Specific Pathogen-Free Organisms

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  Subject Areas on Research

  • Aging and reactivation of latent murine cytomegalovirus. 
  • B cell subsets in pristane-induced autoimmunity. 
  • Binding of rat alpha 1-inhibitor-3-methylamine to the alpha 2-macroglobulin signaling receptor induces second messengers. 
  • CD19 can regulate B lymphocyte signal transduction independent of complement activation. 
  • CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. 
  • Characterization of a developmentally regulated oocyst protein from Eimeria tenella. 
  • Characterization of lung inflammation and its impact on macrophage function in aging. 
  • Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice. 
  • Comparison of fecal biota from specific pathogen free and feral mice. 
  • Cutting Edge: c-Maf Is Required for Regulatory T Cells To Adopt RORγt+ and Follicular Phenotypes. 
  • Deposition, clearance, and translocation of chrysotile asbestos from peripheral and central regions of the rat lung. 
  • Developmental stage-specific expression of the alpha and beta subunits of the HIF-1 protein in the mouse and human fetus. 
  • Differential expression of arginase and iNOS in the lung in sepsis. 
  • Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation. 
  • Effect of preexposure to ultrafine carbon black on respiratory syncytial virus infection in mice. 
  • Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice. 
  • Exposure to low levels of ozone results in enhanced pulmonary retention of inhaled asbestos fibers. 
  • Extracellular domain of 4-1BBL enhanced the antitumoral efficacy of peripheral blood lymphocytes mediated by anti-CD3 x anti-Pgp bispecific diabody against human multidrug-resistant leukemia. 
  • Graft-versus-host disease prevention by rapamycin: cellular mechanisms. 
  • Gut immune maturation depends on colonization with a host-specific microbiota. 
  • High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. 
  • Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells. 
  • Identification of Tgf beta1i4 as a downstream target of Foxc1. 
  • Inducible expression of the alpha2-macroglobulin signaling receptor in response to antigenic stimulation: a study of second messenger generation. 
  • Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cells. 
  • Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. 
  • Kupffer cell depletion by CI2MDP-liposomes alters hepatic cytokine expression and delays liver regeneration after partial hepatectomy. 
  • Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor. 
  • Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity. 
  • Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice. 
  • Mitosis and differentiation in T-cells under cytotoxic action of Echinococcus granulosus hydatid fluid. 
  • Murine cytomegalovirus infection: hematological, morphological, and functional study of lymphoid cells. 
  • NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment. 
  • Osteopontin expression in particle-induced lung disease. 
  • Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission. 
  • Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP. 
  • Quantitative analysis of angiogenesis and growth of bone: effect of indomethacin exposure in a combined in vitro-in vivo approach. 
  • Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. 
  • Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice. 
  • Retinoic acid receptor beta2 inhibition of metastasis in mouse mammary gland xenografts. 
  • Role of granulocyte elastase in indomethacin-induced gastric mucosal lesion formation in rats. 
  • Role of neutrophil elastase in stress-induced gastric mucosal injury in rats. 
  • Soluble ICAM-1, MCP-1, and MIP-2 protein secretion by rat pleural mesothelial cells following exposure to amosite asbestos. 
  • TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α. 
  • Therapeutic effects of diethylcarbamazine and 3'-azido-3'-deoxythymidine on feline leukemia virus lymphoma formation. 
  • Time and pressure dependence of transvascular Clara cell protein, albumin, and IgG transport during ventilator-induced lung injury in mice. 
  • Toll-like receptor agonists as third signals for dendritic cell-tumor fusion vaccines. 
  • Transformation of rat tracheal epithelial cells to immortal growth variants by particulate and soluble nickel compounds. 
  • Tyloxapol confers durable protection against hyperoxic lung injury in the rat. 
  • Ultrafine carbon black particles enhance respiratory syncytial virus-induced airway reactivity, pulmonary inflammation, and chemokine expression. 
  • Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2). 
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  Keywords of People

  • Chen, Jun, Associate Professor of Medicine, Duke Cancer Institute
  • Cianciolo, George James, Associate Professor in Pathology, Pathology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Immunology
  • Lee, Walter T, Associate Professor of Head and Neck Surgery and Communication Sciences, Radiation Oncology