Somatomedins

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  Subject Areas on Research

  • 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression. 
  • Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis. 
  • DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest. 
  • Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-beta on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation. 
  • Distinct function of estrogen receptor α in smooth muscle and fibroblast cells in prostate development. 
  • Embryonic chick cartilage produces its own somatomedin-like peptide to stimulate cartilage growth in vitro. 
  • Epidermal growth factor stimulates glycogen synthesis in fetal rat hepatocytes: comparison with the glycogenic effects of insulin-like growth factor I and insulin. 
  • Evidence for a novel insulin-like growth factor (IGF)-dependent protease regulating IGF-binding protein-4 in dermal fibroblasts. 
  • Food perception without ingestion leads to metabolic changes and irreversible developmental arrest in C. elegans. 
  • Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors. 
  • Growth factor-mediated phosphorylation of proapoptotic BAD reduces tubule cell death in vitro and in vivo. 
  • Growth retardation in the Lesch-Nyhan syndrome. 
  • Homologous and heterologous growth hormones fail to stimulate avian cartilage growth in vitro. 
  • Hormonal activation of ornithine decarboxylase in embryonic chick pelvic cartilage. 
  • Hormonal stimulation of avian embryonic cartilage growth in vitro: histologic and ultrastructural features. 
  • Identification of late larval stage developmental checkpoints in Caenorhabditis elegans regulated by insulin/IGF and steroid hormone signaling pathways. 
  • Impaired growth hormone secretion in the adult population: relation to age and adiposity. 
  • Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer. 
  • Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer. 
  • N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma. 
  • Nutritional regulation of insulin-like growth factor-binding protein gene expression in the ovine fetus and pregnant ewe. 
  • Pervasive Positive and Negative Feedback Regulation of Insulin-Like Signaling in Caenorhabditis elegans. 
  • Rare and low-frequency coding variants alter human adult height. 
  • Regulation and localization of the insulin-like growth factor system in small bowel during altered nutrient status. 
  • Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency. 
  • Somatomedin-C stimulates glycogen synthesis in fetal rat hepatocytes. 
  • Structural and functional characterization of the human T lymphocyte receptor for insulin-like growth factor I in vitro. 
  • Suppression of immune function in growth hormone-deficient children during treatment with human growth hormone. 
  • The 25-kilodalton insulin-like growth factor (IGF)-binding protein inhibits both basal and IGF-I-mediated growth of chick embryo pelvic cartilage in vitro. 
  • The distinct roles of insulin signaling in polyphenic development. 
  • dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest. 
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  Keywords of People

  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology