
Subject Areas on Research

A Notch positive feedback in the intestinal stem cell niche is essential for stem cell selfrenewal.

A duality in aging: the equivalence of mortality models based on radically different concepts.

A genetic stochastic process model for genomewide joint analysis of biomarker dynamics and disease susceptibility with longitudinal data.

A mathematical model of the physiological dynamics of aging and correlated mortality selection. I. Theoretical development and critiques.

A method for modifying the image quality parameters of digital radiographic images.

A model for migratory B cell oscillations from receptor downregulation induced by external chemokine fields.

A model of accelerated aging induced by 5bromodeoxyuridine.

A model of variability in brain stimulation evoked responses.

A neuron model of stochastic resonance using rectangular pulse trains.

A populationbased model of respiratory cancer incidence, progression, diagnosis, treatment, and mortality.

A proportional hazards model for incidence and induced remission of disease.

A randomwalk model of human mortality and aging.

A simulation environment for directional sensing as a phase separation process.

A stochastic biomechanical model for risk and risk factors of noncontact anterior cruciate ligament injuries.

A stochastic compartment model of stomach cancer with correlated waiting time distributions.

A stochastic compartment model representation of chronic disease dependence: techniques for evaluating parameters of partially unobserved age inhomogeneous stochastic processes.

A stochastic evolutionary model for protein structure alignment and phylogeny.

A timedependent statistical model which relates current clinical status to prognosis: application to advanced prostatic cancer.

Active life expectancy estimates for the U.S. elderly population: a multidimensional continuousmixture model of functional change applied to completed cohorts, 19821996.

Addressing biological uncertainties in engineering gene circuits.

Application of singular value decomposition to the analysis of timeresolved macromolecular xray data.

BayFish: Bayesian inference of transcription dynamics from population snapshots of singlemolecule RNA FISH in single cells.

Bayesian analysis of mixtures applied to postsynaptic potential fluctuations.

Bayesian estimation of survival functions under stochastic precedence.

Bayesian hierarchically weighted finite mixture models for samples of distributions.

Bayesian learning from marginal data in bionetwork models.

Bayesian modeling of multiple lesion onset and growth from intervalcensored data.

Bayesian models for multivariate current status data with informative censoring.

Bayesian variable selection for latent class models.

Benchmarking of dynamic Bayesian networks inferred from stochastic timeseries data.

Beyond intuitive modeling: combining biophysical models with innovative experiments to move the circadian clock field forward.

Bioactuarial models of national mortality time series data.

Changes in assembly processes in soil bacterial communities following a wildfire disturbance.

Cohort changes in active life expectancy in the U.S. elderly population: experience from the 19822004 National LongTerm Care Survey.

Compartment model approach to the estimation of tumor incidence and growth: investigation of a model of cancer latency.

Competition and species packing in patchy environments.

Computation of steadystate probability distributions in stochastic models of cellular networks.

Considerations for the implementation of target volume protocols in radiation therapy: in regard to Craig et al., IJROBP 2001;49:241250.

Correctly estimating how environmental stochasticity influences fitness and population growth.

Cortical granule exocytosis is triggered by different thresholds of calcium during fertilisation in sea urchin eggs.

Cortical mechanisms for the segregation and representation of acoustic textures.

Decreases in average bacterial community rRNA operon copy number during succession.

Demographic compensation and tipping points in climateinduced range shifts.

Demography in an increasingly variable world.

Dependent competing risks: a stochastic process model.

Detection of hormesis effect in longevity: simulation approach for heterogeneous population.

Diffusionlimited phase separation in eukaryotic chemotaxis.

Dosimetry and microdosimetry of targeted radiotherapy.

Dynamic paradigms for human mortality and aging.

Ecological forecasts: an emerging imperative.

Envelope control of outer membrane vesicle production in Gramnegative bacteria.

Estimating incrementdecrement life tables with multiple covariates from panel data: the case of active life expectancy.

Estimation of cell survival in tumours heated to nonuniform temperature distributions.

Evolution of dispersal distance.

Evolutionary dynamics of selfincompatibility alleles in Brassica.

Evolutionary dynamics of tumor progression with random fitness values.

Exceptional survivors have lower age trajectories of blood glucose: lessons from longitudinal data.

Feedback control of Tcell receptor activation.

Financial Forecasting and Stochastic Modeling: Predicting the Impact of Business Decisions.

Fitting Nonlinear Ordinary Differential Equation Models with Random Effects and Unknown Initial Conditions Using the Stochastic Approximation ExpectationMaximization (SAEM) Algorithm.

Forecasting health: data needs and implications for model structure.

From subthreshold to firingrate resonance.

Fuzzy set analyses of genetic determinants of health and disability status.

Genetic model for longitudinal studies of aging, health, and longevity and its potential application to incomplete data.

Genome organization and three kinds of heritable changes: general description and stochastic factors (a review).

HIV evolutionary genetics.

HPV clearance and the neglected role of stochasticity.

Hormesis and debilitation effects in stress experiments using the nematode worm Caenorhabditis elegans: the model of balance between cell damage and HSP levels.

Increases in air temperature can promote winddriven dispersal and spread of plants.

Independent sources of quantal variability at single glutamatergic synapses.

Individualbased chaos: extensions of the discrete logistic model.

Inference for nonlinear epidemiological models using genealogies and time series.

Informed consent in human research: what to say and how to say it.

Inhibiting clathrinmediated endocytosis of the leucinerich G proteincoupled receptor5 diminishes cell fitness.

Intercomparison of methods for image quality characterization. II. Noise power spectrum.

Joint analysis of stochastic processes with application to smoking patterns and insomnia.

Joint modeling of DNA sequence and physical properties to improve eukaryotic promoter recognition.

Local frequency dependence and global coexistence.

Logarithmic amplifier for computed tomography tasks using fluoroscopic projections.

Longevity can buffer plant and animal populations against changing climatic variability.

Longitudinal analysis of the dynamics and risk of coronary heart disease in the Framingham Study.

Lotka's game in predatorprey theory: linking populations to individuals.

Low demographic variability in wild primate populations: fitness impacts of variation, covariation, and serial correlation in vital rates.

Lowdimensional chaos in bipolar disorder?

Managing the impact of invasive species: the value of knowing the densityimpact curve.

Maximum likelihood estimation of a stochastic compartment model of cancer latency: lung cancer mortality among white females in the U.S.

Modeling biological systems using Dyneticaa simulator of dynamic networks.

Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts.

Modeling hematopoietic system response caused by chronic exposure to ionizing radiation.

Modeling the axial extension of a transmission line source within iterative reconstruction via multiple transmission sources.

Modeling the effects of biologically incorporated radionuclides and chronic lowdose ionizing radiation exposure on both cancer and chronic noncancer diseases.

Models for forecasting chronic disease processes in adult and elderly populations: effects of stochasticity.

Models of the interaction of mortality and the evolution of risk factor distribution: a general stochastic process formulation.

Mortality and aging in a heterogeneous population: a stochastic process model with observed and unobserved variables.

New stochastic carcinogenesis model with covariates: an approach involving intracellular barrier mechanisms.

Noise reduction by diffusional dissipation in a minimal quorum sensing motif.

Nonneutral vegetation dynamics.

Nonlinear feedforward networks with stochastic outputs: infomax implies redundancy reduction.

On the estimation of the binomial probability in multistage clinical trials.

Optimal timing of implantable cardioverterdefibrillator implantation after myocardial infarction: a decision analysis.

Pvalue calculation for multistage phase II cancer clinical trials.

Phasic ion channel blockade. A kinetic model and parameter estimation procedure.

Phylodynamic inference for structured epidemiological models.

Platelets: a multiscale approach for recovering edges and surfaces in photonlimited medical imaging.

Population models for the health effects of ionizing radiation.

Posttranslational regulation enables robust p53 regulation.

Precision of neural timing: effects of convergence and timewindowing.

Predetermination of sexual fate in a turtle with temperaturedependent sex determination.

Predicted and inferred waiting times for key mutations in the germinal centre reaction: evidence for stochasticity in selection.

Predicting auditory toneinnoise detection performance: the effects of neural variability.

Predicting dynamic range and intensity discrimination for electrical pulsetrain stimuli using a stochastic auditory nerve model: the effects of stimulus noise.

Predicting the threshold of pulsetrain electrical stimuli using a stochastic auditory nerve model: the effects of stimulus noise.

Predicting the threshold of singlepulse electrical stimuli using a stochastic auditory nerve model: the effects of noise.

Predictions of psychophysical measurements for sinusoidal amplitude modulated (SAM) pulsetrain stimuli from a stochastic model.

Propagation of fluctuations in biochemical systems, I: linear SSC networks.

Properties of quantal transmission at CA1 synapses.

Pseudospontaneous activity: stochastic independence of auditory nerve fibers with electrical stimulation.

Psychophysical threshold variability in cochlear implant subjects.

Reconstructing population exposures to environmental chemicals from biomarkers: challenges and opportunities.

Reconstruction of porous material geometry by stochastic optimization based on bulk NMR measurements of the dipolar field.

Reduction of singleneuron firing uncertainty by cortical ensembles during motor skill learning.

Relative inefficiencies in production between solo and group practice physicians.

Reproduction and survival in Mediterranean fruit flies: a "protein and energy" free radical model of aging.

Reproductive uncertainty and the relative competitiveness of simultaneous hermaphroditism versus dioecy.

Resolving the biodiversity paradox.

Robustness and dissipation of mitogenactivated protein kinases signal transduction network: underlying funneled landscape against stochastic fluctuations.

Role of DNA binding sites and slow unbinding kinetics in titrationbased oscillators.

Sensitivity of the population growth rate to demographic variability within and between phases of the disturbance cycle.

Shifting patterns: malaria dynamics and rainfall variability in an African highland.

Slow stochastic Hebbian learning of classes of stimuli in a recurrent neural network.

Soil water balance and ecosystem response to climate change.

Spatial Measures of Genetic Heterogeneity During Carcinogenesis.

Spatial Moran models, II: cancer initiation in spatially structured tissue.

Spatial and temporal integration of visual motion signals for smooth pursuit eye movements in monkeys.

Spatial aspects of interspecific competition.

Stability of forest biodiversity.

Steering most probable escape paths by varying relative noise intensities.

Stochastic E2F activation and reconciliation of phenomenological cellcycle models.

Stochastic facilitation of artificial tactile sensation in primates.

Stochastic hyperelastic constitutive laws and identification procedure for soft biological tissues with intrinsic variability.

Stochastic model for analysis of longitudinal data on aging and mortality.

Stochastic noise characteristics in matrix inversion tomosynthesis (MITS).

Stochastic pairing of heavychain and kappa lightchain variable gene families occurs in polyclonally activated B cells.

Stochastic segment models of eukaryotic promoter regions.

Stochastic sensitivity analysis and kernel inference via distributional data.

Stochastic voyages into uncharted chemical space produce a representative library of all possible druglike compounds.

Stochastic vs. deterministic modeling of intracellular viral kinetics.

Stochastically ordered multiple regression.

Stochasticity in transcriptional regulation: origins, consequences, and mathematical representations.

Strategies for analysing ecological health data: models of the biological risk of individuals.

Strategies of a Bornean tropical rainforest water use as a function of rainfall regime: isohydric or anisohydric?

Strategy to discover diverse optimal molecules in the small molecule universe.

Surfacetosurface bridges formed by reversibly assembled polymers.

The Lagrangian stochastic model for estimating footprint and water vapor fluxes over inhomogeneous surfaces.

The effect of averaging adjacent planes for artifact reduction in matrix inversion tomosynthesis.

The effects of health histories on stochastic process models of aging and mortality.

The effects of host contact network structure on pathogen diversity and strain structure.

The effects of molecular noise and size control on variability in the budding yeast cell cycle.

The evolution of parasite manipulation of host dispersal.

The propagation of uncertainty in human mortality processes operating in stochastic environments.

The statistics of repeating patterns of cortical activity can be reproduced by a model network of stochastic binary neurons.

Tree Topology Estimation.

Twolevel stochastic search variable selection in GLMs with missing predictors.

Ultralow dose of Mycobacterium tuberculosis aerosol creates partial infection in mice.

Variation in stochastic demography between and within central and peripheral regions in a widespread shortlived herb.

Vegetation engineers marsh morphology through multiple competing stable states.

stpm: an R package for stochastic process model.

Keywords of People

Alberts, Susan C.,
Robert F. Durden Professor of Biology,
Duke Science & Society

Badea, Cristian Tudorel,
Professor in Radiology,
Biomedical Engineering

Beratan, David N.,
R.J. Reynolds Professor of Chemistry,
Duke University Energy Initiative

Bradford, William Dalton,
Professor of Pathology,
Pathology

Huettel, Lisa Gresham,
Professor of the Practice in the Department of Electrical and Computer Engineering,
Electrical and Computer Engineering

Kelsoe, Garnett H.,
James B. Duke Professor of Immunology,
Immunology

Marani, Marco,
Adjunct Professor,
Civil and Environmental Engineering

Mattingly, Jonathan Christopher,
Professor of Mathematics,
Mathematics

Pizer, Billy,
Professor in the Sanford School of Public Policy,
Duke Science & Society

Starmer, Charles Franklin,
Professor Emeritus of Computer Science,
Computer Science

Tornai, Martin Paul,
Associate Professor of Radiology,
Radiology

Trivedi, Kishor S.,
Hudson Professor of Electrical and Computer Engineering,
Electrical and Computer Engineering