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Subject Areas on Research
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A disinhibitory circuit mediates motor integration in the somatosensory cortex.
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A phase 2 trial of the somatostatin analog pasireotide to prevent GI toxicity and acute GVHD in allogeneic hematopoietic stem cell transplant.
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A physiologic role for somatostatin 28 as a regulator of insulin secretion.
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Acute restraint stress redirects prefrontal cortex circuit function through mGlu5
receptor plasticity on somatostatin-expressing interneurons.
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Advances in drug therapy for peptic ulcer disease.
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Analysis of the role of E2A-encoded proteins in insulin gene transcription.
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Autofeedback suppression of growth hormone (GH) secretion in transgenic mice expressing a human GH reporter targeted by tyrosine hydroxylase 5'-flanking sequences to the hypothalamus.
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Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum.
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Changes in gamma-aminobutyric acid and somatostatin in epileptic cortex associated with low-grade gliomas.
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Cholecystokinin does not stimulate prosomatostatin-derived peptides in man.
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Clinical uses of gut peptides.
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Contrast dependence and differential contributions from somatostatin- and parvalbumin-expressing neurons to spatial integration in mouse V1.
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Correlation between axonal morphologies and synaptic input kinetics of interneurons from mouse visual cortex.
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Cortical interneurons that specialize in disinhibitory control.
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Cytoprotection by somatostatin of normal and malignant clonogenic cells against the in vitro cytotoxicity of bischloroethylnitrosourea (BCNU).
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Detection of primary breast cancer presenting as metastatic carcinoma of unknown primary origin by 111In-pentetreotide scan.
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Diagnosis and treatment of symptomatic peripancreatic fluid collections after pancreas transplant.
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Differential activity-dependent, homeostatic plasticity of two neocortical inhibitory circuits.
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Distinct behavioural and network correlates of two interneuron types in prefrontal cortex.
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Effect of hypophysectomy on somatostatin-14 and somatostatin-28 biosynthesis in the rat hypothalamus.
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Effect of ingested nutrients on the release of thrittene into the human circulation.
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Effect of somatostatin-28 on dynamics of insulin secretion in perfused rat pancreas.
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Effect of the isoflavone genistein against galactose-induced cataracts in rats.
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Effects of glucagonlike peptide I-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures.
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Endogenous somatostatin-28 modulates postprandial insulin secretion. Immunoneutralization studies in baboons.
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Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active.
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Ethanol diminishes a voltage-dependent K+ current, the M-current, in CA1 hippocampal pyramidal neurons in vitro.
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Experience-dependent modification of a central amygdala fear circuit.
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Fasting and postprandial concentrations of somatostatin-28 and somatostatin-14 in type II diabetes in men.
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GABAergic neurons of mammalian cerebral cortex: widespread subclass defined by somatostatin content.
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Heterogeneity of somatostatin like immunoreactivity (SLI) in extracts of porcine, canine and human pancreas.
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Human ovarian cancers express somatostatin receptors.
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In vivo biosynthesis of arginine vasopressin and oxytocin in hypothalami from intact and hypophysectomized rats.
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Influence of food deprivation on intestinal cholecystokinin and somatostatin.
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Inhibition of PC-3 human androgen-independent prostate cancer and its metastases by cytotoxic somatostatin analogue AN-238.
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Inhibition of basal and meal-stimulated choleresis by somatostatin.
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Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons.
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Levels of Evidence in Medical Research: "Bigger Is Not Always Better".
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Manipulation of small-molecule inhibitory kinetics modulates MCH-R1 function.
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Neonatal immune challenge induces female-specific changes in social behavior and somatostatin cell number.
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Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids.
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Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision.
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Neuropeptides modulate compound postsynaptic potentials in basolateral amygdala.
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Nuclear protein CBP is a coactivator for the transcription factor CREB.
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Opposing central and peripheral actions of brain-gut peptides: a basis for regulation of gastric function.
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Outcomes after Pancreatectomy with Routine Pasireotide Use.
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Pasireotide for postoperative pancreatic fistula.
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Pasireotide for postoperative pancreatic fistula.
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Peptides and neurotransmitters that affect renin secretion.
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Phase III study of pasireotide long-acting release in patients with metastatic neuroendocrine tumors and carcinoid symptoms refractory to available somatostatin analogues.
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Postprandial neurohormonal control of gastric emptying.
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Pre-treatment with somatostatin in the anaesthetic management of a patient with carcinoid syndrome.
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Pseudopod-like basal cell processes in intestinal cholecystokinin cells.
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Radioiodinated metaiodobenzylguanidine in the diagnosis and therapy of carcinoid tumors.
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Recent advances in the neurochemical pathology of Alzheimer's disease. Studies of neuropeptides, cholinergic function and Alzheimer's disease-associated protein.
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Regulation of cholecystokinin gene expression in rat intestine.
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Regulation of intestinal cholecystokinin and somatostatin mRNA by bombesin in rats.
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Safety and Efficacy of 68Ga-DOTATATE PET/CT for Diagnosis, Staging, and Treatment Management of Neuroendocrine Tumors.
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Somatostatin and the treatment of cancer.
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Somatostatin augments the M-current in hippocampal neurons.
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Somatostatin immunohistochemistry of hippocampal slices with lucifer yellow-stained pyramidal neurons responding to somatostatin.
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Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells.
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Somatostatin regulates duodenal cholecystokinin and somatostatin messenger RNA.
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Somatostatin-induced cholestasis can be independent of portal blood flow.
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Spectrophotometry of cerebral cytochrome a, a3 in bloodless rats.
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Spinal CCL2 Promotes Central Sensitization, Long-Term Potentiation, and Inflammatory Pain via CCR2: Further Insights into Molecular, Synaptic, and Cellular Mechanisms.
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Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs.
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TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice.
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Targeted entry via somatostatin receptors using a novel modified retrovirus glycoprotein that delivers genes at levels comparable to those of wild-type viral glycoproteins.
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The Cost of Postoperative Pancreatic Fistula Versus the Cost of Pasireotide: Results from a Prospective Randomized Trial.
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The effect of somatostatin on experimental intestinal obstruction.
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The effects of liver denervation on the regulation of hepatic biliary secretion.
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The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.
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The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding.
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The use of somatostatin and its analogs in the treatment of surgical disorders.
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Therapy With 177
Lu-DOTATATE: Clinical Implementation and Impact on Care of Patients With Neuroendocrine Tumors.
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Thrittene, homologous with somatostatin-28((1-13)), is a novel peptide in mammalian gut and circulation.
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Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn.
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Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB.
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Two-dimensional fluorescence intensity distribution analysis: theory and applications.
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Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex.
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Visual representations by cortical somatostatin inhibitory neurons--selective but with weak and delayed responses.