Spectrum Analysis

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  Subject Areas on Research

  • 3D MRI of impaired hyperpolarized 129Xe uptake in a rat model of pulmonary fibrosis. 
  • A Clinical Study to Assess Diffuse Reflectance Spectroscopy with an Auto-Calibrated, Pressure-Sensing Optical Probe in Head and Neck Cancer. 
  • A backbone lever-arm effect enhances polymer mechanochemistry. 
  • A colorimetric gold nanoparticle sensor to interrogate biomolecular interactions in real time on a surface. 
  • A highly distributed Bragg stack with unique geometry provides effective camouflage for Loliginid squid eyes. 
  • A hyperspectral imaging system for in vivo optical diagnostics. Hyperspectral imaging basic principles, instrumental systems, and applications of biomedical interest. 
  • A kinetic investigation of the interaction of erythro-beta-hydroxyaspartic acid with aspartate aminotransferase. 
  • A low-cost, portable, and quantitative spectral imaging system for application to biological tissues. 
  • A method to correct for spectral artifacts in optical-CT dosimetry. 
  • A peptide model of a protein folding intermediate. 
  • A robust Monte Carlo model for the extraction of biological absorption and scattering in vivo. 
  • A strategy for quantitative spectral imaging of tissue absorption and scattering using light emitting diodes and photodiodes. 
  • A subtransition in a phospholipid with a net charge, dipalmitoylphosphatidylglycerol. 
  • A2E Distribution in RPE Granules in Human Eyes. 
  • AN OPTICAL ROTATORY DISPERSION STUDY OF ASPARTIC AMINO TRANSFERASE. 
  • Accurately Measuring Molecular Rotational Spectra in Excited Vibrational Modes. 
  • Adaptive feature specific spectroscopy for rapid chemical identification. 
  • Advanced imaging and technology in gastrointestinal neoplasia: summary of the AGA-NCI Symposium October 4-5, 2004. 
  • An Ultrahigh Precision, High-Frequency Dissolved Inorganic Carbon Analyzer Based on Dual Isotope Dilution and Cavity Ring-Down Spectroscopy. 
  • An exposure indicator for digital radiography: AAPM Task Group 116 (executive summary). 
  • An overview of digital spectrometers for MR imaging. Instrumentation Subcommittee of the SMRI Basic Science Council. 
  • Analysis of total uncertainty in spectral peak measurements for plasmonic nanoparticle-based biosensors. 
  • Analyzing fibrin clot structure using a microplate reader. 
  • Anti-HIV Agents 45 and Antitumor Agents 205. Two New Sesquiterpenes, Leitneridanins A and B, and the Cytotoxic and Anti-HIV Principles from Leitneria floridana 
  • Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla. 
  • Antitumor agents. 190. Absolute stereochemistry of the cytotoxic germacranolides, tomenphantins A and B, from Elephantopus tomentosus. 
  • Application of Mie theory to determine the structure of spheroidal scatterers in biological materials. 
  • Application of optical imaging and spectroscopy to radiation biology. 
  • Ascaris haemoglobin is a nitric oxide-activated 'deoxygenase'. 
  • Assessing effects of pressure on tumor and normal tissue physiology using an automated self-calibrated, pressure-sensing probe for diffuse reflectance spectroscopy. 
  • Assessment of individual organ doses in a realistic human phantom from neutron and gamma stimulated spectroscopy of the breast and liver. 
  • Assessment of the sensitivity and specificity of tissue-specific-based and anatomical-based optical biomarkers for rapid detection of human head and neck squamous cell carcinoma. 
  • Auditory plasticity in a basal ganglia-forebrain pathway during decrystallization of adult birdsong. 
  • Bacterially driven cadmium sulfide precipitation on porous membranes: Toward platforms for photocatalytic applications. 
  • Biochemistry. Photosynthesis from the protein's perspective. 
  • Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity. 
  • C-nitroso compounds: synthesis, physicochemical properties and biological activities. 
  • Cerebrocortical oxygenation and ventilatory response during sustained hypoxia. 
  • Chain-length-dependent microwave absorption of DNA. 
  • Characterization and property of DNA incorporated bilayer lipid membranes. 
  • Charge Transport across DNA-Based Three-Way Junctions. 
  • Chirality affects aggregation kinetics of single-walled carbon nanotubes. 
  • Cholesteryl esters in flue-cured tobacco. 
  • Chromophore based analyses of steady-state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption. 
  • Coded aperture spectroscopy with denoising through sparsity. 
  • Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging. 
  • Conformation change of horseradish peroxidase in lipid membrane. 
  • Consequences of chemical modifications on the free radical reactions of human hemoglobin. 
  • Contributions of intrinsic membrane dynamics to fast network oscillations with irregular neuronal discharges. 
  • Correlation of breast tissue histology and optical signatures to improve margin assessment techniques. 
  • Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency. 
  • Cost-effective diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering in vivo. 
  • Cross-phase modulation imaging 
  • Cue-invariant networks for figure and background processing in human visual cortex. 
  • Detection of squamous cell carcinoma and corresponding biomarkers using optical spectroscopy. 
  • Determination of the number of regulatory and catalytic sites on aspartate transcarbamylase. 
  • Development of a fluorescence detection system using optical parametric oscillator (OPO) laser excitation for in vivo diagnosis. 
  • Diagnostic Accuracy of Electrographic Seizure Detection by Neurophysiologists and Non-Neurophysiologists in the Adult ICU Using a Panel of Quantitative EEG Trends. 
  • Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury. 
  • Direct comparison of conventional and computed radiography with a dual-image recording technique. 
  • Direct detection of inter-residue hydrogen bonds in polysaccharides by single-molecule force spectroscopy. 
  • Direct detection of the formation of V-amylose helix by single molecule force spectroscopy. 
  • Direct electron transfer between hemoglobin and a glassy carbon electrode facilitated by lipid-protected gold nanoparticles. 
  • Dual window method for processing spectroscopic optical coherence tomography signals with simultaneously high spectral and temporal resolution. 
  • Dynamics and transient absorption spectral signatures of the single-wall carbon nanotube electronically excited triplet state. 
  • ELEMENTARY STEPS IN ENZYME REACTIONS (AS STUDIED BY RELAXATION SPECTROMETRY). 
  • Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women. 
  • Effects of pulse shaping in laser spectroscopy and nuclear magnetic resonance. 
  • Effects of single-walled carbon nanotubes on the bioavailability of PCBs in field-contaminated sediments. 
  • Electromagnetic spectroscopy of normal breast tissue specimens obtained from reduction surgeries: comparison of optical and microwave properties. 
  • Engineering opposite electronic polarization of singlet and triplet states increases the yield of high-energy photoproducts. 
  • Estimation of molar absorptivities and pigment sizes for eumelanin and pheomelanin using femtosecond transient absorption spectroscopy. 
  • Ethyne-bridged (porphinato)zinc(II)-(porphinato)iron(III) complexes: phenomenological dependence of excited-state dynamics upon (porphinato)iron electronic structure. 
  • Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate. 
  • Evidence that CCK-58 has structure that influences its biological activity. 
  • Fabrication of layer-by-layer deposited multilayer films containing DNA and its interaction with methyl green. 
  • Fe(III)-coordination properties of neuromelanin components: 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid. 
  • Feasibility of field-based light scattering spectroscopy. 
  • Femtosecond phase-coherent two-dimensional spectroscopy. 
  • First observation of the P-wave spin-singlet bottomonium states hb(1P) and hb(2P). 
  • Flexible digital signal processing architecture for narrowband and spread-spectrum lock-in detection in multiphoton microscopy and time-resolved spectroscopy 
  • Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein. 
  • Force-induced prolyl cis-trans isomerization in elastin-like polypeptides. 
  • Fourier domain multispectral multiple scattering low coherence interferometry. 
  • Fourier-domain low-coherence interferometry for light-scattering spectroscopy. 
  • Full-electron ligand-to-ligand charge transfer in a compact Re(I) complex. 
  • Furosemide and mannitol suppression of epileptic activity in the human brain. 
  • Further studies on the composition and spectral properties of the photochemical reaction centers of bacteriochlorophyll b-containing bacteria. 
  • Handheld optical-resolution photoacoustic microscopy. 
  • Hemoglobin consumption by P. falciparum in individual erythrocytes imaged via quantitative phase spectroscopy. 
  • High responsivity, low dark current, heterogeneously integrated thin film Si photodetectors on rigid and flexible substrates. 
  • High-speed complex conjugate resolved retinal spectral domain optical coherence tomography using sinusoidal phase modulation. 
  • High-speed photoacoustic microscopy of mouse cortical microhemodynamics. 
  • High-throughput optical imaging and spectroscopy of individual carbon nanotubes in devices. 
  • High-throughput, multiplexed pushbroom hyperspectral microscopy. 
  • Highly conjugated, acetylenyl bridged porphyrins: new models for light-harvesting antenna systems. 
  • How to measure color using spectrometers and calibrated photographs. 
  • Hyperpolarized 129Xe MRI and Spectroscopy of Gas-Exchange Abnormalities in Nonspecific Interstitial Pneumonia. 
  • Identification of a molybdopterin-containing molybdenum cofactor in xanthine dehydrogenase from Pseudomonas aeruginosa. 
  • Identification of sugar isomers by single-molecule force spectroscopy. 
  • Imaginary magnetic tweezers for massively parallel surface adhesion spectroscopy. 
  • Impaired limbic gamma oscillatory synchrony during anxiety-related behavior in a genetic mouse model of bipolar mania. 
  • Implication of mitochondrial involvement in apoptotic activity of fragile histidine triad gene: application of synchronous luminescence spectroscopy. 
  • Improving single molecule force spectroscopy through automated real-time data collection and quantification of experimental conditions. 
  • In vitro interactions between DMSA-coated maghemite nanoparticles and human fibroblasts: A physicochemical and cyto-genotoxical study. 
  • In vivo MRI using real-time production of hyperpolarized 129Xe. 
  • In vivo label-free photoacoustic flow cytography and on-the-spot laser killing of single circulating melanoma cells. 
  • Induced alpha-band oscillations reflect ratio-dependent number discrimination in the infant brain. 
  • Infochemistry and infofuses for the chemical storage and transmission of coded information. 
  • Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia. 
  • Ion channel behavior of amphotericin B in sterol-free and cholesterol- or ergosterol-containing supported phosphatidylcholine bilayer model membranes investigated by electrochemistry and spectroscopy. 
  • Ion-channel sensing of ferricyanide anion based on a supported bilayer lipid membrane. 
  • Isolation of -L-glutaminyl 4-hydroxybenzene and -L-glutaminyl 3,4-benzoquinone: a natural sulfhydryl reagent, from sporulating gill tissue of the mushroom Agaricus bisporus. 
  • Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora. 
  • Label-free biosensing by surface plasmon resonance of nanoparticles on glass: optimization of nanoparticle size. 
  • Laboratory and field trials at Ifakara (Kilombero District, Tanzania) on the plant molluscicide Swartzia madagascariensis. 
  • Loosely packed self-assembled monolayer of N-hexadecyl-3,6-di(p-mercaptophenylacetylene)carbazole on gold and its application in biomimetic membrane research. 
  • Manganese(III) biliverdin IX dimethyl ester: a powerful catalytic scavenger of superoxide employing the Mn(III)/Mn(IV) redox couple. 
  • Mapping Simulated Two-Dimensional Spectra to Molecular Models Using Machine Learning. 
  • Mass spectrometry of N-methylated peptide derivatives. 
  • Mechanical Unfolding and Refolding of NanoLuc via Single-Molecule Force Spectroscopy and Computer Simulations. 
  • Meeting report - NSF-sponsored workshop 'Progress and Prospects of Single-Molecule Force Spectroscopy in Biological and Chemical Sciences'. 
  • Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I). 
  • Microscopy and Cell Biology: New Methods and New Questions. 
  • Microsecond folding dynamics of the F13W G29A mutant of the B domain of staphylococcal protein A by laser-induced temperature jump. 
  • Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins. 
  • Minimizing pulling geometry errors in atomic force microscope single molecule force spectroscopy. 
  • Model accounting for the effects of pulling-device stiffness in the analyses of single-molecule force measurements 
  • Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress. 
  • Modular, Nondegenerate Polyprotein Scaffolds for Atomic Force Spectroscopy. 
  • Molecular imaging and quantitative measurement of epidermal growth factor receptor expression in live cancer cells using immunolabeled gold nanoparticles. 
  • Molecular imaging of epidermal growth factor receptor in live cells with refractive index sensitivity using dark-field microspectroscopy and immunotargeted nanoparticles. 
  • Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms. 
  • Multicolor in vitro translation. 
  • Mössbauer spectroscopic studies of Escherichia coli sulfite reductase. Evidence for coupling between the siroheme and Fe4S4 cluster prosthetic groups. 
  • N2 fixation estimates in real-time by cavity ring-down laser absorption spectroscopy 
  • Neural correlates of the lombard effect in primate auditory cortex. 
  • Neuronal ensemble bursting in the basal forebrain encodes salience irrespective of valence. 
  • Non-invasive monitoring of tissue oxygenation during laparoscopic donor nephrectomy. 
  • Noninvasive optical spectroscopy for identification of non-melanoma skin cancer: Pilot study. 
  • Nonlinear phase dispersion spectroscopy. 
  • On the specificity of creatine kinase. New glycocyamines and glycocyamine analogs related to creatine. 
  • Optical breast cancer margin assessment: an observational study of the effects of tissue heterogeneity on optical contrast. 
  • Optical imaging of tumor hypoxia dynamics. 
  • Origin of overstretching transitions in single-stranded nucleic acids. 
  • Oxidized dimeric Scapharca inaequivalvis. Co-driven perturbation of the redox equilibrium. 
  • Peptide-derivatized shell-cross-linked nanoparticles. 1. Synthesis and characterization. 
  • Performance comparison of aperture codes for multimodal, multiplex spectroscopy. 
  • Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins. 
  • Photoacoustic imaging of 3D-printed vascular networks. 
  • Photoacoustic thermal flowmetry with a single light source. 
  • Photochemical energy conversion in a helical oligoproline assembly. 
  • Photoionization thresholds of melanins obtained from free electron laser-photoelectron emission microscopy, femtosecond transient absorption spectroscopy and electron paramagnetic resonance measurements of oxygen photoconsumption. 
  • Pigment formation from L-tryptophan by a particulate fraction from an Achromobacter species. 
  • Planar integrated optical methods for examining thin films and their surface adlayers. 
  • Plasma cortisol changes following a mile run in conditioned subjects. 
  • Propagation and perception of bioluminescence: factors affecting counterillumination as a cryptic strategy. 
  • Pulsed Doppler spectral analysis of bounded fluid jets. 
  • Pump-probe imaging differentiates melanoma from melanocytic nevi. 
  • Pump-probe nonlinear phase dispersion spectroscopy. 
  • Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli. 
  • Quad-mode functional and molecular photoacoustic microscopy. 
  • Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts. 
  • Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo. 
  • Quantitative physiology of the precancerous cervix in vivo through optical spectroscopy. 
  • Quantitative spectral reflectance imaging device for intraoperative breast tumor margin assessment. 
  • Rapid noninvasive optical imaging of tissue composition in breast tumor margins. 
  • Reaction mechanism of (6-4) photolyase. 
  • Real-Time 3D Single Particle Tracking: Towards Active Feedback Single Molecule Spectroscopy in Live Cells. 
  • Reconfigurable core-satellite nanoassemblies as molecularly-driven plasmonic switches 
  • Reconstructing Undersampled Photoacoustic Microscopy Images Using Deep Learning. 
  • Reconstruction of mechanical unfolding and refolding pathways of proteins with atomic force spectroscopy and computer simulations. 
  • Reductions in interhemispheric motor cortex functional connectivity after muscle fatigue. 
  • Relation between the redox state of iron-based nanoparticles and their cytotoxicity toward Escherichia coli. 
  • Relaxation spectra of adenosine triphosphate-creatine phosphotransferase. 
  • Relaxation spectra of pyruvate kinase. 
  • Role of immersion refractometry for investigating laser-induced effects in cells. 
  • STRUCTURE OF STREPTOLYDIGIN. 
  • Search for a light Higgs boson decaying to long-lived weakly interacting particles in proton-proton collisions at sqrt[s] = 7 TeV with the ATLAS detector. 
  • Sel-association of glucagon. Equilibrium studies. 
  • Signals and noise in micromechanical measurements. 
  • Spatial and spectral detection of protein monolayers with deterministic aperiodic arrays of metal nanoparticles. 
  • Spectral domain phase microscopy for local measurements of cytoskeletal rheology in single cells. 
  • Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors. 
  • Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent. 
  • Spherical beam volume holograms for spectroscopic applications: modeling and implementation. 
  • Static two-dimensional aperture coding for multimodal, multiplex spectroscopy 
  • Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation. 
  • Structure and organization of hexadecanol isomers adsorbed to the air/water interface. 
  • Structure of macromolecular aggregates. I. Aggregation-induced conformational changes in polypeptides. 
  • Structure of macromolecular aggregates. II. Construction of model membranes from phospholipids and polypeptides. 
  • Superoxide dismutase from Streptococcus mutans. Isolation and characterization of two forms of the enzyme. 
  • Synthetic Control of Exciton Dynamics in Bioinspired Cofacial Porphyrin Dimers. 
  • Systemic anti-tumour effects of local thermally sensitive liposome therapy. 
  • Temporal coherence and time-frequency distributions in spectroscopic optical coherence tomography. 
  • The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and influences Trichoplusia ni herbivory. 
  • The development of optical nanosensors for biological measurements. 
  • The laboratory method as a variable in the interpretation of serum bilirubin fractionation. 
  • The role of histidyl residues in zinc-induced precipitation of alpha 2-macroglobulin-proteinase complexes. 
  • The surface oxidation potential of melanosomes measured by free electron laser-photoelectron emission microscopy. 
  • Time and distance dependence of reversible polymer bridging followed by single-molecule force spectroscopy. 
  • Time course and mechanism of alterations in proton relaxation during liver regeneration in the rat. 
  • Towards a field-compatible optical spectroscopic device for cervical cancer screening in resource-limited settings: effects of calibration and pressure. 
  • ULTRAVIOLET ROTATORY DISPERSION OF ASPARTIC AMINOTRANSFERASE. 
  • Ultrafast singlet excited-state polarization in electronically asymmetric ethyne-bridged bis[(porphinato)zinc(II)] complexes. 
  • Understanding the elasticity of fibronectin fibrils: unfolding strengths of FN-III and GFP domains measured by single molecule force spectroscopy. 
  • Variability in net ecosystem exchange from hourly to inter-annual time scales at adjacent pine and hardwood forests: a wavelet analysis 
  • Very-high-resolution tandem Fabry-Perot etalon cylindrical beam volume hologram spectrometer for diffuse source spectroscopy. 
  • Video rate spectral imaging using a coded aperture snapshot spectral imager. 
  • Visible light optical spectroscopy is sensitive to neovascularization in the dysplastic cervix. 
  • Vulnerable plaque intervention: State of the art. 
  • Warhammers for Peaceful Times. 
  • Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp. 
  • [Relaxation spectrometric studies of fast reactions of ATP in aqueous solution]. 
  • pH-dependent conformational changes of ferricytochrome c induced by electrode surface microstructure. 
  • “Humidity-Dependent Dynamic Infrared Linear Dichroism of a Poly(Ester Urethane)” 
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  Keywords of People

  • Driehuys, Bastiaan, Professor of Radiology, Biomedical Engineering
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Esclamado, Ramon Mitra, Richard Hall Chaney, Sr. Distinguished Professor Emeritus of Otolaryngology, Head and Neck Surgery & Communication Sciences
  • Ferguson, P. Lee, Associate Professor of Civil and Environmental Engineering, Civil and Environmental Engineering
  • Fischer, Martin, Research Professor in the Department of Chemistry, Chemistry
  • Lee, Walter T, Professor of Head and Neck Surgery & Communication Sciences, Radiation Oncology
  • Oas, Terrence Gilbert, Professor of Biochemistry, Biochemistry
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering