Spectrin

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  Subject Areas on Research

  • A beta-spectrin isoform from Drosophila (beta H) is similar in size to vertebrate dystrophin. 
  • A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. 
  • A molecular defect in two families with hemolytic poikilocytic anemia: reduction of high affinity membrane binding sites for ankyrin. 
  • A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments. 
  • Aberrant splicing contributes to severe α-spectrin-linked congenital hemolytic anemia. 
  • Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds to spectrin and associates with nuclear promyelocytic leukemia (PML) bodies. 
  • Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons. 
  • Adducin preferentially recruits spectrin to the fast growing ends of actin filaments in a complex requiring the MARCKS-related domain and a newly defined oligomerization domain. 
  • Adducin promotes micrometer-scale organization of beta2-spectrin in lateral membranes of bronchial epithelial cells. 
  • Adducin: Ca++-dependent association with sites of cell-cell contact. 
  • Adducin: a physical model with implications for function in assembly of spectrin-actin complexes. 
  • Adducin: structure, function and regulation. 
  • Alpha-adducin dissociates from F-actin and spectrin during platelet activation. 
  • An Adaptable Spectrin/Ankyrin-Based Mechanism for Long-Range Organization of Plasma Membranes in Vertebrate Tissues. 
  • Ankyrin and spectrin associate with voltage-dependent sodium channels in brain. 
  • Ankyrin and synapsin: spectrin-binding proteins associated with brain membranes. 
  • Ankyrin regulation: an alternatively spliced segment of the regulatory domain functions as an intramolecular modulator. 
  • Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. 
  • Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells. 
  • Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. 
  • Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo. 
  • Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly. 
  • Ankyrin-binding activity of nervous system cell adhesion molecules expressed in adult brain. 
  • Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin. 
  • Association between human erythrocyte calmodulin and the cytoplasmic surface of human erythrocyte membranes. 
  • Beta heavy-spectrin has a restricted tissue and subcellular distribution during Drosophila embryogenesis. 
  • Brain adducin: a protein kinase C substrate that may mediate site-directed assembly at the spectrin-actin junction. 
  • Brain ankyrin. A membrane-associated protein with binding sites for spectrin, tubulin, and the cytoplasmic domain of the erythrocyte anion channel. 
  • Brain ankyrin. Purification of a 72,000 Mr spectrin-binding domain. 
  • Brain spectrin, a membrane-associated protein related in structure and function to erythrocyte spectrin. 
  • Brain spectrin. Isolation of subunits and formation of hybrids with erythrocyte spectrin subunits. 
  • Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function. 
  • Calcium/calmodulin inhibits direct binding of spectrin to synaptosomal membranes. 
  • Characterization of human brain cDNA encoding the general isoform of beta-spectrin. 
  • Colocalization of band 3 with ankyrin and spectrin at the basal membrane of intercalated cells in the rat kidney. 
  • Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly. 
  • Deficient red-cell spectrin in severe, recessively inherited spherocytosis. 
  • Degradation of spectrin and ankyrin in the ischemic rat kidney. 
  • Developmental mechanism of the periodic membrane skeleton in axons. 
  • Diversity in membrane binding sites of ankyrins. Brain ankyrin, erythrocyte ankyrin, and processed erythrocyte ankyrin associate with distinct sites in kidney microsomes. 
  • Drosophila betaHeavy-spectrin is essential for development and contributes to specific cell fates in the eye. 
  • Drosophila spectrin. II. Conserved features of the alpha-subunit are revealed by analysis of cDNA clones and fusion proteins. 
  • Drosophila spectrin: the membrane skeleton during embryogenesis. 
  • Drosophilia spectrin. I. Characterization of the purified protein. 
  • Existence of a flat phase in red cell membrane skeletons. 
  • Expression of functional domains of beta G-spectrin disrupts epithelial morphology in cultured cells. 
  • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. 
  • Human erythrocyte ankyrin. Purification and properties. 
  • Human erythrocyte spectrin: phosphorylation in intact cells and purification of the 32P-labeled protein in a non-aggregated state. 
  • Identification and partial purification of ankyrin, the high affinity membrane attachment site for human erythrocyte spectrin. 
  • Identification of the spectrin subunit and domains required for formation of spectrin/adducin/actin complexes. 
  • Identification of two regions of beta G spectrin that bind to distinct sites in brain membranes. 
  • Immunoreactive forms of erythrocyte spectrin and ankyrin in brain. 
  • In vitro proteolysis of brain spectrin by calpain I inhibits association of spectrin with ankyrin-independent membrane binding site(s). 
  • Intragenic duplication and divergence in the spectrin superfamily of proteins. 
  • Localization and structure of the ankyrin-binding site on beta2-spectrin. 
  • Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin. 
  • Membrane domains based on ankyrin and spectrin associated with cell-cell interactions. 
  • Microtubule-associated protein 2, a microtubule-associated protein from brain, is immunologically related to the alpha subunit of erythrocyte spectrin. 
  • Modulation of spectrin-actin assembly by erythrocyte adducin. 
  • Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates. 
  • Of mice and men: the mice were right. 
  • Organizing the fluid membrane bilayer: diseases linked to spectrin and ankyrin. 
  • Partial deficiency of erythrocyte spectrin in hereditary spherocytosis. 
  • Postmitotic expression of ankyrinR and beta R-spectrin in discrete neuronal populations of the rat brain. 
  • Proteins closely related to spectrin and ankyrin are general components of cell membranes. 
  • Proteins involved in membrane--cytoskeleton association in human erythrocytes: spectrin, ankyrin, and band 3. 
  • Purification of an active proteolytic fragment of the membrane attachment site for human erythrocyte spectrin. 
  • Purification of brain analogs of red blood cell membrane skeletal proteins: ankyrin, protein 4.1 (synapsin), spectrin, and spectrin subunits. 
  • Pyrrole oxidation and protein cross-linking as necessary steps in the development of gamma-diketone neuropathy. 
  • Red blood cell and fibroblast membranes in Duchenne and myotonic muscular dystrophy. 
  • Regulatory domains of erythrocyte ankyrin. 
  • Restriction of 480/270-kD ankyrin G to axon proximal segments requires multiple ankyrin G-specific domains. 
  • Selective association of spectrin with the cytoplasmic surface of human erythrocyte plasma membranes. Quantitative determination with purified (32P)spectrin. 
  • Spectrin and ankyrin in brain. 
  • Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. 
  • Spectrin- and ankyrin-based membrane domains and the evolution of vertebrates. 
  • Spectrin-based membrane skeleton: a multipotential adaptor between plasma membrane and cytoplasm. 
  • Spectrin: a structural mediator between diverse plasma membrane proteins and the cytoplasm. 
  • Synapsin I is a spectrin-binding protein immunologically related to erythrocyte protein 4.1. 
  • Synapsin I: a regulated synaptic vesicle organizing protein. 
  • The actin membrane skeleton in Drosophila development. 
  • The anion exchanger and Na+K(+)-ATPase interact with distinct sites on ankyrin in in vitro assays. 
  • The membrane attachment protein for spectrin is associated with band 3 in human erythrocyte membranes. 
  • The membrane skeleton of human erythrocytes and its implications for more complex cells. 
  • The molecular basis for membrane - cytoskeleton association in human erythrocytes. 
  • The spectrin skeleton: from red cells to brain. 
  • The spectrin-actin junction of erythrocyte membrane skeletons. 
  • The spectrin-based membrane skeleton and micron-scale organization of the plasma membrane. 
  • The spectrin-based membrane skeleton: extensions of the current paradigm. 
  • Tropomyosin: a new component of the erythrocyte membrane skeleton. 
  • Ultrastructural localization of erythrocyte cytoskeletal and integral membrane proteins in Plasmodium falciparum-infected erythrocytes. 
  • Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity. 
  • βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute