Sphingomyelins

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  Subject Areas on Research

  • Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking. 
  • Amniotic fluid phospholipid analysis in the fetus with congenital diaphragmatic hernia. 
  • Apolipoprotein C-III/sphingomyelin recombinants: formation, isolation, and characterization. 
  • Brefeldin A promotes hydrolysis of sphingomyelin. 
  • Chemotherapy-related changes in central nervous system phospholipids and neurocognitive function in childhood acute lymphoblastic leukemia. 
  • Cooperation between the Hepatitis C Virus p7 and NS5B Proteins Enhances Virion Infectivity. 
  • Differences in the long chain (sphingoid) base composition of sphingomyelin from rats bearing Morris hepatoma 7777. 
  • Differential effects of sphingomyelin hydrolysis and resynthesis on the activation of NF-kappa B in normal and SV40-transformed human fibroblasts. 
  • Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes. 
  • Hepatic enzymes of sphingolipid and glycerolipid biosynthesis in rats from Spacelab 3. 
  • High-performance liquid chromatography method for quantifying sphingomyelin in rat brain. 
  • Hydration and steric pressures between phospholipid bilayers. 
  • Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI). 
  • Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle. 
  • Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha. 
  • Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. 
  • Increases in serum sphingomyelin by 17 beta-estradiol. 
  • Influence of lipid composition on physical properties and peg-mediated fusion of curved and uncurved model membrane vesicles: "nature's own" fusogenic lipid bilayer. 
  • Interbilayer interactions between sphingomyelin and sphingomyelin/cholesterol bilayers. 
  • Metabolic network failures in Alzheimer's disease: A biochemical road map. 
  • Metabolomic profiling of sphingolipids in human glioma cell lines by liquid chromatography tandem mass spectrometry. 
  • Plasma sphingomyelin is not associated with microvascular changes in the retina. 
  • Programmed cell death induced by ceramide. 
  • Properties of multilamellar liposomes containing 99mTcO4-: effect of distearoylphosphatidylcholine to sphingomyelin ratio. 
  • Separation & estimation of human serum lipids by silicic acid column chromatography. 
  • Sorting of lens aquaporins and connexins into raft and nonraft bilayers: role of protein homo-oligomerization. 
  • Sorting of lipids and transmembrane peptides between detergent-soluble bilayers and detergent-resistant rafts. 
  • Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion. 
  • Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. 
  • Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry. 
  • Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding. 
  • Structure and cohesive properties of sphingomyelin/cholesterol bilayers. 
  • Structure, composition, and peptide binding properties of detergent soluble bilayers and detergent resistant rafts. 
  • The CLN3 gene is a novel molecular target for cancer drug discovery. 
  • The influence of follicle-stimulating hormone on testicular phospholipids. 
  • The water permeability of lens aquaporin-0 depends on its lipid bilayer environment. 
  • Ultrastructural findings in skin from patients with Niemann-Pick disease, type C. 
  • Use of liposomes as carriers for radiation synovectomy. 
  • Water permeability of aquaporin-4 channel depends on bilayer composition, thickness, and elasticity. 
  • X-ray diffraction to determine the thickness of raft and nonraft bilayers. 
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  Keywords of People

  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Pharmacology & Cancer Biology