odor coding. 
  • Reinforcers in infancy: classical conditioning using stroking or intra-oral infusions of milk as UCS. 
  • Reply to Turin et al.: Vibrational theory of olfaction is implausible. 
  • Responses to olfactory stimuli in spotted hyenas (Crocuta crocuta): I. Investigation of environmental odors and the function of rolling. 
  • Responses to olfactory stimuli in spotted hyenas (Crocuta crocuta): II. Discrimination of conspecific scent. 
  • SR1, a mouse odorant receptor with an unusually broad response profile. 
  • Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic. 
  • Single-cell analysis of olfactory neurogenesis and differentiation in adult humans. 
  • Smelling right: the scent of male lemurs advertises genetic quality and relatedness. 
  • Smelling wrong: hormonal contraception in lemurs alters critical female odour cues. 
  • Social Context Enhances Hormonal Modulation of Pheromone Detection in Drosophila. 
  • Structure and flexibility in cortical representations of odour space. 
  • Structure-Function Relationships of Olfactory and Taste Receptors. 
  • Synapse-specific downregulation of NMDA receptors by early experience: a critical period for plasticity of sensory input to olfactory cortex. 
  • Synaptic Organization of Anterior Olfactory Nucleus Inputs to Piriform Cortex. 
  • Synaptic integration of olfactory information in mouse anterior olfactory nucleus. 
  • Taste and smell complaints in HIV-infected patients. 
  • Taste and smell losses in HIV infected patients. 
  • Taste and smell sensations enhance the satiating effect of both a high-carbohydrate and a high-fat meal in humans. 
  • Taste, smell and neuropsychological performance of individuals at familial risk for Alzheimer's disease. 
  • Taxis assays measure directional movement of mosquitoes to olfactory cues. 
  • The "secret" in secretions: methodological considerations in deciphering primate olfactory communication. 
  • The effect of endoscopic olfactory cleft polyp removal on olfaction. 
  • The genetics of speciation by reinforcement. 
  • The gustatory cortex and multisensory integration. 
  • The human olfactory transcriptome. 
  • The missense of smell: functional variability in the human odorant receptor repertoire. 
  • The molecular biology of olfactory perception. 
  • True paternal care in a multi-male primate society. 
  • Two sniffing strategies in palinurid lobsters. 
  • Unilateral conditioning of an odor aversion in 6-day-old rat pups. 
  • Unirhinal olfactory function in schizophrenia patients and first-degree relatives. 
  • Visualizing an olfactory sensory map. 
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  Keywords of People

  • Alberts, Susan C., Robert F. Durden Distinguished Professor of Biology, Duke Science & Society
  • Tsalik, Ephraim, Associate Professor of Medicine, Molecular Genetics and Microbiology