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Subject Areas on Research
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A beta-spectrin isoform from Drosophila (beta H) is similar in size to vertebrate dystrophin.
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A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier.
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A molecular defect in two families with hemolytic poikilocytic anemia: reduction of high affinity membrane binding sites for ankyrin.
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A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments.
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Aberrant splicing contributes to severe α-spectrin-linked congenital hemolytic anemia.
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Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds to spectrin and associates with nuclear promyelocytic leukemia (PML) bodies.
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Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons.
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Adducin preferentially recruits spectrin to the fast growing ends of actin filaments in a complex requiring the MARCKS-related domain and a newly defined oligomerization domain.
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Adducin promotes micrometer-scale organization of beta2-spectrin in lateral membranes of bronchial epithelial cells.
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Adducin: Ca++-dependent association with sites of cell-cell contact.
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Adducin: a physical model with implications for function in assembly of spectrin-actin complexes.
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Adducin: structure, function and regulation.
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Alpha-adducin dissociates from F-actin and spectrin during platelet activation.
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An Adaptable Spectrin/Ankyrin-Based Mechanism for Long-Range Organization of Plasma Membranes in Vertebrate Tissues.
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Ankyrin and spectrin associate with voltage-dependent sodium channels in brain.
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Ankyrin and synapsin: spectrin-binding proteins associated with brain membranes.
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Ankyrin regulation: an alternatively spliced segment of the regulatory domain functions as an intramolecular modulator.
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Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes.
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Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells.
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Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments.
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Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo.
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Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly.
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Ankyrin-binding activity of nervous system cell adhesion molecules expressed in adult brain.
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Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin.
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Association between human erythrocyte calmodulin and the cytoplasmic surface of human erythrocyte membranes.
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Beta heavy-spectrin has a restricted tissue and subcellular distribution during Drosophila embryogenesis.
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Brain adducin: a protein kinase C substrate that may mediate site-directed assembly at the spectrin-actin junction.
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Brain ankyrin. A membrane-associated protein with binding sites for spectrin, tubulin, and the cytoplasmic domain of the erythrocyte anion channel.
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Brain ankyrin. Purification of a 72,000 Mr spectrin-binding domain.
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Brain spectrin, a membrane-associated protein related in structure and function to erythrocyte spectrin.
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Brain spectrin. Isolation of subunits and formation of hybrids with erythrocyte spectrin subunits.
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Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function.
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Calcium/calmodulin inhibits direct binding of spectrin to synaptosomal membranes.
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Characterization of human brain cDNA encoding the general isoform of beta-spectrin.
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Colocalization of band 3 with ankyrin and spectrin at the basal membrane of intercalated cells in the rat kidney.
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Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly.
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Deficient red-cell spectrin in severe, recessively inherited spherocytosis.
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Degradation of spectrin and ankyrin in the ischemic rat kidney.
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Developmental mechanism of the periodic membrane skeleton in axons.
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Diversity in membrane binding sites of ankyrins. Brain ankyrin, erythrocyte ankyrin, and processed erythrocyte ankyrin associate with distinct sites in kidney microsomes.
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Drosophila betaHeavy-spectrin is essential for development and contributes to specific cell fates in the eye.
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Drosophila spectrin. II. Conserved features of the alpha-subunit are revealed by analysis of cDNA clones and fusion proteins.
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Drosophila spectrin: the membrane skeleton during embryogenesis.
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Drosophilia spectrin. I. Characterization of the purified protein.
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Existence of a flat phase in red cell membrane skeletons.
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Expression of functional domains of beta G-spectrin disrupts epithelial morphology in cultured cells.
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Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
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Human erythrocyte ankyrin. Purification and properties.
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Human erythrocyte spectrin: phosphorylation in intact cells and purification of the 32P-labeled protein in a non-aggregated state.
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Identification and partial purification of ankyrin, the high affinity membrane attachment site for human erythrocyte spectrin.
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Identification of the spectrin subunit and domains required for formation of spectrin/adducin/actin complexes.
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Identification of two regions of beta G spectrin that bind to distinct sites in brain membranes.
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Immunoreactive forms of erythrocyte spectrin and ankyrin in brain.
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In vitro proteolysis of brain spectrin by calpain I inhibits association of spectrin with ankyrin-independent membrane binding site(s).
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Intragenic duplication and divergence in the spectrin superfamily of proteins.
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Localization and structure of the ankyrin-binding site on beta2-spectrin.
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Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin.
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Membrane domains based on ankyrin and spectrin associated with cell-cell interactions.
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Microtubule-associated protein 2, a microtubule-associated protein from brain, is immunologically related to the alpha subunit of erythrocyte spectrin.
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Modulation of spectrin-actin assembly by erythrocyte adducin.
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Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates.
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Of mice and men: the mice were right.
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Organizing the fluid membrane bilayer: diseases linked to spectrin and ankyrin.
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Partial deficiency of erythrocyte spectrin in hereditary spherocytosis.
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Postmitotic expression of ankyrinR and beta R-spectrin in discrete neuronal populations of the rat brain.
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Proteins closely related to spectrin and ankyrin are general components of cell membranes.
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Proteins involved in membrane--cytoskeleton association in human erythrocytes: spectrin, ankyrin, and band 3.
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Purification of an active proteolytic fragment of the membrane attachment site for human erythrocyte spectrin.
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Purification of brain analogs of red blood cell membrane skeletal proteins: ankyrin, protein 4.1 (synapsin), spectrin, and spectrin subunits.
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Pyrrole oxidation and protein cross-linking as necessary steps in the development of gamma-diketone neuropathy.
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Red blood cell and fibroblast membranes in Duchenne and myotonic muscular dystrophy.
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Regulatory domains of erythrocyte ankyrin.
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Restriction of 480/270-kD ankyrin G to axon proximal segments requires multiple ankyrin G-specific domains.
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Selective association of spectrin with the cytoplasmic surface of human erythrocyte plasma membranes. Quantitative determination with purified (32P)spectrin.
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Spectrin and ankyrin in brain.
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Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues.
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Spectrin- and ankyrin-based membrane domains and the evolution of vertebrates.
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Spectrin-based membrane skeleton: a multipotential adaptor between plasma membrane and cytoplasm.
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Spectrin: a structural mediator between diverse plasma membrane proteins and the cytoplasm.
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Synapsin I is a spectrin-binding protein immunologically related to erythrocyte protein 4.1.
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Synapsin I: a regulated synaptic vesicle organizing protein.
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The actin membrane skeleton in Drosophila development.
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The anion exchanger and Na+K(+)-ATPase interact with distinct sites on ankyrin in in vitro assays.
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The membrane attachment protein for spectrin is associated with band 3 in human erythrocyte membranes.
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The membrane skeleton of human erythrocytes and its implications for more complex cells.
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The molecular basis for membrane - cytoskeleton association in human erythrocytes.
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The spectrin skeleton: from red cells to brain.
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The spectrin-actin junction of erythrocyte membrane skeletons.
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The spectrin-based membrane skeleton and micron-scale organization of the plasma membrane.
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The spectrin-based membrane skeleton: extensions of the current paradigm.
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Tropomyosin: a new component of the erythrocyte membrane skeleton.
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Ultrastructural localization of erythrocyte cytoskeletal and integral membrane proteins in Plasmodium falciparum-infected erythrocytes.
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Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity.
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βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport.
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Keywords of People