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Subject Areas on Research
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A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans.
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A cross-sectional study of human serum sphingolipids, diet and physiologic parameters.
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A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samples.
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Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor.
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Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker of exposure to fumonisin-containing feeds in pigs.
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Analysis of sphingoid bases and sphingoid base 1-phosphates by high-performance liquid chromatography.
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Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal.
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Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma.
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Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s).
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Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells.
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Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide.
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Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line.
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Chronic toxicity of fumonisins from Fusarium moniliforme culture material (M-1325) to mink.
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Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.
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Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate.
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Dietary fumonisin B1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: a new mechanism of nephrotoxicity.
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Differences in the long chain (sphingoid) base composition of sphingomyelin from rats bearing Morris hepatoma 7777.
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Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity.
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Dupuytren's fibroblast contractility by sphingosine-1-phosphate is mediated through non-muscle myosin II.
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Effect of FTY720 on the SET-PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity.
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Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus.
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Emerging roles for lysophospholipid mediators in pregnancy.
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Enzymes of ceramide biosynthesis.
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Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes.
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Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala.
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FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes.
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Free sphingosine formation from endogenous substrates by a liver plasma membrane system with a divalent cation dependence and a neutral pH optimum.
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Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture.
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Fumonisin B1 consumption by rats causes reversible, dose-dependent increases in urinary sphinganine and sphingosine.
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Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.
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Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells.
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Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis.
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Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms.
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Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA.
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Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets.
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Impact of Th1/Th2 cytokine polarity induced by invariant NKT cells on the incidence of pregnancy loss in mice.
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In vitro toxicology of fumonisins and the mechanistic implications.
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Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme.
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Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.
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Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme.
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Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristate 13-acetate.
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Metabolomic profiling of sphingolipids in human glioma cell lines by liquid chromatography tandem mass spectrometry.
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Modulation of adaptive immune responses by sphingosine-1-phosphate.
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Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors.
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N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing.
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Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes.
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Pharmacologic manipulation of conventional outflow facility in ex vivo mouse eyes.
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Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae.
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Quantitation of free sphingosine in liver by high-performance liquid chromatography.
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Regulation of membrane release in apoptosis.
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Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases.
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Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility.
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Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.
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S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection.
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S1P₂ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology.
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SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.
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Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors.
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Should we B-leavin' now?
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Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action.
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Sphingolipid biosynthesis by rat liver cells: effects of serine, fatty acids and lipoproteins.
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Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins.
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Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry.
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Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in china.
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Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis.
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Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding.
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Sphingosine-1-phosphate effects on the inner wall of Schlemm's canal and outflow facility in perfused human eyes.
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Sphingosine-1-phosphate enhancement of cortical actomyosin organization in cultured human Schlemm's canal endothelial cell monolayers.
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Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.
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Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells.
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Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis.
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Steroidogenic factor-1 is a sphingolipid binding protein.
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Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain.
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The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.
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The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.
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Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase.
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