Spinal Cord Injuries

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  Subject Areas on Research

  • A Medication Management Intervention for Patients and Families with SCI and ABI. 
  • A catheter based method to activate urethral sensory nerve fibers. 
  • A clinical prediction model for long-term functional outcome after traumatic spinal cord injury based on acute clinical and imaging factors. 
  • A historical study of appendicular fractures in veterans with traumatic chronic spinal cord injury: 2002-2007. 
  • A national survey of spinal cord stimulation trial-to-permanent conversion rates. 
  • A no-laminectomy spinal cord compression injury model in mice. 
  • A non-invasive method to produce pressure ulcers of varying severity in a spinal cord-injured rat model. 
  • A novel paraplegia model in awake behaving macaques. 
  • A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury. 
  • A prospective, multicenter, phase I matched-comparison group trial of safety, pharmacokinetics, and preliminary efficacy of riluzole in patients with traumatic spinal cord injury. 
  • A retrospective review of lower extremity fracture care in patients with spinal cord injury. 
  • A roadmap for advancing neurostimulation approaches for bladder and bowel function after spinal cord injury. 
  • Activation of the external urethral sphincter central pattern generator by a 5-HT(1A) receptor agonist in rats with chronic spinal cord injury. 
  • Acute Adverse Events After Spinal Cord Injury and Their Relationship to Long-term Neurologic and Functional Outcomes: Analysis From the North American Clinical Trials Network for Spinal Cord Injury. 
  • Acute post-injury blockade of α2δ-1 calcium channel subunits prevents pathological autonomic plasticity after spinal cord injury. 
  • Acute spinal cord injury persistently reduces R/G RNA editing of AMPA receptors. 
  • Adaptive trial designs for spinal cord injury clinical trials directed to the central nervous system. 
  • Analysis of Cervical Spine Injuries in Elderly Patients from 2001 to 2010 Using a Nationwide Database: Increasing Incidence, Overall Mortality, and Inpatient Hospital Charges. 
  • Antihyperalgesic effects of vanilloid-1 and bradykinin-1 receptor antagonists following spinal cord injury in rats. 
  • ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury. 
  • Apolipoprotein E epsilon4 allele and outcomes of traumatic spinal cord injury. 
  • Assimilation of virtual legs and perception of floor texture by complete paraplegic patients receiving artificial tactile feedback. 
  • Association of Pneumonia, Wound Infection, and Sepsis with Clinical Outcomes after Acute Traumatic Spinal Cord Injury. 
  • Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. 
  • At the interface: convergence of neural regeneration and neural prostheses for restoration of function. 
  • Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system. 
  • B1 and TRPV-1 receptor genes and their relationship to hyperalgesia following spinal cord injury. 
  • Be good, communicate, and collaborate: a qualitative analysis of stakeholder perspectives on adding a chiropractor to the multidisciplinary rehabilitation team. 
  • Behavioural testing and histological assessments of rabbit spinal cord following intrathecal administration of ondansetron. 
  • Bladder emptying by intermittent electrical stimulation of the pudendal nerve. 
  • Bone Marrow-Derived Monocytes Drive the Inflammatory Microenvironment in Local and Remote Regions after Thoracic Spinal Cord Injury. 
  • Botulinum toxin urethral sphincter injection to restore bladder emptying in men and women with voiding dysfunction. 
  • CB1 cannabinoid receptor agonist inhibits matrix metalloproteinase activity in spinal cord injury: A possible mechanism of improved recovery. 
  • Case study to evaluate a standing table for managing constipation. 
  • Cervical spine injuries in pediatric athletes: mechanisms and management. 
  • Compliance and complications of clean intermittent catheterization in the spinal cord injured patient. 
  • Complications of spinal fusion for scheuermann kyphosis: a report of the scoliosis research society morbidity and mortality committee. 
  • Conditional and continuous electrical stimulation increase cystometric capacity in persons with spinal cord injury. 
  • Conus medullaris nerve root avulsions. 
  • DREZ lesions for relief of pain related to spinal cord injury. 
  • Design and testing of a controlled electromagnetic spinal cord impactor for use in large animal models of acute traumatic spinal cord injury. 
  • Detection of neurogenic detrusor contractions from the activity of the external anal sphincter in cat and human. 
  • Developing a national registry of veterans with spinal cord dysfunction: experiences and implications. 
  • Disability fingerprints: patterns of disability in spinal cord injury and multiple sclerosis differ. 
  • Dorsal root entry zone lesions for intractable pain after trauma to the conus medullaris and cauda equina. 
  • Dorsal root entry zone lesions in the treatment of pain following brachial plexus avulsion, spinal cord injury and herpes zoster. 
  • Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders. 
  • Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS). 
  • Eccentric rehabilitation induces white matter plasticity and sensorimotor recovery in chronic spinal cord injury. 
  • Effect of 5-hydroxytryptamine1 serotonin receptor agonists on noxiously stimulated micturition in cats with chronic spinal cord injury. 
  • Effectiveness of Exercise Programs for Management of Shoulder Pain in Manual Wheelchair Users With Spinal Cord Injury. 
  • Effects of hyperbaric oxygen therapy on long-tract neuronal conduction in the acute phase of spinal cord injury. 
  • Effects of pirenzepine on acute mucosal erosions, gastric acid and mucosal blood flow in the spinal rat stomach. 
  • Electrical stimulation for control of bladder function. 
  • Electrical stimulation for the treatment of lower urinary tract dysfunction after spinal cord injury. 
  • Electrical stimulation of the urethra evokes bladder contractions and emptying in spinal cord injury men: case studies. 
  • Electrical stimulation of the urethra evokes bladder contractions in a woman with spinal cord injury. 
  • Emerging clinical applications of electrical stimulation: opportunities for restoration of function. 
  • Enhanced susceptibility to urinary tract infection in the spinal cord-injured host with neurogenic bladder. 
  • External fixation and surgical fusion for pediatric cervical spine injuries: Short-term outcomes. 
  • Female sexual dysfunction in patients with spinal cord injury: a study from Iran. 
  • Force-pain relationship in functional magnetic and electrical stimulation of subjects with paresis and preserved sensation. 
  • Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats. 
  • Generating artificial sensations with spinal cord stimulation in primates and rodents. 
  • Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. 
  • Immunoneutralization of nerve growth factor in lumbosacral spinal cord reduces bladder hyperreflexia in spinal cord injured rats. 
  • Impact of US hospital center and interhospital transfer on spinal cord injury management: An analysis of the National Trauma Data Bank. 
  • Impact of anesthesia on transcranial electric motor evoked potential monitoring during spine surgery: a review of the literature. 
  • Impact of frailty on complications in patients with thoracic and thoracolumbar spinal fracture. 
  • Impact of secondary health conditions on social role participation for a long-term physical disability cohort. 
  • Implantation of Neonatal Skin-Derived Precursor Schwann Cells Improves Outcomes After Incomplete Cervical Spinal Cord Injury in Rats. 
  • Implementation Science: Lessons Learned From Evaluating Practice Recommendations for the Care of Patients With Spine Injuries. 
  • In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury. 
  • Incidence and severity of acute complications after spinal cord injury. 
  • Incidence of fractures in a cohort of veterans with chronic multiple sclerosis or traumatic spinal cord injury. 
  • Incontinent ileo-vesicostomy urinary diversion in the treatment of lower urinary tract dysfunction. 
  • Influences of external urethral sphincter relaxation induced by alpha-bungarotoxin, a neuromuscular junction blocking agent, on voiding dysfunction in the rat with spinal cord injury. 
  • Inhibition of bladder activity by 5-hydroxytryptamine1 serotonin receptor agonists in cats with chronic spinal cord injury. 
  • Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish. 
  • Inpatient hospital utilization among veterans with traumatic spinal cord injury. 
  • Insurance disparities in the outcomes of spinal cord stimulation surgery. 
  • Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord. 
  • Interfering with inhibition may improve motor function. 
  • Interventions for Gait Training in Children With Spinal Cord Impairments: A Scoping Review. 
  • Intraurethral activation of excitatory bladder reflexes in persons with spinal cord injury. 
  • Intraurethral stimulation evokes bladder responses via 2 distinct reflex pathways. 
  • Laminectomy and fusion after spinal cord injury: national inpatient complications and outcomes. 
  • Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection. 
  • Local anaesthesia for laminectomy surgery. 
  • Long-Term Training with a Brain-Machine Interface-Based Gait Protocol Induces Partial Neurological Recovery in Paraplegic Patients. 
  • Long-term survival of veterans with traumatic spinal cord injury. 
  • Longitudinal Impact of Acute Spinal Cord Injury on Clinical Pharmacokinetics of Riluzole, a Potential Neuroprotective Agent. 
  • Lumbar Myeloid Cell Trafficking into Locomotor Networks after Thoracic Spinal Cord Injury. 
  • Lumbosacral spinal cord epidural stimulation enables recovery of voluntary movement after complete motor spinal cord injury. 
  • Magnesium efficacy in a rat spinal cord injury model. 
  • Management of difficult cases in female urology and neurourology at the Reed M. Nesbit society meeting. Festschrift in honor of Edward J. McGuire, MD. 
  • Mechanisms of reflex bladder activation by pudendal afferents. 
  • Mechanisms underlying reversal of motor unit activation order in electrically evoked contractions after spinal cord injury. 
  • Microglia Promote Increased Pain Behavior through Enhanced Inflammation in the Spinal Cord during Repeated Social Defeat Stress. 
  • Mind out of body. 
  • Morbidity following lower extremity fractures in men with spinal cord injury. 
  • Mortality after lower extremity fractures in men with spinal cord injury. 
  • Multiple Reflex Pathways Contribute to Bladder Activation by Intraurethral Stimulation in Persons With Spinal Cord Injury. 
  • Multiple pudendal sensory pathways reflexly modulate bladder and urethral activity in patients with spinal cord injury. 
  • Nanocarrier-mediated inhibition of macrophage migration inhibitory factor attenuates secondary injury after spinal cord injury. 
  • Nanoparticle-mediated local delivery of Methylprednisolone after spinal cord injury. 
  • Natural History, Predictors of Outcome, and Effects of Treatment in Thoracic Spinal Cord Injury: A Multi-Center Cohort Study from the North American Clinical Trials Network. 
  • Neuroimaging of scuba diving injuries to the CNS. 
  • Neurological outcome in a porcine model of descending thoracic aortic surgery. Left atrial-femoral artery bypass versus clamp/repair. 
  • New onset focal weakness in children with Down syndrome. 
  • Non-invasive, Brain-controlled Functional Electrical Stimulation for Locomotion Rehabilitation in Individuals with Paraplegia. 
  • Outcomes of Ureteroscopic Stone Treatment in Patients With Spinal Cord Injury. 
  • Outcomes of percutaneous and paddle lead implantation for spinal cord stimulation: a comparative analysis of complications, reoperation rates, and health-care costs. 
  • Passive biaxial mechanical properties of the rat bladder wall after spinal cord injury. 
  • Pediatric spinal deformities. 
  • Pharmacology of riluzole in acute spinal cord injury. 
  • Pneumocephalus leading to the diagnosis of cerebrospinal fluid leak and esophageal perforation after cervical spine surgery. 
  • Population-based approaches to treatment and readmission after spinal cord injury. 
  • Possible way to reduce fracture rates in patients with traumatic spinal cord injury? 
  • Predictors of pulmonary complications in blunt traumatic spinal cord injury. 
  • Progesterone is neuroprotective after acute experimental spinal cord trauma in rats. 
  • Psychiatric co-morbidities and patients with head and spinal cord trauma. Effects on acute hospital care. 
  • Pudendal nerve stimulation evokes reflex bladder contractions in persons with chronic spinal cord injury. 
  • Racial disparities in outcomes after spinal cord injury. 
  • Readmission after spinal cord injury: analysis of an institutional cohort of 795 patients. 
  • Relationship between cognitive activity and adjustment in four spinal-cord-injured individuals: a longitudinal investigation. 
  • Relationship between self-reported disability and caregiver hours. 
  • Renal calculi presenting as hyperhidrosis in patient with spinal cord injury. 
  • Repeated botulinum-A toxin injections in the treatment of myelodysplastic children and patients with spinal cord injuries with neurogenic bladder dysfunction. 
  • Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury. 
  • Response to Sabour: Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders: methodological issues. 
  • Riluzole for the treatment of acute traumatic spinal cord injury: rationale for and design of the NACTN Phase I clinical trial. 
  • Risk factors for osteoporotic fractures in persons with spinal cord injuries and disorders. 
  • Ryk controls remapping of motor cortex during functional recovery after spinal cord injury. 
  • S-Nitrosoglutathione protects the spinal bladder: novel therapeutic approach to post-spinal cord injury bladder remodeling. 
  • Sensitization of Endothelial Cells to Ionizing Radiation Exacerbates Delayed Radiation Myelopathy in Mice. 
  • Sensory and circuit mechanisms mediating lower urinary tract reflexes. 
  • Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF. 
  • Sparing of Descending Axons Rescues Interneuron Plasticity in the Lumbar Cord to Allow Adaptive Learning After Thoracic Spinal Cord Injury. 
  • Spatial distribution and acute anti-inflammatory effects of Methylprednisolone after sustained local delivery to the contused spinal cord. 
  • Spinal cord injury pharmacotherapy: Current research & development and competitive commercial landscape as of 2015. 
  • Spinal cord stimulation and rehabilitation in an individual with chronic complete L1 paraplegia due to a conus medullaris injury: motor and functional outcomes at 18 months. 
  • Spinal micturition reflex mediated by afferents in the deep perineal nerve. 
  • Subtle cord magnetic resonance changes in cervical myelomalacia. 
  • Surgical treatment of thoracolumbar fractures. 
  • Sustained delivery of activated Rho GTPases and BDNF promotes axon growth in CSPG-rich regions following spinal cord injury. 
  • Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury. 
  • Synchronous cystoscopy and cystometry in the management of neurogenic bladder dysfunction. 
  • Synthes Award for Resident Research in Spinal Cord & Spinal Column Injury: Statins for the treatment of neurological injury: a role beyond cholesterol lowering. 
  • Tapping into spinal circuits to restore motor function. 
  • Temporal pattern of stimulation modulates reflex bladder activation by pudendal nerve stimulation. 
  • The Incidence of Spinal Cord Injury in Implantation of Percutaneous and Paddle Electrodes for Spinal Cord Stimulation. 
  • The Society of Thoracic Surgeons/American Association for Thoracic Surgery clinical practice guidelines on the management of type B aortic dissection. 
  • The association of anticonvulsant use with fractures in spinal cord injury. 
  • The association of opioid use with incident lower extremity fractures in spinal cord injury. 
  • The impact of blood pressure management after spinal cord injury: a systematic review of the literature. 
  • The impact of facet dislocation on clinical outcomes after cervical spinal cord injury: results of a multicenter North American prospective cohort study. 
  • The reliability of a self-reported measure of disease, impairment, and function in persons with spinal cord dysfunction. 
  • The self-reported functional measure: Predictive validity for health care utilization in multiple sclerosis and spinal cord injury. 
  • The validity in persons with spinal cord injury of a self-reported functional measure derived from the functional independence measure. 
  • Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury. 
  • Thiazide use is associated with reduced risk for incident lower extremity fractures in men with spinal cord injury. 
  • Timing of tracheostomy after anterior cervical spine fixation. 
  • Translating promising strategies for bowel and bladder management in spinal cord injury. 
  • Traumatic Brain and Spinal Cord Fatalities Among High School and College Football Players - United States, 2005-2014. 
  • Treatment of pulmonary disease following cervical spinal cord injury. 
  • Unique Sensory and Motor Behavior in Thy1-GFP-M Mice before and after Spinal Cord Injury. 
  • Urinary diversion in patients with spinal cord injury in the United States. 
  • Use of a free jejunal graft for oesophageal reconstruction following perforation after cervical spine surgery: case report and review of the literature. 
  • Use of data from nonrandomized trial designs in evidence reports: an application to treatment of pulmonary disease following spinal cord injury. 
  • Venous thromboembolism in spine surgery. 
  • Ventilatory management in critical neurologic illness. 
  • tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2. 
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  Keywords of People

  • Faw, Timothy Dale, Medical Instructor in the Department of Orthopaedic Surgery, Orthopaedics, Physical Therapy
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering