Stereoisomerism

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  Subject Areas on Research

  • 1,2-Difunctionalization of Aryl Triflates: A Direct and Modular Access to Diversely Functionalized Anilines. 
  • 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid is a more potent neutrophil chemoattractant than the 12(R) epimer in the rat cornea. 
  • 2-Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones. 
  • 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. 
  • 5-substituted derivatives of 6-halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with low picomolar affinity for alpha4beta2 nicotinic acetylcholine receptor and wide range of lipophilicity: potential probes for imaging with positron emission tomography. 
  • A Convenient Synthesis of Cis and Trans 4-tert-Butoxycarbonyl-Substituted Cyclohexylglycine 
  • A Diastereodivergent and Enantioselective Approach to syn - and anti -Diamines: Development of 2-Azatrienes for Cu-Catalyzed Reductive Couplings with Imines That Furnish Allylic Amines. 
  • A facile and efficient synthesis of 4-hydroxy-2,6-cis-tetrahydropyrans via tandem cross-metathesis/thermal S(N)2' reaction: protecting-group-free synthesis of (+/-)-diospongin A. 
  • A formal synthesis of SCH 351448. 
  • A general strategy for construction of both 2,6-cis- and 2,6-trans-disubstituted tetrahydropyrans: substrate-controlled asymmetric total synthesis of (+)-scanlonenyne 
  • A meta-analysis of CYP2D6 metabolizer phenotype and metoprolol pharmacokinetics. 
  • A multidisciplinary approach to probing enthalpy-entropy compensation and the interfacial mobility model. 
  • A new synthesis of gamma-lactams based on the reaction of vinyl sulfilimines with dichloroketene. 
  • A stereoselective formal synthesis of leucascandrolide A. 
  • A validated chiral HPLC method for the enantiomeric separation of tolterodine tartarate. 
  • Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A. 
  • Affinity chromatography of human platelet alpha 2-adrenergic receptors. 
  • Affinity chromatography of the beta-adrenergic receptor and characterization of antibodies raised against purified receptor preparations. 
  • Alkenylation of C(sp3 )-H Bonds by Zincation/Copper-Catalyzed Cross-Coupling with Iodonium Salts. 
  • Alpha-adrenergic receptor identification by (3H)dihydroergocryptine binding. 
  • Alternative explanation for the apparent "two-step" binding kinetics of high-affinity racemic antagonist radioligands. 
  • Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase. 
  • Amitifadine, a triple reuptake inhibitor, reduces self-administration of the opiate remifentanil in rats. 
  • An efficient synthesis of fluorinated azaheterocycles by aminocyclization of alkenes. 
  • Anthrabenzoxocinones from Streptomyces sp. as liver X receptor ligands and antibacterial agents. 
  • Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors. 
  • Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity. 
  • Anti-AIDS agents. 15. Synthesis and anti-HIV activity of dihydroseselins and related analogs. 
  • Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands. 
  • Anticonvulsant-like actions of baclofen in the rat hippocampal slice. 
  • Antitumor agents, 135. Structure and stereochemistry of polacandrin, a new cytotoxic triterpene from Polanisia dodecandra. 
  • Antitumor agents. 190. Absolute stereochemistry of the cytotoxic germacranolides, tomenphantins A and B, from Elephantopus tomentosus. 
  • Are fluoxetine plasma levels related to outcome in obsessive-compulsive disorder? 
  • Asymmetric total synthesis of ent-(-)-roseophilin: assignment of absolute configuration. 
  • Atomic contributions to the optical rotation angle as a quantitative probe of molecular chirality. 
  • Augmentation of human monocyte chemotactic response by levamisole. 
  • Baclofen has a proepileptic effect in the rat dentate gyrus. 
  • Barbiturate effects on acetylcholine-activated channels in Aplysia neurons. 
  • Barbiturate-induced alterations in the kinetic parameters of slow outward current in Aplysia giant neurons. 
  • Binding of [3H](+)-BW373U86 to delta-opioid receptors in rat brain membranes. 
  • Biochemistry of amino acid racemization and clinical application to musculoskeletal disease. 
  • Bioequivalence of two tablet formulations of nadolol using single and multiple dose data: assessment using stereospecific and nonstereospecific assays. 
  • Biomimetic Hydrogels with Immobilized EphrinA1 for Therapeutic Angiogenesis 
  • Brush border enzyme-cleavable linkers: Evaluation for reducing renal uptake of radiolabeled prostate-specific membrane antigen inhibitors. 
  • CE coupling with end-column electrochemiluminescence detection for chiral separation of disopyramide. 
  • Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity. 
  • Catalytic Enantio- and Diastereoselective Cyclopropanation of 2-Azadienes for the Synthesis of Aminocyclopropanes Bearing Quaternary Carbon Stereogenic Centers. 
  • Catalytic enantioselective olefin metathesis in natural product synthesis. Chiral metal-based complexes that deliver high enantioselectivity and more. 
  • Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites. 
  • Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs. 
  • Characterization and crystal structure of Escherichia coli KDPGal aldolase. 
  • Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide. 
  • Chiral action at a distance: remote substituent effects on the optical activity of calyculins A and B. 
  • Chiral control of current transfer in molecules. 
  • Chiral polyoxometalate-induced enantiomerically 3D architectures: a new route for synthesis of high-dimensional chiral compounds. 
  • Chirality affects aggregation kinetics of single-walled carbon nanotubes. 
  • Cis- and trans-acting ribozymes from a human pathogen, hepatitis delta virus. 
  • Cocaine directly augments the alpha-adrenergic contractile response of the pregnant rabbit uterus. 
  • Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition. 
  • Comparison of specificity of agonist and antagonist radioligand binding to beta adrenergic receptors. 
  • Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering. 
  • Conformational Analysis and Molecular Modeling of 1-Phenyl-, 4-Phenyl-, and 1-Benzyl-1,2,3,4-tetrahydroiso-quinolines as D1 Dopamine Receptor Ligands 
  • Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. 
  • Conformational studies of dithymidine boranomonophosphate diastereoisomers. 
  • Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. 
  • Copper-Catalyzed 1,2-Aminocyanation of Unactivated Alkenes via Cyano Migration. 
  • Copper-catalyzed α-amination of phosphonates and phosphine oxides: a direct approach to α-amino phosphonic acids and derivatives. 
  • Copper-mediated amidation of heterocyclic and aromatic C-H bonds. 
  • Crystal structures of the membrane-binding C2 domain of human coagulation factor V. 
  • Crystallization of the purine salvage enzyme adenine phosphoribosyltransferase. 
  • Cyclization/hydrosilylation of functionalized 1,6-diynes catalyzed by cationic platinum complexes containing bidentate nitrogen ligands. 
  • Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria. 
  • Design and stereoselective preparation of a new class of chiral olefin metathesis catalysts and application to enantioselective synthesis of quebrachamine: catalyst development inspired by natural product synthesis. 
  • Design and synthesis of human immunodeficiency virus entry inhibitors: sulfonamide as an isostere for the alpha-ketoamide group. 
  • Design and synthesis of manganese porphyrins with tailored lipophilicity: investigation of redox properties and superoxide dismutase activity. 
  • Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity. 
  • Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates. 
  • Determining absolute configuration in flexible molecules: a case study. 
  • Differences in Methadone Metabolism by CYP2B6 Variants. 
  • Differences in the Antinociceptive Effects and Binding Properties of Propranolol and Bupranolol Enantiomers. 
  • Differences in the absorption, metabolism and biliary excretion of a diastereomeric pair of alphavbeta3-antagonists in rat: limited role of P-glycoprotein. 
  • Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides. 
  • Direct studies of beta-adrenergic receptors intact frog erythrocytes. 
  • Dissecting the differences between the alpha and beta anomers of the oxidative DNA lesion FaPydG. 
  • Dual hepatic metabolism of cerivastatin--clarifications. 
  • Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry. 
  • Effects of baclofen on synaptically-induced cell firing in the rat hippocampal slice. 
  • Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes. 
  • Enantiomeric metabolic interactions and stereoselective human methadone metabolism. 
  • Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. 
  • Enantiomeric separation of an aryloxyphenoxypropanoic acid by CE and LC. 
  • Enantioselective Intermolecular Addition of Aliphatic Amines to Acyclic Dienes with a Pd-PHOX Catalyst. 
  • Enantioselective Intermolecular Pd-Catalyzed Hydroalkylation of Acyclic 1,3-Dienes with Activated Pronucleophiles. 
  • Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines. 
  • Enantioselective cyclization/hydrosilylation of 1,6-enynes catalyzed by a cationic rhodium bis(phosphine) complex. 
  • Enantioselective determination of methylphenidate and ritalinic acid in whole blood from forensic cases using automated solid-phase extraction and liquid chromatography-tandem mass spectrometry. 
  • Enantioselective diene Cyclization/Hydrosilylation catalyzed by optically active palladium bisoxazoline and pyridine-oxazoline complexes. 
  • Enantioselective synthesis of P-stereogenic phosphinates and phosphine oxides by molybdenum-catalyzed asymmetric ring-closing metathesis. 
  • Enantioselective synthesis of cyclic enol ethers and all-carbon quaternary stereogenic centers through catalytic asymmetric ring-closing metathesis. 
  • Evaluation of Trials Comparing Single-Enantiomer Drugs to Their Racemic Precursors: A Systematic Review. 
  • Exceptionally potent antispermatogenic compounds from 8-halogenation of (4aRS,5SR,9bRS)-hexahydroindeno-[1,2-c]pyridines. 
  • Fatty acid synthase: elementary steps in catalysis and regulation. 
  • First synthesis and structural elucidation of (-)-presphaerene. 
  • Formal Synthesis of (+)-Laurencin by Gold(I)-Catalyzed Intramolecular Dehydrative Alkoxylation. 
  • Glutathionylated 4-hydroxy-2-(E)-alkenal enantiomers in rat organs and their contributions toward the disposal of 4-hydroxy-2-(E)-nonenal in rat liver. 
  • Gold(I)-catalyzed amination of allylic alcohols with cyclic ureas and related nucleophiles. 
  • Gold(I)-catalyzed enantioselective hydroamination of N-allenyl carbamates. 
  • Gold(I)-catalyzed enantioselective intramolecular dehydrative amination of allylic alcohols with carbamates. 
  • Gold(I)-catalyzed intramolecular amination of allylic alcohols with alkylamines. 
  • Gold(I)-catalyzed intramolecular dihydroamination of allenes with N,N'-disubstituted ureas to form bicyclic imidazolidin-2-ones. 
  • Gold(I)-catalyzed intramolecular enantioselective hydroalkoxylation of allenes. 
  • Gold(I)-catalyzed intramolecular enantioselective hydroarylation of allenes with indoles. 
  • Gold(I)-catalyzed stereoconvergent, intermolecular enantioselective hydroamination of allenes. 
  • Guest exchange in an encapsulation complex: a supramolecular substitution reaction. 
  • Highly efficient molybdenum-based catalysts for enantioselective alkene metathesis. 
  • Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function. 
  • Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. 
  • Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury. 
  • IMDA/aldol strategy for transforming carbohydrates into functionalized trans-decalins. 
  • Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal. 
  • Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists. 
  • Ifosfamide enantiomers: pharmacokinetics in children. 
  • Immunoassay of racemic drugs: a problem of enantioselective antisera and a solution. 
  • Intermolecular Hydroamination of Ethylene and 1-Alkenes with Cyclic Ureas Catalyzed by Achiral and Chiral Gold(I) Complexes 
  • Intermolecular hydroamination of allenes with N-unsubstituted carbamates catalyzed by a gold(I) N-heterocyclic carbene complex. 
  • Introduction of the alpha-P-borano-group into deoxynucleoside triphosphates increases their selectivity to HIV-1 reverse transcriptase relative to DNA polymerases. 
  • Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries. 
  • Isolated beta-adrenergic binding sites: a potential assay vehicle for catecholamines. 
  • Isolation, structure, absolute stereochemistry, and HIV-1 integrase inhibitory activity of integrasone, a novel fungal polyketide. 
  • Isolation, structure, and HIV-1 integrase inhibitory activity of Cytosporic acid, a fungal metabolite produced by a Cytospora sp. 
  • Isomer-Selective Detection of Hydrogen-Bond Vibrations in the Protonated Water Hexamer 
  • Ketamine as a probe for medetomidine stereoisomer inhibition of human liver microsomal drug metabolism. 
  • L-glucosylceramide: synthesis, properties, and resistance to catabolism by glucocerebrosidase in vitro. 
  • Like night and day: rods and cones have different pigment regeneration pathways. 
  • Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins. 
  • Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance. 
  • Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities. 
  • Medicare Part D Spending on Single-Enantiomer Drugs Versus Their Racemic Precursors. 
  • Metabolism of benzo[a]pyrene by cultured tracheobronchial tissues from mice, rats, hamsters, bovines and humans. 
  • Metabolism of ketamine stereoisomers by human liver microsomes. 
  • Metabolite gene regulation: imidazole and imidazole derivatives which circumvent cyclic adenosine 3',5'-monophosphate in induction of the Escherichia coli L-arabinose operon. 
  • Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6. 
  • Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells. 
  • Multiplex-PCR-based recombination as a novel high-fidelity method for directed evolution. 
  • N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents. 
  • N-Heterocyclic carbene catalyzed oxidative macrolactonization: total synthesis of (+)-dactylolide. 
  • N-Succinimidyl guanidinomethyl iodobenzoate protein radiohalogenation agents: influence of isomeric substitution on radiolabeling and target cell residualization. 
  • Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys. 
  • Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes. 
  • Novel 3',5'-cyclic nucleotide analogue: adenosine 3',5'-cyclic boranomonophosphate. 
  • Novel biologically active nonpeptidic inhibitors of myristoylCoA:protein N-myristoyltransferase. 
  • Nucleophilic addition of organozinc reagents to 2-sulfonyl cyclic ethers: stereoselective synthesis of manassantins A and B. 
  • Optical characterizations and electronic devices of nearly pure (10,5) single-walled carbon nanotubes. 
  • Optical rotation of noncovalent aggregates. 
  • Optical signatures of molecular dissymmetry: combining theory with experiments to address stereochemical puzzles. 
  • Phospholipid-protein adducts of lipid peroxidation: synthesis and study of new biotinylated phosphatidylcholines. 
  • Photocontrolled micellar aggregation of amphiphilic DNA-azobenzene conjugates. 
  • Platensimycin and platencin congeners from Streptomyces platensis. 
  • Platinum(II)-catalyzed intermolecular hydroamination of monosubstituted allenes with secondary alkylamines. 
  • Platinum(II)-catalyzed intermolecular hydroarylation of unactivated alkenes with indoles. 
  • Preparation of Chiral Allenes through Pd-Catalyzed Intermolecular Hydroamination of Conjugated Enynes: Enantioselective Synthesis Enabled by Catalyst Design. 
  • Radioiodination via D-amino acid peptide enhances cellular retention and tumor xenograft targeting of an internalizing anti-epidermal growth factor receptor variant III monoclonal antibody. 
  • Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor. 
  • Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication. 
  • Rapid stereoselective access to key pumiliotoxin precursors from a common intermediate. 
  • Recent developments in enantioselective gold(I) catalysis. 
  • Regio- and stereoselective synthesis of alkyl allylic ethers via gold(I)-catalyzed intermolecular hydroalkoxylation of allenes with alcohols. 
