Solutions

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  Subject Areas on Research

  • A clinical trial of oral therapy in a rural cholera-treatment center. 
  • A colloidal Au monolayer modulates the conformation and orientation of a protein at the electrode/solution interface. 
  • A comparison of 3% hypertonic saline and mannitol for brain relaxation during elective supratentorial brain tumor surgery. 
  • A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis. CNS Cancer Consortium. 
  • A mechano-chemical model for the passive swelling response of an isolated chondron under osmotic loading. 
  • A simplified mass-transfer model for visual pigments in amphibian retinal-cone outer segments. 
  • A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition. 
  • A unified model for de novo design of elastin-like polypeptides with tunable inverse transition temperatures. 
  • Acid- and base-catalyzed hydrolysis of chloroacetamide herbicides. 
  • An extension of the sign test for replicated measurements. 
  • An investigation of the equilibria between aqueous ribose, ribulose, and arabinose. 
  • Analysis of myocardial function in orthotopic cardiac allografts after prolonged storage in UW solution. 
  • Analytical Debye-Huckel model for electrostatic potentials around dissolved DNA. 
  • Aqueous quaternary ammonium antiseptics and disinfectants. Use and misuse. 
  • Argininamide binding arrests global motions in HIV-1 TAR RNA: comparison with Mg2+-induced conformational stabilization. 
  • Aseptic peritonitis with home peritoneal dialysis. 
  • Binding of tenascin-C to soluble fibronectin and matrix fibrils. 
  • Bioequivalence assessment of zidovudine (Retrovir) syrup, solution, and capsule formulations in patients infected with human immunodeficiency virus. 
  • Calculating solution redox free energies with ab initio quantum mechanical/molecular mechanical minimum free energy path method. 
  • Can regular solution theory be applied to lipid bilayer membranes? 
  • Characterization of the aqueous iron(III) chelation chemistry of a potential Trojan Horse antimicrobial agent: chelate structure, stability and pH dependent speciation. 
  • Characterizing aqueous solution conformations of a peptide backbone using Raman optical activity computations. 
  • Coefficient of restitution for wet particles. 
  • Colorimetric Detection of Staphylococcus aureus Contaminated Solutions without Purification. 
  • Comparative toxicity of C60 aggregates toward mammalian cells: role of tetrahydrofuran (THF) decomposition. 
  • Comparison of various hemoglobin polyoxyethylene conjugate solutions as resuscitative fluids after hemorrhagic shock. 
  • Compatibility and stability of bryostatin 1 in infusion devices. 
  • Compressive cyclic ratcheting and fatigue of synthetic, soft biomedical polymers in solution. 
  • Computational study on the relative acidity of acetic acid by the QM/MM method combined with the theory of energy representation. 
  • Conical intersections in solution: formulation, algorithm, and implementation with combined quantum mechanics/molecular mechanics method. 
  • Consequences of (129)Xe-(1)H cross relaxation in aqueous solutions. 
  • Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes. 
  • Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH. 
  • Copper as a robust and transparent electrocatalyst for water oxidation. 
  • Critical Influence of Cosolutes and Surfaces on the Assembly of Serpin-Derived Amyloid Fibrils. 
  • Crystallization of asymmetric patchy models for globular proteins in solution 
  • Detection and characterization of xenon-binding sites in proteins by 129Xe NMR spectroscopy. 
  • Determining absolute configuration in flexible molecules: a case study. 
  • Dilution-induced disassembly of microtubules: relation to dynamic instability and the GTP cap. 
  • Direct detection of the formation of V-amylose helix by single molecule force spectroscopy. 
  • Does oral experience terminate ingestion? 
  • Domain-specific effector interactions within the central cavity of human adult hemoglobin in solution and in porous sol-gel matrices: evidence for long-range communication pathways. 
  • Dynamic adhesion of umbilical cord blood endothelial progenitor cells under laminar shear stress. 
  • Dynamic and static light scattering studies on self-aggregation behavior of biodegradable amphiphilic poly(ethylene oxide)-poly[(R)-3-hydroxybutyrate]-poly(ethylene oxide) triblock copolymers in aqueous solution. 
  • Effects of ionic surfactant adsorption on single-walled carbon nanotube thin film devices in aqueous solutions. 
  • Effects of processing conditions on mammographic image quality. 
  • Electrical stimulation alters protein adsorption and nerve cell interactions with electrically conducting biomaterials. 
  • Elevated plasma cholecystokinin and appetitive ratings after consumption of a liquid meal in humans. 
  • Elucidating solvent contributions to solution reactions with ab initio QM/MM methods. 
  • Esophageal perforation after ingestion of colon lavage solution. 
  • Evaluating the quality of NMR structures by local density of protons. 
  • Evaluation of solutions for small intestinal preservation. Biochemical changes as a function of storage time. 
  • Evaluation of the oxidation of organic compounds by aqueous suspensions of photosensitized hydroxylated-C60 fullerene aggregates. 
  • Evidence for the intertwined dimer of the cytochrome bc(1) complex in solution. 
  • Experience with combined hepatic, pancreaticoduodenal, and renal procurement with UW solution. 
  • Experimental issues in the measurement of multi-component relaxation times in articular cartilage by microscopic MRI. 
  • Extracorporeal shock wave lithotripsy: the use of chemical treatments for improved stone comminution. 
  • Fatal eosinophilia myalgia syndrome in a marrow transplant patient attributed to total parenteral nutrition with a solution containing tryptophan. 
  • Fatal microvascular pulmonary emboli from precipitation of a total nutrient admixture solution. 
  • Fingerprinting polysaccharides with single-molecule atomic force microscopy. 
  • Flow cytometric analysis of nitric oxide production in human neutrophils using dichlorofluorescein diacetate in the presence of a calmodulin inhibitor. 
  • Free energies of chemical reactions in solution and in enzymes with ab initio quantum mechanics/molecular mechanics methods. 
  • Fullerol cluster formation in aqueous solutions: implications for environmental release. 
  • Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR. 
  • Genetically encoded synthesis of protein-based polymers with precisely specified molecular weight and sequence by recursive directional ligation: examples from the elastin-like polypeptide system. 
  • Glutamine stability in biological tissues evaluated by fluorometric analysis. 
  • Hemodynamic changes during hemodialysis: role of dialyzate. 
  • Hemoglobin-based oxygen-carrying solutions: close but still so far. 
  • High-resolution solution structure of the beryllofluoride-activated NtrC receiver domain. 
  • Influence of the extent of hybridization on the hydrodynamic radius of DNA-functionalized gold nanoparticles. 
  • Inhibition of thermolysin by phosphonamidate transition-state analogues: measurement of 31P-15N bond lengths and chemical shifts in two enzyme-inhibitor complexes by solid-state nuclear magnetic resonance. 
  • Inhibition of tumor necrosis factor release from cultured rat Kupffer cells by agents that reduce graft failure from storage injury. 
  • Insight into the CSA tensors of nucleobase carbons in RNA polynucleotides from solution measurements of residual CSA: towards new long-range orientational constraints. 
  • Insights into Watson-Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m1A. 
  • Integrated optical attenuated total reflection spectrometry of aqueous superstrates using prism-coupled polymer waveguides. 
  • Interaction of synthetic HA2 influenza fusion peptide analog with model membranes. 
  • Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies. 
  • Interfacial phase transition of an environmentally responsive elastin biopolymer adsorbed on functionalized gold nanoparticles studied by colloidal surface plasmon resonance. 
  • Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH. 
  • Kinetic mechanism of RGS9-1 potentiation by R9AP. 
  • Linked folding and anion binding of the Bacillus subtilis ribonuclease P protein. 
  • Liquid ventilation. 
  • Lorentz effect imaging of ionic currents in solution. 
  • Magnitude of the solvation pressure depends on dipole potential. 
  • Measurements of a large anisotropy in the swelling of oriented DNA films in aqueous solution. 
  • Mercury water and cauterizing stones: Nicolas André and tic douloureux. 
  • Methodology for the measurement and analysis of relaxation times in proton imaging. 
  • Mg2+-induced variations in the conformation and dynamics of HIV-1 TAR RNA probed using NMR residual dipolar couplings. 
  • Microrheology probes length scale dependent rheology. 
  • Microwave-field-driven acoustic modes in DNA. 
  • Molecular description of the LCST behavior of an elastin-like polypeptide. 
  • Nitrogen-sparing intravenous fluids in postperative patients. 
  • Nitrosonium-catalyzed decomposition of s-nitrosothiols in solution: a theoretical and experimental study. 
  • On the relationship between computed tomography numbers and specific gravity. 
  • Onset of action of diclofenac potassium liquid-filled capsules in dental surgery patients. 
  • Optical rotatory dispersion of ribonuclease and ribonuclease--nucleotide complexes. 
  • Optical-CT 3D Dosimetry Using Fresnel Lenses with Minimal Refractive-Index Matching Fluid. 
  • Optimized co-solute paramagnetic relaxation enhancement for the rapid NMR analysis of a highly fibrillogenic peptide. 
  • Oral hydration rotavirus diarrhoea: a double blind comparison of sucrose with glucose electrolyte solution. 
  • Oral nicotine solution for smoking cessation: a pilot tolerability study. 
  • Pharmacokinetics and bioequivalence of a liquid formulation of hydroxyurea in children with sickle cell anemia. 
  • Profound increase in viscosity and aggregation of pig gastric mucin at low pH. 
  • Protocol versus ad libitum feeds after laparoscopic pyloromyotomy: a prospective randomized trial. 
  • Quantitative analysis of gas-phase formaldehyde molecular species at equilibrium with formalin solution. 
  • Quantum treatment of intermolecular multiple-quantum coherences with intramolecular J coupling in solution NMR. 
  • Rapid cross-linking of elastin-like polypeptides with (hydroxymethyl)phosphines in aqueous solution. 
  • Rapid preparation and characterization of uniform, large, spherical Ag particles through a simple wet-chemical route. 
  • Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design. 
  • Rehydration and maintenance therapy of cholera patients in Jakarta: citrate-based versus bicarbonate-based oral rehydration salt solution. 
  • Resistance differences between blood and crystalloid cardioplegic solutions with myocardial cooling. 
  • Rheological properties of cysteine-containing elastin-like polypeptide solutions and hydrogels. 
  • Sample preparation for MALDI mass spectrometry using an elastomeric device reversibly sealed on the MALDI target. 
  • Sequencing and characterization of oligosaccharides using infrared multiphoton dissociation and boronic acid derivatization in a quadrupole ion trap. 
  • Signal irreproducibility in high-field solution magnetic resonance experiments caused by spin turbulence. 
  • Silver nanocolloids disrupt medaka embryogenesis through vital gene expressions. 
  • Sliding clamp of the bacteriophage T4 polymerase has open and closed subunit interfaces in solution. 
  • Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation. 
  • Solution structure and function of YndB, an AHSA1 protein from Bacillus subtilis. 
  • Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45. 
  • Solution structure of a sweet protein single-chain monellin determined by nuclear magnetic resonance and dynamical simulated annealing calculations. 
  • Spectral perturbations and oligomer/monomer formation in 124-kilodalton Avena phytochrome. 
  • Spin-trapping of oxygen free radicals in chemical and biological systems: new traps, radicals and possibilities. 
  • Static and dynamic model for 4-aminodiphenyl fluorescence quenching by carbontetrachloride in hexane. 
  • Structural and dynamic analysis of residual dipolar coupling data for proteins. 
  • Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength. 
  • Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: heme activation via reduction-gated exogenous ligand exchange. 
  • Suppression of conformational heterogeneity at a protein-protein interface. 
  • Surfactant solvation effects and micelle formation in ionic liquids. 
  • Syntheses, X-ray crystal structures, and solution behavior of monomeric, cationic, two-coordinate gold(I) pi-alkene complexes. 
  • Synthesis and characterization of 4-methoxy-7-nitroindolinyl-D-aspartate, a caged compound for selective activation of glutamate transporters and N-methyl-D-aspartate receptors in brain tissue. 
  • Test of the Epstein-Plesset model for gas microparticle dissolution in aqueous media: effect of surface tension and gas undersaturation in solution. 
  • The effect of duration of hypothermic cardioplegia on ventricular function. 
  • The hydrolytic susceptibility of prochelator BSIH in aqueous solutions. 
  • The importance of seminal plasma for sperm penetration of human cervical mucus. 
  • The predictive value of donor liver biopsies on the development of primary nonfunction after orthotopic liver transplantation. 
  • The use of UW solution in clinical transplantation. A 4-year experience. 
  • Three Pyrimidine Decarboxylations in the Absence of a Catalyst. 
  • Transamniotic fetal feeding. III. The effect of nutrient infusion on fetal growth retardation. 
  • ULTRASONIC ATTENUATION MEASUREMENTS IN POLY-L-GLUAMIC ACID SOLUTIONS. 
  • Update on preservation of liver grafts. 
  • pH-dependent conformational change of gastric mucin leads to sol-gel transition. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Biomedical Engineering
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. / Guidant Foundation Distinguished Professor of Cardiology, Medicine, Clinical Pharmacology