Stem Cells

• 

  Subject Areas on Research

  • "Feeling the force" in reproduction: Mechanotransduction in reproductive processes. 
  • 3D Culture Facilitates VEGF-Stimulated Endothelial Differentiation of Adipose-Derived Stem Cells. 
  • 3D biofabrication strategies for tissue engineering and regenerative medicine. 
  • 3D patterned stem cell differentiation using thermo-responsive methylcellulose hydrogel molds. 
  • ^* CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments. 
  • A Lin28 homologue reprograms differentiated cells to stem cells in the moss Physcomitrella patens. 
  • A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes. 
  • A New Assay to Measure Intestinal Crypt Survival after Irradiation: Challenges and Opportunities. 
  • A Phase 2 Randomized, Sham-Controlled Trial of Internal Carotid Artery Infusion of Autologous Bone Marrow-Derived ALD-401 Cells in Patients With Recent Stable Ischemic Stroke (RECOVER-Stroke). 
  • A Specialized Few Among Many: Identification of a Novel Lung Epithelial Stem Cell Population. 
  • A collection of cortical crescents: asymmetric protein localization in CNS precursor cells. 
  • A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene. 
  • A deadly game of musical chairs: survival of cells transplanted for myocardial repair. 
  • A device to facilitate limbal stem cell procurement from eye bank donor tissue for keratolimbal allograft procedures. 
  • A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. 
  • A genomic regulatory network for development. 
  • A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division. 
  • A mouse model of familial porphyria cutanea tarda. 
  • A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke. 
  • A non-transformed oligodendrocyte precursor cell line, OL-1, facilitates studies of insulin-like growth factor-I signaling during oligodendrocyte development. 
  • A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. 
  • A phase 3, randomized, double-blinded, active-controlled, unblinded standard of care study assessing the efficacy and safety of intramyocardial autologous CD34+ cell administration in patients with refractory angina: design of the RENEW study. 
  • A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. 
  • A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene. 
  • ABCB5 is a limbal stem cell gene required for corneal development and repair. 
  • ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia. 
  • ALLogeneic Heart STem Cells to Achieve Myocardial Regeneration (ALLSTAR) Trial: Rationale and Design. 
  • ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer. 
  • Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome. 
  • Adherens junctions and stem cells. 
  • Adipose stem cell crosstalk with chemo-residual breast cancer cells: implications for tumor recurrence. 
  • Adipose-derived adult stem cells for cartilage tissue engineering. 
  • Adult olfactory epithelium contains multipotent progenitors that give rise to neurons and non-neural cells. 
  • Adult-derived stem cells and their potential for use in tissue repair and molecular medicine. 
  • Advances in understanding tissue regenerative capacity and mechanisms in animals. 
  • Age-related changes in the cellular composition and epithelial organization of the mouse trachea. 
  • Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration. 
  • Aging and obesity prime the methylome and transcriptome of adipose stem cells for disease and dysfunction. 
  • Aging is not associated with bone marrow-resident progenitor cell depletion. 
  • Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans. 
  • Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling. 
  • Airway epithelial cells: current concepts and challenges. 
  • Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury. 
  • Aldehyde dehydrogenase activity allows reliable EPC enumeration in stored peripheral blood samples. 
  • Aligned multilayered electrospun scaffolds for rotator cuff tendon tissue engineering. 
  • An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis. 
  • An intravital window to image the colon in real time. 
  • Analysis of neurogenesis in a mammalian neuroepithelium: proliferation and differentiation of an olfactory neuron precursor in vitro. 
  • Ank3-dependent SVZ niche assembly is required for the continued production of new neurons. 
  • Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells. 
  • Antibodies to stem cell marker antigens reduce engraftment of hematopoietic stem cells. 
  • Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells. 
  • Antiproliferative effects of interferon alpha on hepatic progenitor cells in vitro and in vivo. 
  • Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration. 
  • Archenteron precursor cells can organize secondary axial structures in the sea urchin embryo. 
  • Arterial homeostasis, inflammation, and erythropoietic growth factors. 
  • Atherosclerosis 2005: recent discoveries and novel hypotheses. 
  • Autologous CD34+ Cell Therapy for Refractory Angina: 2-Year Outcomes From the ACT34-CMI Study. 
  • Autologous endothelial progenitor cell-seeding technology and biocompatibility testing for cardiovascular devices in large animal model. 
  • Automated thawing increases recovery of colony-forming units from banked cord blood unit grafts. 
  • BALO: a "mini lung" model to study cell-cell interactions. 
  • BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors. 
  • BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. 
  • BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1. 
  • Basal cells as stem cells of the mouse trachea and human airway epithelium. 
  • Basal epithelial stem cells are efficient targets for prostate cancer initiation. 
  • Bayesian analysis of signaling networks governing embryonic stem cell fate decisions. 
  • Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation. 
  • Biomanufacturing organized collagen-based microfibers as a Tissue ENgineered Device (TEND) for tendon regeneration. 
  • Bone Marrow Stress Decreases Osteogenic Progenitors. 
  • Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc. 
  • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. 
  • CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality. 
  • CD10 marks non-canonical PPARγ-independent adipocyte maturation and browning potential of adipose-derived stem cells. 
  • CD86 (B7-2) can function to drive MHC-restricted antigen-specific CTL responses in vivo. 
  • CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. 
  • CRISPR genome editing in stem cells turns to gold. 
  • CRISPR/Cas9-Mediated BRCA1 Knockdown Adipose Stem Cells Promote Breast Cancer Progression. 
  • Calcific Aortic Valve Disease: Part 2-Morphomechanical Abnormalities, Gene Reexpression, and Gender Effects on Ventricular Hypertrophy and Its Reversibility. 
  • Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development. 
  • Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. 
  • Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction. 
  • Cardiac cell therapy in vitro: reproducible assays for comparing the efficacy of different donor cells. 
  • Cardiac progenitors and the embryonic cell cycle. 
  • Cardiac regenerative capacity and mechanisms. 
  • Cardiac tissue engineering using stem cells. 
  • Cell biology and physiology of the uroepithelium. 
  • Cell lines derived from pancreatic islets. 
  • Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. 
  • Cell population dynamics model for deconvolution of murine embryonic stem cell self-renewal and differentiation responses to cytokines and extracellular matrix. 
  • Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease. 
  • Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. 
  • Characterization of free-floating spheres from human trabecular meshwork (HTM) cell culture in vitro. 
  • Characterization of potential precursor populations in the mouse olfactory epithelium using immunocytochemistry and autoradiography. 
  • Characterizing functional stem cell-cardiomyocyte interactions. 
  • Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide. 
  • Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. 
  • Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. 
  • Ciliated epithelial cell lifespan in the mouse trachea and lung. 
  • Circulating progenitor cells can be reliably identified on the basis of aldehyde dehydrogenase activity. 
  • Common endothelial progenitor cell assays identify discrete endothelial progenitor cell populations. 
  • Comparative analysis of circulating endothelial progenitor cells in age-related macular degeneration patients using automated rare cell analysis (ARCA) and fluorescence activated cell sorting (FACS). 
  • Comparison of the Viability and Yield of Adipose-Derived Stem Cells (ASCs) from Different Donor Areas. 
  • Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells. 
  • Concise Review: Modulating Cancer Immunity with Hematopoietic Stem and Progenitor Cells. 
  • Conditional telomerase induction causes proliferation of hair follicle stem cells. 
  • Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial design. 
  • Contribution of Polycomb group proteins to olfactory basal stem cell self-renewal in a novel c-KIT+ culture model and in vivo. 
  • Contribution of adipogenesis to healthy adipose tissue expansion in obesity. 
  • Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. 
  • Control of stem cell fate by physical interactions with the extracellular matrix. 
  • Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR. 
  • Correlation of intralesional in vivo chemotherapy of line 10 hepatoma with in vitro drug sensitivity. 
  • Culture of endodermal stem/progenitor cells of the mouse tongue. 
  • Cyclin-dependent kinase 4 expression alters the number of keratinocyte stem cells in the mouse hair follicle. 
  • Decellularized tissue-engineered blood vessel as an arterial conduit. 
  • Deciphering the molecular machinery of stem cells: a look at the neoblast gene expression profile. 
  • Deconstructing the genesis of animal form. 
  • Decreased interferon-alpha production in HIV-infected patients correlates with numerical and functional deficiencies in circulating type 2 dendritic cell precursors. 
  • Dedifferentiation of committed epithelial cells into stem cells in vivo. 
  • Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. 
  • Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures. 
  • Defining the Path from Stem Cells to Differentiated Tissue. 
  • Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement. 
  • Dependence of corneal stem/progenitor cells on ocular surface innervation. 
  • Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo. 
  • Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. 
  • Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies. 
  • Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering. 
  • Development and ecology in the time of systems biology. 
  • Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy. 
  • Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity. 
  • Differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection. 
  • Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension. 
  • Directing and Potentiating Stem Cell-Mediated Angiogenesis and Tissue Repair by Cell Surface E-Selectin Coating. 
  • Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice. 
  • Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus. 
  • Distal-Less Homeobox 5 Is a Therapeutic Target for Attenuating Hypertrophy and Apoptosis of Mesenchymal Progenitor Cells. 
  • Do Adipocytes Emerge from Mural Progenitors? 
  • Dorso-ventral heterogeneity in tracheal basal stem cells. 
  • Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation. 
  • Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells. 
  • Dynamic adhesion of umbilical cord blood endothelial progenitor cells under laminar shear stress. 
  • Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction. 
  • EPC mobilization after erythropoietin treatment in acute ST-elevation myocardial infarction: the REVEAL EPC substudy. 
  • Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state. 
  • Early-outgrowth of endothelial progenitor cells can function as antigen-presenting cells. 
  • Elaboration of tubules with active hedgehog drives parenchymal fibrogenesis in gestational alloimmune liver disease. 
  • Electrospun cartilage-derived matrix scaffolds for cartilage tissue engineering. 
  • Elevated monocytes in patients with critical limb ischemia diminish after bypass surgery. 
  • Elimination of malignant clonogenic T cells from human bone marrow using chemoimmunoseparation with 2'-deoxycoformycin, deoxyadenosine and an immunotoxin. 
  • Embryonic germ cell lines and their derivation from mouse primordial germ cells. 
  • Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages. 
  • Emerging Technologies for Gut Microbiome Research. 
  • Endostatin inhibits the vascular endothelial growth factor-induced mobilization of endothelial progenitor cells. 
  • Endothelial colony forming cells (ECFCs) as a model for studying effects of low-dose ionizing radiation: growth inhibition by a single dose. 
  • Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. 
  • Endothelial progenitor cells: markers of vascular reparative capacity. 
  • Engineered microenvironments for self-renewal and musculoskeletal differentiation of stem cells. 
  • Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. 
  • Enhanced In Vivo Delivery of Stem Cells using Microporous Annealed Particle Scaffolds. 
  • Enhanced chondrogenic differentiation of murine embryonic stem cells in hydrogels with glucosamine. 
  • Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation. 
  • Ependymal/subependymal zone cells of postnatal and adult songbird brain generate both neurons and nonneuronal siblings in vitro and in vivo. 
  • Epithelial Regeneration After Doxorubicin Arises Primarily From Early Progeny of Active Intestinal Stem Cells. 
  • Epithelial progenitor cells in lung development, maintenance, repair, and disease. 
  • Epithelial progenitor cells of the embryonic lung and the role of microRNAs in their proliferation. 
  • Epithelial stem cells of the lung: privileged few or opportunities for many? 
  • Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. 
  • Ethical and policy issues relating to progenitor-cell-based strategies for prevention of atherosclerosis. 
  • Expanding gliogenesis. 
  • Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis. 
  • Expression of EGF receptor and transferrin by F9 and PC13 teratocarcinoma cells. 
  • Expression of alpha(2)-adrenergic receptor subtypes in prenatal rat spinal cord. 
  • Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2. 
  • Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. 
  • Feasibility of four consecutive high-dose chemotherapy cycles with stem-cell rescue for patients with newly diagnosed medulloblastoma or supratentorial primitive neuroectodermal tumor after craniospinal radiotherapy: results of a collaborative study. 
  • Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells. 
  • Frizzled 1/2/7 signaling directs beta catenin nuclearization and initiates endoderm specification in macromeres during sea urchin morphogenesis 
  • GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. 
  • GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells. 
  • Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells. 
  • Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies. 
  • Getting Back to Normal: Can Enhanced Regeneration Maintain Health? 
  • Getting at the root and stem of brain tumors. 
  • Global Consensus on the Management of Limbal Stem Cell Deficiency. 
  • Glucagon-like peptide 2 for intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans. 
  • Graft-extrinsic cells predominate in vein graft arterialization. 
  • Growth signaling at the nexus of stem cell life and death. 
  • Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway. 
  • Hair follicle stem cells feel the pressure. 
  • Hedgehog Signaling is Associated with Liver Response to Fractionated Irradiation in Mice. 
  • Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease. 
  • Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer. 
  • Hedgehog signaling maintains resident hepatic progenitors throughout life. 
  • Helminth-induced reprogramming of the stem cell compartment inhibits type 2 immunity. 
  • Heparin mimicking polymer promotes myogenic differentiation of muscle progenitor cells. 
  • High levels of granulocyte and granulocyte-macrophage colony-stimulating factors in cord blood of normal full-term neonates. 
  • High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. 
  • How the zebrafish gets its stripes. 
  • Human Adipose-Derived Stem Cells Labeled with Plasmonic Gold Nanostars for Cellular Tracking and Photothermal Cancer Cell Ablation. 
  • Human distal lung maps and lineage hierarchies reveal a bipotent progenitor. 
  • Human organoids: a new dimension in cell biology. 
  • Human postnatal CD4- CD8- CD3- thymic T cell precursors differentiate in vitro into T cell receptor delta-bearing cells. 
  • Hydra. 
  • Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development. 
  • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. 
  • I have a gut feeling…. 
  • IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophils. 
  • IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells. 
  • Identification and characterization of small molecule inducers of epidermal keratinocyte differentiation 
  • Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. 
  • Identification of regulators of germ stem cell enwrapment by its niche in C. elegans. 
  • Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. 
  • Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities. 
  • Immune responses in asymptomatic HIV-1-infected patients after HIV-DNA immunization followed by highly active antiretroviral treatment. 
  • Immunohistochemical characterization of the hepatic progenitor cell compartment in medaka (Oryzias latipes) following hepatic injury. 
  • Immunologic suppression mediated by genetically modified hepatocytes expressing secreted allo-MHC class I molecules. 
  • Improved efficacy of stem cell labeling for magnetic resonance imaging studies by the use of cationic liposomes. 
  • Improving human β-cell maturation in vitro. 
  • In vitro functional testing of endothelial progenitor cells that overexpress thrombomodulin. 
  • In vitro survival and differentiation of neurons derived from epidermal growth factor-responsive postnatal hippocampal stem cells: inducing effects of brain-derived neurotrophic factor. 
  • Inducible depletion of adult skeletal muscle stem cells impairs the regeneration of neuromuscular junctions. 
  • Inflammation and circulating endothelial progenitor cells in patients with coronary artery disease and residual platelet reactivity. 
  • Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness. 
  • Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways. 
  • Injection of immature dendritic cells into adjuvant-treated skin obviates the need for ex vivo maturation. 
  • Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture. 
  • Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations. 
  • Insights from a chimpanzee adipose stromal cell population: opportunities for adult stem cells to expand primate functional genomics. 
  • Insights into muscle stem cell dynamics during postnatal development. 
  • Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord. 
  • Interleukin-13 disrupts type 2 pneumocyte stem cell activity. 
  • Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone. 
  • Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. 
  • Intradialytic hypertension and its association with endothelial cell dysfunction. 
  • Isolation and characterization of stem cells from the human parathyroid gland. 
  • Isolation and expansion of oligodendrocyte progenitor cells from cryopreserved human umbilical cord blood. 
  • Jagged2 controls the generation of motor neuron and oligodendrocyte progenitors in the ventral spinal cord. 
  • Kinetics of TCR use in response to repeated epitope-specific immunization. 
  • Late outgrowth endothelial progenitor cells in patients with age-related macular degeneration. 
  • Late-outgrowth endothelial progenitors from patients with coronary artery disease: endothelialization of confluent stromal cell layers. 
  • Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites. 
  • Lesch-Nyhan syndrome. Engineering mutant mice. 
  • Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions. 
  • Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. 
  • Ligament-derived matrix stimulates a ligamentous phenotype in human adipose-derived stem cells. 
  • Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds. 
  • Live Monitoring of Blastemal Cell Contributions during Appendage Regeneration. 
  • Loss of HDAC3 results in nonreceptive endometrium and female infertility. 
  • Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration. 
  • Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self-renewal of colonic stem and progenitor cells. 
  • Loss of basal cells precedes bronchiolitis obliterans-like pathological changes in a murine model of chlorine gas inhalation. 
  • Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma. 
  • Lower levels of circulating progenitor cells are associated with low physical function and performance in elderly men with impaired glucose tolerance: a pilot substudy from the VA Enhanced Fitness trial. 
  • Lung organoids: current uses and future promise. 
  • Lung stem cells: looking beyond the hype. 
  • MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction. 
  • Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation. 
  • Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice. 
  • Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells. 
  • Metabolic Teamwork in the Stem Cell Niche. 
  • Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling. 
  • Mice lacking Bmp6 function. 
  • MicroRNA miR396 Regulates the Switch between Stem Cells and Transit-Amplifying Cells in Arabidopsis Roots. 
  • MicroRNAs and Cardiac Regeneration. 
  • Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue. 
  • Mobilization of dendritic cells from patients with breast cancer into peripheral blood stem cell leukapheresis samples using Flt-3-Ligand and G-CSF or GM-CSF. 
  • Modeling human peri-implantation placental development and function†. 
  • Modeling the Placenta with Stem Cells. 
  • Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. 
  • Molecular diffusion in tissue-engineered cartilage constructs: effects of scaffold material, time, and culture conditions. 
  • Morphogenesis and Compartmentalization of the Intestinal Crypt. 
  • Morphogenesis in sea urchin embryos: linking cellular events to gene regulatory states. 
  • Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines. 
  • Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation. 
  • Multi-site evaluation of the BD Stem Cell Enumeration Kit for CD34(+) cell enumeration on the BD FACSCanto II and BD FACSCalibur flow cytometers. 
  • Multilayered electrospun scaffolds for tendon tissue engineering. 
  • Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity. 
  • Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling. 
  • Myocardial infarction and intramyocardial injection models in swine. 
  • Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury. 
  • Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy. 
  • Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF. 
  • N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. 
  • NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity. 
  • NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma. 
  • NOTCH signaling in skeletal progenitors is critical for fracture repair. 
  • NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine. 
  • Neighborhood watch orchestrates liver regeneration. 
  • Neurite outgrowth from progeny of epidermal growth factor-responsive hippocampal stem cells is significantly less robust than from fetal hippocampal cells following grafting onto organotypic hippocampal slice cultures: effect of brain-derived neurotrophic factor. 
  • Neurogenic differentiation of murine and human adipose-derived stromal cells. 
  • Neuronal regulation of the spatial patterning of neurogenesis. 
  • New neuroblast markers and the origin of the aCC/pCC neurons in the Drosophila central nervous system. 
  • Niche-mediated BMP/SMAD signaling regulates lung alveolar stem cell proliferation and differentiation. 
  • Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation. 
  • Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells. 
  • Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis. 
  • Notch signaling in cancer stem cells. 
  • Notch signaling maintains Leydig progenitor cells in the mouse testis. 
  • Notch-dependent differentiation of adult airway basal stem cells. 
  • Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. 
  • Novel type of proliferating lymphoplasmacytoid cell with a characteristic spotted immunofluorescence pattern. 
  • Numb antagonizes Notch signaling to specify sibling neuron cell fates. 
  • Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells. 
  • Off-target properties of pharmacotherapy and the importance of mechanistic investigations in early clinical phase drug development. 
  • Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice. 
  • Out of Eden: stem cells and their niches. 
  • Out-foxing fate; molecular switches create neuronal diversity in the retina. 
  • Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. 
  • Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease. 
  • Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway. 
  • PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo. 
  • PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. 
  • Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. 
  • Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults. 
  • Paracrine signals from mesenchymal cell populations govern the expansion and differentiation of human hepatic stem cells to adult liver fates. 
  • Parallel-plate flow chamber and continuous flow circuit to evaluate endothelial progenitor cells under laminar flow shear stress. 
  • Parent stem cells can serve as niches for their daughter cells. 
  • Patient-derived endothelial progenitor cells improve vascular graft patency in a rodent model. 
  • Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice. 
  • Perivascular Fibro-Adipogenic Progenitor Tracing during Post-Traumatic Osteoarthritis. 
  • Persistent expression of MNF identifies myogenic stem cells in postnatal muscles. 
  • Pharmacologic targeting of β-catenin improves fracture healing in old mice. 
  • Physically Associated Synthetic Hydrogels with Long-Term Covalent Stabilization for Cell Culture and Stem Cell Transplantation 
  • Piceatannol in combination with low doses of cyclosporine A prolongs kidney allograft survival in a stringent rat transplantation model. 
  • Plasticity in the adult human oligodendrocyte lineage. 
  • Plasticity in the lung: making and breaking cell identity. 
  • Poly(ethylene glycol) hydrogel system supports preadipocyte viability, adhesion, and proliferation. 
  • Positron Emission Tomography-Computed Tomography Imaging of Selective Lobar Delivery of Stem Cells in Ex Vivo Lung Model of Mechanical Ventilation. 
  • Preclinical efficacy of MEK inhibition in Nras-mutant AML. 
  • Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. 
  • Preoteomics, metabolomics and circulating endothelial progenitor cells in acute coronary syndromes. 
  • Preoteomics, metabolomics and progenitor cells in acute coronary syndromes. 
  • Preparing for the first breath: genetic and cellular mechanisms in lung development. 
  • Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair. 
  • Priming for virus-specific CD8+ but not CD4+ cytotoxic T lymphocytes with synthetic lipopeptide is influenced by acylation units and liposome encapsulation. 
  • Probing the mechanisms of intradialytic hypertension: a pilot study targeting endothelial cell dysfunction. 
  • Progenitor Hyperpolarization Regulates the Sequential Generation of Neuronal Subtypes in the Developing Neocortex. 
  • Progenitor cell mobilization enhances bone healing by means of improved neovascularization and osteogenesis. 
  • Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth. 
  • Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells. 
  • Pulmonary hypoplasia. 
  • Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse. 
  • Purification and direct transformation of epithelial progenitor cells from primary human prostate. 
  • Quantitative analysis of diffusion tensor imaging data in serial assessment of Krabbe disease. 
  • Quantitative enumeration of vascular smooth muscle cells and endothelial cells derived from bone marrow precursors in experimental choroidal neovascularization. 
  • RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro. 
  • Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization. 
  • Radiation-induced brain injury: low-hanging fruit for neuroregeneration. 
  • Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection. 
  • Ras controls melanocyte expansion during zebrafish fin stripe regeneration. 
  • Receptor binding, endocytosis, and mitogenesis of insulin-like growth factors I and II in fetal rat brain neurons. 
  • Reconstructing regulatory network transitions. 
  • Recruitment of host progenitor cells in rat liver transplants. 
  • Reelin signals survival through Src-family kinases that inactivate BAD activity. 
  • Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish. 
  • Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. 
  • Regulated spindle orientation buffers tissue growth in the epidermis. 
  • Regulation of Division and Differentiation of Plant Stem Cells. 
  • Regulation of plant stem cell quiescence by a brassinosteroid signaling module. 
  • Regulatory Circuits and Bi-directional Signaling between Stem Cells and Their Progeny. 
  • Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. 
  • Requirement of MIP-1 alpha for an inflammatory response to viral infection. 
  • Retinal ganglion cell genesis requires lakritz, a Zebrafish atonal Homolog. 
  • Retroviral gene transduction of circulating progenitor cells in patients with metastatic breast cancer. 
  • Retroviral vector-mediated gene transfer into umbilical cord blood-derived megakaryocyte and platelet progenitors. 
  • Robust control of mitotic spindle orientation in the developing epidermis. 
  • SHP-2 is required for the maintenance of cardiac progenitors. 
  • SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression. 
  • Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. 
  • Signaling the tips: regulation of stem cell function in plants. 
  • Signals from dying hepatocytes trigger growth of liver progenitors. 
  • Single-Cell RNA Sequencing Identifies Yes-Associated Protein 1-Dependent Hepatic Mesothelial Progenitors in Fibrolamellar Carcinoma. 
  • Site-specific silencing of regulatory elements as a mechanism of X inactivation. 
  • Skin-derived precursors differentiate into skeletogenic cell types and contribute to bone repair. 
  • Sonic Hedgehog-induced proliferation requires specific Gα inhibitory proteins. 
  • Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base. 
  • Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells. 
  • Spatial coordination between stem cell activity and cell differentiation in the root meristem. 
  • Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina. 
  • Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract. 
  • Stem Cells in Cardiovascular Diseases: 30,000-Foot View. 
  • Stem cell differentiation indicated by noninvasive photonic characterization and fractal analysis of subcellular architecture. 
  • Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche. 
  • Stem cell research goes underground: the RETINOBLASTOMA-RELATED gene in root development. 
  • Stem cell source and outcome after hematopoietic stem cell transplantation (HSCT) in children and adolescents with acute leukemia. 
  • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. 
  • Stem cells for the ischaemic heart. 
  • Stem cells in the treatment of stroke. 
  • Stem cells of the adult lung: their development and role in homeostasis, regeneration, and disease. 
  • Stem cells, multiorgan failure in radiation emergency medical preparedness: a U.S./European Consultation Workshop. 
  • Stem cells: A tale of two kingdoms. 
  • Stemming Lung Disease? 
  • Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells. 
  • Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. 
  • Summary: present and future challenges for stem cell research. 
  • Surface projections of titanium substrates increase antithrombotic endothelial function in response to shear stress. 
  • Surface protein characterization of human adipose tissue-derived stromal cells. 
  • Sustained release of BMP-2 in a lipid-based microtube vehicle. 
  • Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury. 
  • T cell stemness and dysfunction in tumors are triggered by a common mechanism. 
  • Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells. 
  • Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. 
  • Telomere dysfunction causes alveolar stem cell failure. 
  • Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling. 
  • The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells. 
  • The Amino Acid Sensor Eif2ak4/GCN2 Is Required for Proliferation of Osteoblast Progenitors in Mice. 
  • The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. 
  • The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool. 
  • The biocompatibility of titanium cardiovascular devices seeded with autologous blood-derived endothelial progenitor cells: EPC-seeded antithrombotic Ti implants. 
  • The c-kit proto-oncogene receptor is expressed on a subset of human CD3-CD4-CD8- (triple-negative) thymocytes. 
  • The coenrichment of stem cells, prothymocytes, and stromal elements with ecotropic retrovirus-producing cells from the bone marrow of leukemia-prone AKR mice. 
  • The diversity and plasticity of adult hepatic progenitor cells and their niche. 
  • The effect of aspirin on endothelial progenitor cell biology: preliminary investigation of novel properties. 
  • The effects of smoking on levels of endothelial progenitor cells and microparticles in the blood of healthy volunteers. 
  • The exon junction complex component Magoh controls brain size by regulating neural stem cell division. 
  • The genetic regulation of pigment cell development. 
  • The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells. 
  • The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene. 
  • The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice. 
  • The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. 
  • The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. 
  • The role of biomaterials in stem cell differentiation: applications in the musculoskeletal system. 
  • The significance of microbial cultures of the hematopoietic support for patients receiving high-dose chemotherapy. 
  • The stem cell niche in health and malignancy. 
  • The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. 
  • The β-adrenoceptor agonist isoproterenol rescues acetaminophen-injured livers through increasing progenitor numbers by Wnt in mice. 
  • Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome. 
  • Thymic microenvironment reconstitution after postnatal human thymus transplantation. 
  • Tissue Repair: A Tendon-see to Regenerate. 
  • Tissue engineered bone mimetics to study bone disorders ex vivo: Role of bioinspired materials. 
  • Tissue engraftment of hypoxic-preconditioned adipose-derived stem cells improves flap viability. 
  • Total colony-forming units are a strong, independent predictor of neutrophil and platelet engraftment after unrelated umbilical cord blood transplantation: a single-center analysis of 435 cord blood transplants. 
  • Toward a blueprint for regeneration. 
  • Transcriptional profile of the Arabidopsis root quiescent center. 
  • Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. 
  • Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells. 
  • Transcriptional switches direct plant organ formation and patterning. 
  • Transcriptome analysis of mouse stem cells and early embryos. 
  • Transferrin receptor 1 is differentially required in lymphocyte development. 
  • Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. 
  • Transplantation of multipotent progenitors from the adult olfactory epithelium. 
  • Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice. 
  • Treating cancer with embryonic stem cells: rationale comes from aging studies. 
  • Two distinct origins for Leydig cell progenitors in the fetal testis. 
  • UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans. 
  • Umbilical Cord Blood-Derived Mononuclear Cells Exhibit Pericyte-Like Phenotype and Support Network Formation of Endothelial Progenitor Cells In Vitro. 
  • Underlying potential: cellular and molecular determinants of adult liver repair. 
  • Use of autologous blood-derived endothelial progenitor cells at point-of-care to protect against implant thrombosis in a large animal model. 
  • Use of human gametes obtained from anonymous donors for the production of human embryonic stem cell lines. 
  • Using human neural stem cells to model neurological disease. 
  • Vascular leukocytes contribute to tumor vascularization. 
  • Vertebrate Reproduction. 
  • Viral infection of human progenitor and liver-derived cells encapsulated in three-dimensional PEG-based hydrogel. 
  • What can knockout mice contribute to an understanding of hypertension? 
  • Wnt addiction of genetically defined cancers reversed by PORCN inhibition. 
  • Wnt signaling suppresses MAPK-driven proliferation of intestinal stem cells. 
  • Wnt-signaling in retinal development and disease. 
  • Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies. 
  • Zebrafish kit mutation reveals primary and secondary regulation of melanocyte development during fin stripe regeneration. 
  • Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function. 
  • Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. 
  • [Recent advances in atherothrombotic diseases]. 
  • miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways. 
  • p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner. 
  • β-importin Tnpo-SR promotes germline stem cell maintenance and oocyte differentiation in female Drosophila. 
• 

  Keywords of People

  • Allen, Tyler, Postdoctoral Associate, Duke Cancer Institute
  • Allori, Alexander C, Associate Professor of Surgery, Surgery, Plastic, Maxillofacial, and Oral Surgery
  • Bareja, Akshay, Assistant Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition
  • Bursac, Nenad, Professor of Biomedical Engineering, Biomedical Engineering
  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Kabiri, Zahra, Assistant Professor in Surgery, Pathology
  • Landstrom, Andrew Paul, Associate Professor of Pediatrics, Cell Biology
  • Lee, Chang Lung, Assistant Professor in Radiation Oncology, Pathology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Pomeroy, Jordan, Clinical Associate in the Department of Medicine, Medicine, Cardiology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology
  • Turkington, Timothy Garvey, Associate Professor in Radiology, Radiology
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology