Solubility

• 

  Subject Areas on Research

  • 3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility. 
  • 440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons. 
  • A competitive enzyme-linked immunoassay (ELISA) for the measurement of soluble human interleukin-2 receptors (IL-2R, Tac protein). 
  • A kinetic study of the binding of an ADP fluorescent analog to mitochondrial ATPase. 
  • A new erythrocyte membrane-associated protein with calmodulin binding activity. Identification and purification. 
  • A new simplified procedure for C1 inhibitor purification. A novel use for jacalin-agarose. 
  • A novel role for erythropoietin during fibrin-induced wound-healing response. 
  • A solubility-enhancement tag (SET) for NMR studies of poorly behaving proteins. 
  • A soluble factor(s) secreted from CD8(+) T lymphocytes inhibits human immunodeficiency virus type 1 replication through STAT1 activation. 
  • A soluble inhibitor of T lymphocyte function induced by HIV-1 infection of CD4+ T cells: characterization of a cellular protein and its relationship to p15E. 
  • A thermally responsive biopolymer for intra-articular drug delivery. 
  • Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma. 
  • Acute toxicity of lead particulates on pulmonary alveolar macrophages. Ultrastructural and microanalytical studies. 
  • Acute tubular necrosis. An experimental model detailing the biochemical events accompanying renal injury and recovery. 
  • Adeno-associated viral vectors based on serotype 3b use components of the fibroblast growth factor receptor signaling complex for efficient transduction. 
  • Affinity chromatography of human platelet alpha 2-adrenergic receptors. 
  • Affinity chromatography of the D1 dopamine receptor from rat corpus striatum. 
  • Affinity chromatography of the anterior pituitary D2-dopamine receptor. 
  • AglQ is a novel component of the Haloferax volcanii N-glycosylation pathway. 
  • Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass. 
  • Amyloid-beta-protein isoforms in brain of subjects with PS1-linked, beta APP-linked and sporadic Alzheimer disease. 
  • An inhibitor of macrophage chemotaxis produced by neoplasms. 
  • Analytical and clinical evaluation of a novel high-sensitivity assay for measurement of soluble ST2 in human plasma--the Presage ST2 assay. 
  • Anti-diarrhoeal evaluation of Clerodendrum phlomidis Linn. leaf extract in rats. 
  • Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton. 
  • Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. 
  • Aqueous humor sCD44 concentration and visual field loss in primary open-angle glaucoma. 
  • Assembly of translocation-competent proteoliposomes from detergent-solubilized rough microsomes. 
  • Assessment of antibody responses against gp41 in HIV-1-infected patients using soluble gp41 fusion proteins and peptides derived from M group consensus envelope. 
  • Association between high-dose erythropoiesis-stimulating agents, inflammatory biomarkers, and soluble erythropoietin receptors. 
  • Base stacking and molecular polarizability: effect of a methyl group in the 5-position of pyrimidines. 
  • Beta-Adrenergic receptors: solubilization of (-)(3H)alprenolol binding sites from frog erythrocyte membranes. 
  • Binding of tenascin-C to soluble fibronectin and matrix fibrils. 
  • Bioaccessibility testing of cobalt compounds. 
  • Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site. 
  • Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL. 
  • Biological evaluation of some biphenyl analogs of acetyl-seco-hemicholinium No. 3. 
  • Biomineralized matrices dominate soluble cues to direct osteogenic differentiation of human mesenchymal stem cells through adenosine signaling. 
  • Boranophosphates support the RNase H cleavage of polyribonucleotides. 
  • C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1. 
  • CD8+ cell lines isolated from HIV-1-infected children have potent soluble HIV-1 inhibitory activity that differs from beta-chemokines. 
  • CLL cell apoptosis induced by nitric oxide synthase inhibitors: correlation with lipid solubility and NOS1 dissociation constant. 
  • Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins. 
  • Characterization of nuclear angiotensin-II-binding sites in rat liver and comparison with plasma membrane receptors. 
  • Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes. 
  • Chemical aspects of siderophore mediated iron transport. 
  • Comparative Analysis of the Glycosylation Profiles of Membrane-Anchored HIV-1 Envelope Glycoprotein Trimers and Soluble gp140. 
  • Comparative proteomic characterization of articular cartilage tissue from normal donors and patients with osteoarthritis. 
  • Comparison between admission natriuretic peptides, NGAL and sST2 testing for the prediction of worsening renal function in patients with acutely decompensated heart failure. 
  • Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport. 
  • Conformation-specific precipitation of human alpha 2-macroglobulin by divalent zinc or calf thymus histone H3. 
  • Copper-chelatin: purification and properties of a copper-binding protein from rat liver. 
  • Correlations between water-soluble organic aerosol and water vapor: a synergistic effect from biogenic emissions? 
  • Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors, distinct from CrmB, that binds TNF but not LT alpha. 
  • Cross-linking of fibrin by fibrin=stabilizing factor. 
  • Cutting edge: trimolecular interaction of TCR with MHC class II and bacterial superantigen shows a similar affinity to MHC:peptide ligands. 
  • Cysteine-induced modifications of zero-valent silver nanomaterials: implications for particle surface chemistry, aggregation, dissolution, and silver speciation. 
  • Dephosphorylation of ezrin as an early event in renal microvillar breakdown and anoxic injury. 
  • Design and synthesis of manganese porphyrins with tailored lipophilicity: investigation of redox properties and superoxide dismutase activity. 
  • Detergents linked to polysaccharides: preparation and effects on membranes and cells. 
  • Determination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics. 
  • Development of lipophilic anticancer agents for the treatment of brain tumors by the esterification of water-soluble chlorambucil. 
  • Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology. 
  • Differential extraction and enrichment of human sperm surface proteins in a proteome: identification of immunocontraceptive candidates. 
  • Differential solubilization of placental lactogen (PL)- and growth hormone-binding sites: further evidence for a unique PL receptor in fetal and maternal liver. 
  • Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. 
  • Dopamine receptor of the porcine anterior pituitary gland. Solubilization and characterization. 
  • Effect of coronary thrombolysis on the plasma concentration of osteonectin (SPARC, BM40) in patients with acute myocardial infarction. 
  • Effect of detergents on the thermal behavior of elastin-like polypeptides. 
  • Effect of oxidative stress on homer scaffolding proteins. 
  • Effect of protein fusion on the transition temperature of an environmentally responsive elastin-like polypeptide: a role for surface hydrophobicity? 
  • Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells. 
  • Effect of tissue transglutaminase on the solubility of proteins containing expanded polyglutamine repeats. 
  • Effects of Natural Organic Matter Properties on the Dissolution Kinetics of Zinc Oxide Nanoparticles. 
  • Elevated serum L-selectin levels and abnormal regulation of L-selectin expression on leukocytes in atopic dermatitis: soluble L-selectin levels indicate disease severity. 
  • Engineering soluble major histocompatibility molecules: why and how. 
  • Enzymatic susceptibility and spontaneous release of human melanoma tumor-associated antigens. 
  • Equilibrium binding of nucleotides to beef heart mitochondrial adenosine triphosphatase. 
  • Erosion of microbicide formulation coating layers: effects of contact and shearing with vaginal fluid or semen. 
  • Evaluation of the lipid-soluble diaminopyrimidines, metoprine and etoprine, in the avian sarcoma virus rat glioma model. 
  • Extraction and identification by mass spectrometry of undecaprenyl diphosphate-MurNAc-pentapeptide-GlcNAc from Escherichia coli. 
  • Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying. 
  • Flightin is essential for thick filament assembly and sarcomere stability in Drosophila flight muscles. 
  • Human endometrial transforming growth factor-alpha: a transmembrane, surface epithelial protein that transiently disappears during the midsecretory phase of the menstrual cycle. 
  • Human erythrocyte ankyrin. Purification and properties. 
  • Human immunodeficiency virus type 1 subtype B ancestral envelope protein is functional and elicits neutralizing antibodies in rabbits similar to those elicited by a circulating subtype B envelope. 
  • IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha. 
  • Identification of ENV determinants in V3 that influence the molecular anatomy of CCR5 utilization. 
  • Identification of calcium oxalate crystals using alizarin red S stain. 
  • Identification of quinone-binding and heme-ligating residues of the smallest membrane-anchoring subunit (QPs3) of bovine heart mitochondrial succinate:ubiquinone reductase. 
  • Immunoaffinity purification of epitope-tagged human beta 2-adrenergic receptor to homogeneity. 
  • Impacts of silver nanoparticle coating on the nitrification potential of Nitrosomonas europaea. 
  • Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1. 
  • Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model. 
  • Inhibition of lead chromate clastogenesis by ascorbate: relationship to particle dissolution and uptake. 
  • Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. 
  • Interaction of halothane with lipid bilayers. 
  • Interactions between precipitating and nonprecipitating antibodies in the formation of immune complexes. 
  • Interconversion of two kinetically distinct states of the membrane-bound and solubilised H+-translocating ATPase from Rhodospirillum rubrum. 
  • Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine. 
  • Isolation and characterization of a receptor for type 1 fimbriae of Escherichia coli from guinea pig erythrocytes. 
  • Isolation of an ankyrin-band 3 oligomer from human erythrocyte membranes. 
  • Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease. 
  • Learning about Biomolecular Solvation from Water in Protein Crystals. 
  • Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. 
  • Lipid solubility modulates pH potentiation of local anesthetic block of Vmax reactivation in guinea pig myocardium. 
  • Maintaining functional islets through encapsulation in an injectable saccharide-peptide hydrogel. 
  • Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. 
  • Manganese porphyrins and related compounds as mimics of superoxide dismutase. 
  • Mast cell-derived particles deliver peripheral signals to remote lymph nodes. 
  • Mathematical modeling of spatio-temporal dynamics of a single bone multicellular unit. 
  • Methylation of mercury by bacteria exposed to dissolved, nanoparticulate, and microparticulate mercuric sulfides. 
  • Microglassification™: a novel technique for protein dehydration. 
  • Molecular profile and partial functional analysis of novel endothelial cell-derived growth factors that regulate hematopoiesis. 
  • Molecular umbrella-amphotericin B conjugates. 
  • Monitoring of kidney and simultaneous pancreas-kidney transplantation rejection by release of donor-specific, soluble HLA class I. 
  • Morphological and neoplastic transformation of C3H/10T1/2 Cl 8 mouse embryo cells by insoluble carcinogenic nickel compounds. 
  • Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. 
  • New real-time technique to measure the size distribution of water-insoluble aerosols. 
  • New sensitive micro-measurements of dynamic surface tension and diffusion coefficients: Validated and tested for the adsorption of 1-Octanol at a microscopic air-water interface and its dissolution into water. 
  • Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways. 
  • On the assessment of similarity for dissolution profiles of two drug products. 
  • Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design. 
  • Overcoming the solubility limit with solubility-enhancement tags: successful applications in biomolecular NMR studies. 
  • PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation. 
  • Permeability of four disposable protective-clothing materials to seven antineoplastic drugs. 
  • Permeability of latex and polyvinyl chloride gloves to 20 antineoplastic drugs. 
  • Phasic ion channel blockade. A kinetic model and parameter estimation procedure. 
  • Phosphorylation state, solubility, and activity of calcium/calmodulin-dependent protein kinase II alpha in transient focal ischemia in mouse brain. 
  • Physico-chemical incompatibilities of parenteral admixtures Aramine and Solu-Cortef. 
  • Physicochemical characteristics and biological effects of nickel oxides. 
  • Phytotoxicity of soluble graphitic nanofibers to model plant species. 
  • Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery. 
  • Polymersomes: a new multi-functional tool for cancer diagnosis and therapy. 
  • Polypeptides of mammalian oncornaviruses. IV. Structural components of murine leukemia virus released as soluble antigens in cell culture. 
  • Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors. 
  • Preferential DNA-protein cross-linking by NiCl2 in magnesium-insoluble regions of fractionated Chinese hamster ovary cell chromatin. 
  • Probability lower bounds for USP/NF tests. 
  • Production and characterization of antipeptide antibodies against human O6-methylguanine-DNA methyltransferase. 
  • Protein kinase C isoforms in human aortic smooth muscle cells. 
  • Purification and characterization of papain-solubilized HLA antigens from human platelets. 
  • Purification and characterization of the human platelet alpha 2-adrenergic receptor. 
  • Quantification of the effects of chain length and concentration on the thermal behavior of elastin-like polypeptides. 
  • Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner. 
  • Recombinant hydrophilic region of murine retroviral protein p15E inhibits stimulated T-lymphocyte proliferation. 
  • Reconstitution of protein translocation from detergent-solubilized Escherichia coli inverted vesicles: PrlA protein-deficient vesicles efficiently translocate precursor proteins. 
  • Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults. 
  • Relationship between structure and sodium channel blockade by lidocaine and its amino-alkyl derivatives. 
  • Secretion of HLA-A and -B antigens via an alternative RNA splicing pathway. 
  • Sel-association of glucagon. Equilibrium studies. 
  • Selective antiviral activity of synthetic soluble L-tyrosine and L-dopa melanins against human immunodeficiency virus in vitro. 
  • Selenium speciation in coal ash spilled at the Tennessee Valley Authority Kingston site. 
  • Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity. 
  • Serial measurement of serum interleukin-2 receptor levels in patients with rheumatoid arthritis: limited evidence for a role of T cell activation in clinical exacerbations. 
  • Sex-related difference in the metabolism of isosorbide dinitrate following incubation in human blood. 
  • Soft matter perspective on protein crystal assembly. 
  • Solubilization and characterization of D2-dopamine receptors in an estrone-induced, prolactin-secreting rat pituitary adenoma. 
  • Solubilization and partial isolation of human melanoma tumor-associated antigens. 
  • Solubilization and reconstitution of renal brush border Na+-H+ exchanger. 
  • Solubilization of rat liver alpha 1-adrenergic receptors. Agonist specific alteration in receptor binding affinity. 
  • Soluble Envelope Glycoprotein Trimers from a CD4-Independent HIV-1 Elicit Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Guinea Pigs. 
  • Soluble P-selectin is not a surrogate marker for platelet P-selectin: evidence from a multicenter chest pain study group. 
  • Soluble factor in normal tissues that stimulates high-molecular-weight sialoglycoprotein production by human colon carcinoma cells. 
  • Soluble interleukin-2 receptor alpha is elevated in sera of patients with benign ovarian neoplasms and epithelial ovarian cancer. 
  • Soluble miniagrin enhances contractile function of engineered skeletal muscle. 
  • Soluble monomeric P-selectin containing only the lectin and epidermal growth factor domains binds to P-selectin glycoprotein ligand-1 on leukocytes. 
  • Soluble vs insoluble hexavalent chromate. Relationship of mutation to in vitro transformation and particle uptake. 
  • Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45. 
  • Solving the problem at the source: Controlling Mn release at the sediment-water interface via hypolimnetic oxygenation. 
  • Sorption-desorption characteristics of methyl parathion by clays. 
  • Spectrophotometric analysis of molecular transport in gels. 
  • Steady state kinetics of soluble and membrane-bound mitochondrial ATPase. 
  • Strain variation in antiphagocytic activity of capsular polysaccharides from Cryptococcus neoformans serotype A. 
  • Structural analysis of some soluble elastins by means of FT-IR and 2D IR correlation spectroscopy. 
  • Structural and functional characterization of monomeric soluble P-selectin and comparison with membrane P-selectin. 
  • Structural model of human ceruloplasmin based on internal triplication, hydrophilic/hydrophobic character, and secondary structure of domains. 
  • Structural requirements regulate endoproteolytic release of the L-selectin (CD62L) adhesion receptor from the cell surface of leukocytes. 
  • Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis. 
  • Sulfidation of silver nanoparticles: natural antidote to their toxicity. 
  • Synaptic vesicle membrane proteins interact to form a multimeric complex. 
  • Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist. 
  • Synthesis, purification, and in vitro stability of 211At- and 125I-labeled amidobisphosphonates. 
  • Systemic soluble Tie2 expression inhibits and regresses corneal neovascularization. 
  • The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. 
  • The absorption of tristearin and stearic acid and tripalmitin and palmitic acid. Studies on the rate-limiting steps in rats. 
  • The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. 
  • The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases. 
  • The effect of soluble complement receptor type 1 on hyperacute allograft rejection. 
  • The effects of adipokines on cartilage and meniscus catabolism. 
  • The effects of nonsteroidal antiinflammatory drug therapy in early rheumatoid arthritis on serum levels of soluble interleukin 2 receptor, CD4, and CD8. 
  • The rat testicular A1 adenosine receptor-adenylate cyclase system. 
  • The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. 
  • The soluble metalloendoprotease required in myoblast fusion remains intracellular. 
  • The synthesis and secretion of gamma-globulin by lymph node cells. V. The dissociation of the microsome-antibody complex with enzymatically and chemically altered gamma-globulins. 
  • Three-dimensional structures of uterine elastic fibers: scanning electron microscopic studies. 
  • Treatment of neoplastic meningitis with intrathecal temozolomide. 
  • Two distinct forms of soluble MHC class I molecules synthesized by different mechanisms in normal rat cells in vitro. 
  • Two types of mechanosensitive channels in the Escherichia coli cell envelope: solubilization and functional reconstitution. 
  • Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin. 
  • Urinary and biliary excretion of 14C-gossypol in swine. 
  • Use of short-term assays to evaluate the potential toxicity of two new biosoluble glasswool fibers. 
  • Usefulness of combining necrosis and platelet markers in triaging patients presenting with chest pain to the emergency department. 
  • Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C. 
  • VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF. 
  • Vascular effects of ambient pollutant particles and metals. 
  • Water-soluble treatments to enhance glucose permeability of protein-resistant polymer overlayers. 
  • X-ray diffraction to determine the thickness of raft and nonraft bilayers. 
  • ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets. 
• 

  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Charles, Hal Cecil, Associate Professor of Radiology, Radiology
  • Craciunescu, Oana, Associate Professor of Radiation Oncology, Radiation Oncology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Hirschey, Matthew, Associate Professor in Medicine, Pharmacology & Cancer Biology
  • Hsu-Kim, Heileen, Mary Milus Yoh and Harold L. Yoh, Jr. Associate Professor of Civil and Environmental Engineering, Civil and Environmental Engineering
  • Katz, David F., Nello L. Teer, Jr. Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering, Biomedical Engineering
  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology
  • Meyer, Joel, Truman and Nellie Semans/Alex Brown and Sons Associate Professor of Molecular Environmental Toxicology, Duke University Energy Initiative
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Starmer, Charles Franklin, Professor Emeritus of Computer Science, Computer Science
  • Vengosh, Avner, Professor of Earth and Ocean Sciences, Duke University Energy Initiative
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology