Somatostatin

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  Subject Areas on Research

  • A disinhibitory circuit mediates motor integration in the somatosensory cortex. 
  • A phase 2 trial of the somatostatin analog pasireotide to prevent GI toxicity and acute GVHD in allogeneic hematopoietic stem cell transplant. 
  • A physiologic role for somatostatin 28 as a regulator of insulin secretion. 
  • Acute restraint stress redirects prefrontal cortex circuit function through mGlu₅ receptor plasticity on somatostatin-expressing interneurons. 
  • Advances in drug therapy for peptic ulcer disease. 
  • Analysis of the role of E2A-encoded proteins in insulin gene transcription. 
  • Autofeedback suppression of growth hormone (GH) secretion in transgenic mice expressing a human GH reporter targeted by tyrosine hydroxylase 5'-flanking sequences to the hypothalamus. 
  • Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum. 
  • Changes in gamma-aminobutyric acid and somatostatin in epileptic cortex associated with low-grade gliomas. 
  • Cholecystokinin does not stimulate prosomatostatin-derived peptides in man. 
  • Clinical uses of gut peptides. 
  • Contrast dependence and differential contributions from somatostatin- and parvalbumin-expressing neurons to spatial integration in mouse V1. 
  • Correlation between axonal morphologies and synaptic input kinetics of interneurons from mouse visual cortex. 
  • Cortical interneurons that specialize in disinhibitory control. 
  • Cytoprotection by somatostatin of normal and malignant clonogenic cells against the in vitro cytotoxicity of bischloroethylnitrosourea (BCNU). 
  • Detection of primary breast cancer presenting as metastatic carcinoma of unknown primary origin by 111In-pentetreotide scan. 
  • Diagnosis and treatment of symptomatic peripancreatic fluid collections after pancreas transplant. 
  • Differential activity-dependent, homeostatic plasticity of two neocortical inhibitory circuits. 
  • Distinct behavioural and network correlates of two interneuron types in prefrontal cortex. 
  • Effect of hypophysectomy on somatostatin-14 and somatostatin-28 biosynthesis in the rat hypothalamus. 
  • Effect of ingested nutrients on the release of thrittene into the human circulation. 
  • Effect of somatostatin-28 on dynamics of insulin secretion in perfused rat pancreas. 
  • Effect of the isoflavone genistein against galactose-induced cataracts in rats. 
  • Effects of glucagonlike peptide I-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures. 
  • Endogenous somatostatin-28 modulates postprandial insulin secretion. Immunoneutralization studies in baboons. 
  • Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active. 
  • Ethanol diminishes a voltage-dependent K+ current, the M-current, in CA1 hippocampal pyramidal neurons in vitro. 
  • Experience-dependent modification of a central amygdala fear circuit. 
  • Fasting and postprandial concentrations of somatostatin-28 and somatostatin-14 in type II diabetes in men. 
  • GABAergic neurons of mammalian cerebral cortex: widespread subclass defined by somatostatin content. 
  • Heterogeneity of somatostatin like immunoreactivity (SLI) in extracts of porcine, canine and human pancreas. 
  • Human ovarian cancers express somatostatin receptors. 
  • In vivo biosynthesis of arginine vasopressin and oxytocin in hypothalami from intact and hypophysectomized rats. 
  • Influence of food deprivation on intestinal cholecystokinin and somatostatin. 
  • Inhibition of PC-3 human androgen-independent prostate cancer and its metastases by cytotoxic somatostatin analogue AN-238. 
  • Inhibition of basal and meal-stimulated choleresis by somatostatin. 
  • Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. 
  • Levels of Evidence in Medical Research: "Bigger Is Not Always Better". 
  • Manipulation of small-molecule inhibitory kinetics modulates MCH-R1 function. 
  • Neonatal immune challenge induces female-specific changes in social behavior and somatostatin cell number. 
  • Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids. 
  • Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. 
  • Neuropeptides modulate compound postsynaptic potentials in basolateral amygdala. 
  • Nuclear protein CBP is a coactivator for the transcription factor CREB. 
  • Opposing central and peripheral actions of brain-gut peptides: a basis for regulation of gastric function. 
  • Outcomes after Pancreatectomy with Routine Pasireotide Use. 
  • Pasireotide for postoperative pancreatic fistula. 
  • Pasireotide for postoperative pancreatic fistula. 
  • Peptides and neurotransmitters that affect renin secretion. 
  • Phase III study of pasireotide long-acting release in patients with metastatic neuroendocrine tumors and carcinoid symptoms refractory to available somatostatin analogues. 
  • Postprandial neurohormonal control of gastric emptying. 
  • Pre-treatment with somatostatin in the anaesthetic management of a patient with carcinoid syndrome. 
  • Pseudopod-like basal cell processes in intestinal cholecystokinin cells. 
  • Radioiodinated metaiodobenzylguanidine in the diagnosis and therapy of carcinoid tumors. 
  • Recent advances in the neurochemical pathology of Alzheimer's disease. Studies of neuropeptides, cholinergic function and Alzheimer's disease-associated protein. 
  • Regulation of cholecystokinin gene expression in rat intestine. 
  • Regulation of intestinal cholecystokinin and somatostatin mRNA by bombesin in rats. 
  • Safety and Efficacy of 68Ga-DOTATATE PET/CT for Diagnosis, Staging, and Treatment Management of Neuroendocrine Tumors. 
  • Somatostatin and the treatment of cancer. 
  • Somatostatin augments the M-current in hippocampal neurons. 
  • Somatostatin immunohistochemistry of hippocampal slices with lucifer yellow-stained pyramidal neurons responding to somatostatin. 
  • Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells. 
  • Somatostatin regulates duodenal cholecystokinin and somatostatin messenger RNA. 
  • Somatostatin-induced cholestasis can be independent of portal blood flow. 
  • Spectrophotometry of cerebral cytochrome a, a3 in bloodless rats. 
  • Spinal CCL2 Promotes Central Sensitization, Long-Term Potentiation, and Inflammatory Pain via CCR2: Further Insights into Molecular, Synaptic, and Cellular Mechanisms. 
  • Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs. 
  • TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice. 
  • Targeted entry via somatostatin receptors using a novel modified retrovirus glycoprotein that delivers genes at levels comparable to those of wild-type viral glycoproteins. 
  • The Cost of Postoperative Pancreatic Fistula Versus the Cost of Pasireotide: Results from a Prospective Randomized Trial. 
  • The effect of somatostatin on experimental intestinal obstruction. 
  • The effects of liver denervation on the regulation of hepatic biliary secretion. 
  • The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. 
  • The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding. 
  • The use of somatostatin and its analogs in the treatment of surgical disorders. 
  • Therapy With ¹⁷⁷ Lu-DOTATATE: Clinical Implementation and Impact on Care of Patients With Neuroendocrine Tumors. 
  • Thrittene, homologous with somatostatin-28((1-13)), is a novel peptide in mammalian gut and circulation. 
  • Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn. 
  • Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. 
  • Two-dimensional fluorescence intensity distribution analysis: theory and applications. 
  • Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex. 
  • Visual representations by cortical somatostatin inhibitory neurons--selective but with weak and delayed responses.