  • Regulation of adenylate cyclase coupled beta-adrenergic receptors. 
  • Review of the use of mirtazapine in the treatment of depression. 
  • Rh(I)-catalyzed ring opening of an IMDAF-derived oxabicyclo cycloadduct as the key step in the synthesis of (+/-)-epi-zephyranthine. 
  • Robust IR-based detection of stable and fractionally populated G-C+ and A-T Hoogsteen base pairs in duplex DNA. 
  • Role of CYP2B6 in stereoselective human methadone metabolism. 
  • Specific binding of -adrenergic catecholamines to a subcellular fraction from cardiac muscle. 
  • Stereochemical aspects of itraconazole metabolism in vitro and in vivo. 
  • Stereochemical course of nucleotidyl transfer catalyzed by bacteriophage T7 induced DNA polymerase. 
  • Stereochemical recognition of doubly functional aminotransferase in 2-deoxystreptamine biosynthesis. 
  • Stereochemistry and mechanism of the Brønsted acid catalyzed intramolecular hydrofunctionalization of an unactivated cyclic alkene. 
  • Stereochemistry of the reactions catalyzed by chicken liver fatty acid synthase. 
  • Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation. 
  • Stereocontrolled synthesis of cis-dibenzoquinolizine chlorofumarates: curare-like agents of ultrashort duration. 
  • Stereoselective Bupropion Hydroxylation by Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase Genetic Variants. 
  • Stereoselective Ketamine Metabolism by Genetic Variants of Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase. 
  • Stereoselective Steady-State Disposition and Bioequivalence of Brand and Generic Bupropion in Adults. 
  • Stereoselective analysis of bupropion and hydroxybupropion in human plasma and urine by LC/MS/MS. 
  • Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity. 
  • Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes. 
  • Stereoselective metabolism of enflurane by human liver cytochrome P450 2E1. 
  • Stereoselective synthesis and osteogenic activity of subglutinols A and B 
  • Stereoselective synthesis of 2,6-cis- and 2,6-trans-piperidines through organocatalytic aza-Michael reactions: a facile synthesis of (+)-myrtine and (-)-epimyrtine. 
  • Stereoselective synthesis of 2,6-cis-tetrahydropyrans through a tandem allylic oxidation/oxa-Michael reaction promoted by the gem-disubstituent effect: synthesis of (+)-neopeltolide macrolactone. 
  • Stereoselective synthesis of 2,6-trans-tetrahydropyran via primary diamine-catalyzed oxa-conjugate addition reaction of α,β-unsaturated ketone: total synthesis of psymberin. 
  • Stereoselective synthesis of tetrahydrofuran lignans via BF(3) x OEt(2)-promoted reductive deoxygenation/epimerization of cyclic hemiketal: synthesis of (-)-odoratisol C, (-)-futokadsurin A, (-)-veraguensin, (+)-fragransin A(2), (+)-galbelgin, and (+)-talaumidin. 
  • Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase. 
  • Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl] [[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leukotriene D4 receptor antagonist. 
  • Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase. 
  • Stereospecificity of monoacylglycerol acyltransferase activity from rat intestine and suckling rat liver. 
  • Steric factors moderate conformational fluidity and contribute to the high proton sensitivity of Root effect hemoglobins. 
  • Structural and pH dependence of excited state PCET reactions involving reductive quenching of the MLCT excited state of [RuII(bpy)2(bpz)]2+ by hydroquinones. 
  • Structural characteristics for inhibition of [3H] norepinephrine uptake into rat brain synaptic vesicles by beta-carboline, indolealkylamine, phenethylamine and n-alkylamine derivatives. 
  • Structure-activity studies of 2,3,4,4a,5,9b-hexahydroindeno[1,2-c]pyridines as antispermatogenic agents for male contraception. 
  • Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. 
  • Synthesis and NK(1)/NK(2) binding activities of a series of diacyl-substituted 2-arylpiperazines. 
  • Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. 
  • Synthesis and pharmacological evaluation of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for a novel receptor with sigma-like neuromodulatory activity. 
  • Synthesis and receptor affinities of some conformationally restricted analogues of the dopamine D1 selective ligand (5R)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl- 1H-3-benzazepin-7-ol. 
  • Synthesis and separation of diastereomers of uridine 2',3'-cyclic boranophosphate. 
  • Synthesis and structure-activity relationship of a novel series of aminoalkylindoles with potential for imaging the neuronal cannabinoid receptor by positron emission tomography. 
  • Synthesis of C3 heteroatom-substituted azetidinones that display potent cholesterol absorption inhibitory activity. 
  • Synthesis of Hsp90 dimerization modulators. 
  • Synthesis of ortho-haloaminoarenes by aryne insertion of nitrogen-halide bonds. 
  • Synthesis of prodrug candidates: conjugates of amino acid with nucleoside boranophosphate. 
  • Synthesis of ultra-short-acting neuromuscular blocker GW 0430: a remarkably stereo- and regioselective synthesis of mixed tetrahydroisoquinolinium chlorofumarates. 
  • Synthetic and model computational studies of molar rotation additivity for interacting chiral centers: a reinvestigation of van't Hoff's principle. 
  • Synthetic efforts towards the stereoselective synthesis of NF00659B₁ . 
  • Synthetic peptide inhibitors of prorenin activation. 
  • Systematic assignment of the configuration of flexible natural products by spectroscopic and computational methods: the bistramide C analysis. 
  • The Efficacy and Safety of Evekeo, Racemic Amphetamine Sulfate, for Treatment of Attention-Deficit/Hyperactivity Disorder Symptoms: A Multicenter, Dose-Optimized, Double-Blind, Randomized, Placebo-Controlled Crossover Laboratory Classroom Study. 
  • The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity. 
  • The chiroptical signature of achiral metal clusters induced by dissymmetric adsorbates. 
  • The effect of a single boranophosphate substitution with defined configuration on the thermal stability and conformation of a DNA duplex. 
  • The glutamate transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate indirectly evokes NMDA receptor mediated neurotoxicity in rat cortical cultures. 
  • The natural diterpene tonantzitlolone A and its synthetic enantiomer inhibit cell proliferation and kinesin-5 function. 
  • The non-covalent interaction of pyrrolo[2, 1-c] [1, 4]benzodiazepine-5, 11-diones with DNA. 
  • The preparation of stereospecific tritium-labeled reduced nicotinamide adenine dinucleotide phosphate. 
  • The regio- and stereospecific intermolecular dehydrative alkoxylation of allylic alcohols catalyzed by a gold(I) N-heterocyclic carbene complex. 
  • The resolution, isolation, and pharmacological characterization of the enantiomers of a benzamide containing a chiral sulfoxide. 
  • The role of protein kinase C in laminin-mediated neurite outgrowth. 
  • The significance of degenerate processes to enantioselective olefin metathesis reactions promoted by stereogenic-at-Mo complexes. 
  • Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid. 
  • Too Small, Too Big, and Just Right – Optical Sensing of Molecular Conformations in Self-assembled Capsules 
  • Total syntheses of (-)-haemanthidine, (+)-pretazettine, and (+)-tazettine. 
  • Total synthesis of himandravine. 
  • Total synthesis, assignment of the absolute stereochemistry, and structure-activity relationship studies of subglutinols A and B. 
  • Towards Raman optical activity calculations of large molecules. 
  • Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium. 
  • Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases. 
  • Variable temperature infrared spectroscopy of cytosine-guanine base pairs: tautomerism versus polarization. 
  • Warfarin enantiomer disposition: determination by stereoselective radioimmunoassay. 
  • [A new quality of the therapy of anxiety and depression--escitalopram]. 
  • [Chiral separation of enantiomers of pazufloxacin by capillary electrophoresis]. 
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  Keywords of People

  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Cell Biology
  • Middleton, John Paul, Professor of Medicine, Medicine, Nephrology