Reflex, Startle

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  Subject Areas on Research

  • Acoustic startle and prepulse inhibition predict smoking lapse in posttraumatic stress disorder. 
  • Alterations in PKCgamma in the mouse hippocampus after prenatal exposure to heroin: a link from cell signaling to behavioral outcome. 
  • Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats. 
  • Attenuation of auditory startle and prepulse inhibition by unexpected changes in ambient illumination through dopaminergic mechanisms. 
  • Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder. 
  • Behavioral characterization of P311 knockout mice. 
  • Behavioral effects of chronic exposure to low concentrations of halothane during development in rats. 
  • Behavioral treatment of a persistent post-traumatic startle response. 
  • Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding. 
  • Clozapine treatment reverses dizocilpine-induced deficits of pre-pulse inhibition of tactile startle response. 
  • Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity. 
  • Development of behaviors in preterm infants: relation to sleeping and waking. 
  • Developmental exposure of zebrafish to vitamin D receptor acting drugs and environmental toxicants disrupts behavioral function. 
  • Developmental exposure to a complex PAH mixture causes persistent behavioral effects in naive Fundulus heteroclitus (killifish) but not in a population of PAH-adapted killifish. 
  • Developmental exposure to low concentrations of two brominated flame retardants, BDE-47 and BDE-99, causes life-long behavioral alterations in zebrafish. 
  • Developmental exposure to organophosphate flame retardants causes behavioral effects in larval and adult zebrafish. 
  • Differential effects of the antidepressant mirtazapine on amphetamine- and dizocilpine-induced PPI deficits. 
  • Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities. 
  • Dopamine D1 and D2 receptor antagonism during development alters later behavior in zebrafish. 
  • Effects of smoking on the acoustic startle response and prepulse inhibition in smokers with and without posttraumatic stress disorder. 
  • Effects of unexpected changes in visual scenes on the human acoustic startle response and prepulse inhibition. 
  • Expecting the worst: observations of reactivity to sound in young children with Williams syndrome. 
  • Fear-potentiated startle response is unrelated to social or emotional functioning in adolescents with autism spectrum disorders. 
  • Goosey patients: relationship to jumping Frenchmen, Myriachit, Latah and tic convulsif. 
  • Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. 
  • Histamine H1 receptor involvement in prepulse inhibition and memory function: relevance for the antipsychotic actions of clozapine. 
  • Individuals with autism spectrum disorder show normal responses to a fear potential startle paradigm. 
  • Long-term behavioral impairment following acute embryonic ethanol exposure in zebrafish. 
  • Low-frequency parietal repetitive transcranial magnetic stimulation reduces fear and anxiety. 
  • MK-801 impedes the acquisition of a spatial memory task in rats. 
  • Mechanistic link between right prefrontal cortical activity and anxious arousal revealed using transcranial magnetic stimulation in healthy subjects. 
  • Meclizine enhancement of sensorimotor gating in healthy male subjects with high startle responses and low prepulse inhibition. 
  • Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear. 
  • Modeling geriatric depression in animals: biochemical and behavioral effects of olfactory bulbectomy in young versus aged rats. 
  • Neurobehavioral impairments caused by developmental imidacloprid exposure in zebrafish. 
  • Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for autism. 
  • Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories. 
  • Neurotoxicity of FireMaster 550® in zebrafish (Danio rerio): Chronic developmental and acute adolescent exposures. 
  • Neurotoxicity of manganese chloride in neonatal and adult CD rats following subchronic (21-day) high-dose oral exposure. 
  • Nicotine and clozapine actions on pre-pulse inhibition deficits caused by N-methyl-D-aspartate (NMDA) glutamatergic receptor blockade. 
  • PPI deficit induced by amphetamine is attenuated by the histamine H1 antagonist pyrilamine, but is exacerbated by the serotonin 5-HT2 antagonist ketanserin. 
  • Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion. 
  • Persistent behavioral effects following early life exposure to retinoic acid or valproic acid in zebrafish. 
  • Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish. 
  • Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior. 
  • Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit. 
  • Role of nicotinic receptors in the lateral habenula in the attenuation of amphetamine-induced prepulse inhibition deficits of the acoustic startle response in rats. 
  • Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience. 
  • Spatial proximity amplifies valence in emotional memory and defensive approach-avoidance. 
  • Startle and prepulse inhibition as a function of background noise: a computational and experimental analysis. 
  • The effect of nicotine and trauma context on acoustic startle in smokers with and without posttraumatic stress disorder. 
  • The functions of nonsuicidal self-injury: support for cognitive-affective regulation and opponent processes from a novel psychophysiological paradigm. 
  • The gene encoding proline dehydrogenase modulates sensorimotor gating in mice. 
  • The impact of dose rate on the neurotoxicity of acrylamide: the interaction of administered dose, target tissue concentrations, tissue damage, and functional effects. 
  • The impact of trauma and disaster on young children. 
  • The α₂-adrenergic antagonist idazoxan counteracts prepulse inhibition deficits caused by amphetamine or dizocilpine in rats. 
  • Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits. 
  • Zebrafish show long-term behavioral impairments resulting from developmental vitamin D deficiency. 
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  Keywords of People

  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology